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1 BI Biomedicine International 2013; 4:. REVIEW The Diaphragma Sellae: A Concise Review Mohammadali M. Shoja 1, 2, Koichi Watanabe 1, Marios Loukas 3, Elias Rizk 1, R. Shane Tubbs 1 1 Pediatric Neurosurgery, Children s Hospital, Birmingham, AL, USA 2 Medical Philosophy and History Research Center, Tabriz University of Medical Sciences, Tabriz, Iran 3 Department of Anatomical Sciences, St. George s University, Grenada ABSTRACT The diaphragma sellae may be involved in pathology at the skull base. Therefore, a clear understanding of its anatomy and variations is important for surgeons who operate the skull base and radiologists who interpret imaging of the sellar region. The present paper reviews the anatomy and relation to disease of the diaphragma sellae. Biomed. Int. 2013; 4: Biomedicine International, Inc. Key words: anatomy, cavernous sinus, neurosurgery, pituitary gland, skull base INTRODUCTION The diaphragma sellae (DS) is a small horizontal duplicated dural fold that makes the roof of the sellae turcica and is formed by the anterior extension of the tentorium cerebelli and regional parasellar dura. 1,2 Some have referred to it as the so-called tentorium or operculum of the hypophysis. 3 The DS is attached anteriorly to the tuberculum sellae and posteriorly to the dorsum sellae (Figure 1). Laterally, it tends to be thicker and wider, and connects to the anterior and posterior clinoid processes. 4 Centrally, the DS has a central opening (diaphragmatic foramen) for the pituitary stalk. 4 Along its anterior and posterior margins runs the anterior and posterior intercavernous sinus, respectively, that may become confluent resulting in the formation of the so-called circular sinus. An infradiaphragmatic cistern is sometimes present. 5 The DS is usually concave upward or flat 6 and slopes downward toward the sellae. 2 The widths of the dural portion of the DS are approximately 4.5 mm laterally and 1.5 anteriorly or posteriorly. 7 The opening of DS is round in 54% of specimens and is in the form of a transverse oval in 46% of individuals. 6 The defect in the DS for the pituitary stalk may enlarge with age. 4 Bergland et al. 8 observed that the defect for the stalk is often less than 5 mm in diameter, with only 39% of the specimens measuring greater than 5 mm. Won et al. 9 found that the average horizontal and vertical diameters of the DS opening to be 7.9 and 7.6 mm, respectively. The diaphragmatic opening can be large (Figure 1) especially in women who have had several children as the result of intermittent swelling of the pituitary gland. 10 Campero et al. 7 classified DS based on its opening as Group A with an opening diameter of less than 4 mm (20% of specimens), Group B with an opening diameter of 4 to Address correspondence to R. Shane Tubbs, PhD, Pediatric Neurosurgery, Children s Hospital, th Avenue South ACC 400, Birmingham, Alabama 35233, USA. Phone: Fax: Shane.Tubbs@childrensal.org Submitted on January 17, 2013; accepted February 14, For online access, see
2 BIOMED INT (2013) 4:40 44 / THE DIAPHRAGMA SELLAE 8 mm (40% of specimens), and Group C with an opening greater than 8 mm (40% of specimens). Busch 11 has yet presented another classification for the DS composed of three types; a type in which DS has a small opening for the pituitary stalk (41.9%) (Figure 2), an incomplete DS with an opening for the stalk of less than 3 mm (37.6%) and a DS represented by a very thin rim of tissue of less than 2 mm (20.5%). These data imply that the DS has a considerable variation among individuals. The DS may be visible as an elongated line on lateral radiographs of the head. 12 Figure 1: Cadaveric skull base with a very large diagphragma sellae. Figure 2: Cadaveric skull base with a very small diaphragma sellae. The superior hypophyseal arteries pass through the DSD. 12 Lee et al. 13 found that the blood supply to the DS may also arise from the inferior hypophyseal artery, a branch of the meningohypophyseal trunk, and/or directly from the cavernous portion of the internal P a g e 41
3 TUBBS ET AL. / BIOMED INT (2013) 4:40 44 carotid artery through the inferior and anterior capsular arteries. Lang found that the superior hypophyseal arteries often pass through the DS in route to the anterior lobe of the pituitary gland and sometimes penetrate it. 4 The sensory innervation to the DS is provided by the meningeal branches of the trigeminal nerve. CLINICAL ASPECTS The term empty sellae was coined by Busch 11 in 1951 to describe a deficient DS, a slightly enlarged sellae and no visible pituitary gland. An elegant review on the empty sellae syndrome has been given by Lenz and Root. 14 The incidence of this syndrome in the pediatric population ranges from 1.2% in individuals with endocrinopathy to 68% in those without endocrinopathy. 14 The primary empty sellae syndrome occurs when a defect in the DS allows cerebrospinal fluid to enter the sellae turcica and compress the pituitary gland against the bony boundary of the sellae. 11,14 The secondary forms of empty sellae can be the consequence of regional surgeries or pituitary apoplexy among other etiologies. 14 Figure 3: Coronal T1-weighted MRI noting the pituitary stalk and hints of the diagphrama sellae. Sunderland 5 found that the DS was tightly applied to the pituitary stalk in 20% of his specimens (Figure 2). Moreover, this author found that in childhood, there is normally no arachnoid below the level of the diaphragma foramen, thus no extension of the subarachnoid space into the pituitary fossa (Figure 3). In adults, he found atrophy of the gland with advancing age with descent of the arachnoid and subarachnoid space through many foramina. Roussy and Mosinger 15 found that the pia in this region divides with an anterior position fusing to the DS and a posterior layer descending between the pituitary stalk and pars tuberalis. Wislocki 16, in fetal specimens, concluded that the dura developing around the body of the hypophysis and forming the sellar diaphragm fuses with the surface of the anterior and neural lobes and hence prevents permanently the development of pia arachnoid or of a subdural space around the body of the pituitary. Hollinshead 17 stated that the subarachnoid space extends through the DS over the upper surface of the pituitary gland and except on it upper surface, however, the outer portion P a g e 42
4 BIOMED INT (2013) 4:40 44 / THE DIAPHRAGMA SELLAE of the gland is fused to the dura, so that the gland is held in place both by the diaphragm and its dural attachments. Some have opined that the DS, when fully formed, acts as a protective barrier against the pulsating action of CSF on the pituitary gland. 18 Ferreri et al. 18 have found that the DS is a factor in determining the morphology of the sellae turcica and its contents. For example, absence of or a small DS may be associated with a smaller pituitary gland. Sage et al. 19 found that even with a normal pituitary gland, a defect in the DS may lead to expansion of the bony contour of the sellae turcica with greater downward bowing of the floor. These authors also found a correlation between the size of the defect and the depth of the intrasellar cistern that resulted from the downward extension of the suprasellar cistern. The DS can be expanded without rupture with growth of pituitary tumors. 20 Cushing 20 believed that a defective DS allowed for escape for some pituitary tumors. More recently, Hekimsoy et al. 21 opined that normal functions of the pituitary gland may be impaired when the gland is compressed onto the floor of the sellar by arachnoid tissue extending through an impaired DS. SURGICAL ASPECTS Surgically, the DS is commonly assumed to provide a physical barrier between the sellae turcica and intracranial space during trans-sphenoidal procedures. 7 However, Bergland et al. 8 found that 10% of DS are too thin to serve as a reliable barrier against penetration with such procedures. The DS may be adherent to the pituitary stalk and thus necessitate dissection from the stalk during surgery in this area. 10 Additionally, upward displacement of the DS may provide early evidence of an expanding pituitary lesion. 19 Tumors of the peri-chiasmatic region have variable extension into the sellar cavity. Wang et al. 3 found that craniopharyngiomas with prechiasmatic growth had subdiaphragmatic portions while only 3 (27%) of tumors with retrochiasmatic extension had subdiaphragmatic parts. These authors noted that tumors were less adherent to the optic nerves when covered by the DS. CONCLUSION The relevance of the DS in intracranial pathologies like empty sellae syndrome and perichiasmatic tumors is evident from the literature. A clear understanding of the anatomy of DS and its variability is important for surgeons who operate the skull base and radiologists who interpret imaging of the sellar region. ACKNOWLEDGEMENTS The authors confirm that there are no conflicts of interest. REFERENCES 1. Jinkins JR. Atlas of Neuroradiologic Embryology, Anatomy, and Variants. Philadelphia, Lippincott Williams & Wilkins, Pribram HW, du Boulay GH. Sellae turcica in radiology of the skull and brain. In: Newton TH, Potts DG (Eds.). The Skull. Saint Louis, CV Mosby, 1971: pp Wang KC, Kim SK, Choe G. Growth patterns of craniopharyngioma in children: role of the diaphragma sellae and its surgical implications. Surg Neurol 2002; 57: P a g e 43
5 TUBBS ET AL. / BIOMED INT (2013) 4: Lang J. Hypophyseal region- anatomy of the operative approaches. Neurosurg Rev 1985; 8: Sunderland S. The meningeal relations of the human hypophysis cerebri. J Anat 1956; 79: Renn WH, Rhoton AL. Micro-surgical anatomy of the sellar region. J Neurosurg 1975; 43: Campero A, Martins C, Yasuda A: Microsurgical anatomy of the diaphragma sellae and its role in directing the pattern of growth of pituitary adenomas. Neurosurgery 2008; 62: Bergland R, Ray B, Torack R. Anatomical variations in the pituitary gland and adjacent structures in 225 human autopsy cases. J Neurosurg 1968; 28: Won HS, Han SH, Oh CS, Lee JI, Chung IH, Kim SH. Topographic variations of the optic chiasm and the foramen diaphragma sellae. Surg Radiol Anat 2010; 32: Prescher A, Brors D, von Ammon K. New anatomical description of the cavernous sinus surface and its significance in microsurgery. Skull Base Surg 1997; 7: Busch W. Die Morphologie der sellae turcica und ihre Beziehungen zur Hypophyse. Arch path Anat 1951; 320: McLachlan MSF, Williams ED, Doyle FH. Applied anatomy of the pituitary gland and fossa. Br J Radiol 1968; 41: Lee KF, Parke W, Lin SR, Choi HY, Schatz NJ. The vasculature of the diaphragm sellae. A postmortem injection study. Neuroradiology 1978; 16: Lenz AM, Root AW. Empty sellae syndrome. Pediatr Endocrinol Rev. 2012; 9(4): Roussy G, Mosinger M. Etude anatomique et physiologique de l hypothalamus. Rev Neurol 1934; 1: Wislocki GB. The meningeal relations of the hypophysis cerebri. Amer J Anat 1937; 61: Hollinshead WH. Anatomy for Surgeons: Vol 1, The Head and Neck (2 nd ed). New York, Harper & Row, Ferreri AJ, Garrido SA, Markarian MG, Yanez A. Relationship between the development of diaphragm sellae and the morphology of the sellae turcica and its content. Surg Radiol Anat 1992; 14: Sage MR, Blumbergs PC, Fowler GW. The diaphragm sellae: its relationship to normal sellar variations in frontal radiographic projections. Radiology 1982; 145: Cushing H. Dyspituitarism: Twenty years later. Arch Int Med 1933; 51: Hekimsoy Z, Yunten N, Sivrioglu S. Coexisting acromegaly and primary empty sellae syndrome. Neuro Endocrinol Lett 2004; 25: P a g e 44
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