6 th Auger Symposium. An International Meeting on Physical, Molecular and Cellular Aspects of Auger Processes. 5 th - 7 th July 2007

Transcription

1 6 th Auger Symposium An International Meeting on Physical, Molecular and Cellular Aspects of Auger Processes 5 th - 7 th July 2007 PROGRAMME AND ABSTRACTS Organising Committee: Amin I. Kassis (Harvard Medical School, Boston, USA) S. James Adelstein (Harvard Medical School, Boston, USA) Hooshang Nikjoo (NASA Johnson Space Center, Houston, USA) Alice Carmel (Harvard Medical School, Boston, USA) Pavel Pospisil (Webmaster Harvard Medical School, Boston, USA) Scientific Committee: S.J. Adelstein (USA) R.W. Howell (USA) A.I. Kassis (USA) R.F. Martin (Australia) H. Nikjoo (USA) E. Pomplun (Germany) M. Terrissol (France) R. Watanabe (Japan) L. Yasui (USA) Contact Details: Dr. Amin I. Kassis Tel: Harvard Medical School Fax: Longwood Avenue auger6@hms.harvard.edu Boston, MA Web page: USA 1

2 PROGRAMME Thursday 5 th July :00 18:00 REGISTRATION/RECEPTION Friday 6 th July :00 10:20 OPENING SESSION 09:00 09:10 WELCOME Amin I. Kassis 09:10 10:00 CONFERENCE LECTURE Auger Processes in the 21st Century Speaker: Roger W. Howell Introducer: S. James Adelstein 10:00 10:20 COFFEE 10:20 12:20 SESSION I MOLECULAR EFFECTS Chair: Roger F. Martin 10:20 11:00 Thomas Winters Introducer: Roger F. Martin 11:00 11:20 Balagurumoorthy, P 11:20 11:40 Lobachevsky, PN 11:40 12:00 Martin, RF 12:00 12:20 Gaynutdinov, TI Understanding 125 I decay-induced DNA doublestrand break molecular structure: Possible roles of such structures in cytotoxicity. DNA DSB Induced by decay of 123 I-labeled Hoechst 33342: Role of DNA topology. DNA Breakage from decay of iodine-124. Plasmid breakage by 125 I-labelled DNA ligands: Effect of DNA iodine atom distance on breakage efficiency. Iodine-125 radioprobing of intramolecular quadruplex conformation of human telomeric DNA: Effects of flanking sequences, ionic conditions, and quadruplex-specific drugs. 12:20 13:30 LUNCH 13:30 14:30 POSTER VIEWING 2

3 Friday 6 th July :30 16:30 SESSION II FUNDAMENTAL PROPERTIES, PHYSICS & DOSIMETRY Chair: Ekkehard Pomplun 14:30 15:15 Hooshang Nikjoo Introducer: Michel Terrissol The Auger effect and radiationless transitions in physical and biological research. 15:15 15:35 Terrissol, M 15:35 15:55 Goorley, T 15:55 16:15 Girard, PM DNA Damage in plasmid pbr322 after iodine- 123 and iodine-125 decay. Calculated strand breaks from iodine-125 in coiled DNA. Simulation of radioprobing experiments to study DNA quadruplex structure and topology. 16:15 16:30 COFFEE 16:30 17:55 SESSION III SYNCHROTRON RADIATION INDUCED AUGER PROCESSES Chair: Michel Terrissol 16:30 17:15 Akinari Yokoya Studies of soft-x-ray-induced Auger effect on the induction of DNA damage. Introducer: Hooshang Nikjoo 17:15 17:35 Fujii, K 17:35 17:55 Akamatsu, K Induction of strand breaks, base lesions, and clustered damage in dry plasmid DNA films induced by carbon, nitrogen, and oxygen KLL Auger process. Auger and photo-electron effects on strand breaks and base lesions in plasmid DNA irradiated with ultrasoft x-rays. 19:00 22:00 CONFERENCE DINNER 3

4 Saturday 7 th July :00 12:30 SESSION IV CELLULAR EFFECTS Chair: Linda Yasui 09:00 09:20 Schomaecker, K 09:20 09:40 Neti, PVSV 09:40 10:00 Fischer, T Radiation Damage to keratinocytes, tumour cells and human embryo stem cells by 125 I- labelled deoxyuridine (du). Intercellular Communication in Testicular Responses to DNA-incorporated 125 I. Diethylstilbestrol (DES) labeled with Auger emitters: Potential radiopharmaceutical for therapy of estrogen receptor-positive tumours and their metastases? 10:00 10:30 COFFEE 10:30 10:50 Costantini, DL 10:50 11:10 Cai, Z 11:10 11:30 Yasui, LS 111 In-Labeled trastuzumab (Herceptin) modified with nuclear localization sequences: Auger electron-emitting radiotherapeutic agent for HER2/neu-amplified breast cancer. DNA damage produced by 111 In-DTPA-hEGF correlates with EGFR expression level and radiosensitivity in breast cancer cell lines. Gadolinium neutron capture in glioblastoma multiforme cells. 11:30 12:30 POSTER VIEWING 12:30 14:00 LUNCH 4

5 Saturday 7 th July :00 16:15 SESSION V CANCER THERAPY Chair: R. Howell 14:00 14:20 Rousseau, J 14:20 14:40 Mattes, MJ 14:40 15:00 Pouget, JP 15:00 15:20 Balosso, J 15:20 15:40 SUMMARY Iodine-enhanced synchrotron stereotactic radiotherapy. Therapy of carcinoma xenografts with 111 Inconjugated Abs to EGFr and HER-2. Biological Efficiency of 125 I in radioimmunotherapy of small solid tumors: In vitro and in vivo Studies. First human treatment of resistant neoplastic meningitis by intrathecal administration of MTX plus 125 IUdR. S. James Adelstein 15:40 CLOSE OF MEETING Amin I. Kassis 5