PHARMACEUTICALS IN MEDICAL IMAGING
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1 PHARMACEUTICALS IN MEDICAL IMAGING Radiopaque Contrast Media Radiopharmaceuticals Enhancement Agents for Magnetic Resonance Imaging and Ultrasound MACMILLAN PUBLISHING CO., INC. New York COLLIER MACMILLAN CANADA, INC. Toronto COLLIER MACMILLAN PUBLISHERS London
2 Contents Section I: Radiopaque Contrast Media 1 CHAPTER 1: Angiographic Contrast Media 1 P.C. Shetty, M.D. David J. Kastan, M.D. S. Ned Gregorio, R.Ph. Nancy Rollins, M.D. Pharmacoangiography 48 Christopher K. Shier, M.D. CHAPTER 2: CHAPTER 3: CHAPTER 4: Urographic Contrast Media: Excretory and Retrograde Mark Weingarden, M. D. Contrast Media for Computed Tomography: Intra vascular, Intracavitary, Xenon, Reticuloendothelial 99 Dennis P. Swanson, R.Ph. M.S. Michael B. Alpern, M.D. Myelographic Contrast Media 125 Roushdy S. Boulos, M.D. 78 CHAPTER 5: Gastrointestinal Contrast Media: Barium Sulfate and Water-Soluble Iodinated Agents 155 Robert D. Halpert, M.D. CHAPTER 6: Cholecystographic and Cholangiographic Contrast Media Stuart M. Simms, M.D. 184 CHAPTER 7: Miscellaneous Radiopaque Contrast Media I. Arthrographic Contrast Media Burton I. Ellis, M.D. xiii 221
3 xiv II. Hysterosalpingographic Contrast Media Carol J. Maywood, M.D. III. Lymphographic Contrast Media P.C. Shetty, M.D. IV. Bronchographic Contrast Media Rajinder P. Sharma, M.D. CHAPTER 8: Adverse Reactions to Contrast Media: Etiology, Incidence, Treatment, and Prevention 253 CHAPTER 9: Section II: Radiopharmaceuticals 279 Fundamentals of Radiopharmaceuticals Richard L. Witcofski, Ph.D. 279 CHAPTER 10: Radiopharmaceuticals for Central Nervous System Imaging: Blood-Brain Barrier, Function, Receptor-Binding, Cerebral Spinal Fluid Dynamics 305 I. Radiopharmaceuticals for Conventional Brain Imaging II. Receptor-Specific Radiopharmaceutical William C. Eckelman, Ph.D. III. Imaging of Cerebral Spinal Fluid Dynamics Robert J. Cowan, M.D. CHAPTER 11: Radiopharmaceuticals for Endocrine Imaging 343 I. Thyroid Imaging II. Parathyroid Scintigraphy III. Adrenocortical Imaging IV. Adrenomedullary Imaging NeilA. Petry, R.Ph., M.S. Brahm Shapiro, M.D., Ch.D., Ph.D.
4 XV CHAPTER 12: Radiopharmaceuticals for Lung Imaging 394 Henry M. Chilton, Pharm.D. James D. Ball, M.D. I. Regional Pulmonary Perfusion Imaging II. Ventilation Imaging CHAPTER 13: Radiopharmaceuticals for Cardiac Imaging: Myocardial Infarction, Perfusion, Metabolism and Ventricular Function (Blood Pool) 419 Henry M. Chilton, Pharm.D. Ronald J. Callahan, Ph.D. CHAPTER 14: Radiopharmaceuticals for Abdominal and Gastrointestinal Imaging: Reticuloendothelial, Hepatobiliary and Intestinal 462 Manuel L. Brown, M.D. CHAPTER 15: Radiopharmaceuticals for Genitourinary Imaging: Glomerular and Tubular Function, Anatomy, Urodynamics, and Testicular 501 Nat E. Watson, Jr., M.D. CHAPTER 16: Radiopharmaceuticals for Bone and Bone Marrow Imaging 537 Marion D. Francis, CHAPTER 17: Radiopharmaceuticals for Imaging Tumors and Inflammatory Processes: Gallium, Antibodies, and Leukocytes 564 Scott W. Burchiel, Ph.D. Nat E. Watson, Jr., M.D. CHAPTER 18: Therapeutic Applications of Radiopharmaceuticals: Thyroid Disease, Polycythermia Vera, and Malignant Effusion 599 CHAPTER 19: Radiopharmaceuticals for Hematological Applications 616 I. Blood Volume Measurements
5 xvi II. Schilling Test III. Radioferrokinetic Studies IV. Venous Thromobosis Detection Section III: Enhancement Agents for Magnetic Resonance Imaging and Ultrasound 645 CHAPTER 20: Enhancement Agents for Magnetic Resonance Imaging: Fundamentals 645 Susan C. Jackels, Ph.D. CHAPTER 21: Enhancement Agents for Magnetic Resonance Imaging: Clinical Applications 662 Sanjay Saini, M.D. Joseph T. Ferrucci, M.D. CHAPTER 22: Enhancement Agents for Ultrasound: Fundamentals 682 A: Units of Radioactivity 688 Appendices B: Method for Prevention of Thyroid Uptake of Radioiodine 689 C: Drugs for the Mitigation of Internal Radiocontamination 690 Terry J. Dick, Pharm. D.
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