starbase Pan-Cancer Tutorial

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1 starbase Pan-Cancer Tutorial , Jianhua Yang at Sun Yat-sen University For comments, suggestions on the starbase platform, please contact us: On commercial use, contact:

2 Overview: starbase Pan-Cancer Platform

3 Homepage tumor sample number Print or export figure normal sample total sample Sample Distribution of 14 Cancer Types

4 Pan-Cancer mirna-lncrna Select Number of Cancer Types Note: Number of Cancer Types(Pan-Cancer) can be used to explore anti-correlation (pearson correlation: r<0, p- value<0.05) between mirna and target genes across diverse cancer types. For example, cancer type >=1 means that expression of mirna and target gene is anti-correlation (pearson correlation: r<0, p-value<0.05) at least one cancer type.

5 Query Results: Pan-Cancer mirna-lncrna Click mirna to get detail and Pan-Cancer Expression Profiles Click lncrna to get detail and Pan-Cancer Expression Profiles Click cancer Number to get detail and Pan-Cancer Expression Profiles for mirna-lncrna interactions

6 Query Results: Pan-Cancer mirna-lncrna 1 Pan-Cancer mirna expression profiles Select Pan-Cancer or single Cancer Type Print or export figure Expression Mean Value (log2) of normal samples Mean Value (log2) of cancer samples Fold-Change of Cancer/Normal samples Cancer Types

7 Query Results: Pan-Cancer mirna-lncrna 1 Box-Plot mirna expression profiles Select single Cancer Type Fold-Change and t test p-value Print or export figure Click Case Id to get clinical information sample information Normal samples Cancer samples

8 Query Results: Pan-Cancer mirna-lncrna 1 Box-Plot lncrna expression profiles Select single Cancer Type Fold-Change and t test p-value Print or export figure Click Case Id to get clinical information sample information Normal samples Cancer samples

9 Query Results: Pan-Cancer mirna-lncrna 1 Pan-Cancer mirna-lncrna interactions click here Cancer Types Sample Number r, p-value and False discovery rate (FDR) of pearson correlation analysis

10 Query Results: Pan-Cancer mirna-lncrna 1 Pan-Cancer mirna-lncrna interactions click here Select Chart Type Select single Cancer Type r value and p-value of pearson correlation analysis Print or export figure Click Case Id to get clinical information sample information

11 ***Above-mentioned Tutorials can be applied to the following*** Pan-Cancer Networks Pan-Cancer mirna-mrna Networks Note: Number of Cancer Types(Pan-Cancer) can be used to explore anti-correlation (pearson correlation: r<0, p- value<0.05) between mirna and target genes across diverse cancer types. For example, cancer type >=1 means that expression of mirna and target gene is anti-correlation (pearson correlation: r<0, p-value<0.05) at least one cancer type. Pan-Cancer cerna Networks Note: Number of Cancer Types(Pan-Cancer) can be used to explore positive-correlation (pearson correlation: r>0, p- value<0.05) between cerna1 and cerna2 across diverse cancer types. For example, cancer type >=1 means that expression of cerna1 and cerna2 is positive-correlation (pearson correlation: r>0, p-value<0.05) at least one cancer type. Pan-Cancer RBP-RNA Networks Note: Number of Cancer Types(Pan-Cancer) can be used to explore correlation (pearson correlation: p- value<0.05) between RNA-Binding Proteins (RBPs) and targets across diverse cancer types. For example, cancer type >=1 means that expression of RBP and target is correlation (pearson correlation: p-value<0.05) at least one cancer type.

12 Thanks for your interest in our starbase Pan-Cancer Platform!!! We hope our starbase Pan-Cancer platform will greatly help biologists to explore the impact of lncrna, mirna, mrna, RNA-Binding Protein(RBP) genes and their regulatory networks on human cancers and other diseases. We are looking forward to hearing your feedback!!!

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