RETRACTED ARTICLE. Cutaneous mast cell tumor (Mastocytoma): Cyto- histopathological and haematological investigations
|
|
- Jack Adam Gibbs
- 5 years ago
- Views:
Transcription
1 Hosseini et al. Diagnostic Pathology 2014, 9:9 CASE REPORT Cutaneous mast cell tumor (Mastocytoma): Cyto- histopathological and haematological investigations Ehsan Hosseini 1, Behnam Pedram 2, Ali Mohammad Bahrami 1*, Mohammad Hossein Jaberi Moghaddam 3, Javad Javanbakht 4, Fatemeh Emami Ghomi 5, Najme Jaberi Moghaddam 6, Mobin Koohestani 3 and Radmehr Shafiee 7 Abstract Open Access Cutaneous mast cell tumours (MCTs) are the most common skin tumours in dogs. Due to the prevalence of canine MCTs and the variable biologic behavior of this disease, accurate prognostication and a thorough understanding of MCT biology are critical for the treatment of this disease. A cytologic diagnosis of mast cell tumor with evidence of prior hemorrhage was made, and the masses were surgically removed. Cytological evaluation of fine-needle aspirates from the cutaneous mass from the axillary comprised many well-differentiated, highly granulated mast cells with moderate numbers of eosinophils. Nuclei were varied in size and shape with high nuclear to cytoplasmic ratio, prominent nucleoli, marked atypical and mitotic figures. Microscopically, mass consisted of sheets of neoplastic round cells that formed nonencapsulated nodules in the dermis and infiltrated into the adjacent dermal collagen, and also there was diffuse subcutis invasion of round to pleomorphic tumor cells. Tumor cells had moderate to abundant cytoplasm, round to ovoid nuclei with scattered chromatin, and mitotic figures. In this tumor, cytoplasmic granules showed atypical metachromasia. In addition, eosinophils were scattered among the mast cells at the periphery of the nodules. The presence of eosinophils and the observation, at high magnification, of cells with cytoplasmic metachromatic granules. Invasion of the deep subcutaneous fat or cutaneous muscles were a common feature of grade III tumour. Finally, a diagnosis of grade III cutaneous mast cell tumor was made. Virtual slides: The virtual slide(s) of this article can be found here: vs/ Keywords: Cytology, Pathology, Dog, Mast cell tumor, Grading Background Mast cell tumors (MCTs) are highly invasive and metastatic and are the most frequent round cell tumors in dogs, comprising 16 21% of all cutaneous tumors diagnosed [1,2], and are the most common skin tumors in dogs [3], representing about 7% to 21% of all dog skin tumors and 11% to 27% of malignant skin tumors in this species [4]. Canine MCTs have variable biologic behaviors, ranging from solitary benign masses that can be cured with surgery alone to systemic and potentially fatal metastatic disease [5], and are always considered potentially malignant, but their true metastatic potential is not entirely known [6]. Round cell tumors consist of discrete cells that are round to oval rather than fusiform. Included in this group are mast cell tumor, histiocytoma, lymphosarcoma (including reticulum cell sarcoma) and transmissible venereal tumor. The differential diagnosis of round cell tumors by histologic examination without concomitant cytologic characterization may, in some instances, depend more on age of animal, growth rate, location of tumor, number of tumors and lymph node involvement rather than histologic criteria. Mastocytosis is a rare group of diseases characterized by abnormal proliferation and infiltration of mast cells within the tissues. The skin is most frequently involved but mast cells also * Correspondence: am.bahrami@ilam.ac.ir 1 Faculty of Para Veterinary Medicine, Ilam University, Ilam, Iran Full list of author information is available at the end of the article 2014 Hosseini et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.
2 Hosseini et al. Diagnostic Pathology 2014, 9:9 Page 2 of 5 accumulate in the bone marrow, gastrointestinal tract, lymph nodes, spleen, and liver. Mast cell tumors in association with oncocytes thus should be considered supportive evidence of an FNA diagnosis of adenolymphoma. Mastocytosis should be considered in the differential diagnosis of urticaria and solitary mastocytomas may remain active into adolescence, raising concern for systemic progression [7-13]. MCTs are most often graded histologically by the scheme described by Patnaik et al. [14]. Tumours of grade I are circumscribed, mainly dermal in location, and consist of welldifferentiated mast cells with prominent metachromatic cytoplasmic granules. Poor cellular differentiation, aggressive growth pattern, moderate to high mitotic activity, mitotic atypia and sparse to absent cytoplasmic granulation are the major features of grade III tumours. Grade II MCTs constitute an intermediary form between the two other grades, but they tend to infiltrate more deeply than grade I neoplasms [14,15]. MCTs are routinely diagnosed by cytology and histopathology. Case presentation Animal ethics The animal was placed in shade, in standard conditions, water ad libitum, and without restriction of movement according to the guidelines of Institutional Animal Ethical Committee of the Tehran University of Animal Science, Iran. Surgery was performed under aseptic conditions and sedation by injection of Xylazine hydrochloride (0.05 mg/kg) followed by 2% Lignocaine hydrochloride. Clinical case reports In October 2013, a 5-year-old, 7 kg, female black terrier dog was presented to the clinic at the college of Veterinary Medicine, university of Tehran, with a growing mass around axillary and mobility problems related to the mass, and euthanasia was applied upon the owner s request and also taking into consideration the age of the animal and the size of the mass. The mass spreading into subcutis is of proximal right front leg, was of cm size and 185 g weight (Figure 1). The mass was surgically resected and an impression smear of the tissue was prepared and stained with Giemsa. The rest of the tissue was subjected to histopathologic evaluation. One formalin-fixed, paraffin wax-embedded section of each neoplasm was stained with haematoxylin and eosin (HE). Tumour was classified independently by two pathologists in order to confirm the diagnosis according to the WHO criteria [16]. Also tumour was graded according to the criteria proposed by Patnaik et al. [14] and Kiupel et al. [17], as well, moderately or poorly differentiated (grades I, II or III, respectively) [14,17]. These criteria included the following histomorphological features: extent of tumour (invasiveness), cellular morphology, size of cytoplasmic granules, mitotic activity and stromal reaction. Invasiveness was assessed as follows: noninvasive (tumours confined to the superficial dermis and interfollicular spaces); moderately invasive (tumours with lower dermal and limited subcutaneous tissue invasion); highly invasive (tumours with massive infiltration of subcutaneous and deep tissue). Mitotic activity was assessed on toluidine blue-stained sections, five high power fields (hpfs) being evaluated in each case with a 40 objective. The data were expressed as mean number of mitoses per hpf (mitotic index) and tumours were classified according to the following grading system: 0 (mitotic figures absent); 1 (mitotic index ranging from 0 to 2 mitoses/hpf); 2 (mitotic index > 2/hpf). Invasiveness and mitotic activity assessment were used to define the histological grade, and also as individually evaluated parameters. Hematological findings A complete blood work was performed. No changes were noticed in the erythrogram, however, leukogram changes included leukocytosis (55,245 leukocytes/μl), neutrophilia (27,644 neutrophils/μl) with mild regenerative left shift (4,376 band cells/μl). Cytological findings Cytological examination indicated mast cells with numerous metachromatic stained granules. Nuclei were varied in size and shape with high nuclear to cytoplasmic ratio, prominent nucleoli, marked atypical and mitotic figures. The background was filled with granules from ruptured cells and a moderate eosinophils were also present (Figure 2A and 2B). Histopathological findings Histopathologically, MCT tumour cells were less well circumscribed by connective tissue and neoplastic cells often exhibited an aggressive behavior, high cellularity, cellular pleomorphism, and various morphologic patterns. However, in some regions of the tumor tissue shows neoplastic cells extending into the subcutis. Neoplastic cells had distinct cell borders and widely variable amounts of pale to brightly eosinophilic cytoplasm. Furthermore, tumour had neoplastic cells containing numerous fine eosinophilic to basophilic cytoplasmic granules consistent with mast cell granules and also highly pleomorphic tumour cells with a high mitotic index, anisokaryosis and infiltration of the surrounding dermis and subcutis were observed (Figure 2C and 2D). Pathology grading of cutaneous mast cell tumor In this case is characterized by one or more of the following criteria: at least 3 mitotic figures in 5 hpf, at least 2 multinucleated (2 or more nuclei) cells in 5 hpf, at
3 Hosseini et al. Diagnostic Pathology 2014, 9:9 Page 3 of 5 Figure 1 Cytohistophatology of dermal mass from the axillary of the dog. Representative photomicrographs of mass cell tumuor of Patnaik grade. (A and B) grade III. High-grade mast cell tumour was characterized by highly pleomorphic tumour cells with a high mitotic index, anisokaryosis and infiltration of the surrounding dermis and subcutis. Haematoxylin and eosin stain. Bar, 50 μm. the smears show n were prepared at the initial presentation and stained with Wrigth-Giemsa solution. Histopathologically, The presence of eosinophils and the observation, at high magnification, of cells with cytoplasmic metachromatic granules and also, neoplastic cells often exhibited an aggressive behavior, high cellularity, cellular pleomorphism, and various morphologic patterns. Eosinophils are present at the periphery of the mass (Figure 1C and D, H&E, 400x). least 2 bizarre nuclei (highly atypical with marked indentations, segmentation, and irregular shape) in 5 hpf; karyomegaly (ie, nuclear diameters of at least 10% of neoplastic mast cells vary by at least 2-fold). The selected field was it that was most highly mitotically active or had the highest degree of anisokaryosis. Canine cutaneous MCTs were graded according to the Patnaik and the Kiupel systems [14,17]. Grade III MCT was poorly demarcated accumulations of poorly differentiated mast cells with severe nuclear pleomorphism. Invasion of the deep subcutaneous fat or cutaneous muscles were a common feature of grade III tumour. Finally, a diagnosis of grade III cutaneous mast cell tumor was made. Discussion Dogs are at risk for cutaneous MCT, which accounts for up to 21% of all skin tumours [3]. The diagnosis of MCT by cytology or histopathology is straight forward in the majority of cases, but forming an accurate prognosis is more challenging [5]. Prognostic factors of significance included grading (cytology and histopathology), staging (regional and distant metastases), breed, tumour localisation and treatment (surgery, radiation and chemotherapy). Cytological examination after fine needle aspiration is useful in establishing the diagnosis but histopathology is needed for grading [18]. Cytology often is helpful in the diagnosis of MCTs because of the characteristic appearance of mast cells with routine staining. As is the case with findings from other species, Wright Giemsa stain resulted in more intensely stained granules in the neoplastic mast cells. The mechanism of the differences in staining is unclear. Several subtypes of mast cells have been identified in humans and dog based primarily on granule contents and biological function. This study clearly showed a cellular infiltrate of mast cells, mononuclear cells and eosinophils in the thickened, hyperplastic, and hyperkeratinized epidermis. Mast
4 Hosseini et al. Diagnostic Pathology 2014, 9:9 Page 4 of 5 Figure 2 Macroscopical examination of a cutaneous cell tumor in a black terrier. The mass spreading into subcutis is of proximal right front leg. cells and eosinophils, as opposed to the mononuclear cells of delayed hypersensitivity, predominated, suggesting an immediate hypersensitivity reaction. Once activated, mast cells at the edge of a wound are known to release inflammatory mediators within injured tissue by degranulation [19]. Thus, it would seem that immediate hypersensitivity reactions may be responsible for the development of skin lesions due to tumor in dogs. However, the present results suggest that the intense proliferation of mast cells following tumor occurs predominantly in the skin. The results of this study suggest that cellular proliferation plays a significant role in the progression of canine MCTs. Although the results of this study confirm the results of previous studies that have shown the prognostic significance of cellular proliferation in canine MCTs [14,15,18,19] cellular proliferation should not be evaluated as a single prognostic factor for canine MCTs but should be evaluated in tandem with additional prognostic indicators. Furthermore, the histologic characteristics of the MCT cells in this affected dog was moderate to abundant cytoplasm, round nuclei with scattered chromatin, fibrous stroma, and eosinophil infiltration. Little necrosis was seen. Several grading systems have been proposed to classify canine mast cell tumors. The system most commonly used classifies the tumor from grades I to III, depending on how well the mast cells are differentiated, mitotic activity, location within the skin, invasiveness, and the presence of inflammation or necrosis, with grade III being the most aggressive (characterized by the presence of undifferentiated, immature mast cells with a high potential for metastasis) [20,21]. In the current case, the presence of multiple large nodules, the extension into the dermis, and the poorly differentiated mast cells could be comparable to grade III described for dogs. Recently, a new 2-tier histologic classification for canine cutaneous tumors has been proposed [22]. This grading system is based on the presence of mitotic figures, multinucleated cells, bizarre nuclei, and karyomegaly to predict biological behavior, likely time to metastasis, new tumor development, and survival time. In the present case, although the neoplasia did not show any of these histological parameters, the presence of multiple cutaneous tumors suggests a malignant behavior. Grade III tumours have a very poor prognosis even with treatment, which might discourage owners from extensive surgery. This may explain the discrepancy in surgery performed in MCT cases of different grades. This result agrees with the findings by Murphy et al. [23] that showed dogs with poorly differentiated tumours had a significantly shorter survival time. These results suggest that all multiple cutaneous MCTs should be treated as individual neoplasms and prognosis should be dependent on individual variables such as grade and not related to the number of tumours present, which was shown not to affect survival. Mitotic index and size were not found to be independent predictors of survival. Conclusions In conclusion, this study described cytohistopathology features of canine cutaneous MCTs of the skin region. The histological features of these tumours would suggest that most should be classified as high-grade MCTs. A cutaneous MCT may be diagnosed on the basis of observing the histopathological pattern described in present study. Moreover, the use of grading system for a tumor type may be helpful in distinguishing this type of neoplasm from other malignancies with similar morphology. Furthermore, this study demonstrated that in canine cutaneous MCTs, may be used as a sensitive prognostic indicator of post-surgical tumour behaviour; in addition, it is related to other histopathological variables that are widely accepted as having prognostic value. Competing interests The authors declare that they have no competing interests. Authors contributions EH, BP and AMB participated in the histopathological evaluation, performed the literature review, acquired photomicrographs and drafted the manuscript and gave the final histopathological diagnosis. MHJM, FEGH, JJ, NJM, MK and RSH designed and carried out all the experiments and the principal investigators of the laboratory in which the research were performed and contributed to the interpretation of the data and writing of the manuscript. All authors read and approved the final manuscript. Acknowledgements The authors thank staff of the Department of pathology, Faculty of Veterinary Medicine, Tehran University for their valuable technical assistance.
5 Hosseini et al. Diagnostic Pathology 2014, 9:9 Page 5 of 5 Author details 1 Faculty of Para Veterinary Medicine, Ilam University, Ilam, Iran. 2 Department of Pathobiology, Susangerd Branch, Islamic Azad University, Susangerd, Iran. 3 Graduate, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran. 4 Department of Pathobiology, Faculty of Veterinary Medicine, Tehran University, Tehran, Iran. 5 Graduate, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran. 6 MSc, Clinical Biochemistry, Tarbiat Modares University, Tehran, Iran. 7 Graduate, Faculty of Veterinary Medicine, Tehran University, Tehran, Iran. Received: 11 December 2013 Accepted: 5 January 2014 Published: 20 January 2014 References 1. Misdorp W: Mast cell and canine mast cell tumors: a review. Vet Q 2004, 26: Brodey RS: Canine and feline neoplasia. Adv in Vet Sci Comp Med 1970, 14: Thamm DH, Vail DM: Mast cell tumors. Fourthth edition. Saunders Elsevier, St. Louis: Withrow and MacEwen s Small Animal Clinical Oncology; 2007: Newman SJ, Mrkonjich L, Walker KK, Rohrbach BW: Canine subcutaneous mast cell tumour: diagnosis and prognosis. J Comp Pathol 2007, 136 (4): Welle MM, Rohrer Bley C, Howard J, R ufenacht S: Canine mast cell tumours: a review of the pathogenesis, clinical features, pathology and treatment. Vet Dermatol 2008, 19: Webster J, Yuzbasiyan-Gurkan V, Miller R, Kaneene J, Kiupel M: Cellular proliferation in canine cutaneous mast cell tumors: associations with c-kit and its role in prognostication. Vet Pathol 2007, 44: Maki K, Chihoko H, Yukiko M, Fumi K, Shigeo H, Hiroshi M, Tomoo I: Primary submucosal nodular plasmacytoma of the stomach: a poorly recognized variant of gastric lymphoma. Diagn Pathol 2013, 8: Rong-Jun M, Zhi-Ming J, Hui-Zhen Z, Xiong-Zeng Z, Qing-Ling Z: Clinical and pathological characteristics of giant cell angioblastoma: a case report. Diagn Pathol 2012, 7: Armah HB, Anil V: Malignant perivascular epithelioid cell tumor (PEComa) of the uterus with late renal and pulmonary metastases: a case report with review of the literature: Parwani. Diagn Pathol 2007, 2: Shafiee R, Javanbakht J, Atyabi N, Bahrami A, Kheradmand D, Safaei R, Khadivar F, Hosseini E: Comparative value of clinical, cytological, and histopathological features in feline mammary gland tumors; an experimental model for the study of human breast cancer. Diagn Pathol 2013, 8: Shafiee R, Javanbakht J, Atyabi N, Kheradmand P, Kheradmand D, Bahrami A, Daraei H, Khadivar F: Diagnosis, classification and grading of canine mammary tumours as a model to study human breast cancer: an Clinico- Cytohistopathological study with environmental factors influencing public health and medicine. Cancer Cell Int 2013, 13(1): Khaki F, Javanbakht J, Sasani F, Gharagozlou MJ, Bahrami A, Moslemzadeh H, Sheikhzadeh R: Cervical type AB thymoma (Mixed) tumour diagnosis in a mynah as a model to study human: clinicohistological, immunohistochemical and cytohistopathological study. Diagn Pathol 2013, 8(1): Tavasoly A, Javanbakht J, Khaki F, Hosseini E, Bahrami A, Hassan MA, Mirabad M: Ulnar malignant peripheral nerve sheath tumour diagnosis in a mixed-breed dog as a model to study human: histologic, immunohistochemical, and clinicopathologic study. Diagn Pathol 2013, 8(1): Patnaik AK, Ehler WY, MacEwen EG: Canine cutaneous mast cell tumors: morphologic grading and survival time in 83 dogs. Vet Pathol 1984, 21: Gross TL, Ihrke PJ, Walder EJ, Affolter VR: Epithelial Neoplasms and Other Tumors. 2nd edition. Blackwell Publishing: Skin Diseases of the Dog and Cat: Clinical and Histopathologic Diagnosis; 2005: Section 2, Part I. 16. Goldschmidt MH, Hendrick MJ: Tumors of the skin and soft tissues.. In Tumors in Domestic Animals. 4th edition. Edited by Meuten DJ. Ames, Iowa: Iowa State Press; Blackwell. Publishing Company; 2002: Kiupel M, Webster JD, Bailey KL, Best S, Delay J, Detrisac CJ, Fitzgerald SD: Proposal of a 2-tier histologic grading system for canine cutaneous mast cell tumors to more accurately predict biological behavior. Vet Pathol 2011, 48: Bronden LB, Eriksen T, Kristensen AT: Mast cell tumours and other skin neoplasia in Danish dogs data from the danish veterinary cancer registry. Acta Vet Scand 2010, 22: Noli C, Miolo A: The mast cell in wound healing. Vet Dermatol 2001, 12: Bostock DE: Neoplasms of the skin and subcutaneous tissues in dogs and cats. Br Vet J 1986, 142: Weisse C, Shofer FS, Sorenmo K: Reoccurrence rates and sites for grade II canine cutaneous mast cell tumors following complete surgical excision. J Am Anim Hosp Assoc 2002, 38: Simoes JP, Schoning P, Butine M: Prognosis of canine mast cell tumors: a comparison of three methods. Vet Pathol 1994, 31: Murphy S, Sparkes AH, Blunden AS, Brearley MJ, Smith KC: Effects of stage and number of tumours on prognosis of dogs with cutaneous mast cell tumours. Vet Rec 2006, 158(9): doi: / Cite this article as: Hosseini et al.: Cutaneous mast cell tumor (Mastocytoma): Cyto- histopathological and haematological investigations. Diagnostic Pathology :9. Submit your next manuscript to BioMed Central and take full advantage of: Convenient online submission Thorough peer review No space constraints or color figure charges Immediate publication on acceptance Inclusion in PubMed, CAS, Scopus and Google Scholar Research which is freely available for redistribution Submit your manuscript at
FORELIMB SWEAT GLAND ADENOCARCINOMA IN A CAT
I: 2047-2051 ISSN: 2277 4998 FORELIMB SWEAT GLAND ADENOCARCINOMA IN A CAT ABEDI G 1, HESARAKI S 2, ASGHARI A 1* 1: Department of Clinical Science, Science and Research branch, Islamic Azad University,
More informationRETRACTED ARTICLE. Uterine mast cell tumor: a clinical and cytohistopathological study
Bahrami et al. Journal of Ovarian Research 2014, 7:105 CASE REPORT Uterine mast cell tumor: a clinical and cytohistopathological study Ali Mohammad Bahrami 1, Fariba Khaki 2, Shahram Zehtabian 3, Javad
More informationScience & Technologies A RETROSPECTIVE STUDY OF CANINE SKIN ROUND CELL TUMOURS
A RETROSPECTIVE STUDY OF CANINE SKIN ROUND CELL TUMOURS Radostin Simeonov Department of General and Clinical Pathology, Faculty of Veterinary Medicine, Trakia University, Stara Zagora, Bulgaria, e-mail:
More informationPROGNOSTIC TESTING INTO FELINE CUTANEOUS MAST CELL TUMOURS
Vet Times The website for the veterinary profession https://www.vettimes.co.uk PROGNOSTIC TESTING INTO FELINE CUTANEOUS MAST CELL TUMOURS Author : Melanie Dobromylskyj Categories : Vets Date : October
More informationCutaneous mast cell tumours staging and histological grading
Vet Times The website for the veterinary profession https://www.vettimes.co.uk Cutaneous mast cell tumours staging and histological grading Author : MELANIE DOBROMYLSKYJ Categories : Vets Date : September
More informationDisorders of Cell Growth & Neoplasia. Histopathology Lab
Disorders of Cell Growth & Neoplasia Histopathology Lab Paul Hanna April 2010 Case #84 Clinical History: 5 yr-old, West Highland White terrier. skin mass from axillary region. has been present for the
More informationCanine Mast Cell Tumors
Canine Mast Cell Tumors By: Dr. Custead WVRC Introduction Mast cells Resident inflammatory cell of the skin, lungs, gastro- intestinal tract Reactions secondary to IgE binding Allergic reactions Granules
More informationA case of giant cell tumour of soft parts in a horse Francesco Cian 1, Sarah Whiteoak 2, Jennifer Stewart 1
A case of giant cell tumour of soft parts in a horse Francesco Cian 1, Sarah Whiteoak 2, Jennifer Stewart 1 1 Animal Health Trust, Newmarket, UK 2 608 Equine and Farm Vets, Rowington, UK Signalment: Horse,
More informationMalignant Peripheral Nerve Sheath Tumor
C H A P T E R 120 Malignant Peripheral Nerve Sheath Tumor Currently, malignant peripheral nerve sheath tumor (MPNST) is the most commonly used generic name for the neoplasms known in the past as neurosarcoma,
More informationCLINICAL AND PATHOLOGICAL ASPECTS IN 2 CASES OF CANINE MASTOCYTOMA
CLINICAL AND PATHOLOGICAL ASPECTS IN 2 CASES OF CANINE MASTOCYTOMA C. MURESAN 1, P. BOLFA 2, C. CATOI 2, A. GAL 2, M. TAULESCU 2, F. TABARAN 2, A. NAGY 2 1 Emergency Hospital, 2 Discipline of Pathology
More informationNEW PERSPECTIVES WITH CANINE MAST CELL TUMORS Brian Husbands, DVM, Diplomate ACVIM (oncology)
NEW PERSPECTIVES WITH CANINE MAST CELL TUMORS Brian Husbands, DVM, Diplomate ACVIM (oncology) Overview of Canine Mast Cell Tumors Mast cell tumors are the most common canine skin tumor in dogs accounting
More informationAlmost any suspected tumor can be aspirated easily and safely. Some masses are more risky to aspirate including:
DOES THIS PATIENT HAVE CANCER? USING IN-HOUSE CYTOLOGY TO HELP YOU MAKE THIS DIAGNOSIS. Joyce Obradovich, DVM, Diplomate, ACVIM (Oncology) Animal Cancer & Imaging Center, Canton, Michigan Almost every
More informationPrinciples of Surgical Oncology. Winnie Achilles Tierklinik Hollabrunn Lastenstrasse Hollabrunn
Principles of Surgical Oncology Winnie Achilles Tierklinik Hollabrunn Lastenstrasse 2 2020 Hollabrunn boexi@gmx.de The first surgery provides the best chance for a cure in an animal with a tumor Clinical
More informationNUCLEAR MORPHOMETRY IN RELATION TO METASTASES IN CANINE SPONTANEOUS CUTANEOUS SQUAMOUS CELL CARCINOMAS
Trakia Journal of Sciences, Vol. 8, No. 1, pp 74-78, 2010 Copyright 2009 Trakia University Available online at: http://www.uni-sz.bg ISSN 1313-7050 (print) ISSN 1313-3551 (online) Original Contribution
More informationVeterinary Pathology Online
Veterinary Pathology Online http://vet.sagepub.com/ Proposal of a 2-Tier Histologic Grading System for Canine Cutaneous Mast Cell Tumors to More Accurately Predict Biological Behavior M. Kiupel, J. D.
More informationأملس عضلي غرن = Leiomyosarcoma. Leiomyosarcoma 1 / 5
Leiomyosarcoma 1 / 5 EPIDEMIOLOGY Exact incidence is unknown, but older studies suggest that leiomyosarcomas comprise approximately 3 percent of soft-tissue sarcomas. Superficial leiomyosarcoma occurs
More informationOutcomes of Dogs with Grade 3 Mast Cell Tumors: 43 Cases ( )
RETROSPECTIVE STUDIES Outcomes of Dogs with Grade 3 Mast Cell Tumors: 43 Cases (1997 2007) Carrie Tupper Hume, VMD, Diplomate ACVIM*, Matti Kiupel, BS, MS, PhD, Diplomate ACVP, Lora Rigatti, VMD, Frances
More informationSelected Pseudomalignant Soft Tissue Tumors of the Skin and Subcutis
Selected Pseudomalignant Soft Tissue Tumors of the Skin and Subcutis Andrew L. Folpe, M.D. Professor of Laboratory Medicine and Pathology Mayo Clinic, Rochester, MN folpe.andrew@mayo.edu 2016 MFMER slide-1
More informationEPIDEMIOLOGICAL AND MORPHOLOGICAL CHARACTERISTICS OF CUTANEOUS ROUND CELL TUMORS DIAGNOSED USING ASPIRATIVE CYTOLOGY IN DOGS
Scientific Works. Series C. Veterinary Medicine. Vol. LXIII (1) ISSN 2065-1295; ISSN 2343-9394 (CD-ROM); ISSN 2067-3663 (Online); ISSN-L 2065-1295 Abstract EPIDEMIOLOGICAL AND MORPHOLOGICAL CHARACTERISTICS
More informationDiplomate of the American Board of Pathology in Anatomic and Clinical Pathology
A 33-year-old male with a left lower leg mass. Contributed by Shaoxiong Chen, MD, PhD Assistant Professor Indiana University School of Medicine/ IU Health Partners Department of Pathology and Laboratory
More informationA Canine Case of Complex Carcinoma of the Mammary Gland with Metastasis to the Axillary Lymph Node
A Canine Case of Complex Carcinoma of the Mammary Gland with Metastasis to the Axillary Lymph Node Kenjiro Hashimoto 1), Atsushi Kawabata 1), Tamio Ohmuro 2), Kinji Shirota 1, 3) * 1) Research Institute
More informationCytology of NeoPlasia
PEEr reviewed Cytology of NeoPlasia An Essential Component of Diagnosis Anne Barger, DVM, MS, Diplomate ACVP Cytology is a quick, easy, and inexpensive diagnostic tool. It is commonly used for the diagnosis
More informationCutaneous mast cell tumours in canines diagnosis and staging
Vet Times The website for the veterinary profession https://www.vettimes.co.uk Cutaneous mast cell tumours in canines diagnosis and staging Author : KELLY BOWLT, MIKE STARKEY, SUE MURPHY Categories : Vets
More informationSESSION 1: GENERAL (BASIC) PATHOLOGY CONCEPTS Thursday, October 16, :30am - 11:30am FACULTY COPY
SESSION 1: GENERAL (BASIC) PATHOLOGY CONCEPTS Thursday, October 16, 2008 9:30am - 11:30am FACULTY COPY GOAL: Describe the basic morphologic (structural) changes which occur in various pathologic conditions.
More informationMast Cell Tumors in Dogs
Mast Cell Tumors in Dogs 803-808-7387 www.gracepets.com These notes are provided to help you understand the diagnosis or possible diagnosis of cancer in your pet. For general information on cancer in pets
More informationINTERACTIVE CASE MANAGEMENT
INTERACTIVE CASE MANAGEMENT A N U D E P R U N G S I P I P A T, D V M ( H O N S ), P H D, D T B V P, C E R T E S A V S ( O N C O L O G Y ) C O M P A N I O N A N I M A L C A N C E R R E S E A R C H U N I
More informationCanine Cutaneous Melanoma
Canine Cutaneous Melanoma By Elizabeth Downing Clinical Advisor: Dr. Angharad Waite, VMD Basic Science Advisor: Dr. Cheryl Balkman, DVM, DACVIM Senior Seminar Paper Cornell University College of Veterinary
More informationHistopathology: skin pathology
Histopathology: skin pathology These presentations are to help you identify, and to test yourself on identifying, basic histopathological features. They do not contain the additional factual information
More informationDiagnostic Cytology of Cancer Cases
Diagnostic Cytology of Cancer Cases Somporn Techangamsuwan Companion Animal Cancer Research Unit (CAC-RU) Department of Pathology, Faculty of Veterinary Science, Chulalongkorn University 1 Tumor or Non-tumor
More informationSynonyms. Mast cell disease Mast cell proliferative disease
Mastocytosis Definition Mastocytosis is a proliferation of mast cells and their subsequent accumulation in one or more organ systems. Mast cells are derived from hematopoietic progenitors, thus mastocytosis
More informationNeoplasia 2018 Lecture 2. Dr Heyam Awad MD, FRCPath
Neoplasia 2018 Lecture 2 Dr Heyam Awad MD, FRCPath ILOS 1. List the differences between benign and malignant tumors. 2. Recognize the histological features of malignancy. 3. Define dysplasia and understand
More informationCase Report A Rare Cutaneous Adnexal Tumor: Malignant Proliferating Trichilemmal Tumor
Case Reports in Medicine Volume 2015, Article ID 742920, 4 pages http://dx.doi.org/10.1155/2015/742920 Case Report A Rare Cutaneous Adnexal Tumor: Malignant Proliferating Trichilemmal Tumor Omer Alici,
More informationWhat s new for Mast Cell Tumors in Dogs?
What s new for Mast Cell Tumors in Dogs? Pascale C Salah, Dr. vet. med., DACVIM (oncology) Michael Mison, DVM, DACVS Lili Duda, VMD, MBE, DACVR(RO) Amy Durham, MS, VMD, DACVP (Anatomic Pathology) University
More informationCase Scenario 1: Thyroid
Case Scenario 1: Thyroid History and Physical Patient is an otherwise healthy 80 year old female with the complaint of a neck mass first noticed two weeks ago. The mass has increased in size and is palpable.
More informationEpidemiological Aspects and Differential Diagnosis of the Cutaneous Round Cell Tumors in Dogs
Epidemiological Aspects and Differential Diagnosis of the Cutaneous Round Cell Tumors in Dogs Roxana CORA, Adrian Florin GAL*, Marian TAULESCU, Flaviu TᾸBᾸRAN, Andras NAGY, Mihai NEGRU, Cornel CǍTOI Faculty
More informationRETRACTED ARTICLE. Shafiee et al. Diagnostic Pathology 2013, 8:136 (Continued on next page)
Shafiee et al. Diagnostic Pathology 2013, 8:136 RESEARCH Comparative value of clinical, cytological, and histopathological features in feline mammary gland tumors; an experimental model for the study of
More informationRETROSPECTIVE STUDY OF THE EPIDEMIOLOGICAL AND MORPHOLOGICAL ASPECTS OF CUTANEOUS MALIGNANT MESENCHYMAL TUMORS IN DOG
RETROSPECTIVE STUDY OF THE EPIDEMIOLOGICAL AND MORPHOLOGICAL ASPECTS OF CUTANEOUS MALIGNANT MESENCHYMAL TUMORS IN DOG Georgeta Dinescu, Selda Curtseit, Bucică Laura, Manuella Militaru Faculty of Veterinary
More informationCharalampos Attipa, Rachel Hampel, Simon L. Priestnall, Kate English Pathobiology and Population Sciences, Royal Veterinary College, Hatfield, UK
SUBCUTANEOUS MASS OVER THE SCAPULA IN A CAT Charalampos Attipa, Rachel Hampel, Simon L. Priestnall, Kate English Pathobiology and Population Sciences, Royal Veterinary College, Hatfield, UK Signalment:
More informationSpecial slide seminar
Special slide seminar Tomáš Rozkoš The Fingerland Department of Pathology Charles University Medical Faculty and Faculty Hospital in Hradec Králové Czech Republic Case history, 33 years old resistance
More informationLymphoma. Types of Lymphoma. Clinical signs
Lymphoma Lymphoma is a tumour originating from lymphoid tissue, either nodal (lymph ) or extranodal (thymus, spleen, mucosa, conjunctiva, or skin-associated lymphoid tissue). It is one of the most common
More informationAn Alphabet Soup of Thyroid Neoplasms
Overall Objectives An Alphabet Soup of Thyroid Neoplasms Lester D. R. Thompson www.lester-thompson.com What is the current management of papillary carcinoma? What are the trends and what can we do differently?
More informationDisclosures. Parathyroid Pathology. Objectives. The normal parathyroid 11/10/2012
Disclosures Parathyroid Pathology I have nothing to disclose Annemieke van Zante MD/PhD Assistant Professor of Clinical Pathology Associate Chief of Cytopathology Objectives 1. Review the pathologic features
More informationOncocytic carcinoma: A rare malignancy of the parotid gland
ISPUB.COM The Internet Journal of Pathology Volume 8 Number 2 Oncocytic carcinoma: A rare malignancy of the parotid gland K Mardi, J Sharma Citation K Mardi, J Sharma.. The Internet Journal of Pathology.
More informationInternational Society of Gynecological Pathologists Symposium 2007
International Society of Gynecological Pathologists Symposium 2007 Anais Malpica, M.D. Department of Pathology The University of Texas M.D. Anderson Cancer Center Grading of Ovarian Cancer Histologic grade
More informationInternational Journal of Veterinary Science
International Journal of Veterinary Science www.ijvets.com P-ISSN: 2304-3075 E-ISSN: 2305-4360 editor@ijvets.com CASE REPORT Histiocytic Sarcoma with Visceral Spread Resembling Metastasizing Poorly Differentiated
More informationDiagnostic problems in uterine smooth muscle tumors
Diagnostic problems in uterine smooth muscle tumors Marina Kos Ljudevit Jurak Clinical Department of Pathology, Clinical Hospital Center Sestre milosrdnice, Zagreb Institute of Pathology, University of
More informationProceedings of the 36th World Small Animal Veterinary Congress WSAVA
www.ivis.org Proceedings of the 36th World Small Animal Veterinary Congress WSAVA Oct. 14-17, 2011 Jeju, Korea Next Congress: Reprinted in IVIS with the permission of WSAVA http://www.ivis.org 14(Fri)
More informationNODULAR CYSTIC HIDRADENOMA OVER THE GLUTEAL REGION: A RARE CYTOMORPHOLOGICAL DIAGNOSIS
NODULAR CYSTIC HIDRADENOMA OVER THE GLUTEAL REGION: A RARE CYTOMORPHOLOGICAL DIAGNOSIS Abstract: The primary as well as metastatic tumours of the skin can be diagnosed by fine needle aspiration cytology
More informationCellular Neurothekeoma
Cellular Neurothekeoma Scott W Binder, MD Pritzker Professor of Pathology & Dermatology Sr. Vice Chair Director, Pathology Clinical Services Chief, Dermatopathology Geffen/UCLA School of Medicine Clinical
More informationNeoplasms of the Canine, Feline and Lemur Liver:
Neoplasms of the Canine, Feline and Lemur Liver: Classification and Prognosis Annual Seminar of the French Society of Veterinary Pathology John M. Cullen VMD PhD DACVP North Carolina State University Primary
More informationNormal thyroid tissue
Thyroid Pathology Overview Normal thyroid tissue Normal thyroid tissue with follicles filled with colloid. Thyroid cells form follicles, spheres of epithelial cells (always single layered in health, usually
More informationFinancial disclosures
Mesenchymal Neoplasms with Melanocytic Differentiation By Konstantinos Linos MD, FCAP, FASDP Bone, Soft Tissue and Dermatopathology Assistant Professor of Pathology Dartmouth-Hitchcock Medical Center Geisel
More informationLarge subcutaneous tumour in a roe deer
Large subcutaneous tumour in a roe deer Contributors: Alexandra Penrose a, Sonja Jeckel a, Norelene Harrington a, Carlo Bianco a,b, Laureen Peters a a Department of Pathobiology and Population Sciences,
More informationNeoplasia literally means "new growth.
NEOPLASIA Neoplasia literally means "new growth. A neoplasm, defined as "an abnormal mass of tissue the growth of which exceeds and is uncoordinated with that of the normal tissues and persists in the
More informationA 25 year old female with a palpable mass in the right lower quadrant of her abdomen
May 2016 A 25 year old female with a palpable mass in the right lower quadrant of her abdomen Contributed by: Paul Ndekwe, MD, Resident Physician, Indiana University School of Department of Pathology and
More informationBenign and malignant epithelial lesions: Seborrheic keratosis: A common benign pigmented epidermal tumor occur in middle-aged or older persons more
Benign and malignant epithelial lesions: Seborrheic keratosis: A common benign pigmented epidermal tumor occur in middle-aged or older persons more common on the trunk; but extremities, head and neck are
More informationProceedings of the World Small Animal Veterinary Association Mexico City, Mexico 2005
Close this window to return to IVIS Proceedings of the World Small Animal Veterinary Association Mexico City, Mexico 2005 Hosted by: Reprinted in the IVIS website with the permission of the WSAVA Cutaneous
More informationSEBACEOUS NEOPLASMS. Dr. Prachi Saraogi Clinical Fellow in Dermatology
SEBACEOUS NEOPLASMS Dr. Prachi Saraogi Clinical Fellow in Dermatology Sebaceous neoplasms Sebaceous adenoma (Benign) Sebaceous carcinoma (Malignant) SEBACEOUS ADENOMA Benign tumours composed of incompletely
More informationPitfalls in thyroid tumor pathology. Prof.Valdi Pešutić-Pisac MD, PhD
Pitfalls in thyroid tumor pathology Prof.Valdi Pešutić-Pisac MD, PhD Too many or... Tumour herniation through a torn capsule simulating capsular invasion fibrous capsule with a sharp discontinuity, suggestive
More informationNote: The cause of testicular neoplasms remains unknown
- In the 15- to 34-year-old age group, they are the most common tumors of men. - Tumors of the testis are a heterogeneous group of neoplasms that include: I. Germ cell tumors : 95%; all are malignant.
More informationSubmission of samples. Cytology of Lumps and Bumps. Evaluation of samples. Use caution interpreting. Criteria of malignancy.
Submission of samples Cytology of Lumps and Bumps Paul Avery VMD, PhD, DACVP paul.avery@colostate.edu Air dry only No wet fixation using formalin or ethanol Stain 1-2 on-site to evaluate quality Send all
More informationnumber Done by Corrected by Doctor Maha Shomaf
number 16 Done by Waseem Abo-Obeida Corrected by Zeina Assaf Doctor Maha Shomaf MALIGNANT NEOPLASMS The four fundamental features by which benign and malignant tumors can be distinguished are: 1- differentiation
More information, , 2011 HODGKIN LYMPHOMA
European Federation of Cytology Societies 4tu Annual Tutorial in Cytopathology Trieste, June 6-10, 2011 HODGKIN LYMPHOMA Classification The World Health Organization Classification of Lymphomas (2001)
More informationSlide seminar. Asist. Prof. Jože Pižem, MD, PhD Institute of Pathology Medical Faculty, University of Ljubljana
Slide seminar Asist. Prof. Jože Pižem, MD, PhD Institute of Pathology Medical Faculty, University of Ljubljana Case 5 A 57-year-old man with a dermal/subcutaneous lesion on the scalp, which was interpreted
More informationDiagnosis of a granular cell tumour at the abdominal wall using fine needle aspiration cytology and histology: Case report
Case Report Diagnosis of a granular cell tumour at the abdominal wall using fine needle aspiration cytology and histology: Case report Journal of International Medical Research 2015, Vol. 43(4) 592 596!
More informationVETERINARY HEMATOLOGY ATLAS OF COMMON DOMESTIC AND NON-DOMESTIC SPECIES COPYRIGHTED MATERIAL SECOND EDITION
VETERINARY HEMATOLOGY ATLAS OF COMMON DOMESTIC AND NON-DOMESTIC SPECIES SECOND EDITION COPYRIGHTED MATERIAL CHAPTER ONE HEMATOPOIESIS GENERAL FEATURES All blood cells have a finite life span, but in normal
More informationDiagnostic Value of Fluorescence Method on Melanoma in Dogs
Jpn J Vet Dermatol 2003; 9 (4): 159 164 Diagnostic Value of Fluorescence Method on Melanoma in Dogs Masahiko Nagata 1), Atsuhiko Hasegawa 2) 1) Animal Dermatology Center, ASC 2) Department of Pathobiology,
More informationBREAST PATHOLOGY. Fibrocystic Changes
BREAST PATHOLOGY Lesions of the breast are very common, and they present as palpable, sometimes painful, nodules or masses. Most of these lesions are benign. Breast cancer is the 2 nd most common cause
More informationKidney Case 1 SURGICAL PATHOLOGY REPORT
Kidney Case 1 Surgical Pathology Report February 9, 2007 Clinical History: This 45 year old woman was found to have a left renal mass. CT urography with reconstruction revealed a 2 cm medial mass which
More informationPathology of Sarcoma ELEANOR CHEN, MD, PHD, ASSISTANT PROFESSOR DEPARTMENT OF PATHOLOGY UNIVERSITY OF WASHINGTON
Pathology of Sarcoma ELEANOR CHEN, MD, PHD, ASSISTANT PROFESSOR DEPARTMENT OF PATHOLOGY UNIVERSITY OF WASHINGTON Presentation outline Background and epidemiology of sarcomas Sarcoma classification Sarcoma
More informationCase year female. Routine Pap smear
Case 1 57 year female Routine Pap smear Diagnosis? 1. Atypical glandular cells of unknown significance (AGUS) 2. Endocervical AIS 3. Endocervical adenocarcinoma 4. Endometrial adenocarcinoma 5. Adenocarcinoma
More informationMAMMARY GLAND TUMORS General Information Pathology History & Clinical Signs
MAMMARY GLAND TUMORS Philip J. Bergman DVM, MS, PhD, DACVIM (Oncology) Chief Medical Officer, BrightHeart Veterinary Centers, Armonk, NY 10504 pbergman@brightheartvet.com (914) 219-5415 (office), 219-5417
More informationHISTOPATHOLOGY. Shannon Martinson
HISTOPATHOLOGY Shannon Martinson March 2013 Case #1 History: 8 year old beagle Neck pain for the past couple of weeks Paresis, followed by paralysis developed over the past few days Gross Description courtesy
More informationThe Relevance of Cytologic Atypia in Cutaneous Neural Tumors
The Relevance of Cytologic Atypia in Cutaneous Neural Tumors Recent Findings - New Developments New Problems Zsolt B. Argenyi, M.D. Professor of Pathology & Dermatology Director of Dermatopathology Department
More informationDIAGNOSIS AND REPORTING OF FOLLICULAR-PATTERNED THYROID LESIONS BY FINE NEEDLE ASPIRATION
Follicular-patterned thyroid lesions, WC Faquin 1 DIAGNOSIS AND REPORTING OF FOLLICULAR-PATTERNED THYROID LESIONS BY FINE NEEDLE ASPIRATION William C. Faquin, M.D., Ph.D Department of Pathology, Massachusetts
More informationCYTOMORPHOLOGY OF CANINE TRANSMISSIBLE VENEREAL TUMORS
International Journal of Science, Environment and Technology, Vol. 5, No 4, 2016, 2239 2244 ISSN 2278-3687 (O) 2277-663X (P) CYTOMORPHOLOGY OF CANINE TRANSMISSIBLE VENEREAL TUMORS Sudha Rani Chowdary CH*
More informationJournal of International Academy of Forensic Science & Pathology (JIAFP)
Journal of International Academy of Forensic Science & Pathology (JIAFP) ISSN 2395-0722 MICROCYSTIC ADNEXAL CARCINOMA-A CASE REPORT WITH REVIEW OF LITERATURE Case Report Sulakshana M S 1,Natarajan M 2
More informationUniversity Journal of Pre and Para Clinical Sciences
ISSN 2455 2879 Volume 2 Issue 1 2016 Metaplastic carcinoma breast a rare case report Abstract : Metaplastic carcinoma of the breast is a rare malignancy with two distinct cell lines described as a breast
More informationStating the obvious. The Whats, Wheres, and Hows of Treating Companion Animal Cancer. Lethargic. Steven Suter VMD PhD ACVIM (Oncology)
The Whats, Wheres, and Hows of Treating Companion Animal Cancer Steven Suter VMD PhD ACVIM (Oncology) Stating the obvious Animals with cancer usually don t come to you with a diagnosis or a treatment plan.
More informationHistiocytic Neoplasms of the Dog and Cat
Histiocytic Neoplasms of the Dog and Cat V.E. Valli DVM Histiocytic and Dendritic Cell Populations Both lineages are bone marrow derived. Macrophages are part of the innate immune system that are phagocytic
More informationCase Report A Case of Primary Submandibular Gland Oncocytic Carcinoma
Case Reports in Otolaryngology Volume 2013, Article ID 384238, 4 pages http://dx.doi.org/10.1155/2013/384238 Case Report A Case of Primary Submandibular Gland Oncocytic Carcinoma Kunihiko Tokashiki, Kiyoaki
More information3/27/2017. Pulmonary Pathology Specialty Conference. Disclosure of Relevant Financial Relationships. Clinical History:
Pulmonary Pathology Specialty Conference Saul Suster, M.D. Medical College of Wisconsin Disclosure of Relevant Financial Relationships USCAP requires that all planners (Education Committee) in a position
More informationHistopathology of Melanoma
THE YALE JOURNAL OF BIOLOGY AND MEDICINE 48, 409-416 (1975) Histopathology of Melanoma G. J. WALKER SMITH Department ofpathology, Yale University School ofmedicine, 333 Cedar Street, New Haven, Connecticut
More informationCase Presentation. Maha Akkawi, MD, Fatima Obeidat, MD, Tariq Aladily, MD. Department of Pathology Jordan University Hospital Amman, Jordan
Case Presentation Maha Akkawi, MD, Fatima Obeidat, MD, Tariq Aladily, MD Department of Pathology Jordan University Hospital Amman, Jordan The 25th Annual Congress of the ADIAP The 8/11/2013 1 5th International
More informationIdentification and correlation of cytologic criteria to histologic grade in canine cutaneous mast cell tumors
Retrospective Theses and Dissertations Iowa State University Capstones, Theses and Dissertations 2007 Identification and correlation of cytologic criteria to histologic grade in canine cutaneous mast cell
More informationCOLUMNS. Diagnostic Exercise: Epithelioid Hemangiosarcoma Mimicking Metastatic Prostatic Neoplasia in a Dog
COLUMNS Vet Pathol 46:548 552 (2009) DOI: 10.1354/vp.08-VP-0245-L-DEX Diagnostic Exercise: Epithelioid Hemangiosarcoma Mimicking Metastatic Prostatic Neoplasia in a Dog S. SHOR, S. C. HELFAND, E. GORMAN,
More informationOcular Neoplasia What s Common? What s New? Richard R Dubielzig
Ocular Neoplasia What s Common? What s New? Richard R Dubielzig Orbit 288 6% Tumors of the globe make up 3225 out of 6110 total neoplasms = 53%. Tumors of the conjunctiva make up 1192 out of 6110 total
More informationCytology of Neoplasms that Occur on the Limbs Rick Alleman, DVM, PhD, DABVP, DACVP
Cytology of Neoplasms that Occur on the Limbs Rick Alleman, DVM, PhD, DABVP, DACVP I. Introduction The purpose of this material is to provide information that may be useful in the identification of tumors
More informationencapsulated thyroid nodule with a follicular architecture and some form of atypia. The problem is when to diagnose
Histological Spectrum of Papillary Carcinoma of Thyroid A Two Years Study Gomathi Srinivasan 1, M. Vennila 2 1 Associate Professor Pathology, Government Medical College, Omandurar Estate, Chennai 600 002
More informationProceeding of the SEVC Southern European Veterinary Conference
www.ivis.org Proceeding of the SEVC Southern European Veterinary Conference Oct. 17-19, 2008 Barcelona, Spain http://www.sevc.info Reprinted in the IVIS website with the permission of the SEVC www.ivis.org
More informationMody. AIS vs. Invasive Adenocarcinoma of the Cervix
Common Problems in Gynecologic Pathology Michael T. Deavers, M.D. Houston Methodist Hospital, Houston, Texas Common Problems in Gynecologic Pathology Adenocarcinoma in-situ (AIS) of the Cervix vs. Invasive
More information21/07/2017. Hobnail endothelial cells are not the same as epithelioid endothelial cells
UPDATE IN CUTANEOUS VASCULAR S DERMATOPATHOLOGY SESSION BELFAST PATHOLOGY JUNE 21/2017 Dr E Calonje St John s Institute of Dermatology, London, United Kingdom THE FAMILY OF VASCULAR S WITH EPITHELIOID
More informationCPC 4 Breast Cancer. Rochelle Harwood, a 35 year old sales assistant, presents to her GP because she has noticed a painless lump in her left breast.
CPC 4 Breast Cancer Rochelle Harwood, a 35 year old sales assistant, presents to her GP because she has noticed a painless lump in her left breast. 1. What are the most likely diagnoses of this lump? Fibroadenoma
More informationperformed to help sway the clinician in what the appropriate diagnosis is, which can substantially alter the treatment of management.
Hello, I am Maura Polansky at the University of Texas MD Anderson Cancer Center. I am a Physician Assistant in the Department of Gastrointestinal Medical Oncology and the Program Director for Physician
More informationEDUCATIONAL COMMENTARY MORPHOLOGIC ABNORMALITIES IN LEUKOCYTES
EDUCATIONAL COMMENTARY MORPHOLOGIC ABNORMALITIES IN LEUKOCYTES Educational commentary is provided through our affiliation with the American Society for Clinical Pathology (ASCP). To obtain FREE CME/CMLE
More informationRespiratory Tract Cytology
Respiratory Tract Cytology 40 th European Congress of Cytology Liverpool, UK Momin T. Siddiqui M.D. Professor of Pathology and Laboratory Medicine Director of Cytopathology Emory University Hospital, Atlanta,
More informationPathology of the Thyroid
Pathology of the Thyroid Thyroid Carcinoma Arising from Follicular Cells 2015-01-19 Prof. Dr. med. Katharina Glatz Pathologie Carcinomas Arising from Follicular Cells Differentiated Carcinoma Papillary
More informationPresentation material is for education purposes only. All rights reserved URMC Radiology Page 1 of 98
Presentation material is for education purposes only. All rights reserved. 2011 URMC Radiology Page 1 of 98 Radiology / Pathology Conference February 2011 Brooke Koltz, Cytopathology Resident Presentation
More informationThis is the second learning component (Learning Component 2) in our first learning module (Learning Module 1). In this component we review a very
This is the second learning component (Learning Component 2) in our first learning module (Learning Module 1). In this component we review a very basic response to injury inflammation. We ll look at examples
More informationNeoplasia part I. Dr. Mohsen Dashti. Clinical Medicine & Pathology nd Lecture
Neoplasia part I By Dr. Mohsen Dashti Clinical Medicine & Pathology 316 2 nd Lecture Lecture outline Review of structure & function. Basic definitions. Classification of neoplasms. Morphologic features.
More information