Shih-Chieh Lin ( 林世杰 ), Ph.D.

Transcription

1 Shih-Chieh Lin ( 林世杰 ), Ph.D. Research Assistant Professor Department of Physiology College of Medicine National Cheng Kung University Gender: Male Birthday: 07/09/1980 Marital Status: married Jaylin@mail.ncku.edu.tw shihjay.lin@gmail.com RESEARCH INTEREST Endocrinology, Reproductive Physiology, Translational medicine, Cancer biology, and Bioinformatics EDUCATION Bachelor of Science (09/1998~06/2002) Department of Biology, National Cheng Kung University Master of Science (09/2002~06/2004) Department of Physiology, College of Medicine, National Cheng Kung University Thesis: Expression of Pituitary Tumor Transforming Gene-1(PTTG1) in Uterine Leiomyoma Research assistant (06/2004~01/2005) Military Service (01/2005~05/2006) Research assistant (05/2006~08/2007) Philosophy of Doctor (09/2007~07/2011) Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University Thesis: The roles of dual specificity phosphatase-2 (DUSP2) in tumor progression and drug resistance 1

2 Post Doc National Cheng Kung University (08/2011~02/2013) Ming-Jer Tsai & Sophia-Tsai s Lab, Department of Molecular and Cellular Biology, Baylor College of Medicine (03/2013~12/2014) National Cheng Kung University (01/2015~01/2016) Project Faculty National Cheng Kung University (02/2016~present) AWARD The Best Oral Presentation Award (Basic group), Asian Conference on endometriosis (ACE) symposium, Osaka, Japan, 2016 Postdoctoral Research Abroad Program (2-years) supported from National Science Council, 03/2013~03/2015 ISE Travel Award, ICE/ENDO symposium, 2014 Outstanding Paper Award in Wang Ming-Ning memorial Foundation, 2011 Poster Award in7th Congress of the Federations of Asian and Oceanian Physiological Societies (FAOPS), 2011 University, 2011 University, 2010 University, 2009 GRANT 2016 MOST grant (2 years: 08/01/2016~07/31/2018) Grant #: B MY2 Project title: To investigate the function of YAP1 in endometriosis INVITED PRESENTATION 2

3 2017 Society of Chinese Bioscientists in America (SCBA) international symposium, Hangzhou, China Title: The role of COUP-TFII-miR-21-YAP1 regulation axis in enzalutamideresistant prostate cancer 2017 Bilateral Biomedical Science meeting in SCBA international symposium, Hangzhou, China Title: The function of mirnas-coup-tfii-foxm1-cenpf axis in the pathogenesis of prostate cancer th Asian Conference on endometriosis (ACE) symposium, Osaka, Japan Title: Is LATS1 the last hope for endometriosis? (Best oral presentation in basic research) 2015 Society of Chinse Bioscientists in America (SCBA) international symposium, Academia Sinica, Taipei, Taiwan Title: A reciprocal regulation of microrna and COUP-TFII promotes prostate cancer malignancy 2014 ICE/ENDO symposium, Chicago Title: A reciprocal regulation of microrna and COUP-TFII promotes prostate cancer growth and metastasis 2012 Phosphatases in Cell signaling, Development and Human Diseases The First Taiwan Phosphatase Conference, Taiwan Title: Breaking the brake of ERK signaling pathway by hypoxia PUBLICATIONS 1. PC Hou, YH Li, SC Lin SC Lin, JC Lee, PW Lin, JP Liou, JY Chang, C-C Kuo, YM Liu, HS Sun and SJ Tsai. Hypoxia-Induced Downregulation of DUSP-2 Phosphatase Drives Colon Cancer Stemness Cancer Res. Aug 15;77(16): IF:9.122; Rank: 15/217 (Oncology). 2. SC Lin, HC Lee, PC Hou, JL Fu, MH Wu and SJ Tsai. Targeting hypoxia-mediated YAP1 nuclear translocation ameliorates pathogenesis of endometriosis without compromising material fertility J Pathol. (Cover page) 2017 Aug;242(4): doi: /path IF: 7.381; Rank: 3/78 (Pathology). 3. HJ Lee, CY Kao, SC Lin, M Xu, X Xie, S Y Tsai, MJ Tsai. Dysregulation of nuclear receptor COUP-TFII impairs skeletal muscle development Sci Rep Jun 9;7(1):3136. doi: /s SC Lin *, KY Hsiao *, N Chang, PC Hou, and SJ Tsai. Loss of dual specificity 3

4 phosphatase-2 promotes angiogenesis and metastasis via upregulation of interleukin-8 in colon cancer. J Pathol Dec 27. doi: /path [Epub ahead of print] IF: 7.381; Rank: 3/78 * : SC Lin and KY Hsiao contributed equally to this study. 5. SC Lin, CY Kao, HJ Lee, CJ Creighton, MM Ittmann, SJ Tsai, SY Tsai, MJ Tsai. Dysregulation of mirnas-coup-tfii-foxm1-cenpf axis contributes to the metastasis of prostate cancer Nat Commun Apr 25;7: doi: /ncomms IF: ; Rank: 3/63 (Multidisciplinary Sciences) 代表作 6. YH Liu, YS Tsai, SC Lin, NS Liao, MS Jan, CT Liang, SW Hsu, WC Chen, JM Sung, N Maeda, PJ Tsai. Quantitative PPARγ expression affects the balance between tolerance and immunity. Sci Rep May 25;6: doi: /srep IF: 5.228; Rank: 7/63 (Multidisciplinary Sciences) 7. HC Tai, PJ Tsai, JY Chen, CH Lai, KC Wang, SH Teng, SC Lin, A Chang, MJ Jiang, YH Li, HL Wu, N Maeda, YS Tsai. PPARγ level contributes to structural integrity and component production of elastic fibers in the aorta Hypertension 2016 Apr 4. pii: HYPERTENSIONAHA [Epub ahead of print] IF:6.294; Rank: 3/63 (Peripheral Vascular Disease) 8. CW Chien, PC Hou, HC Wu, YL Chang, SC Lin, SC Lin, BW Lin, JC Lee, YJ Chang, HS Sun, SJ Tsai. Targeting TYRO3 inhibits epithelial-mesenchymal transition and increases drug sensitivity in colon cancer. Oncogene May 2. doi: /onc [Epub ahead of print] IF: 7.932; Rank: 15/213 (Oncology) 9. L Wang, M Xu, J Qin, SC Lin, HJ Lee, SY Tsai, MJ Tsai. MPC1, a key gene in cancer metabolism, is regulated by COUP-TFII in human prostate cancer Oncotarget 2016 Feb 15. doi: /oncotarget [Epub ahead of print] IF: 5.008; Rank: 36/213 (Oncology) 10. KY Hsiao, SC Lin, MH Wu, SJ Tsai. Pathological functions of hypoxia in endometriosis. Front Biosci (Elite Ed) Jan 1;7: IF: 3.736; Rank: 73/291 (BIOCHEMISTRY & MOLECULAR BIOLOGY) 11. KY Hsiao, N Chang, SC Lin, YH Li and MH Wu. Inhibition of dual specificity phosphatase-2 by hypoxia promotes interleukin-8-mediated angiogenesis in endometriosis. Hum Reprod Dec;29(12): IF: 4.621; Rank: 4/80(Obstetrics & Gynecology). 12. J Qin, HJ Lee, SP Wu, SC Lin, RB Lanz, CJ Creighton, FJ DeMayo, SY Tsai, MJ Tsai. Androgen deprivation-induced NCoA2 promotes metastatic and castration resistant prostate cancer. J Clin Invest Nov;124(11): IF: ; Rank: 3/124 (Medicine, Research & Experimental) 13. SC Lin *, YH Li *, MH Wu, YF Chang, DK Lee, SY Tsai, MJ Tsai, SJ Tsai. Suppression of COUP-TFII by proinflammatory cytokines contributes to the pathogenesis of endometriosis. * : SC Lin, YH Li contributed equally to this study. J Clin Endocrinol Metab Mar; 99(3):E doi: /jc Epub 2014 Jan 1 IF: 5.531; Rank: 16/131 (Endocrinology and Metabolism) 14. HC Wang, TK Kooi, HY Kao, SC Lin, SJ Tsai. Using positive and negative patterns 4

5 to extract information from journal articles regarding the regulation of a target gene by a transcription factor. Comput Biol Med Dec;43(12): IF: 1.521; Rank: 27/56 (MATHEMATICAL & COMPUTATIONAL BIOLOGY). 15. SC Lin *, CC Wang *, MH Wu, SH Yang, YH Li, and SJ Tsai. Hypoxia-induced microrna-20a expression increases ERK phosphorylation and angiogenic gene expression in endometriotic stromal cells. J Clin Endocrinol Metab Aug; 97(8):E * : SC Lin, CC Wang contributed equally to this study. IF: 5.531; Rank: 16/131 (Endocrinology and Metabolism) 16. MH Wu *, SC Lin *, KY Hsiao, and SJ Tsai. Hypoxia-inhibited dual specificity phosphatase-2 expression in endometriotic cells regulates cyclooxygenase-2 expression. J Pathol Nov; 225(3): doi: /path Epub 2011 Aug 24. * : MH Wu, SC Lin contributed equally to this study. IF: 7.381; Rank: 3/78 (Pathology) 17. CW Lu, SC Lin, CW Chien, SC Lin, CT Lee, BW Lin, JC Lee, and SJ Tsai* 2011 Overexpression of pyruvate dehydrogenase kinase-3 increases drug resistance and predicts poor prognosis of colon cancer. Am J Pathol Sep;179(3): Epub 2011 Jul 18. IF: 4.206; Rank: 11/78 (Pathology) 18. SC Lin, CW Chien, JC Lee, YC Yeh, KF Hsu, YY Lai, SC Lin, SJ Tsai. Suppression of dual-specificity phosphatase-2 by hypoxia increases chemoresistance and malignancy in human cancer cells. J Clin Invest. 2011;121(5): IF: ; Rank: 3/124 (Medicine, Research & Experimental) 代表作 19. YC Yeh, WC Wei, YK Wang, SC Lin, JM Sung, MJ Tang. Transforming growth factor-{beta}1 induces Smad3-dependent {beta}1 integrin gene expression in epithelial-to-mesenchymal transition during chronic tubulointerstitial fibrosis. Am J Pathol Oct;177(4): Epub 2010 Aug 13. IF: 4.206; Rank: 11/78 (Pathology) 20. CW Chien, SC Lin, YY Lai, BW Lin, SC Lin, JC Lee, SJ Tsai. Regulation of CD151 by hypoxia controls cell adhesion and metastasis in colorectal cancer. Clin Cancer Res Dec 15;14 (24): Epub 2008 Dec 10 IF: 8.738; Rank: 12/213 (Oncology) 21. CW Lu, SC Lin, KF Chen, YY Lai, SJ Tsai. Induction of pyruvate dehydrogenase kinase-3 by hypoxia-inducible factor-1 promotes metabolic switch and drug resistance. J Biol Chem Oct 17;283(42): (Name changed from SJ Lin to SC Lin) IF: 4.258; Rank: 71/289 (BIOCHEMISTRY & MOLECULAR BIOLOGY) 22. MH Wu, KF Chen, SC Lin, CW Lgu, SJ Tsai. Aberrant Expression of Leptin in Human Endometriotic Stromal Cells Is Induced by Elevated Levels of Hypoxia Inducible Factor-1. Am. J. Pathol Feb; 170 (2): IF: 4.206; Rank: 11/78 (Pathology) Name changed from SJ Lin to SC Lin 23. SJ Tsai *,SJ Lin *, YM Cheng, HM Chen, and LYC Wing. Expression and functional analysis of pituitary tumor transforming gene-1 in uterine leiomyomas. J Clin Endocrinol Metab Jun; 90(6): * :Tsai SJ and SJ Lin contributed equally to this study. IF: 5.531; Rank: 16/131 (Endocrinology and Metabolism) 5