CURRICULUM VITAE Name : Gender : Birth Place : address : Contact Tel : Education: Training and Working Experiences: Awards:

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1 Name : Szu-Hua Pan Gender : Female Birth Place : Taipei, Taiwan address : shpan@ntu.edu.tw Contact Tel : ext CURRICULUM VITAE Education: 1991~1994 B.S., Department of Nutrition and Health, Taipei Medical University 1994~1996 M.S., Graduate Institute of Medical Sciences, Taipei Medical University 2002~2009 Ph.D., Graduate Institute of Life Sciences, National Defense Medical Center Training and Working Experiences: 1996~2002 Teaching assistant, Department of Chemistry, National Taiwan Normal University 2009~2010 Postdoctoral Fellow, Department of Internal Medicine, College of Medicine, National Taiwan University 2010~2012 Postdoctoral Fellow, Institute of Biomedical Sciences, Academia Sinica 2012~2013 Project-Appointed Assistant Professor, Graduate Institute of Medical Genomics and Proteomics, College of Medicine, National Taiwan University 2013~present Assistant Professor, Graduate Institute of Medical Genomics and Proteomics, College of Medicine, National Taiwan University Awards: 1995~1996 Outstanding Graduate student scholarship, Ministry of Education, Taipei, Taiwan 1998 Outstanding Research Award, National Science Council, Taipei, Taiwan 2006 Excellent Thesis Award of Chien-Tien Hsu Foundation in 14th Symposium on Recent Advances in Cellular and Molecular Biology, Taipei, Taiwan 2006 Excellent Thesis Award in 6th symposium of PhD student in Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan 2007 Award for Attending International Conferences, The Chinese Society of Cell and Molecular Biology, Taipei, Taiwan 2008 Poster Competition Award for Attending International Conferences, Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan 2009 Thesis Award of Foundation Medicine in 14th Taiwan Joint Cancer Conference, Taipei, Taiwan

2 Fields of Expertise: 1. Cancer Biology and Metastasis 2. Functional Proteomics 3. Signal transduction 4. Cytoskeleton rearrangement 5. Cell Image and Animal model Publications: (A) Journal articles 1. Chen WJ, Ho CC, Chang YL, Chen HY, Lin CA, Ling TY, Yu SL, Yuan SS, Chen YU, Lin CY, Pan SH, Chou HY, Chen YJ, Chang GC, Chu WC, Lee YM, Lee JY, Lee PJ, Li KC, Chen HW, Yang PC (2014) Cancer-associated fibroblasts regulate the plasticity of lung cancer stemness via paracrine signaling. Nat Commun. (In press, SCI ) 2. Wang WL, Huang HC, Hsu YC, Chang YL, Wu CT, Pan SH, Li KC, Wang YT, Chen YJ, Kao SH, Hung PF, Wang SP, Hong TM, Yang PC (2014) Slug is temporally regulated by cyclin E in cell cycle and controls genomic stability. Oncogen (In press, SCI 7.414) 3. Chen CY, Jan CI, Lo JF, Yang SC, Chang YL, Pan SH, Wang WL, Hong TM, Yang PC (2013) Tid1-L inhibits EGFR signaling in lung adenocarcinoma by enhancing EGFR Ubiquitinylation and degradation. Cancer Res. 73(13): (SCI 8.65) 4. Lin CW, Chang YL, Chang YC, Lin JC, Chen CC, Pan SH, Wu CT, Chen HY, Yang SC, Hong TM, Yang PC (2013) MicroRNA-135b promotes lung cancer metastasis by regulating multiple targets in the Hippo pathway and LZTS1. Nat Commun. 4: (SCI ) 5. Hung PF, Hong TM, Hsu YC, Chen HY, Chang YL, Wu CT, Chang GC, Jou YS, Pan SH*, Yang PC* (2013) The motor protein KIF14 inhibits tumor growth and cancer metastasis in lung adenocarcinoma. PLoS One. 8(4): e61664 (equal corresponding, SCI 4.411) 6. Chang CC, Yang MH, Lin BR, Chen ST, Pan SH, Hsiao M, Lai TC, Lin SK, Jeng YM, Chu CY, Chen RH, Yang PC, Chin YE, Kuo ML (2013) CCN2 inhibits lung cancer metastasis through promoting DAPK-dependent anoikis and inducing EGFR degradation. Cell Death Differ. 20(3): (SCI 8.849) 7. Liang CH, Chiu SY, Hsu IL, Wu YY, Tsai YT, Ke JY, Pan SH, Hsu YC, Li KC, Yang PC, Chen YL, Hong TM. (2013) α-catulin drives metastasis by activating ILK and driving an αvβ3 integrin signaling axis. Cancer Res. 73(1): (SCI 7.856) 8. Wang WL, Hong TM, Chang YL, Wu CT, Pan SH*, Yang PC* (2012) Phosphorylation of LCRMP-1 by GSK3β promotes filopoda formation, migration and invasion abilities in lung cancer cells. PLos One 7(2): e31689 (equal corresponding, SCI 4.411) 9. Pan SH, Chao YC, Hung PF, Chen HY, Yang SC, Chang YL, Wu CT, Chang CC, Wang WL, Chan WK, Wu YY, Che TF, Wang LK, Lee YC, Kuo ML, Lee CH, Chen JJ, Hong TM, Yang PC (2011) The ability of LCRMP-1 to promote cancer invasion by enhancing filopodia formation is antagonized by CRMP-1. J Clin Invest. 121 (8): (SCI )

3 10. Wu YY, Peck K, Chang YL, Pan SH, Cheng YF, Lin JC, Yang RB, Hong TM, Yang PC (2011) SCUBE3 is an endogenous TGF-β receptor ligand and regulates the epithelial-mesenchymal transition in lung cancer. Oncogene 30(34): (SCI 7.414) 11. Wang YT, Tsai CF, Hong TC, Tsou CC, Lin PY, Pan SH, Hong TM, Yang PC, Sung TY, Hsu WL, Chen YJ (2010) An Informatics-assisted Label-free Quantitation Strategy that Depicts Phosphoproteomic Profiles in Lung Cancer Cell Invasion. J Proteome Res. 9 (11): (SCI 5.46) 12. Pan SH, Chao YC, Chen HY, Hung PF, Lin PY, Lin CW, Chang YL, Wu CT, Lee YC, Hong TM, Yang PC (2010) Long Form Collapsin Response Mediator Protein-1 (LCRMP-1) Expression is Associated with Clinical Outcome and Lymph node Metastasis in Non-small cell Lung Cancer Patients. Lung Cancer 67 (1): (SCI 3.356) 13. Chao YC, Pan SH, Yang SC, Yu SL, Che TF, Lin CW, Tsai MS, Chang GC, Wu CH, Wu YY, Lee YC, Hong TM, Yang PC (2009) Claudin-1 is a metastasis suppressor and correlates with clinical outcome in lung adenocarcinoma. Am J Respir Crit Care Med. 179 (2): (SCI ) 14. Wu MH, Hong TM, Cheng HW, Pan SH, Liang YR, Hong HC, Chiang WF, Wong TY, Shieh DB, Shiau AL, Jin YT, Chen YL (2009) Galectin-1-mediated tumor invasion and metastasis, up-regulated matrix metalloproteinase expression, and reorganized actin cytoskeletons. Mol Cancer Res. 7(3):311-8 (SCI 4.373) 15. Hong TM, Chen YL, Wu YY, Yuan A, Chao YC, Chung YC, Wu MH, Yang SC, Pan SH, Shih JY, Chan WK, Yang PC (2007) Targeting neuropilin 1 as an antitumor strategy in lung cancer. Clin Cancer Res. 13(16): (SCI 7.338) 16. Pan SH, Mou TC, Chiang CC and Lee HM (1997) Rates of Advanced Glycosylation End Products (AGEPs) formation stimulated by different sugars in vitro. Nutritional Sciences Journal 22(2): (in Chinese). (B) Conference papers: 1. Lin SY, Lai YH, Chen HY, Yu SL, Pan SH, Chen J. JJ. Identification of the promoter region of p54nrb/ NonO gene in NSCLC. 72nd Annual Meeting of the Japanese Cancer Association 2013, Poster section, Yokohama, Japan, October Hsu YL, Pan SH and Wang CC. The functional characterization of Inhibition of DNA binding 4 in human lung adenocarcinoma cells. 72nd Annual Meeting of the Japanese Cancer Association 2013, Oral presentation, Yokohama, Japan, October Kuo TC, Wang YT, Chen YJ, Pan SH and Yang PC. To discover the EGFR TKI resistant targets in Non-small cell lung cancer by using phosphoproteomics approach. 72nd Annual Meeting of the Japanese Cancer Association 2013, Oral presentation, Yokohama, Japan, October Lin CY, Han CL, Chen YJ, Yang PC and Pan SH. Membrane proteome profiling for EGFR signal pathway associated with TKI resistance in lung cancer. 72nd Annual Meeting of the

4 Japanese Cancer Association 2013, Oral Presentation, Yokohama, Japan, October Kuo TC, Lin CY, Cheng HW, Wong CH, Yang PC and Pan SH. Development of novel therapeutic molecules for EGFR-TKI resistant lung cancers. 18th Taiwan Joint Cancer Conference 2013, Oral presentation, Taipei, Taiwan, July Wang WL, Pan SH, Chang YL, Wu CT, Hong TM and Yang PC. Phosphorylation of LCRMP-1 by GSK3β promotes filopoda formation, migration and invasion abilities in lung cancer cells. 103th AACR Annual Meeting 2012, Poster section, Chicago, Illinois, March 31-April 4. (2012: 5304) 7. Pan SH, Chen CH, Hung PF, Chao YC, Chang YL, Wu CT, Deng WP, Chen JJ, Hong TM and Yang PC. Refinement of Lung Metastasis Model by Orthotopic Thoracic Implantation of Non-small cell Lung Cancer Cells in Mice. 14th World Conference on Lung Cancer, 2011, Poster section, Amsterdam Rai, The Netherlands, July Hung PF, Pan SH, Chang YL, Wu CT, Hong TM and Yang PC. Motor protein KIF14 as a tumor suppressor in lung cancer. 14th World Conference on Lung Cancer, 2011, Poster section, Amsterdam Rai, The Netherlands, July Wang WL, Kao SH, Wang SP, Pan SH, Hong TM, and Yang PC. The EMT regulator Slug controls the DNA replication and genomic instability. 14th World Conference on Lung Cancer, 2011, Poster section, Amsterdam Rai, The Netherlands, July Lin CW, Lin JC, Chang YL, Chen HY, Pan SH, Hong TM and Yang PC. The role of a novel oncomir, mir-135b, in lung cancer metastasis and clinical application. 102th AACR Annual Meeting 2011, Poster section, Orlando, Florida, USA, April 2-6. (2011: 3976) 11. Pan SH, Chao YC, Hung PF, Chen HY, Yang SC, Chang YL, Hong TM, and Yang PC. LCRMP-1/CRMP-1: A Novel Pathway that Regulates Cancer Invasion and Metastasis. Taiwan Genomics and Genetics Symposium Translational Medicine, 2010, Poster section, Taichung, Taiwan, December Pan SH, Hung PF, Chang YL, Wu CT, Chang CC, Hong TM, and Yang PC. The Role of AACR/JCA 8 th Joint Conference 2010, Poster section, Waikoloa, Hawaii, February Pan SH, Hung PF, Chang YL, Wu CT, Chang CC, Hong TM, and Yang PC. The Role of Taiwan Genomics and Genetics Symposium Translational Medicine, 2009, Oral presentation, Sitou, Taiwan, December Pan SH, Hung PF, Chang YL, Wu CT, Chang CC, Hong TM, and Yang PC. The Role of 15th Taiwan Joint Cancer Conference 2009, Poster section, Taipei, Taiwan. May Pan SH, Chao YC, Chen HY, Hung PF, Chang YL, Wu CT, Lin CW, Hong TM, and Yang PC. Long form Collapsin Response Mediator Protein-1 (LCRMP-1) promotes Metastasis and the Signature of LCRMP-1 Predicts Survival and Relapse in Lung Cancer. 100th AACR

5 Annual Meeting 2009, Poster section, Denver, USA, April (2009: 1038) 16. Wu YY, Pan SH, Lin JC, Peck K, Yang RB, Hong TM, Yang PC. SCUBE3 functions as a novel invasion promoter in lung cancer progression. 100th AACR Annual Meeting 2009, Oral presentation, Denver, USA, April (2009: 3891) 17. Pan SH, Chao YC, Chen HY, Hung PF, Chang YL, Wu CT, Hong TM, Yang PC. LCRMP-1/CRMP-1: A Novel Pathway that Regulates Cancer Invasion and Metastasis. 14th Taiwan Joint Cancer Conference 2009, Oral presentation, Taipei, Taiwan. May Pan SH, Ieong PS, Kao SH, Hong TM, Yang PC. CapG can promote cancer cell invasion and predict lung cancer outcome. 98th AACR Annual Meeting 2007, Poster section, Los Angeles, CA, U.S.A., April (#2007:1363) 19. Pan SH, Hong TM, Chao YC, Wu YY, Yang SC, Wang WL, Ieong PS, and Yang PC. Long form collapsin response mediator protein-1(lcrmp-1) is a novel invasion enhancer: Yin-Yang regulation of cancer cell invasion by LCRMP-1 and CRMP-1. 97th AACR Annual Meeting 2006, Poster section, Washington, D.C. U.S.A., April 5-9 (2006: 823) (C) Thesis 1. Ph.D. thesis Graduate Institute of Life Sciences, National Defense Medical Center The Role of Long Form Collapsin Response Mediator Protein-1 (LCRMP-1) in Lung Cancer Metastasis Student: Szu-Hua Pan Advisor: Dr. Pan-Chyr Yang Master thesis: Graduate Institute of Medical Sciences, Taipei Medical University Application of Advanced Glycosylation End Products in Clinical Laboratory Student: Szu-Hua Pan Advisor: Horng-Mo Lee Ph.D (D) Text book: Chen HR, Pan SH, Wang JY, Tasi YJ, Lin SJ. Biochemisty Experiment (in Chinese) 2005 March, Gau Lih Book Co., Ltd