Sensing Hypoxia in the Cell and the Organism

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1 Sensing Hypoxia in the Cell and the Organism Essen, Germany COST ACTION TD0901

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3 Meeting chairmen: Prof. Joachim FANDREY, Essen Prof. Eric METZEN, Essen Scientific Advisory Committee: Dr. Eoin CUMMINS, Dublin Prof. Max GASSMANN, Zurich Prof. Dörthe KATSCHINSKI, Göttingen Dr. Olga KRIZANOVA, Bratislava Prof. José LÓPEZ-BARNEO, Sevilla Prof. Patrick MAXWELL, London Prof. Johanna MYLLYHARJU, Oulu Dr. Lara OGUNSHOLA, Zurich Prof. Silvia PASTOREKOVA, Bratislava Prof. Christopher PUGH, Oxford Dr. Cormac TAYLOR, Dublin Prof. Roland WENGER, Zurich Meeting Sponsors:

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5 Thursday, Sept. 20, :00 13:50 Registration, light lunch 13:50 Welcome 14:00 16:00 Basic Science Workgroup 1 Roland Wenger M. Coleman 2-Oxoglutarate Oxygenases Target the Protein Synthesis Apparatus S. Lee Switching proteome in response to oxygen tension D. Mole Dissecting the transcriptional and epigenetic response to hypoxia across the genome A. Görlach Hypoxia and NOX enzymes H. Mairbäurl AMPK or hypoxia, what dominates the mitochondria? 16:00 16:30 Coffee 16:30 18:30 Technology Workgroup 2 Johanna Myllyharju M. Percy The region C terminal to the hydroxyacceptor proline of HIF-2alpha crucial for its regulation A. Bremm HIF-1alpha regulation by the Lys11-specific deubiquitinase Cezanne M. Queisser Hoil-1L ubiquitin-ligase regulates cellular adaptation to hypoxia D. Hoogewijs A novel oxygen-binding globin expressed in the hypoxic testis L. Poellinger Epigenetic Mechanisms Regulating the Hypoxic Response 18:30 20:00 Dinner buffet 20:00 H. Franklin Bunn: "Hypoxia, Erythropoiesis and Novel Approaches to Treating Anemias"

6 Friday, Sept. 21, :30 10:30 Pharmacology Workgroup 3 Teresa Pereira O. Krizanova NF-κB inhibition significantly upregulates the norepinephrine transporter system, causes apoptosis in pheochromocytoma cell lines and prevents metastasis in an animal model P. McLoughlin Gremlin plays a key, lung specific role in hypoxic pulmonary hypertension L. Ogunshola Hypoxia and blood-brain barrier dysfunction: Is HIF-1 the culprit? P. Sonveaux Targeting the lactate transporter MCT1 inhibits lactate-induced HIF-1 activation and tumor angiogenesis V. Sée Cellular adaptation to low oxygen environment; live cell imaging and systems biology approaches 10:30 11:00 Coffee 11:00 11:30 Celeste Simon: Hypoxia, Metabolism, and Tumor Progression 11:30 13:00 Translational medicine Workgroup 4 Max Gassmann M. Schneider Translational aspects of oxygen sensing in visceral medicine M. Bernaudin Hypoxia, Erythropoietin and Brain Tumor J. Myllyharju Transmembrane prolyl 4-hydroxylase is a fourth prolyl 4-hydroxylase regulating EPO production and erythropoiesis T. Serebrovskaya How different intermittent hypoxia training (IHT) modalities influence tissue oxygenation and mitochondrial metabolism 13:00 14:00 Lunch buffet 14:00 16:00 Inflammatory Hypoxia Thorsten Cramer 16:00 16:30 Coffee C. Taylor Hydroxylase-dependent regulation of Interleukin-1-induced inflammatory pathways B. Brüne Impact of hypoxia/hif-1 on plasmacytoid DC development B. Marteyn Local hypoxia induction during Shigella infection M. von Köckritz-Blickwede Novel role of HIF-1Α in the formation of antimicrobial mast cell extracellular traps S. Walmsley Regulation of neutrophilic inflammation by the HIF/PHD pathway V. Kempf Activation of HIF-1 in infections: mechanisms and functional consequences 16:30 18:30 10 short selected presentations from posters Carine Michiels Bakker, W (#2) Binó, L (#5) Bonafé, M (#6) Bosco, M (#7) Gardie, B (#12) Kunze, R (#21) Mylonis, I (#27) Neumann, D (#29) Papkovsky, D (#31) Skapare, E (#35) 18:30 21:30 Running dinner poster session combined with industrial exhibition and presentation

7 Saturday, Sept. 22, :30 10:30 Workshop Animal Models in Hypoxia Research Chris Pugh 10:30 11:00 Coffee V. Haase Insights into oxygen-dependent regulation of erythropoiesis from animal models S. Renshaw "Zebrafish as a model for studying hypoxia signalling in vivo D. Abele Marine fish and invertebrates - a bottom up view of HIF pathway evolution A. Avivi Hypoxia-Tolerance and Cancer Resistance in the Subterranean Rodent, the Blind Mole-Rat, Spalax T. Hankeln Respiration in insects: the evolution and functional relevance of globins 11:00 11:30 Peter J. Ratcliffe: Oxygen sensing by 2-OG oxygenases 11:30 12:30 Transcriptional Regulation Eric Metzen P. Jaakola P62/SQSTM1 regulates Hypoxia Response by Attenuating PHD3 Activity through Aggregate Sequestration and Enhanced Degradation J. Schödel Genome-wide HIF-binding in renal cancer D. Villar Lozano Cooperativity of stress-responsive transcription factors in core hypoxia-inducible factor binding regions 12:30 13:30 Lunch buffet 13:30 15:30 Metabolism Dörthe Katschinski J. Aragonés López The role of the HIF2α oxygen-sensing pathway on mtorc1 activity M. Deckers Mitochondrial dynamics S. Behrends Heme oxygenase isoforms differ in their subcellular trafficking during hypoxia and are differentially modulated by cytochrome P450 reductase N. Forsyth BMP2 repression and engineered oxygen control measures promote human mesenchymal stem cell recovery B. Wielockx HIF-1α is a Protective Factor in Conditional PHD2 Deficient Mice Suffering from Severe HIF-2α-Induced Excessive Erythropoiesis 15:30 16:00 Walk/transfer to Margarethenhöhe 16:00 19:00 "Industrial Essen Wealth and Responsibility" 19:00 Conference Dinner Hülsmannshof

8 Sunday, Sept. 23, :00 10:30 Oncology George Simos S. Chouaib influence of hypoxic stress on anti-tumor response M. Evans Ion channel regulation by the LKB1-AMPK signalling pathway: the key to carotid body activation by hypoxia and metabolic homeostasis at the whole body level T. Gorr Endogenous myoglobin in breast cancer cells and its unorthodox roles: an update E. Cummins Mechanisms of hydroxylase-dependent intestinal epithelial cell protection E. Berra The role of PHD3 SUMOylation in the cellular response to hypoxia 10:30 11:00 Coffee 11:00 13:00 Systemic aspects Martina Muckenthaler T. Acker The Hypoxic Tumor Niche: Mechanisms and Therapeutic Perspectives J. Dulak HIF-regulated gene therapy for hind limb ischemia S. Rocha Oxygen Sensing and Key Biological Processes in the Cell N. Weissmann Mechanisms of ischemia-reperfusion induced lung Injury NADPH oxidases and TRPC channels G. Cairo Hepcidin-dependent control of body iron homeostasis by erythropoiesis 13:00 Lunch, End of scientific meeting 14:00 16:00 Management Committee Business Meeting (MC members only)