Minority Institution/ Cancer Center Partnership

Transcription

1 Cancer Health Disparities Summit 08 Eliminating Cancer Health Disparities Through Science, Training and Community Minority Institution/ Cancer Center Partnership Dr. H. Nelson Aguila Center to Reduce Cancer Health Disparities July 14, 2008

2 MI/CCP Partnership Model Education Minority Training Community Trust and Participation MSI CC Cancer Research Expertise State-of-the-Art Cancer Facilities State-of-the-Art Cancer Treatments Build research capacity and training at MSIs Create stable, long-term collaborations between MSIs and CCs in research, training, career development, and outreach Improve effectiveness of CC research, education and outreach for underserved populations Export successful approaches for addressing disparities to all CCs and other key networks and consortiums Reduce Cancer Health Disparities

3 Current Distribution of NCI-Sponsored MI/CCP Guam U54-7 partnerships U56-10 partnerships P20-9 partnerships Univ. of Puerto Rico Ponce School of Med

4 MI/CCP Partnership Program Structure MI/CCP Program Structure MINORITY SERVING INSTITUTION CANCER CENTER RESEARCH, TRAINING, OUTREACH, EDUCATION P20 Feasibility Studies U56 Cooperative Comprehensive Planning Grant U54 Comprehensive Grant F31, Career Awards, R03, R21, R01, R25, T32, P01 F31/32/33, Career Awards, R03, R21, R01, R25, T32, P01

5 MI/CCP P20 Mechanism PAR Next submission due date: April 15, 2009 Primary Objective: Target Areas: Duration: Funding: Final Objective: To provide support for cancer projects and Programs for a limited duration of time to perform feasibility studies/obtain preliminary data/submission of competitive grant applications. Research; Training and Career Development; Education Up to 4 years Direct Cost up to $275K per partnership/year: Administrative and Developmental Costs planning; priority setting; implementation) Submission of competitive grant applications (i.e. R series, K series, T32, R25T, F31, R25E) funded by NIH/NCI and/or comparable grant funding organizations.

6 Number of Cancer Research Studies U54/ U56 Research Projects All Project Types CHD Projects Project Types Cancer Types Breast Prostate Head & Neck Lung CRC Gynecologic Total Pilot Full Total

7 U54/U56 Research Publications Aurora B Kinase Maintains Chromatin Organization During the Ml and Mll Transition in Surf Clam Oocytes Cell Cycle 5:2648, 2006 Breast Cancer Education for Native American Women Clinical J Oncology Nursing 9(6): 689, 2005 BRCA1 Antitumor activity in breast, ovarian, and prostate cancers Oncogene 26:6031, 2007 Regulation of Drosophila Life Span by Olfaction and Food- Derived Odors Science 315: 1133, 2007 Cispaltin and Fluoruracil Alone or with Docetaxel in Head and Neck Cancer N Engl J Med 357:1705, 2007

8 U54/U56 Research Competitive Grants 150 Number of Grants Submitted Funded Pending

9 U54/ U56 Training, Career Development and Education 21 Med Students 25 Med Fellows 178 Master Students 157 Pre-Docs 34 Post-Docs 72 Junior Faculty 881 Trainees 70 New MSI Faculty 13 New CC Faculty 35 Post-Bac 338 Undergrad 21 High School Students

10 Education Curricula to build critical mass of diverse investigators in cancer research through competitive R25 grants, institutional support and leveraged funds New Mexico State University at Las Cruces and the Fred Hutchinson Cancer Research Center Biology 385: An Introduction to Cancer University of the District of Columbia and The Lombardi CCC (R25 grant) Master s Degree in Cancer Biology, Prevention, and Control Tuskegee University, University of AL at Birmingham CC, Morehouse School of Medicine Foundations of Cancer Biology (BIOL 0540) Biosciences Research and Ethics (IBSC 0601) Northern Arizona University and Arizona Cancer Center Chemical Carcinogenesis (MS level course) Patient Navigation program for Native American students San Francisco State University and UCSF Hellen Diller Family CCC (state funding) Ph.D. Program for Nurses in clinical nursing oncology

11 Training and Career Development MSI Junior Investigator Successes Dr. Marcia Cruz-Correa (Assistant Professor) UPRCC / MDACC K22CA Clinicopathology of IGF2 Loss of Imprinting in Colon Neoplasia R03CA Familial Colorectal Cancer in Puerto Rico: A Feasibility Study Dr. James Lillard (Assistant Professor) TU / MSM / UAB DOD New Investigator Award CCL25-CCR9 Prostate Cancer Cell Survival and Metastasis Dr. Alecia Malin Fair (Assistant Professor) MMC / VUCC ACS Career Development Award (MRSGT CPHPS) Mammography Follow-up in Minority and Medically Underserved Women Dr. Maribel Vazquez (Associate Professor) CCNY / MSKCC R21GM71703 Mycrosystems to manipulate fibroblast chemotaxis R21CA A mu migration assay for temporal protein localization

12 MI/CCP- AACR Forum Showcased the Accomplishments of the MI/CCP Junior Investigators April 14, 2008 Basic Research - Dr. LaMonica V. Stewart, Meharry Medical College, Nashville, TN Clinical Research - Dr. Barbara H. Jung, University of California San Diego, La Jolla, CA Population Research - Dr. Gary Bennett, Harvard School of Public Health, Boston, MA Investing in the Future - Dr. Rachael Leon Guerrero, University of Guam, Mangilao, GU

13 U54/U56 Outreach Using hypothesis driven interventions, Arizona CC and NAU are working with Native Americans, and the Hawaii CC and University of Guam are working with Pacific Islander populations, to increase cancer screenings through print and electronic mediums. Partnering with local community coalitions, MMC/VICC and TSU is reaching African American and Hispanic communities through cancer prevention workshops and symposiums. The purpose is to develop community-based participatory research.

14 Next steps and challenges Increase publications and grant submissions Evaluation of the impact of the MI/CCP program (NCI and Partnerships) Increase training and mentoring of students and junior investigators Tracking and evaluation of training and educational programs Improve communication among partnerships Increasing outreach activities Increasing clinical activities Develop new funding mechanisms (NCI)

15 Selected MI/CCP Presentations July 14 1:00 2:30 Session 6: Models of Training Programs Dr. Marian Manciu P20 UT El Paso/ UT Hlth. Sci. Ctr. San Antonio Dr. Louis Canfield U54 AZCC/ Northern Arizona University Dr. Christi Patten P20 Mayo Clinic/ Dine College 2:45 4:00 Session 2: Recruitment and Retention Issues Dr. Samuel Adunyah U54 MMC/ VICC Session 3: Role of Physical Activity and Nutritional Factors Dr. Rachel Leon-Guerrero U56 Univ. of Guam/ Hawaii CC Session 6: Cancer Health Disparities: Epidemiology & Risks Factors Dr. Pamela Hull U54 MMC/ VICC (TSU)

16 Selected MI/CCP Presentations July 15 1:00 2:30 Session 3: A Greater Understanding of Breast & Cervical Cancer Dr. Tu-Uyn Nguyen U56 UCSF CC/ SFSU Session 5: Innovative Research Methods Dr. Alecia Fair (Malin) U54 MMC/ VICC 2:45 4:00 Session 1: Cancer Therapeutics & Radiopharmaceuticals Res. Dr. Marcia Cruz-Correa U54 UPRCC/ MD Anderson

17 Contacts Dr. Nelson Aguila Program Director Dr. Peter Ogunbiyi Program Director Telephone

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19 P20 Program Accomplishments (FY01 FY08) Total of 17 Partnerships P20 Students trained 234 Faculty career development 36 Faculty hired 3 Courses developed 9 Publications 49 Publications (under review) 20 Applications submitted 23 Grants awarded 12 Numbers

20 P20 Accomplishments Students Trained 146 Undergraduate 65 Graduate 23 Medical/ Dental New Courses Cancer Biology 101 Cancer Causes & Prevention Cancer Biology & Bioinformatics Tumor Biology Bioethics Cancers in Minority Populations Breast Prostate Colorectal Cervical Grants Awarded R01 P20 U56 U54 DoD Private Foundation