Capecitabine in the treatment of metastatic renal cell carcinoma
|
|
- Felix Hart
- 6 years ago
- Views:
Transcription
1 British Journl of Cncer (2000) 83(5), doi: / bjoc , vilble online t on Cpecitbine in the tretment of metsttic renl cell crcinom K Oevermnn 1, J Buer 1, R Hoffmnn 1, A Frnzke 1, A Schrder 1, T Ptzelt 2, H Kirchner 1 nd J Atzpodien 1,2,3 1 Medizinische Hochshule Hnnover, Deprtment of Hemtology nd Oncology, Crl-Neuberg-Strsse 1, Hnnover, Germny 2 Europen Institute for Tumor Immunology nd Prevention (EUTIP), Gotenstr. 152, Bonn, Germny 3 Robert Jnker Cncer Center, Villenstr. 4, Bonn, Germny Summry To evlute the therpeutic effects nd systemic toxicities of cpecitbine-bsed home therpy regimen in ptients with metsttic renl cell crcinom, 30 ptients were enrolled in phse II clinicl tril. Tretment consisted of orl cpecitbine combined with subcutneous recombinnt humn interferon-α 2, recombinnt humn interleukin-2 nd orl 13-cis-retinoic cid. There were two (7%) complete responses (CRs) nd eight (27%) prtil remissions (PRs), for n overll objective response rte of 34% (95% CI 17 53%). Except one, ll responses re ongoing, with medin durtion of 9+ nd 8+ months for CRs nd PRs, respectively. Additionlly, 12 ptients (40%) reched stble disese. Eight ptients (27%) showed continued disese progression despite tretment. Therpy ws well tolerted nd ws given in the outptient setting. Cpecitbine-relted World Helth Orgniztion (WHO) grde 2 nd 3 toxicities were observed in five nd two ptients respectively, nd were limited to ftigue, nuse/vomiting, dirrhoe, stomtitis, dermtitis nd hnd-nd-foot syndrome. The substitution of cpecitbine for 5-FU in the pre-existing biochemotherpy regimen did not result in reduced therpeutic efficcy nd showed significnt nti-tumour ctivity in ptients with dvnced renl cell crcinom. Keywords: renl cell crcinom; cpecitbine; 13-cis-retinoic cid; lph-interferon Renl cell crcinom is known to be mostly chemotherpy-resistnt (Hrusshesky nd Murphy, 1977; Duensing et l, 1994; Ygod et l, 1995). While the prognosis of ptients with metsttic renl cell crcinom remins poor, objective nd durble remissions cn be reched in pproximtely one third of ptients using pllitive biochemotherpies, especilly employing combined cytokines nd 5-fluorourcil (Lopez et l, 1996; Ellerhorst et l, 1997). Cpecitbine is n orlly dministered fluoropyrimidine crbmte, ctivted by three-step converstion process to the cytotoxic gent 5-FU. After orl dministrtion, cpecitbine is first metbolized in the liver to 5 -DFCR. Second, 5 -DFCR is converted to 5 -DFUR by cytidine deminse, locted in high concentrtions in the liver nd tumour tissues (Tkebyshi et l, 1996; Miw et l, 1998). Finlly, converstion of 5 -DFUR to 5- FU occurs by thymidine phosphorylse, which is present t higher concentrtions in tumour thn in norml tissue, thus minimizing the exposure of helthy body tissues to 5-FU (Tkebyshi et l, 1996; Ishikw et l, 1998; 1998b). The efficcy nd fvourble sfety profiles of cpecitbine hve been demonstrted in ptients with common solid tumours such s colorectl nd brest cncer (Blum et l, 1999; Mcken et l, 1998; Schüller et l, 1997). So fr, no results hve been reported in dvnced renl crcinom. Here we report phse II clinicl tril of p.o. cpecitbine combined with s.c. interferon-α2, s.c. interleukin-2 nd p.o. 13- cis-retinoic cid. Systemic toxicity nd therpeutic response were evluted in 30 ptients with progressive metsttic renl cell crcinom. The results of this study re presented. Received 9 June 1999 Revised 10 My 2000 Accepted 17 My 2000 Correspondence to: J Atzpodien PATIENTS AND METHODS The study protocol ws pproved by the Clinicl Institutionl Ethicl Review Bord of the University of Hnnover. Between June 1998 nd December 1998 we entered 30 ptients in phse II clinicl tril, (Tble 1). All ptients presented with histologiclly confirmed metsttic renl cell crcinom in dvnced stte, ged yers, expected survivl of more thn 3 months, Krnofsky sttus of 70%, nd signed informed consent. Ptients received the following cpecitbine-bsed outptient chemo-immunotherpy regimen. Interferon-α ws dministered subcutneously t 5 MIU m 2 on dy 1 of weeks 5 8. Interleukin-2 ws dministered subcutneously t 10 MIU m 2 on dys 3, 4 nd 5 of weeks 1 nd 4, nd t 5 MIU m 2 on dys 1, 3 nd 5 of weeks 2 nd 3. Cpecitbine ws dministered orlly on dys 1 5 of weeks 5 8 t 1000 mg m 2 twice dily. In ddition, orl 13-cisretinoic cid ws given t 34 mg m 2 dily during weeks 1 8. Concomitnt mediction ws given s needed to control dverse effects of immunotherpy. Ptients were treted on n outptient bsis. Tble 2 summrizes the therpy regimen used in this study. 8-week tretment cycles were repeted for up to three courses. Number of tretment cycles vried exclusively bsed on progressive disese of the ptients. Re-evlution of the ptients tumour sttus ws performed between tretment cycles. Response to therpy ws evluted ccording to World Helth Orgniztion (WHO) criteri: complete response = disppernce of ll signs of disese for minimum of 8 weeks; prtil response = 50% or more reduction in sum of products of the gretest perpendiculr dimeters of mesurble lesions, no increse in lesion size nd no new lesions; stble disese = less thn prtil response with no disese progression for t lest 8 weeks; progressive disese = 25% nd more increse in sum of the products in the 583
2 584 K Oevermnn et l Tble 1 Chrcteristics longest perpendiculr dimeters of mesurble lesions, or development of new lesions. Systemic toxicity ws evluted t weekly intervls using grding system dpted from the World Helth Orgniztion (WHO). Tretment efficcy ws ssessed on intent-to-tret bsis. RESULTS Ptients chrcteristics Ptients Entered 30 Sex mle 24 femle 6 Age (yers) medin 60 rnge Tumour nephrectomy yes 29 no 1 Metstses lung 23 bone 14 lymph nodes 12 liver 9 pleur 4 renl 4 drenl glnd 3 locl relpse 1 other 5 Prognosis b good 5 poor 25 No. of tretment cycles 46 (rnge 1 3) Tumour thrombus, soft tissue, pericrdium, myelon (n = 2); b Good prognosis ws defined by the presence of lung metstses nd the bsence of bone metstses, ESR < 70 mm fter 1 h, serum lctic dehydrogense < 280 units l 1, neutrophilic grnulocytes < 6000 µl 1 nd hemoglobin > 100 gm l 1 poor prognosis ptients included ll others Medin follow-up nd survivl Medin follow-up of ll ptients is 8 months; except for three ptients, ll ptients re still live. Tretment response Out of 30 ptients, two (7%) chieved complete response, nd eight (27%) hd prtil remission (Tble 3). The overll response rte in this study ws 34% (95% CI 17 53%). Complete responses (CRs) occurred in lung (n = 1), liver (n = 1), pleur (n = 1) nd kidney (n = 1), while prtil remissions (PRs) were seen in lung (n = 4), liver (n = 3) (Figure 1), bone (n = 1), pleur (n = 1) nd locl relpse (n = 1). The medin response durtion for CRs nd PRs were 9+ nd 8+ months, respectively, with rnge from months (Tble 4). Except for one ptient who developed brin metstses, ll ptients re in sustined remission. In ddition, 12 ptients (40%) chieved stble disese upon chemoimmunotherpy (medin durtion of 8+ months). Eight ptients (27%) hd continued disese progression despite tretment. Toxicity In ll ptients, cpecitbine therpy ws completed without modifiction of dosge or chnge of time-intervl. 25 of 30 ptients reported cpecitbine-ssocited, mostly mild sideeffects (Tble 5). No grde 4 toxicity ws observed nd only two ptients reported grde 3 mlise, one of them with concomitnt grde 3 nuse/vomiting nd stomtitis. Grde 2 stomtitis, dermtitis, hnd-nd-foot syndrome, norexi, dirrhoe nd mlise were observed in four, two, two, two, one nd one ptients, respectively. Mild grde 1 gstrointestinl side-effects were reported in 16, nd mild norexi in nine ptients with moderte dermtitis, five showed erly stges of hnd-nd-foot syndrome in the upper extremity nd/or nil disorders. Few ptients (n = 9) developed grde 1 neurologicl symptoms including trnsient presthesisis, hedche nd dizziness; eight ptients reported mild mylgi. Grde 1 neutropeni ws seen in one ptient. No crdic toxicity ws noted; one ptient with history of severe ortic stenosis tolerted cpecitbine without tretment-ssocited crdic symptoms. In ll ptients tretmentrelted toxicities resolved fter cesstion of therpy. No toxic deth occurred. DISCUSSION The use of biologic therpies hs n estblished role in the tretment of metsttic renl cell crcinom (Quesd, 1988; Belldegrun et l, 1991; Atzpodien et l, 1995; Hofmockel et l, 1997). Potentilly better results cn be obtined using combintion therpies with cytokines nd 5-fluorourcil (Lopez et l, 1996; Hofmockel et l, 1997). Retinoids re known to control mny importnt biologicl processes, including differenttion, morphogenesis, growth nd tissue homeostsis (Wrrel, 1994). Clinicl nd pre-clinicl results provide evidence for n ntiprolifertive effect of 13-cis-retinoic cid in IFN-α-treted ptients with renl cell crcinom (Buer et l, 1995; Motzer et l, 1995). Furthermore, it seems to hve fvourble effect in the tretment of renl Tble 2 Home therpy regimen Therpeutic gent Dose Regimen Recombinnt interferon-α2 5 Million IU m 2 s.c. Once dily, dy 1, weeks 1 nd 4; dys 1,3,5, week 2 nd 3 10 Million IU m 2 s.c. Once dily, dys 1,3,5, weeks 5 8 Recombinnt interleukin-2 10 Million IU m 2 s.c. Twice dily, dys 3,4,5, weeks 1 nd 4 5 Million IU m 2 s.c. Once dily, dys 1,3,5, weeks 2 nd 3 Cpecitbine 1000 mg m 2 p.o. Twice dily, dys 1 5, weeks cis-retinoic cid 35 mg m 2 p.o. Dily, dys 1 7, weeks 1 8 Ptients were entered between June 1998 nd December Ptients received cytokines nd chemotherpy t home. Tretment cycles were repeted every 2 months for n verge of 1.5 cycles (rnge 1 3) unless disese progression occurred British Journl of Cncer (2000) 83(5),
3 Cpecitbine in metsttic renl cell crcinom 585 Tble 3 Response to therpy Tumour site Response Complete Prtil Stble Progressive Totl remission remission disese disese Lung Bone Lymph nodes Liver Pleur Kidney Adrenl glnd Locl relpse 1 1 Other 1 b 3 c 1 d 5 Ptients Risk e Good/Poor 1/1 2/6 2/10 0/8 5/25 Ptients my hve hd more thn one tumour site; b Soft tissue; c tumor thrombus, pericrdium, myelon; d myelon; e Good Prognosis ws defined by the presence of lung metstses nd the bsence of bone metstses, ESR < 70 mm fter 1 h, serum lctic dehydrogense < 280 units l 1 neutrophilic grnulocytes < 6000 µl 1 nd hemoglobin > 100 gm l 1, poor prognosis ptients included ll others Tble 4 Remissions Age Sex Intervl between first Sites of metsttic Prognosis Mximl response Remission durtion Sttus (yers) dignosis nd ppernce disese upon cpecitbine, upon strt to cpecitbine, αinf, (months) from strt of metstses (months) αinf, IL2, 13-cis-RA of therpy IL2, 13-cis-RA of cpecitbine, αinf, IL2, 13-cis-RA 64 m 11 Lung Good CR 9+ live 71 f 14 Kidney, pleur, bone Poor CR 9+ live 41 f 0 Lung, lymph nodes, liver, bone Poor PR 4 b live 50 m 0 Lung Good PR 9+ live 57 m 10 Lung, liver, locl relpse Poor PR 8+ live 57 m 25 Bone, soft tissue Poor PR 10+ live 58 m 8 Liver, lymph nodes Poor PR 7+ live 58 m 19 Lung, liver, pleur Good PR 8+ live 64 m 23 Lung Poor PR 5+ live 69 m 12 Lung, bone Poor PR 8+ live Good prognosis ws defined by the presence of lung metstses nd the bsence of bone metstses, ESR < 70 mm fter 1 h, serum lctic dehydrogense < 280 units l 1 neutrophilic grnulocytes < 6000 µ l 1 nd hemoglobin > 100 gm l 1, poor prognosis ptients included ll others; b This ptient developed brin metstses cncer, when dded to immuno-chemotherpy regimens (Atzpodien et l, 1995b). Cpecitbine, s novel fluoropyrimidine crbmte which is converted to 5-fluorourcil by three enzymes locted in the liver nd in tumours, shows promising response rtes nd remission durtions while being very well tolerted in ptients with metsttic renl cell crcinom. Due to four-fold higher thymidine phosphorylse (5-DFUR to 5-FU) ctivity in tumour compred to djcent helthy tissue (Frings, 1998), cpecitbine llows for more specific nti-tumour therpy thn conventionl i.v. fluorourcil. In the present home-therpy tril, we treted 30 ptients with progressive metsttic renl cell crcinom with combintion of p.o. cpecitbine, s.c. IFN-α, s.c. IL-2 nd 13-cis-RA. The dose of cpecitbine ws dpted on n empiricl bsis from the recommend dose (Roche Lbortories Inc, 1998). The continued dministrtion over n extended tretment intervl of 4 weeks in combintion with s.c. IFN-α, s opposed to n dministrtion for 2 weeks followed by 1-week rest period, required both reduction in the dily dose of cpecitbine nd > 50% reduction in cumultive 8-week cpecitbine dosges. Cpecitbine shows promising objective response rtes in vrious solid tumours (Frings, 1998). We report first clinicl results of cpecitbine in the tretment of dvnced renl cncer. Tumour regressions occurred in 34% of ptients evluted, with 7% CRs, nd medin response durtion of 8+ months. These results were comprble to other 5-FU-bsed therpy regimens in renl cell crcinom (Sell et l, 1994; Joffe et l, 1996; Hofmockel et l, 1997; Tourni et l, 1998). In the ptients reported here, the rte of cpecitbine-relted toxicity ws low, nd side-effects were moderte overll. Predominnt side-effects included gstrointestinl toxicities with dirrhoe, nuse/vomiting, dyspepsi nd stomtitis, nd cutneous symptoms including dermtitis nd erly stges of hndnd-foot syndrome. A few ptients experienced mild mlise nd mild neurologicl/musculoskeletl side-effects. Cpecitbine-ssocited systemic toxicities were mostly limited to WHO grde 1, rrely grde 2. Only two ptients experienced WHO grde 3 effects. It should be noted tht in ddition to cpecitbine ll ptients were simultneously treted with s.c. IFN-α nd p.o. 13-cis-RA. This confirmed the excellent tolerbility reported in other mlignncies t vrious dosges nd tretment intervls of British Journl of Cncer (2000) 83(5),
4 586 K Oevermnn et l Tble 5 Systemic toxicity of cpecitbine A Side-effects b (WHO criteri) No. of ptients Grde 1 Grde 2 Grde 3 Grde 4 Gstrointestinl Dirrhoe 6 1 Nuse 15 1 Vomiting Stomtits Abdominl pin 7 Constiption 6 Dyspepsi 9 Skin nd subcutneous 17 2 Hnd-nd-foot syndrome 5 2 Dermtitis 17 2 Nil disorder 4 Generl Ftigue Pyrexi 7 Neurologicl 9 Presthesi 1 Hedche 5 Dizziness 6 Insomni Metbolism 9 2 Anorexi 9 2 Dehydrtion 2 Eye 1 Eye irrittion 1 Muscoloskeletl 8 Mylgi 8 Crdic Oedem Blood 1 Neutropeni 1 Thrombocytopeni Anemi Lymphopeni Heptobiliry Hyperbilirubinemi B C Cpecitbine ssocited toxicities were evluted during weeks 5 8 of ech tretment cycle ccording to WHO criteri nd were observed in 25 of 30 ptients. Grde 2 toxicity ws seen in five ptients nd grde 3 toxicity occured in two ptients; b Ptients my hve hd severl side-effects. cpecitbine (Budmn et l, 1998; Mcken et l, 1998). Per orl dministrtion of cpecitbine, in contrst to most chemotherpeutic gents tht re pplied intrvenously, llows tretment in n outptient or home therpy setting. This dvntge will reduce expenses nd could enhnce qulity of life in the pllitive setting. Unless rndomized dt become vilble, the contribution of cpecitbine nd its potentil therpeutic fesibility cnnot be definitively ssessed. Therefore, we hve initited prospectively controlled rndomized clinicl tril to investigte the role of cpecitbine in ptients with dvnced renl cell crcinom. Figure 1 Liver CT scns of 58-yer-old ptient with history of dvnced renl cell crcinom, post-surgicl of tumour nephrectomy nd prtil liver resection who (A) subsequently developed extensive metsttic lesions in his liver. (B) Prtil remission of metsttic liver disese fter the first 8-week tretment cycle with p.o. cpecitbine, s.c. INF-α; s.c. IL-2 nd p.o. 13-cisRA. (C) Further tumour regression upon completion of the third consecutive tretment cycle. ACKNOWLEDGEMENT Jens Atzpodien nd Jn Buer re supported by the Deutsche Krebshilfe. REFERENCES Atzpodien J, Lopez HE, Kirchner H, Bodenstein H, Pfreundschuh M, Rebmnn U, Metzner B, Illiger HJ, Jkse G nd Niesel T (1995) Multiinstitutionl hometherpy tril of recombinnt humn interleukin-2 nd interferon lf-2 in progressive metsttic renl cell crcinom. J Clin Oncol 13: Atzpodien J, Kirchner H, Duensing S, Lopez HE, Frnzke A, Buer J, Probst M, Anton P nd Poliwod H (1995b) Biochemotherpy of dvnced metsttic renl-cell crcinom: results of the combintion of interleukin-2, lphinterferon, 5-fluorourcil, vinblstine, nd 13-cis-retinoic cid. World J Urol 13: Belldegrun A, Abi-Ad AS, Figlin RA nd dekernion JB (1991) Renl cell crcinom: bsic biology nd current pproches to therpy. Semin Oncol 18: Blum JL, Jones SE, Buzdr AU, LoRusso PM, Kuter I, Vogel C, Osterwlder B, Burger HU, Brown CS nd Griffin T (1999) Multicenter phse II study of British Journl of Cncer (2000) 83(5),
5 Cpecitbine in metsttic renl cell crcinom 587 cpecitbine in pclitxel-refrctory metsttic brest cncer. J Clin Oncol 17: Budmn DR, Meropol NJ, Reigner B, Creven PJ, Lichtmn SM, Berghorn E, Behr J, Gordon RJ, Osterwlder B nd Griffin T (1998) Preliminry studies of novel orl fluoropyrimidine crbmte: cpecitbine. J Clin Oncol 16: Buer J, Probst M, Gnser A nd Atzpodien J (1995) Response to 13-cis-retinoic cid plus interferon lph2 in two ptients with therpy refrctory dvnced renl cell crcinom. J Clin Oncol 13: Duensing S, Dllmnn I, Grosse J, Buer J, Lopez HE, Deckert M, Storkel S, Kirchner H, Poliwod H nd Atzpodien J (1994) Immunocytochemicl detection of P-glycoprotein: initil expression correltes with survivl in renl cell crcinom ptients. Oncology 51: Ellerhorst JA, Sell A, Amto RJ, Tu SM, Millikn RE, Finn LD, Bnks M nd Logothetis CJ (1997) Phse II tril of 5-fluorourcil, interferon-lph nd continuous infusion interleukin-2 for ptients with metsttic renl cell crcinom. Cncer 80: Frings S (1998) Cpecitbine novel orl tumor ctivted fluoropyrimidine. Onkologie 21: Hofmockel G, Theiss M, Gruss A, Lnger W nd Frohmuller H (1997) Immunochemotherpy of metsttic renl cell crcinom with interleukin 2, interferon-lph nd 5-fluorourcil. Urologe A 36: Hrusshesky WJ nd Murphy GP (1977) Currents sttus of the therpy of dvnced renl cell crcinom. J Surg Oncol 9: Ishikw T, Fukse Y, Ymmoto T, Sekiguchi F nd Ishitsuk H (1998) Antitumor ctivities of novel fluoropyrimidine, N4-pentyloxycrbonyl-5 -deoxy-5- fluorocytidine (cpecitbine). Biol Phrm Bull 21: Ishikw T, Sekiguchi F, Fukse Y, Swd N nd Ishitsuk H (1998b) Positive correltion between the efficcy of cpecitbine nd doxifluridine nd the rtio of thymidine phosphorylse to dihydropyrimidine dehydrogense ctivities in tumors in humn cncer xenogrfts. Cncer Res 58: Joffe JK, Bnks RE, Forbes MA, Hllm S, Jenkins A, Ptel PM, Hll GD, Velikov G, Adms J, Crossley A, Johnson PW, Whicher JT, nd Selby PJ (1996) A phse II study of interferon-lph, interleukin-2 nd 5-fluorourcil in dvnced renl crcinom: clinicl dt nd lbortory evidence of protese ctivtion. Br J Urol 77: Lopez HE, Kirchner H nd Atzpodien J (1996) Interleukin-2 bsed home therpy of metsttic renl cell crcinom: risks nd benefits in 215 consecutive single institution ptients. J Urol 155: Mcken M, Plnting A, Twelves C, Schellens J, Allmn D, Osterwlder B, Reigner B, Griffin T, Kye S nd Verweij J (1998) Phse I nd phrmcologic study of intermittent twice-dily orl therpy with cpecitbine in ptients with dvnced nd/or metsttic cncer. J Clin Oncol 16: Miw M, Ur M, Nishid M, Swd N, Ishikw T, Mori K, Shimm N, Umed I nd Ishitsuk H (1998) Design of novel orl fluoropyrimidine crbmte, cpecitbine, which genertes 5-fluorourcil selectively in tumours by enzymes concentrted in humn liver nd cncer tissue. Eur J Cncer 34: Motzer RJ, Schwrtz L, Murry-Lw T, Murphy BA, Hoffmn AD, Albino AP, Vlmis V nd Nnus DM (1995) Interferon lph2 nd cis-retinoic cid in renl cell crcinom: Antitumor ctivity in phse II tril nd interctions in vitro. J Clin Oncol 13: Quesd JR (1988) Biologic response modifiers in the therpy of metsttic renl cell crcinom. Semin Oncol 15: Roche Lbortories Inc. (1998) Xelod (cpecitbine) prescribing informtion Roche Lbortories: USA Schüller J, Cssidy J nd Reigner B (1997) Tumor selective ctivtion of Cpecitbine in colorectl cncer ptients. Onkologie 20: 189 Sell A, Kilbourn RG, Gry I, Finn L, Zukiwski AA, Ellerhorst J, Amto RJ nd Logothetis CJ (1994) Phse I study of interleukin-2 combined with interferonlph nd 5-fluorourcil in ptients with metsttic renl cell cncer. Cncer Biother 9: Tkebyshi Y, Akiym S, Akib S, Ymd K, Miyder K, Sumizw T, Ymd Y, Murt F nd Aikou T (1996) Clinicopthologic nd prognostic significnce of n ngiogenic fctor, thymidine phosphorylse, in humn colorectl crcinom [see comments]. J Ntl Cncer Inst 88: Tourni JM, Pfister C, Berdh JF, Benhmmoud A, Slze P, Monnier A, Pule B, Guillet P, Chretien Y, Brewer Y, Di Plm M, Untereiner M, Mlurie E, Tdrist Z, Pvlovitch JM, Huteville D, Mejen A, Azgury M, Myeur D, Lucs V, Krkowski I, Lrregin-Fournier D, Abourchid H, Andrieu JM nd Chstng C Subcutneous Administrtion Propeukin Progrm Coopertive Group. (1998) Outptient tretment with subcutneous interleukin-2 nd interferon lf dministrtion in combintion with fluorourcil in ptients with metsttic renl cell crcinom: results of sequentil nonrndomized phse II study. J Clin Oncol 16: Wrrel RP (1994) Applictions for retinoids in cncer therpy. Semin Hemtol 31(Suppl.): 1 13 Ygod A, Abi-Rched B nd Petrylk D (1995) Chemotherpy for dvnced renlcell crcinom: Semin Oncol 22: British Journl of Cncer (2000) 83(5),
Efficacy of Pembrolizumab in Patients With Advanced Melanoma With Stable Brain Metastases at Baseline: A Pooled Retrospective Analysis
Efficcy of Pembrolizumb in Ptients With Advnced Melnom With Stble Brin Metstses t Bseline: A Pooled Retrospective Anlysis Abstrct 1248PD Hmid O, Ribs A, Dud A, Butler MO, Crlino MS, Hwu WJ, Long GV, Ancell
More informationCheckMate 153: Randomized Results of Continuous vs 1-Year Fixed-Duration Nivolumab in Patients With Advanced Non-Small Cell Lung Cancer
CheckMte 53: Rndomized Results of Continuous vs -Yer Fixed-Durtion Nivolumb in Ptients With Advnced Non-Smll Cell Lung Cncer Abstrct 297O Spigel DR, McCleod M, Hussein MA, Wterhouse DM, Einhorn L, Horn
More informationIntroduction. These patients benefit less from conventional chemotherapy than patients identified as MMR proficient or microsatellite stable 3-5
Nivolumb + Ipilimumb Combintion in Ptients With DNA Mismtch Repir-Deficient/Microstellite Instbility-High Metsttic Colorectl Cncer: First Report of the Full Cohort From CheckMte-142 Abstrct 553 André T,
More informationA review of the patterns of docetaxel use for hormone-resistant prostate cancer at the Princess Margaret Hospital
MEDICAL ONCOLOGY A review of the ptterns of docetxel use for hormone-resistnt prostte cncer t the Princess Mrgret Hospitl S.N. Chin MD,* L. Wng MSc, M. Moore MD,* nd S.S. Sridhr MD MSc* ABSTRACT Bckground
More informationEfficacy of Sonidegib in Patients With Metastatic BCC (mbcc)
AAD 216 eposter 3368 Efficcy of Sonidegib in Ptients With Metsttic BCC (mbcc) Colin Morton, 1 Michel Migden, 2 Tingting Yi, 3 Mnish Mone, 3 Dlil Sellmi, 3 Reinhrd Dummer 4 1 Stirling Community Hospitl,
More informationSponsor / Company: Sanofi Drug substance(s): AVE0005 (aflibercept)
These results re supplied for informtionl purposes only. Prescribing decisions should be mde bsed on the pproved pckge insert in the country of prescription. Sponsor / Compny: Snofi Drug substnce(s): AVE0005
More informationIMpower133: Primary PFS, OS, and safety in a Ph1/3 study of 1L atezolizumab + carboplatin + etoposide in extensive-stage SCLC
IMpower133: Primry PFS, OS, nd sfety in Ph1/3 study of 1L tezolizumb + crbopltin + etoposide in extensive-stge SCLC S. V. Liu, 1 A. S. Mnsfield, 2 A. Szczesn, 3 L. Hvel, 4 M. Krzkowski, 5 M. J. Hochmir,
More informationGemmis Injection 38 mg/ml
Gemmis Injection 8 mg/ml Gemcitbine (Gemcitbine HCl) is nucleoside nlogue tht exhibits nti-tumor ctivity. The empiricl formul for Gemcitbine HCl is C 9H 11F 2N O.HCl. It hs moleculr weight of 299.66. Gemcitbine
More informationSafety and Tolerability of Subcutaneous Sarilumab and Intravenous Tocilizumab in Patients With RA
Sfety nd Tolerbility of Subcutneous Srilumb nd Intrvenous Tocilizumb in Ptients With RA Pul Emery, 1 Jun Rondon, 2 Anju Grg, 3 Hubert vn Hoogstrten, 3 Neil M.H. Grhm, 4 Ming Liu, 4 Nncy Liu, 3 Jnie Prrino,
More informationThe RUTHERFORD-2 trial in heterozygous FH: Results and implications
The RUTHERFORD-2 tril in heterozygous FH: Results nd implictions Slide deck kindly supplied s n eductionl resource by Professor Derick Rl MD PhD Crbohydrte & Lipid Metbolism Reserch Unit University of
More informationClinical Study Report Synopsis Drug Substance Naloxegol Study Code D3820C00018 Edition Number 1 Date 01 February 2013 EudraCT Number
EudrCT Number 2012-001531-31 A Phse I, Rndomised, Open-lbel, 3-wy Cross-over Study in Helthy Volunteers to Demonstrte the Bioequivlence of the Nloxegol 25 mg Commercil nd Phse III Formultions nd to Assess
More informationAbstract. Background. Aim. Patients and Methods. Patients. Study Design
Impct of the Use of Drugs nd Substitution Tretments on the Antivirl Tretment of Chronic Heptitis C: Anlysis of Complince, Virologicl Response nd Qulity of Life (CHEOBS). Melin, 1 J.-. Lng, D. Ouzn, 3 M.
More informationSee 17 for PATIENT COUNSELING INFORMATION. Revised: 02/2011 FULL PRESCRIBING INFORMATION: CONTENTS*
HIGHLIGHTS OF PRESCRIBING INFORMATION These highlights do not include ll the informtion needed to use GEMZAR sfely nd effectively. See full prescribing informtion for GEMZAR. GEMZAR (gemcitbine for injection)
More informationSYNOPSIS Final Abbreviated Clinical Study Report for Study CA ABBREVIATED REPORT
Finl Arevited Clinicl Study Report Nme of Sponsor/Compny: Bristol-Myers Squi Ipilimum Individul Study Tle Referring to the Dossier (For Ntionl Authority Use Only) Nme of Finished Product: Yervoy Nme of
More informationReference Slide Deck. Abstract 553 Abstract 554 Abstract 560
Clinicl Spotlight Immunotherpy Advnces for Colorectl Crcinom in 2018: Newly Relesed Dt From the Gstrointestinl Cncers Symposium in Sn Frncisco Reference Slide Deck Abstrct 553 Abstrct 554 Abstrct 560 Mismtch
More informationDOSAGE FORMS AND STRENGTHS HIGHLIGHTS OF PRESCRIBING INFORMATION
HIGHLIGHTS OF PRESCRIBING INFORMATION These highlights do not include ll the informtion needed to use ALIMTA sfely nd effectively. See full prescribing informtion for ALIMTA. ALIMTA (pemetrexed disodium)
More informationImmune-Mediated Adverse Reactions Management Guide
Immune-Medited Adverse Rections Mngement Guide INDICATIONS AND USAGE YERVOY (ipilimumb) is indicted for: Tretment of unresectble or metsttic melnom in dults nd peditric ptients (12 yers nd older) Adjuvnt
More informationAdverse Events Grading Card
Adverse Events Grding Crd Common Terminology Criteri for Adverse Events* In clinicl studies, 2 of the most common dverse events reported with ALAVEN were peripherl neuropthy nd neutropeni. 1 With this
More informationSee 17 for PATIENT COUNSELING INFORMATION and FDAapproved
HIGHLIGHTS OF PRESCRIBING INFORMATION These highlights do not include ll the informtion needed to use ALIMTA sfely nd effectively. See full prescribing informtion for ALIMTA. ALIMTA (pemetrexed for injection),
More informationThe potential future of targeted radionuclide therapy: implications for occupational exposure? P. Covens
The potentil future of trgeted rdionuclide therpy: implictions for occuptionl exposure? Introduction: Trgeted Rdionuclide Therpy (TRT) Systemic tretment Molecule lbelled with rdionuclide delivers toxic
More informationPrognostic significance of pretreatment serum levels of albumin, LDH and total bilirubin in patients with nonmetastatic
Crcinogenesis, 2015, Vol. 36, No. 2, 243 248 doi:10.1093/crcin/bgu247 Advnce Access publiction December 18, 2014 Originl Mnuscript originl mnuscript Prognostic significnce of pretretment serum levels of
More informationManagement of Relapsed/Refractory Follicular Lymphoma
April 2018 Volume 16, Issue 4, Supplement 10 Mngement of Relpsed/Refrctory Folliculr Lymphom n How I Tret Relpsed/Refrctory Folliculr Lymphom: An Expert Perspective n Highlights from: The 2017 Americn
More informationStart ORKAMBI today. INDICATIONS AND USAGE IMPORTANT SAFETY INFORMATION. Sydney Age 4
F O R H E A L T H C A R E P R O F E S S I O N A L S For ptients ge 2 yers nd older who re homozygous for the F508del muttion 1,2 Modify the course. Strt tody. Sydney Age 4 F508del/F508del INDICATIONS AND
More informationImpact of Positive Nodal Metastases in Patients with Thymic Carcinoma and Thymic Neuroendocrine Tumors
Originl Article Impct of Positive Nodl Metstses in Ptients with Thymic Crcinom nd Thymic Neuroendocrine Tumors Benny Weksler, MD, Anthony Holden, MD, nd Jennifer L. Sullivn, MD Introduction: Thymic crcinoms
More informationPNEUMOVAX 23 is recommended by the CDC for all your appropriate adult patients at increased risk for pneumococcal disease 1,2 :
PNEUMOVAX 23 is recommended y the CDC for ll your pproprite dult ptients t incresed risk for pneumococcl disese 1,2 : Adults ged
More informationSupplementary Online Content
Supplementry Online Content Zulmn DM, Pl Chee C, Ezeji-Okoye SC, et l. Effect of n intensive outptient progrm to ugment primry cre for high-need Veterns Affirs ptients: rndomized clinicl tril. JAMA Intern
More informationPegylated liposomal doxorubicin in the treatment of AIDS-related Kaposi s sarcoma
REVIEW Pegylted liposoml doxorubicin in the tretment of AIDS-relted Kposi s srcom Ashish Udhrin 1 Keith M Skubitz 2 Donld W Northfelt 3 1 Deprtment of Medicine, Myo Clinic Arizon, AZ, USA; 2 Division of
More informationFor Adults With Previously Treated Advanced Non-Small Cell Lung Cancer (NSCLC)
For Adults With Previously Treted Advnced Non-Smll Cell Lung Cncer (NSCLC) individuls depicted re models used for illustrtive purposes only. It cn be overwhelming to lern tht your previously treted dvnced
More informationUniversity of Texas Health Science Center, San Antonio, San Antonio, Texas, USA
Lung Cncer Chemotherpy Given Ner the End of Life by Community Oncologists for Advnced Non-Smll Cell Lung Cncer Jose R. Murillo, Jr., Jim Koeller b,c Methodist Hospitl, Houston, Texs, USA; b University
More informationComparative Safety of Filgrastim versus Sargramostim in Patients Receiving Myelosuppressive Chemotherapy
Comprtive Sfety of Filgrstim versus Srgrmostim in Ptients Receiving Myelosuppressive Chemotherpy Gry Milkovich, B.S., Ronld J. Moleski, Phrm.D., John F. Reitn, Phrm.D., Dvid M. Dunning, M.D., Gene A. Gibson,
More informationClinical Study. Oncology 2006;71:32 39 DOI: /
Oncology Clinicl Study Oncology 2006;71:32 39 DOI: 10.1159/000100447 Received: My 29, 2006 Accepted fter revision: December 9, 2006 Published online: Mrch 5, 2007 Efficcy of Consolidtion High-Dose Chemotherpy
More informationPresented at the 75 th Annual Meeting of the American Academy of Dermatology, Orlando, FL, March 3-7, 2017 METHODS INTRODUCTION OBJECTIVE
Seven-Yer Interim Results from the ESPRIT 10-Yer Postmrketing Surveillnce Registry of Adlimumb for Moderte to Severe Psorisis Frncisco Kerdel, 1 Aln Menter, 2 Jshin J. Wu, 3 Mreike Bereswill, 4 Dilek Arikn,
More informationOral UFT (uracil plus futrafur) for neoadjuvant chemotherapy of gastric cancer
64 Gstric Cncer (1999) 2: 64 73 Y. Nio et l.: Neodjuvnt UFT for gstric cncer 1999 by Interntionl nd Jpnese Gstric Cncer Associtions Originl rticle Orl UFT (urcil plus futrfur) for neodjuvnt chemotherpy
More informationSee 17 for PATIENT COUNSELING INFORMATION and Medication Guide. Revised: 10/2017
HIGHLIGHTS OF PRESCRIBING INFORMATION These highlights do not include ll the informtion needed to use sfely nd effectively. See full prescribing informtion for. (ipilimumb) injection, for intrvenous use
More informationOne of the most important biological mechanisms of
Brief Report Serum Thymidine Kinse 1 Activity in the Prognosis nd Monitoring of Chemotherpy in Lung Cncer Ptients: A Brief Report Benjmin Nismn, PhD,* Hovv Nechushtn, MD, PhD,* Him Birn, MD, Hds Gntz-Sorotsky,
More informationSee 17 for PATIENT COUNSELING INFORMATION and FDAapproved. Revised: 01/2019
HIGHLIGHTS OF PRESCRIBING INFORMATION These highlights do not include ll the informtion needed to use ALIMTA sfely nd effectively. See full prescribing informtion for ALIMTA. ALIMTA (pemetrexed for injection),
More informationTarget: 10 mg/day within several days Schizophrenia in adolescents (2.1)
HIGHLIGHTS OF PRESCRIBING INFORMATION These highlights do not include ll the informtion needed to use ZYPREXA sfely nd effectively. See full prescribing informtion for ZYPREXA. ZYPREXA (olnzpine) Tblet
More informationkey words: bortezomib, multiple myeloma, retrospective analysis, treatment outcomes, subcutaneous, intravenous
reserch report Effect of Route of Bortezomib Administrtion on Tretment Outcomes in Previously Untreted Ptients with Multiple Myelom: A Retrospective Anlysis from US Community Oncology Prctices Robert M
More information1 Indications and Usage
HIGHLIGHTS OF PRESCRIBING INFORMATION These highlights do not include ll the informtion needed to use ERBITUX sfely nd effectively. See full prescriing informtion for ERBITUX. ERBITUX (cetuxim) injection,
More informationPROFILE OF A PATIENT WITH mbc with visceral metastases
Ptient P.V. PRFILE F A PATIENT WIT mbc with viscerl metstses Indiction Metsttic Brest Cncer ALAVEN (eribulin mesylte) Injection is indicted for the tretment of ptients with metsttic brest cncer (mbc) who
More informationOriginal Article. Breast Care 2016;11: DOI: /
Originl Article Brest Cre 2016;11:323 327 DOI: 10.1159/000452079 Published online: October 24, 2016 Neodjuvnt Chemotherpy with Docetxel, Crbopltin nd Weekly Trstuzumb Is Active in HER2-Positive Erly Brest
More informationSee 17 for PATIENT COUNSELING INFORMATION. Revised: 09/2017 FULL PRESCRIBING INFORMATION: CONTENTS*
HIGHLIGHTS OF PRESCRIBING INFORMATION These highlights do not include ll the informtion needed to use Gemzr sfely nd effectively. See full prescriing informtion for Gemzr. GEMZAR (gemcitine for injection),
More informationRevised: 6/2018 History of severe hypersensitivity reaction to pemetrexed. (4)
HIGHLIGHTS OF PRESCRIBING INFORMATION ------------------------ WARNINGS AND PRECAUTIONS ----------------------- These highlights do not include ll the informtion needed to use ALIMTA sfely nd effectively.
More informationYERVOY (ipilimumab) injection, for intravenous use Initial U.S. Approval: 2011
HIGHLIGHTS OF PRESCRIBING INFORMATION These highlights do not include ll the informtion needed to use sfely nd effectively. See full prescribing informtion for. (ipilimumb) injection, for intrvenous use
More informationCheckMate-142 Study Design
Nivolumb + Ipilimumb Combintion in Ptients With DNA Mismtch Repir-Deficient/Microstellite Instbility-High Metsttic Colorectl Cncer: First Report of the Full Cohort From CheckMte-142 Thierry André, 1 Sr
More informationXALKORI (crizotinib) Is Available Through Specialty Pharmacies
XALKORI (crizotinib) Is Avilble Through Specilty Phrmcies Specilty Phrmcy Ordering Process The Provider s Office Submits XALKORI prescriptions to the specilty phrmcy vi: Phone Fx Internet Submits ny supporting
More informationClinical Study. Oncology 2010;79: DOI: /
Oncology Clinicl Study DOI: 10.59/000320625 Received: June 24, 2010 Accepted: July 27, 2010 Published online: Mrch 1, 20 Prospective Multicenter Rndomized Phse III Study of Weekly versus Stndrd Docetxel
More informationTR Spitzer 1, CJ Friedman 2, W Bushnell 2, SR Frankel 3, J Raschko 4. Summary:
(2000) 26, 203 210 2000 Mcmilln Publishers Ltd All rights reserved 0268 3369/00 $15.00 www.nture.com/bmt Double-blind, rndomized, prllel-group study on the efficcy nd sfety of orl grnisetron nd orl ondnsetron
More informationThe incidence of melanoma, the most serious
Efectiveness nd sfety of ipilimumb therpy in dvnced melnom: evidence from clinicl prctice sites in the US Kim A Mrgolin, MD, Ahmd Trhini, MD, PhD, b Sumti Ro, PhD, c Monic Ktyl, JD, MPH, d I-Fen Chng,
More informationLung cancer is the most common cause of cancer deaths in
Originl Article A Phse I/II Study of Bortezomib in Combintion with Pclitxel, Crbopltin, nd Concurrent Thorcic Rdition Therpy for Non Smll-Cell Lung Cncer North Centrl Cncer Tretment Group (NCCTG)-N0321
More informationMOLECULAR AND CLINICAL ONCOLOGY 7: , 2017
MOLECULAR AND CLINICAL ONCOLOGY 7: 787-797, 2017 Evlution of epiderml growth fctor receptor serum levels nd their ssocition with clinicopthologicl chrcteristics in ptients with colorectl cncer MEHMET KARABULUT
More informationClinical Evidence for Second- and Third-Line Treatment Options in Advanced Non-Small Cell Lung Cancer
Clinicl Evidence for Second- nd Third-Line Tretment Options in Advnced Non-Smll Cell Lung Cncer Filippo de Mrinis, Frncesco Grossi b Thorcic Oncology Unit I, Deprtment of Lung Diseses, Sn Cmillo nd Forlnini
More informationA retrospective study on combination therapy with ifosfamide, adriamycin and cisplatin for progressive or recurrent uterine sarcoma
MOLECULAR AND CLINICAL ONCOLOGY 2: 591-595, 2014 A retrospective study on combintion therpy with ifosfmide, drimycin nd cispltin for progressive or recurrent uterine srcom WATARU YAMAGAMI, NOBUYUKI SUSUMU,
More informationResults. Table 1: Demographic and Baseline Characteristics, Open-Label Safety Population Prior Double-Blind OC/APAP ER (n=77)
Open-Lbel Extension of Rndomized, Double-Blind, Plcebo-Controlled, Phse 3 Study of the Sfety nd Anlgesic Efficcy of MNK-795 Oxycodone/Acetminophen Extended-Relese (OC/APAP ER) Tblets in n Acute Pin Model
More informationShort-term therapy with lasting relief 2
# 1 PRESCRIBED MEDICATION APPROVED FOR IBS-D 1 * Short-term therpy with lsting relief 2 provided up to 6 months of symptom relief with 2-week tretment 2 Rnge of 6 to 24 weeks; medin of 10 weeks. Convenient
More informationEVALUATION OF DIFFERENT COPPER SOURCES AS A GROWTH PROMOTER IN SWINE FINISHING DIETS 1
Swine Dy 2001 Contents EVALUATION OF DIFFERENT COPPER SOURCES AS A GROWTH PROMOTER IN SWINE FINISHING DIETS 1 C. W. Hstd, S. S. Dritz 2, J. L. Nelssen, M. D. Tokch, nd R. D. Goodbnd Summry Two trils were
More informationPatient Monitoring Checklist
Ptient Monitoring Checklist Ptient nme Dte This checklist is intended for nurses or other helthcre professionls (HCPs) to use prior to dosing ech ptient nd t ny follow-up visits or clls with the ptient
More informationAddendum to the Evidence Review Group Report on Aripiprazole for the treatment of schizophrenia in adolescents (aged years)
Addendum to the Evidence Review Group Report on Aripiprzole for the tretment of schizophreni in dolescents (ged 15-17 yers) Produced by Authors Correspondence to Southmpton Helth Technology Assessments
More informationAntiviral Therapy 2015; 20: (doi: /IMP2920)
Antivirl Therpy 2015; 20:397 405 (doi: 10.3851/IMP2920) Originl rticle Sfety, tolerbility nd phrmcokinetics of dorvirine, novel HIV non-nucleoside reverse trnscriptse inhibitor, fter single nd multiple
More informationEmerging Options for Thromboprophylaxis After Orthopedic Surgery: A Review of Clinical Data
Emerging Options for Thromboprophylxis After Orthopedic Surgery: A Review of Clinicl Dt Bob L. Lobo, Phrm.D. In four rndomized, controlled studies of ptients undergoing orthopedic surgery, the ntithrombotic
More information58 % 50 % REDUCTION IN RISK OF OVERT HE RECURRENCE 1
FOR ADULT PATIENTS WITH OVERT HEPATIC ENCEPHALOPATHY (HE) significntly reduced the risk of overt HE recurrence nd HE-relted hospitliztions 1 58 % 50 % REDUCTION IN RISK OF OVERT HE RECURRENCE 1 REDUCTION
More informationLung cancer is the leading cause of cancer death worldwide, EGFR Mutation and Brain Metastasis in Pulmonary Adenocarcinomas
Originl Article EGFR Muttion nd Brin Metstsis in Pulmonry Adenocrcinoms Dong-Yeop Shin, MD,* Im Il N, MD,* Cheol Hyeon Kim, MD, PhD, Sunhoo Prk, MD, PhD, HeeJong Bek, MD, PhD, nd Sung Hyun Yng, MD, PhD*
More informationFULL PRESCRIBING INFORMATION
HIGHLIGHTS OF PRESCRIBING INFORMATION These highlights do not include ll the informtion needed to use Herceptin sfely nd effectively. See full prescriing informtion for Herceptin. HERCEPTIN (trstuzum)
More informationClinicalTrials.gov Identifier: NCT
Efficcy of Drtumumb, Lenlidomide, nd Dexmethsone Versus Lenlidomide nd Dexmethsone in Relpsed or Refrctory Multiple Myelom Ptients With to 3 Prior Lines of Therpy: Updted Anlysis of POLLUX Sd Z. Usmni,
More informationFirst-line and Maintenance Treatment with ALIMTA therapy for advanced nonsquamous non-small cell lung cancer (NSCLC)
YOUR LIFE. First-line nd Mintennce Tretment with ALIMTA therpy for dvnced nonsqumous non-smll cell lung cncer (NSCLC) ALIMTA is pproved by the FDA in combintion with cispltin (nother chemotherpy drug)
More informationSee 17 for PATIENT COUNSELING INFORMATION and FDAapproved patient labeling. Revised: 6/2016 FULL PRESCRIBING INFORMATION: CONTENTS*
1 HIGHLIGHTS OF PRESCRIBING INFORMATION These highlights do not include ll the informtion needed to use BASAGLAR sfely nd effectively. See full prescribing informtion for BASAGLAR BASAGLAR (insulin glrgine
More informationOptimisation of diets for Atlantic cod (Gadus morhua) broodstock: effect of arachidonic acid on egg & larval quality
Optimistion of diets for Atlntic cod (Gdus morhu) roodstock: effect of rchidonic cid on egg & lrvl qulity Dr Gordon Bell, Ms. An Blnco, Dr Bill Roy, Dr Derek Roertson, Dr Jim Henderson nd Mr Richrd Prickett,
More informationFor Adults with Metastatic Melanoma
For Adults with Metsttic Melnom The + YERVOY Regimen ws shown to reduce the risk of disese progression by nerly 60% compred to YERVOY lone. Hlf of the ptients on + YERVOY were live t 11.5 months without
More informationEFFECTS OF AN ACUTE ENTERIC DISEASE CHALLENGE ON IGF-1 AND IGFBP-3 GENE EXPRESSION IN PORCINE SKELETAL MUSCLE
Swine Dy 22 Contents EFFECTS OF AN ACUTE ENTERIC DISEASE CHALLENGE ON IGF-1 AND IGFBP-3 GENE EXPRESSION IN PORCINE SKELETAL MUSCLE B. J. Johnson, J. P. Kyser, J. D. Dunn, A. T. Wyln, S. S. Dritz 1, J.
More informationOlanzapine for the prophylaxis and rescue of chemotherapyinduced nausea and vomiting (CINV): a retrospective study
Originl Article Olnzpine for the prophylxis nd rescue of chemotherpyinduced nuse nd vomiting (CINV): retrospective study Leonrd Chiu, Nichols Chiu, Ronld Chow, Liying Zhng, Mrk Psetk, Jordn Stinson, Brenne
More informationOpioid Use and Survival at the End of Life: A Survey of a Hospice Population
532 Journl of Pin nd Symptom Mngement Vol. 32 No. 6 December 2006 NHPCO Originl Article Opioid Use nd Survivl t the End of Life: A Survey of Hospice Popultion Russell K. Portenoy, MD, Un Sibircev, BA,
More informationEffects of physical exercise on working memory and prefrontal cortex function in post-stroke patients
Effects of physicl exercise on working memory nd prefrontl cortex function in post-stroke ptients M Moriy, C Aoki, K Sktni Grdute School of Helth Sciences Reserch, Mjor of Physicl Therpy, TeikyoHeisei
More informationHIGHLIGHTS OF PRESCRIBING INFORMATION
HIGHLIGHTS OF PRESCRIBING INFORMATION These highlights do not include ll the informtion needed to use ALIMTA sfely nd effectively. See full prescriing informtion for ALIMTA. ALIMTA (pemetrexed for injection)
More informationOriginal Article. T Akter 1, N Islam 2, MA Hoque 3, S Khanam 4, HA khan 5, BK Saha 6. Abstract:
Fridpur Med. Coll. J. 214;9(2):61-67 Originl Article Nebuliztion by Isotonic Mgnesium Sulphte Solution with Provide Erly nd Better Response s Compred to Conventionl Approch ( Plus Norml Sline) in Acute
More informationThe Role of Intraoperative Radiation Therapy (IORT) in the Treatment of Locally Advanced Gynecologic Malignancies
The Role of Intropertive Rdition Therpy (IORT) in the Tretment of Loclly Advnced Gynecologic Mlignncies MARCELA G. DEL CARMEN, JAMES F. MCINTYRE, b ANNEKATHRYN GOODMAN Vincent Gynecologic Oncology Service,
More information308 nm excimer lamp in combination with topical tacrolimus: A retrospective study of its efficacy and safety in childhood vitiligo
ORIGINAL ARTICLE 308 nm excimer lmp in comintion with topicl tcrolimus: A retrospective study of its efficcy nd sfety in childhood vitiligo BS Chndrshekr, N Shoh, P Deprtment of Dermtology, Cutis, Acdemy
More informationThe Acute Time Course of Concurrent Activation Potentiation
Mrquette University e-publictions@mrquette Exercise Science Fculty Reserch nd Publictions Exercise Science, Deprtment of 1-1-2010 The Acute Time Course of Concurrent Activtion Potentition Luke Grceu Mrquette
More informationP (RCC) was first done in the late 1930s and reported in
Pulmonry Resection of Metsttic Renl Cell Crcinom Robert J. Cerfolio, MD, Mrk S. Allen, MD, Clude Deschmps, MD, Richrd C. Dly, MD, Steven L. Wllrichs, BS, Victor F. Trstek, MD, nd Peter C. Pirolero, MD
More informationMulticenter Randomized Phase 2 Clinical Trial of a Recombinant Human Endostatin Adenovirus in Patients with Advanced Head and Neck Carcinoma
The Americn Society of Gene & Cell Therpy originl rticle Multicenter Rndomized Phse Clinicl Tril of Recombinnt Humn Endosttin Adenovirus in Ptients with Advnced Hed nd Neck Crcinom Wen Ye, Rnyi Liu, Chngchun
More informationWSU Tree Fruit Research and Extension Center, Wenatchee (509) ext. 265;
FINAL REPORT WTFRC Project # AH-1-5 WSU Project # 13C-355-3 Project title: PI: Orgniztion: Coopertors: of Sunburn in Apples with RAYNOX Lrry Schrder, Horticulturist WSU Tree Fruit Reserch nd Extension
More informationUsing Paclobutrazol to Suppress Inflorescence Height of Potted Phalaenopsis Orchids
Using Pcloutrzol to Suppress Inflorescence Height of Potted Phlenopsis Orchids A REPORT SUBMITTED TO FINE AMERICAS Linsey Newton nd Erik Runkle Deprtment of Horticulture Spring 28 Using Pcloutrzol to Suppress
More informationIntradermal Vaccinations With RNA Coding for TAA Generate CD8 + and CD4 + Immune Responses and Induce Clinical Benefit in Vaccinated Patients
originl rticle The Americn Society of Gene & Cell Therpy Intrderml Vccintions With RNA Coding for TAA Generte CD8 + nd CD4 + Immune Responses nd Induce Clinicl Benefit in Vccinted Ptients Susnne M Rittig
More informationT max (hr) 1.5 ± ± ± 0.6 AUC (0-10) (ng hr/ml)
Progesterone Cpsules (progesterone, USP), 100 mg nd 200 mg WARNING: CARDIOVASCULAR DISORDERS, BREAST CANCER nd PROBABLE DEMENTIA FOR ESTROGEN PLUS PROGESTIN THERAPY Crdiovsculr Disorders nd Probble Dementi
More informationSubcutaneous Immunotherapy with a Depigmented Polymerized Birch Pollen Extract A New Therapeutic Option for Patients with Atopic Dermatitis
Originl Pper DOI: 10.1159/000320058 Received: June 16, 2010 Accepted fter revision: August 6, 2010 Published online: Februry 2, 2011 Subcutneous Immunotherpy with Depigmented Polymerized Birch Pollen Extrct
More informationTumor Vascularity Does Not Predict Response to Yttrium-90 Radioembolization for Hepatic Metastases from Colorectal Cancer
Originl Article 3 Tumor Vsculrity Does Not Predict Response to Yttrium-90 Rdioemboliztion for Heptic Metstses from Colorectl Cncer Alipi V. Nydenov Willim P. Hrris 2 Guy E. Johnson 3 Dniel S. Hippe 4 Siddhrth
More informationPROVEN ANTICOCCIDIAL IN NEW FORMULATION
PROVEN ANTICOCCIDIAL IN NEW FORMULATION Coxidin 100 microgrnulte A coccidiosttic dditive for roilers, chickens rered for lying nd turkeys Contins 100 g of monensin sodium per kg Aville s homogenous grnules
More informationof comorbid conditions, interventions Diagnosis and treatment, treatment reduction of risk factors for CVD to slow disease progression,
Tble 5.1. NKF Clssifiction of Chronic Kidney Disese nd Clinicl Fetures Stge Description GFR (ml/ min/1.73 m 2 ) U.S. Prevlence, b # Affected (%) Clinicl Fetures Action Pln c At incresed risk for CKD >60
More information2.3. with type 1 diabetes <3 years of age. (8.4)
1 HIGHLIGHTS OF PRESCRIBING INFORMATION These highlights do not include ll the informtion needed to use HUMALOG sfely nd effectively. See full prescribing informtion for HUMALOG. HUMALOG (insulin lispro
More informationImproved prognosis of postoperative hepatocellular carcinoma patients when treated with functional foods: a prospective cohort study
Journl of Heptology 37 (2002) 78 86 www.elsevier.com/locte/jhep Improved prognosis of postopertive heptocellulr crcinom ptients when treted with functionl foods: prospective cohort study Yoichi Mtsui*,
More informationCase Report INTRODUCTION CASE REPORT. pissn eissn X
pissn 2287-2728 eissn 2287-285X Cse Report Clinicl nd Moleculr Heptology 2018;24:424-429 Complete cure of dvnced heptocellulr crcinom with right drenl glnd metstsis nd portl vein thrombosis by multiple
More informationEsophageal carcinoma is the eighth most common cancer
ORIGINAL ARTICLE Tumor-Strom Rtio Is n Independent Predictor for Survivl in Esophgel Squmous Cell Crcinom Ki Wng, MD,* Wei M, MD,* Jinbo Wng, MD,* Ling Yu, MD, Xiomei Zhng, MD, Zhenbo Wng, MD, Bingxu Tn,
More informationEconomic evaluation of sublingual vs subcutaneous allergen immunotherapy Jitka Pokladnikova, MSc, Pharm*; Irena Krcmova, MD ; and Jiri Vlcek, PhD*
Economic evlution of sublingul vs subcutneous llergen immunotherpy Jitk Pokldnikov, MSc, Phrm*; Iren Krcmov, MD ; nd Jiri Vlcek, PhD* Bckground: Sublingul llergen immunotherpy (SLIT) is commonly used lterntive
More informationSensor-controlled scalp cooling to prevent chemotherapy-induced alopecia in female cancer patients
ORIGINAL ARTICLE Sensor-controlled sclp cooling to prevent chemotherpy-induced lopeci in femle cncer ptients M.K. Fehr md,* J. Welter mph,* W. Sell md,* R. Jung,* nd R. Felberbum md ABSTRACT Bckground
More informationINVEGA SUSTENNA (paliperidone palmitate) extended-release injectable
(pliperidone plmitte) extended-relese injectble suspension, for intrmusculr use HIGHLIGHTS OF PRESCRIBING INFORMATION These highlights do not include ll the informtion needed to use sfely nd effectively.
More informationAge related differences in prognosis and prognostic factors among patients with epithelial ovarian cancer
MOLECULAR AND CLINICAL ONCOLOGY 9: 329-334, 2018 Age relted differences in prognosis nd prognostic fctors mong ptients with epithelil ovrin cncer KENJI YOSHIKAWA, TAKESHI FUKUDA, RYO UEMURA, HIROAKI MATSUBARA,
More informationAcademia Pharma Intersect: Lung Cancer. A. JOHN IAFRATE c
The Oncologist Acdemi Phrm Intersect: Lung Cncer Crizotinib for the Tretment of ALK-Rerrnged Non-Smll Cell Lung Cncer: A Success Story to Usher in the Second Decde of Moleculr Trgeted Therpy in Oncology
More informationY. Yazici 1, D. Moniz Reed 2, C. Klem 2, L. Rosenblatt 2, G. Wu 2, J.M. Kremer 3
Greter remission rtes in ptients with erly versus long-stnding disese in biologic-nive rheumtoid rthritis ptients treted with btcept: post hoc nlysis of rndomised clinicl tril dt Y. Yzici 1, D. Moniz Reed
More informationSymptom Management and Supportive Care
This mteril is protected y U.S. Copyright lw. Unuthorized reproduction is prohiited. For reprints contct: Reprints@AlphMedPress.com Symptom Mngement nd Supportive Cre Erly Intervention with Epoetin Alf
More informationIMPORTANT Reminders for Patients. IMPORTANT Information for Doctors/Nurses
Monitor Your Signs nd Symptoms (nivolum) is prescription medicine used in comintion with YERVOY (ipilimum) to tret type of skin cncer clled melnom tht hs spred or cnnot e removed y surgery (dvnced melnom).
More information