Vadim Ivanov, M.D., Ph.D. Micronutrients in controlling INFLAMMATION Webinar June 12, 2012
|
|
- Thomasina Adams
- 5 years ago
- Views:
Transcription
1 Vadim Ivanov, M.D., Ph.D. Micronutrients in controlling INFLAMMATION Webinar June 12, 2012
2 1. What is Inflammation? 2. Acute and Chronic Inflammation 3. Role of Chronic Inflammation in Modern Human Diseases 4. Beneficial Micronutrients in Chronic Inflammation 5. Molecular Mechanisms of Inflammation 6. Research on Micronutrients and Inflammation at Dr Rath Research Institute
3 Inflammation is a reaction of organism to irritation, injury, or infection.
4
5 Acute inflammation Pain Redness Immobility Swelling Heat
6
7 Inflammatory Cytokines
8 Outcomes of Acute Inflammation 1. Resolution
9 Outcomes of Acute Inflammation 2. Fibrosis
10 Outcomes of Acute Inflammation 3. Abscess formation Acute Appendicitis
11 Outcomes of Acute Inflammation 4. Chronic inflammation
12 Role of Chronic Inflammation in Modern Human Diseases a. Cardiovascular Disease b. Cancer c. Chronic Infections d. Arthritis e. Allergy f. Alzheimer g. Parkinson h. Multiple Sclerosis
13 Beneficial Micronutrients and Food Products in Chronic Inflammation 1. Vitamins A, B, C, D, E 2. Protein Proline, Lysine, Arginine 3. Fats and Oils Omega-3 and Monounsaturated Fatty Acids 4. Phytochemicals Green Tea, Citrus, Ginger, Pomegranate, Chokeberry, Cabbage, Turmeric, Walnut
14 Inflammation in Cardiovascular Disease Macrophage Lipids Smooth Muscle Cell Accumulation Deposition Proliferation
15
16 Inflammatory Cytokines
17 Micronutrients decrease inflammatory response of human aorta smooth muscle cells Inhibition of Cytokines Secretion Pro-IL1beta 89% IL-1beta 87% Caspase-1 63% IL-1alpha 55% IL-6 70% Ivanov et al., Research Communications in Pharmacology and Toxicology, 2004, 9:3-16
18 MCP-1 secretion % Micronutrients Decrease Secretion of Monocyte Chemoattractant Protein (MCP-1) MCP-1 Decrease 43% Control TNFa TNFa+NS 100 mcg/ml
19 Role of COX-2 in Inflammation
20 PGE-2 secretion pcg/ml Regulation by PG-E2 production by Nutrient Mixture 1400 PG-E2 Secretion p<0.001 vs LPS Control 10 mcg/ml LPS LPS+NM Ivanov V. et al., International Journal of Molecular Medicine. 2008;22(6):
21 PG-E2 formation, pg/ml Inhibition of COX-2 Activity by Nutrients COX-2 Activity p<0.05 for a trend Nutrient Mixture mcg/ml Ivanov V. et al., International Journal of Molecular Medicine. 2008;22(6):
22 Regulation of Inflammation (cytokines release) by PG-E2 signaling Activation (NFkb) COX-2 gene expression Synthesis of COX-2 enzyme PG-E2 Production by COX-2 from Arachidonic Acid Induction of Cytokine Release by PG-E2
23 Phosphorylated p65 increase, % INFLAMMATION Regulation by PG-E2 signaling Activation (NFkb) COX-2 gene expression p<0.05 vs Synthesis of COX- 2 enzyme PG-E2 Production LPS LPS + EFC Ivanov V. et al., International Journal of Molecular Medicine. 2008;22(6):
24 COX-2 RNA relative to B- Actin INFLAMMATION Regulation by PG-E2 signaling Activation (NFkb) COX-2 gene expression Synthesis of COX- 2 enzyme PG-E2 Production p=0.02 vs LPS Control LPS LPS+Nutrient Mixture Ivanov V. et al., International Journal of Molecular Medicine. 2008;22(6):
25 COPX2/bActin Ratio, % of LPS INFLAMMATION Regulation by PG-E2 signaling Activation (NFkb) COX-2 gene expression Synthesis of COX- 2 enzyme PG-E2 Production p<0.005 vs LPS 0 Control LPS LPS+NM Ivanov V. et al., International Journal of Molecular Medicine. 2008;22(6):
26 PGE-2 secretion pcg/ml INFLAMMATION Regulation by PG-E2 signaling Activation (NFkb) COX-2 gene expression PG-E2 Secretion Synthesis of COX-2 enzyme PG-E2 Production p<0.001 vs LPS Control 10 mcg/ml LPS LPS+NM Nutrient Mixture Regulates PG-E2 Production by Both: Direct Inhibition of COX-2 Activity Inhibition of COX-2 Synthesis Ivanov V. et al., International Journal of Molecular Medicine. 2008;22(6):
27 CONCLUSIONS Micronutrients can effectively control pathological processes involved in the development and maintaining of chronic inflammation by multiple molecular actions
Depression, omega 3 fatty acid therapy 13
Subject Index Adhesion molecules fish oil effects 12, 13 omega 3 fatty acid desaturase transfection effects on expression in endothelial cells 31 Alzheimer s disease (AD), omega 6 fatty acid/omega 3 fatty
More informationFROM ABSTRACT Patients with rheumatoid arthritis (RA) improve on a vegetarian diet or supplementation with fish oil.
Anti-inflammatory effects of a low arachidonic acid diet and fish oil in patients with rheumatoid arthritis Rheumatol Int (2003) 23: 27 36 Olaf Adam, Corinna Beringer, Thomas Kless, Christa Lemmen, Alexander
More informationTop 10 Foods that Protect Cartilage and Prevent Arthritis
Top 10 Foods that Protect Cartilage and Prevent Arthritis Deblina Biswas Treatments Arthritis is a common joint disorder that is caused due to inflammation of the joints. Although there are 100 different
More informationGSCI 2202 Food product and beverage for health
GSCI 2202 Food product and beverage for health Functional food is any fresh or processed food claimed to have a health promoting or disease preventing property beyond the basic function of supplying
More informationManaging Post-Exercise Inflammation: From Ibuprofen to Cherries
Managing Post-Exercise Inflammation: From Ibuprofen to Cherries Roberta Anding, MS, RD/LD, CDE, CSSD, FAND Baylor College of Medicine Rice University Owls Opinions expressed are the presenter s own and
More informationFUNCTIONAL INGREDIENTS
FUNCTIONAL INGREDIENTS Kauai has included a range of functional ingredients in our smoothies and meals. These ingredients are selected as they have super nutrient density this may be because they are high
More informationArteriosclerosis & Atherosclerosis
Arteriosclerosis & Atherosclerosis Arteriosclerosis = hardening of arteries = arterial wall thickening + loss of elasticity 3 types: -Arteriolosclerosis -Monckeberg medial sclerosis -Atherosclerosis Arteriosclerosis,
More informationFUNCTIONAL INGREDIENTS
FUNCTIONAL INGREDIENTS Kauai has included a range of functional ingredients in our smoothies and meals. These ingredients are selected as they have super nutrient density this may be because they are high
More informationAnti-Inflammatory Effects of Fish Oils
Anti-Inflammatory Effects of Fish Oils A. Macrophage Production of Eicosanoids B. w-3 PUFA Supplementation of Macrophages C. w-3 PUFA in IR & diabetes Oswald Quehenberger Departments of Medicine and Pharmacology
More informationVitamin K & Antioxidants. NUT1602 E-Tutor 2018
Vitamin K & Antioxidants NUT1602 E-Tutor 2018 Vitamin K O Can be obtained from non-food source O Bacteria in the GI tract O Acts primarily in blood clotting O Prothrombin O Metabolism of bone proteins
More informationA holistic approach to targeting breast cancer part II: Micronutrient synergy. Presented by: Dr. Neha Shanker DRRI
A holistic approach to targeting breast cancer part II: Micronutrient synergy Presented by: Dr. Neha Shanker DRRI Overview of the previous webinar In the last presentation we talked about: Increase in
More informationNutrition and Age-Associated Inflammation :Role of Nutritional Intervention Simin Nikbin Meydani, DVM, PhD.
Nutrition and Age-Associated Inflammation :Role of Nutritional Intervention Simin Nikbin Meydani, DVM, PhD simin.meydani@tufts.edu Outline 1) Role of immune and inflammatory responses in age-related diseases
More informationUnit title: Human Health and Nutrition
Unit title: Human Health and Nutrition Unit code: F/601/0234 QCF level: 5 Credit value: 15 Aim This unit provides an understanding of the fundamental role of nutrients in maintaining health in relation
More informationFeatured Topic: Boswellia for IBS (4 slides)
Featured Topic: Boswellia for IBS (4 slides) IBS and 5-LOX Question: What do diseases including asthma, rheumatoid arthritis, and irritable bowel (IBS) have in common? Answer: Inflammation. Especially
More informationFAT. Dr. Shamsul Azahari Zainal Badari Department of Resource Management and Consumer Studies Faculty of Human Ecology
FAT Dr. Shamsul Azahari Zainal Badari Department of Resource Management and Consumer Studies Faculty of Human Ecology OBJECTIVES LECTURE By the end of this lecture, student can: Define what is lipid/fat
More information2018 Product Catalog NLRx Nutrition
NLRx Nutrition About NLRx Nutrition At NLRx Nutrition, we are committed to delivering effective, all natural wellness solutions that create opportunities for outcomes to exceed both provider & patient
More informationLecture 8. Section B (Week 2): Environmental and Chemical Triggers of Immune System Function and Dysfunction
Lecture 8 Section B (Week 2): Environmental and Chemical Triggers of Immune System Function and Dysfunction 6. How does the environment affect our immune system function? 7. Effects of Diet on the immune
More informationPHM142 Lecture 4: Platelets + Endothelial Cells
PHM142 Lecture 4: Platelets + Endothelial Cells 1 Hematopoiesis 2 Platelets Critical in clotting - activated by subendothelial matrix proteins (e.g. collagen, fibronectin, von Willebrand factor) and thrombin
More informationDo pigs benefit from omega-3 fatty acids?
Do pigs benefit from omega-3 fatty acids? Denise Beaulieu Assistant Professor Animal & Poultry Science Introduction What are omega-3 fatty acids? Outline Why would we consider augmenting the diet of growing
More informationFighting Pain with Food The Healing Kitchen
Fighting Pain with Food The Healing Kitchen Kimberly Evans MS RD Whole Health Nutrition and UVMMC Dianne Villani APRN, FNP-C Trillium Integrative Medicine Shannon McKenna BS nutrition Objectives 1. Understand
More information9/8/17. Reducing Inflammation + Supporting the Immune System. Module #2 Fighting Inflammation
Reducing Inflammation + Supporting the Immune System 1 Table of Contents Module 1: What is Inflammation? Inflammatory markers Signs and symptoms Chronic disease risk Module 2: Fighting Inflammation Acidity/alkalinity
More informationSubstrates in clinical nutrition Ilze Jagmane
Substrates in clinical nutrition Ilze Jagmane Latvian Society of Parenteral and Enteral Nutrition September, 2013 Introduction Food contains one or more of the following nutrients: Water Carbohydrate Lipids
More informationDiet, Digestive Health & Autoimmune Disease
Diet, Digestive Health & Autoimmune Disease Brad Leech (BHSc Nut Med, Adv Dip Ayur) Clinical Nutritionist, Ayurvedic Herbalist and Researcher into Autoimmune Disease. www.bradleech.com Bradgleech@gmail.com
More informationFlavonoids and Inflammation
Flavonoids and Inflammation David Heber MD,PHD Professor of Medicine and Public Health Director, UCLA Center for Human Nutrition David Geffen School of Medicine, UCLA Phytonutrient Classes Carotenoids
More informationDecision tree for the safety assessment of botanical cosmetic ingredients. Personal Care Products Council CIR Science and Support Committee
Decision tree for the safety assessment of botanical cosmetic ingredients Personal Care Products Council CIR Science and Support Committee Using the Decision Tree Provided as a guidance tool for finished
More informationMicroglia preconditioning (priming) in central nervous system pathologies
Microglia preconditioning (priming) in central nervous system pathologies Florence Perrin florence.perrin@umontpellier.fr Montpellier, October 2018 1 Spanish anatomists Glia = glue in Greek Santiago Ramon
More informationBODY CHEMISTRY TEST. Sample Report
BODY CHEMISTRY TEST * Sample Report Ver. 1.0, Date created: Nov 5, 2017 Disclaimer: VitaminLab is for informational purposes only. lease discuss your results or concerns with your health care professional
More informationBiomarkers of inflammation in human nutrition studies
NIHR Southampton Biomedical Research Centre in nutrition Biomarkers of inflammation in human nutrition studies Philip Calder Professor of Nutritional Immunology University of Southampton The NIHR Southampton
More informationMediterranean Diet: Choose this heart-healthy diet option
Mediterranean Diet: Choose this heart-healthy diet option The Mediterranean diet is a heart-healthy eating plan combining elements of Mediterraneanstyle cooking. Here s how to adopt the Mediterranean diet.
More informationDietary supplementation in treating non-alcoholic fatty liver disease Dr. Ahmad Saedi Associate Professor School of Nutritional Sciences and
Dietary supplementation in treating non-alcoholic fatty liver disease Dr. Ahmad Saedi Associate Professor School of Nutritional Sciences and Dietetics Tehran University of Medical Sciences Honorary Academic
More informationSpeaker: Paul De Smet. Thursday June 4th 2015
Speaker: Paul De Smet Thursday June 4th 2015 Your logo Stress Support: the nutritional answer to stress, infection and disease Thursday June 4th 2015 Table of content Stress Support: the nutritional answer
More informationOlive Oil and Nuts Reduce Risk of Heart Disease
Olive Oil Olive Oil and Nuts Reduce Risk of Heart Disease Study of 7,000 people in Spain Group 1 ate the Mediterranean diet plus 4 tablespoons of olive oil a day Group 2 ate the Mediterranean diet plus
More informationLiving Better Series Brain Health: Nutrition
Living Better Series Brain Health: Nutrition 2018 What is Brain Health Brain health refers to the ability to remember, learn, plan, concentrate and maintain a clear, active mind. According to NeuroHealth
More informationPage 39 of 44. 8h LTA & AT h PepG & AT h LTA
Page 39 of 44 Fig. S1 A: B: C: D: 8h LTA 8h LTA & AT7519 E: F: 8h PepG G: 8h PepG & AT7519 Fig. S1. AT7519 overrides the survival effects of lipoteichoic acid (LTA) and peptidoglycan (PepG). (A) Human
More informationFatty acids and allergy a fishy story?
Fatty and allergy a fishy story? JOHAN CARLSSON, Nutritionist / PhD student UNIVERSITY OF GOTHENBURG Sahlgrenska Academy Institute of Biomedicine Department of Infectious Diseases johan.carlsson@microbio.gu.se
More informationTPN and lipid. RCT of 57 patients. TPN with lipid vs TPN without lipid. TPN associated with increased infectious complications
TPN and lipid RCT of 57 patients TPN with lipid vs TPN without lipid TPN associated with increased infectious complications * * * * Battistella FD, et al. J Trauma 1997; 43:52. Data Needed 1. New TPN trials
More informationCompany Overview. How Powering the Immune System Can Benefit Athletic Performance. March 2013
How Powering the Immune System Can Benefit Athletic Performance March 2013 Company Overview Privately held Minnesota biotechnology company founded in 1997. Technology platform focused on the innate immune
More informationLearning Objectives 7/5/2017. Participants Will:
Diet Can Reduce Your Alzheimer s Disease Risk Sue Linja, RDN, LD Idaho Health Care Association NED Talk d Learning Objectives Participants Will: Understand the connection between diet and brain health
More informationObjectives 4/4/2013. Healing with Fats and Fatty Acids-- an Integrative approach. Inflammation Nation. A silent attack on the modern human race
Healing with Fats and Fatty Acids-- an Integrative approach Tracy S. Hunter, RPh, MS, PhD Professor Wingate University School of Pharmacy Charlotte Metro-area, NC 1 Objectives Explain the relationship
More informationFatty Acids: The Basics
Fatty Acids: The Basics Fatty Acids 101 Fatty acids are necessary nutrients found in our food. The problem is how much we eat of each: The historical ratio of omega-6s to omega- 3s may have been 1-to-1.
More informationTHE LIVER AND THE GUT
THE LIVER AND THE GUT Liver & Gut A quintessential relationship One does not work well without the other There is a continuous bidirectional communication between these organs through the bile, hormones,
More informationSlide 1 THE LIVER AND THE GUT. Slide 2 Liver & Gut. Slide 3 Gut Health For Detoxing
Slide 1 THE LIVER AND THE GUT Slide 2 Liver & Gut A quintessential relationship One does not work well without the other There is a continuous bidirectional communication between these organs through the
More informationThe Anti-Inflammatory Guide
The Anti-Inflammatory Guide Discover why inflammation is the underlying cause your dis-ease and what you can do to manage symptoms ErinBriggsWellness.com Contents What is Inflammation? 3 What Causes Inflammation?
More informationSTROKE & DIETARY INFLUENCES ON COGNITION IN AGING
How Nutrition Changes the Aging Brain STROKE & DIETARY INFLUENCES ON COGNITION IN AGING Nafisa Jadavji, PhD nafisa.jadavji@carleton.ca REMINDER! Purpose of Course To present information about how nutrition
More informationBODY CHEMISTRY TEST. Jannet s Report
BODY CHEMISTRY TEST * Jannet s Report Ver. 1.0, Date created: Nov 15, 01 Disclaimer: VitaminLab is for informational purposes only. lease discuss your results or concerns with your health care professional
More informationThere are three major types of omega-3 fatty acids that are ingested in foods and used by the body:
Long-chain fatty acids (LC-PUFAs: ARA, DHA and EPA) AT A GLANCE Introduction LC-PUFAs or long chain polyunsaturated fatty acids are mainly found in the form of two families of conditionally essential fatty
More informationRoles of Lipids in the body
Roles of Lipids in the body 1- Energy storage : Lipids contain a lot of calories in a small space. Since Lipids are generally insoluble in polar substances such as water, they are stored in special ways
More informationThe Potential Effects of Flaxseed and its Related Products on the Reproductive Performances of Sows
The Potential Effects of Flaxseed and its Related Products on the Reproductive Performances of Sows L. Eastwood and P. Leterme Department of Animal and Poultry Science, University of Saskatchewan Saskatoon,
More informationWeight Loss NOTES. [Diploma in Weight Loss]
Weight Loss NOTES [Diploma in Weight Loss] Fat s: The good, the bad and the ugly Fat s function in your body 1. Energy stores 2. Muscle fuel 3. Transportation 4. Cell membrane 5. Padding 6. Muscle fuel
More informationCellular Nutrition. A Matter of Life & Death. Dick Couey, Ph.D.
Cellular Nutrition A Matter of Life & Death Dick Couey, Ph.D. richard_couey@baylor.edu Phase One The Human Cell The Human Cell Many varieties of cells The body contains between 80-100 trillion cells Muscle,
More informationDavid M. Klurfeld Agricultural Research Service Beltsville, MD
David M. Klurfeld Agricultural Research Service Beltsville, MD Disclaimers The views presented here are those of the speaker and do not necessarily reflect official positions of the USDA or the Agricultural
More informationIndex. Anesthesiology Clin N Am 24 (2006) Note: Page numbers of article titles are in boldface type.
Anesthesiology Clin N Am 24 (2006) 419 425 Index Note: Page numbers of article titles are in boldface type. A Abdominal surgery, synbiotics for control of inflammation and infection in, 312 Adaptive immunity,
More informationCan seal oil contribute to better human health?
Can seal oil contribute to better human health? Bjarne Østerud and Edel O. Elvevoll, Faculty of Medicine and NFH, University of Tromsø E-mail: bjarne@fagmed. Historical background Old food lore of seafood
More informationInflammation in the clinic
Inflammation in the clinic Stephen T. Holgate MRC Clinical Professor of Immunopharmacology ILSI Europe Workshop, Seville, May 14-15 2012 The immune system acts in four general ways to ensure host defence
More informationIL-24 AND ITS ROLE IN WOUND HEALING
IL-24 AND ITS ROLE IN WOUND HEALING Nancy J. Poindexter, Ryan Williams, Garth Powis, Sunil Chada, and Elizabeth A. Grimm & Introgen Therapeutics, Inc., Houston, TX IL-24/MDA 24/MDA-77 is a Tumor Suppressor
More informationCell-Derived Inflammatory Mediators
Cell-Derived Inflammatory Mediators Introduction about chemical mediators in inflammation Mediators may be Cellular mediators cell-produced or cell-secreted derived from circulating inactive precursors,
More informationOptimize Your Omega-3 Status Personalized Blood Test Reveals a Novel Cardiac Risk Factor
http://www.lef.org/ Life Extension Magazine May 2010 Optimize Your Omega-3 Status Personalized Blood Test Reveals a Novel Cardiac Risk Factor By Julius Goepp, MD Suppose you could assess with precision
More informationInvolvement of n-3 PUFA-derived lipid mediators in the resolution of brain inflammation
The 1 th Nutrition-Neuroscience meeting The 27 th of march 217 Involvement of n-3 PUFA-derived lipid mediators in the resolution of brain inflammation Charlotte Rey- PhD student Acute inflammatory response
More informationThe Relationship between Dietary Fatty Acids and Inflammatory Genes on the Obese Phenotype and Serum Lipids
Nutrients 2013, 5, 1672-1705; doi:10.3390/nu5051672 Review OPEN ACCESS nutrients ISSN 2072-6643 www.mdpi.com/journal/nutrients The Relationship between Dietary Fatty Acids and Inflammatory Genes on the
More informationMAJOR DIFFERENCES BETWEEN COBRAM ESTATE EXTRA VIRGIN OLIVE OIL, VIRGIN OLIVE OIL AND OLIVE OIL (REFINED BLENDS)
, VIRGIN OLIVE OIL AND OLIVE OIL (REFINED BLENDS) NATURAL OLIVE OILS OBTAINED BY SOLE MECHANICAL/PHYSICAL MEANS NO ALTERATIONS IN THE OIL REFINED OLIVE OILS REFINING PROCESS LEADS TO ALTERATIONS IN NATURAL
More informationHYPERSENSITIVITY REACTIONS D R S H O AI B R AZ A
HYPERSENSITIVITY REACTIONS D R S H O AI B R AZ A HYPERSENSITIVITY REACTIONS Are exaggerated immune response upon antigenic stimulation Individuals who have been previously exposed to an antigen are said
More informationulcer healing role 118 Bicarbonate, prostaglandins in duodenal cytoprotection 235, 236
Subject Index Actin cellular forms 48, 49 epidermal growth factor, cytoskeletal change induction in mucosal repair 22, 23 wound repair 64, 65 polyamine effects on cytoskeleton 49 51 S-Adenosylmethionine
More informationEICOSANOID METABOLISM
1 EICOSANOID METABOLISM EICOSANOIDS C20 polyunsaturated fatty acids e.g. Arachidonic acid Eicosanoids physiologically, pathologically and pharmacologically active compounds PG Prostaglandins TX - Thromboxanes
More informationFeatured Topic: Christmas Message
Featured Topic: Christmas Message Wishing You Peace and Health I would like to extend a holiday greeting to each of you. At the close of the year, I hope you take some time to reflect positively on the
More informationCELLULAR HEALTH COMMUNICATIONS Volume 1, Number 1, 2001
CELLULAR HEALTH COMMUNICATIONS Volume 1, Number 1, 2001 Editorial Information Editor -in- Chief: Matthias Rath, M.D. Associate Editor: Aleksandra Niedzwiecki, Ph.D. Managing Editor: Beth Gillespie, N.C.
More information: Overview of EFA metabolism
Figure 1 gives an overview of the metabolic fate of the EFAs when consumed in the diet. The n-6 and n-3 PUFAs when consumed in the form of dietary triglyceride from various food sources undergoes digestion
More informationNutrients Beyond the NRC: Designing the Ideal Ration
Beyond the NRC: Designing the Ideal Ration Meri Stratton Phelps, DVM, MPVM, DACVIM (LAIM), DACVN When it comes to proper nutrition, veterinarians, horse owners and nutritionists all have the same goal
More informationGSE is loaded with Proanthocyanidins which are the very potent antioxidants called bioflavonoids, resveratrol, vitamins & minerals.
GSE is loaded with Proanthocyanidins which are the very potent antioxidants called bioflavonoids, resveratrol, vitamins & minerals. GSE offers antioxidants that are 50 times more potent than vitamin E,
More informationThe Effects of Lipids on the Body
The Effects of Lipids on the Body Review: 3 general types 1. Triglycerides Major type of fat found in food and in bodies 2. Phospholipids In body: Carry food back and forth across cell membranes In food:
More informationAge and Nutrition-induced changes in Immune and Inflammatory Response: Implications for Disease Prevention Simin Nikbin Meydani, DVM, PhD
Age and Nutrition-induced changes in Immune and Inflammatory Response: Implications for Disease Prevention Simin Nikbin Meydani, DVM, PhD Tufts University, Jean Mayer United States Department of Agriculture
More informationA real life example In human studies, we quantify ~120 plasma related proteins Monocytes MMP9 Macrophages TNFα IL1ß platelet derived growth factor IFNγ MMP1 MMP8 MMP13 Myeloid Related Protein14 CD40
More information2.28E E AKT/CAT P-3-4:
Supplemental Table 1: IPA network analysis of the microarray data presented in Figure 6 showing the most significant molecular and cellular function classifications along with the respective number of
More informationSupplementary Materials:
Supplementary Materials: Supplemental Figure 1: Profibrotic markers in wt/wt or ex/ex mouse kidneys 42 days post IRI. The levels of fibronectin and αsma were examined by immunostaining in ADAM17 wt/wt
More informationMorphogens: What are they and why should we care?
Morphogens: What are they and why should we care? Historic, Theoretical Mechanism of Action Nucleoprotein: the specific trophic cellular material extracted from the cell nucleus. DNA and RNA which regulates
More informationNutrition & oral health
Nutrition & oral health Eating well for a healthy mouth Preventive dentistry II Nutrition and oral diseases Local effect traditional, well-known Systemic effect new aspect Periodontal diseases Progression
More informationNutrients. Chapter 25 Nutrition, Metabolism, Temperature Regulation
Chapter 25 Nutrition, Metabolism, Temperature Regulation 25-1 Nutrients Chemicals used by body to produce energy, provide building blocks or function in other chemical reactions Classes Carbohydrates,
More informationPhysiology Unit 1 CELL SIGNALING: CHEMICAL MESSENGERS AND SIGNAL TRANSDUCTION PATHWAYS
Physiology Unit 1 CELL SIGNALING: CHEMICAL MESSENGERS AND SIGNAL TRANSDUCTION PATHWAYS In Physiology Today Cell Communication Homeostatic mechanisms maintain a normal balance of the body s internal environment
More informationFeatured Topic: Fibromyalgia (4 slides)
Featured Topic: Fibromyalgia (4 slides) Fibromyalgia is a pain condition Fibromyalgia = chronic pain along with fatigue, sleep, memory and mood issues Dr. Jacob Teitelbaum, chronic fatigue and fibromyalgia
More informationInflammasome-mediated caspase-1 activity Gatekeeper of inflammation in the adipose tissue. Rinke Stienstra
Inflammasome-mediated caspase-1 activity Gatekeeper of inflammation in the adipose tissue Rinke Stienstra Obesity promotes the development of insulin resistance and type 2 diabetes County-level Estimates
More informationPro-health effects of active substances of Omee3 med bars for proper growth and development of children.
Pro-health effects of active substances of Omee3 med bars for proper growth and development of children. Presently, there is no doubt that essential polyunsaturated fatty acids (PUFA)* omega-3 and omega-6
More informationLiver-Resident Macrophage Necroptosis Orchestrates Type 1 Microbicidal Inflammation and Type-2- Mediated Tissue Repair during Bacterial Infection
Liver-Resident Macrophage Necroptosis Orchestrates Type 1 Microbicidal Inflammation and Type-2- Mediated Tissue Repair during Bacterial Infection Camille Blériot, Théo Dupuis, Grégory Jouvion, Gérard Eberl,
More informationa new age of Health Phytobiology and Cellular MediCine
Journal of Phytobiology and Cellular MediCine TM a new age of Health Perspectives for the natural control of cardiovascular disease, cancer and other global health challenges Published by dr. rath research
More informationHesperidin. Keep Health, Keep Happiness
Hesperidin Kang-Hui Keep Health, Keep Happiness Table of Contents 01 Brief Introduction 03 Functions 02 Technical Description 04 Experimental Data 05 Product Application 06 Highlights Brief Introduction
More informationAlpha CRS+ (NPN #: )
PRODUCT INFORMATION PAGE Alpha CRS+ (NPN #: 80076697) Complex Made with SLS-free vegetable capsules PRODUCT DESCRIPTION dōterra Alpha CRS+ Complex is a proprietary formula combining naturallysourced botanical
More informationFATTY ACIDS --- BRAIN STRUCTURE AND FUNCTION
FATTY ACIDS --- BRAIN STRUCTURE AND FUNCTION Studies on Fatty Acids in the Brain Bourre JM. Importance of Exogenous Saturated Fatty Acids During Brain Development and Mylenization in mice. Ann. Biol Anim
More information13/09/2012. Dietary fatty acids. Triglyceride. Phospholipids:
CARDIOVASCULAR DISEASES (CVD) and NUTRITION Major cause of morbidity & mortality in Canada & other developed countries e.g., majority of approved health claims on food labels relate to lowering CVD Relation
More informationCoQ10/Ubiquinol- Statin medications deplete this valuable nutrient.
Nutraceuticals that we recommend and why: CoQ10/Ubiquinol- Statin medications deplete this valuable nutrient. It is vital to our survival. Has shown to help hypertension, migraine, Parkinson s, diabetes
More informationMichael van Straten s Healthy and Essential Fact Sheet with Classic Gold Radio
Michael van Straten s Healthy and Essential Fact Sheet with Classic Gold Radio Inflammation Infection, irritation or injury can all cause pain, swelling, heat or local areas of redness, all as a result
More informationSphingolipids. Sphingolipids are an additional type of membrane lipids, after glycerophospholipids, galactolipids and sulfolipids
Lipids 2 Steven E. Massey, Ph.D. Assistant Professor of Bioinformatics Department of Biology and Environmental Sciences University of Puerto Rico Río Piedras Office & Lab: Bioinformatics Lab NCN#343B Tel:
More informationNutrition Essentials Improving your PKU diet through balanced nutrition
Nutrition Essentials Improving your PKU diet through balanced nutrition Sharon L Ernst, MPH, RD, CSP, FAND Associate Professor Chief Metabolic Dietitian Division of Medical Genetics Department of Pediatrics
More informationOBJECTIVE. Lipids are largely hydrocarbon derivatives and thus represent
Paper 4. Biomolecules and their interactions Module 20: Saturated and unsaturated fatty acids, Nomenclature of fatty acids and Essential and non-essential fatty acids OBJECTIVE The main aim of this module
More informationSteroid Hormones Synthesis
*I ll try my best to incorporate the Slides in this Sheet; you don t need to study the slides if you study this sheet. Steroid Hormones Synthesis - The figure to the right is the Steroid nucleus, it has
More informationDr Ahmad Shaltut Othman Anaesthesiologist & Intensivist Hosp Sultanah Bahiyah Alor Setar
FEEDING WITH FISH OIL Dr Ahmad Shaltut Othman Anaesthesiologist & Intensivist Hosp Sultanah Bahiyah Alor Setar New horizons in clinical nutrition from Support to Therapy Landmarks in Parenteral Nutrition
More informationSubject Index. neuronal survival promotion by insulinlike growth factor-i , 162 regulatory proteins 148, 162
Subject Index Acid-labile subunit (ALS) evaluation 84 function 84 growth hormone activity marker 91 growth hormone insensitivity levels 102, 104 Alzheimer s disease, insulin-like growth factor-i neuroprotection
More informationSummary & conclusion
Summary & conclusion Cancer is the prime cause of death in developed countries and the second major cause of death in developing world. The early diagnosis is very crucial for the effective treatment of
More informationDiosgenin, antagonism of LXRs 36 DNA microarray, sesame seed lignan regulation of liver fatty acid metabolism gene expression 12 18, 22, 23
Subject Index ACC, see Acyl-CoA carboxylase 1 -Acetoxychavicol acetate, inducible nitric oxide synthase suppression in cancer chemoprevention 199, 200 Acetylene carotenoids, anti-inflammatory activity
More informationChapter 2 Nutrition Tools Standards and Guidelines
Chapter 2 Nutrition Tools Standards and Guidelines MULTICHOICE 1. Which of the following statements best describes the recommended dietary allowances (RDA)? (A) they are average nutrient intake goals that
More informationCigarette Smoke Exposure and HIV-Related Neurologic Disease Progression Basic Mechanisms and Clinical Consequences
Cigarette Smoke Exposure and HIV-Related Neurologic Disease Progression Basic Mechanisms and Clinical Consequences Walter Royal, III, MD Professor of Neurology University of Maryland School of Medicine
More informationBlood Pressure. And Natural Strategies for Optimizing C O N T E N T S. What is Blood Pressure?
Blood Pressure And Natural Strategies for Optimizing Blood Pressure What is Blood Pressure? As the heart beats, it pumps blood throughout the body carrying nutrients and oxygen to the cells and removing
More informationChewing the fat about fat!
Chewing the fat about fat! When we talk about fat, most people think of fatty foods, like fries and fatty meats. But fat is an essential nutrient. It plays an important role in the many functions that
More information