Joint Banff/CST Program Committee Co-chairs: Dr. Alexandre Loupy and Dr. Prosanto Chaudhury. Joint Banff/CST Finance Committee

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Norman Shields
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Michael Mengel Members: Anthony Jevnikar, David Rush, Denis Glotz, Kim Solez, Marcelo

2 2015 Banff/CST Meeting Organizing Corporation ( 2015 MOC ) Co-Directors: Dr. John Gill, Dr. Michael Mengel Members: Anthony Jevnikar, David Rush, Denis Glotz, Kim Solez, Marcelo Cantarovich, Mark Haas, Steven Paraskevas Joint Banff/CST Program Committee Co-chairs: Dr. Alexandre Loupy and Dr. Prosanto Chaudhury Joint Banff/CST Finance Committee

3 The Banff Schema was first developed at a meeting of pathologists, clinicians and surgeons in Banff, Alberta, Canada, August 2-4, 1991 and has become the worldwide standard for the interpretation of transplant biopsies.

6 1991 First Conference 1993 First Kidney International publication 1995 Integration with CADI 1997 Integration with CCTT classification 1999 Second KI paper. Clinical practice guidelines. Implantation biopsies Classification of antibody-mediated rejection: Regulatory agencies participating 2003 Genomics focus, ptc cell accumulation scoring 2005 Gene chip analysis. Elimination of CAN, identification of chronic antibodymediated rejection First meeting far from a town called Banff La Coruna, Spain Working groups. Meeting in Banff, Alberta, Canada 2013 Establishment of Banff Foundation for Allograft Pathology

The Banff Process Consensus communication in renal

thesis-antithesis-synthesis The Banff community

participate established by consensus in 1991 Banff

tentative refinement thresholds The Banff classification

Biostaticians Molecular Biologists Omics -specialists a

7 The Banff Process Consensus communication in renal transplantation moderated Banff meetings thesis-antithesis-synthesis The Banff community Pathologists Nephrologists Tx-Surgeons Lab-Medicine participate established by consensus in 1991 Banff Working Groups The Banff lesions g, i, t, v - score tentative refinement thresholds The Banff classification Current consensus for diagnostics New members Biostaticians Molecular Biologists Omics -specialists a Feedback concerning weaknesses and strengths by results from independent research Off-springs Liver Pancreas Lung, Heart CTA

Organizational structure of the Banff Foundation For Allograft Pathology Board of Trustees: K. Solez (Chair), L. Racusen, D. Glotz, J. Demetris, M. Mengel, M. Mihatsch, D.

Schmidt reports to Secretary/Treasurer: Michael Mengel support reports to funding reports to Organ Steering committee Chairs: Composite tissues: Linda Cendales Heart :

Alex Loupy (Chair) Mark Haas, Banu Sis, Kathryn Tinkham, Candice Rofousse, Chris Bellamy, Lynn Cornell, Carmen LeFaucheur Composite tissues: Linda Cendales Heart : Rene

Working Group (BWG) Leads: Molecular transplantation pathology: Michael Mengel, Banu Sis Isolated v-lesions: Banu Sis, Ed Kraus Quality assurance in transplantation

8 Organizational structure of the Banff Foundation For Allograft Pathology Board of Trustees: K. Solez (Chair), L. Racusen, D. Glotz, J. Demetris, M. Mengel, M. Mihatsch, D. Seron, N. Schmidt reports to Secretary/Treasurer: Michael Mengel support reports to funding reports to Organ Steering committee Chairs: Composite tissues: Linda Cendales Heart : Rene Rodriguez Kidney: Mark Haas Liver: Jake Demetris Lung: William Wallace and Carol Farver Pancreas: Cinthia Drachenberg collaboration 2015 Scientific program committee: Alex Loupy (Chair) Mark Haas, Banu Sis, Kathryn Tinkham, Candice Rofousse, Chris Bellamy, Lynn Cornell, Carmen LeFaucheur Composite tissues: Linda Cendales Heart : Rene Rodriguez Liver: Jake Demetris Lung: William Wallace and Carol Farver Pancreas/Islets: Cinthia Drachenberg and John Papadimitriou collaboration progress reports to Banff Working Group (BWG) Leads: Molecular transplantation pathology: Michael Mengel, Banu Sis Isolated v-lesions: Banu Sis, Ed Kraus Quality assurance in transplantation diagnostics: Michael Mengel and Parmjeet Randhawa C4d-negative ABMR: Mark Haas, Banu Sis, Alexandre Loupy Fibrosis scoring: Robert Colvin, Brad Farris, Michael Mengel Digital Pathology in Transplantation: Jake Demetris collaboration Budged proposal and accountability for meeting costs 2015 Local Conference chair: Michael Mengel collaboration

9 Significance of Banff papers 4244 citations of the 9 Banff meeting reports 790 Banff / Transplantation papers in PubMed Banff 2003 meeting report (ABMR criteria) = most cited AJT paper 3 Banff meeting reports are among the top 4 cited AJT articles

10 The Banff Conferences on Allograft Pathology: I The Centre For Conferences - Banff, AB Canada II. III. IV The Centre For Conferences - Banff, AB Canada 1995 The Centre For Conferences - Banff, AB Canada 1997 The Banff Springs Hotel - Banff, AB Canada V The Banff Springs Hotel - Banff, AB Canada VI. VII. VIII. IX The Rimrock Resort Hotel - Banff, AB Canada 2003 The University of Aberdeen - Aberdeen, Scotland 2005 The Fairmont Hotel Macdonald - Edmonton, AB Canada 2007 La Coruña, Spain X The Rimrock Resort Hotel - Banff, AB Canada XI. XII. XIII Enghien-les-Bains, France 2013 Comandatuba-Bahia, Brazil 2015 Vancouver, Canada

11 Target Audience for the 2015 joint CST/Banff meeting: total ~600 expected delegates Basic Scientists Pathologists Immunogeneticists and HLA experts Transplant Physicians: Internal Medicine, Surgery, Infectious Diseases, Critical Care Allied Health Care Students, Trainees, Fellows

12 Joint Program Structure Banff activies Joint activities CST activities 2015 CST / Banff meeting program Day 1: Monday Day 2: Tuesday Day 3: Wednesday Day 4: Thursday Day 5: Friday Day 6: Saturday Session Potential Banff-premeeting Plenary Session: Progress Report Banff Working groups Joint Pleanary session I: Joint Pleanary session II: Concurrent sessions: Banff meeting summary and CST symposia 08:00-08:30 08:30-09:00 09:00-09:30 09:30-10:00 10:00-10:30 Coffee break Coffee break Coffee break Coffee break Coffee break Coffee break 10:30-11:00 11:00-11:30 11:30-12:00 12:00-01:00 Working Lunch: Banff registration open Working Lunch: Working Lunch: CST registration open Working Lunch: Lunch: Banff adjourns Lunch: Session Potential Banff-premeeting Concurrent Organ Sessions Concurrent sessions: Banff Organ sessions and CST Working groups Concurrent sessions: Banff Organ sessions and CST symposia 01:00-01:30 01:30-02:00 02:00-02:30 02:30-03:00 03:00-03:30 Coffee break Coffee break Coffee break Coffee break Coffee break Coffee break 03:30-04:00 04:00-04:30 04:30-05:00 05:00-05:30 05:30-06:00 Events 6:30 Welcome Reception - Cocktails and snacks. Open bar Case presentations from varioous organs with Wine Beer and Food Joint Poster Session with reception CST Awards and Joint CST/Banff Gala Dinner CST President's dinner

Pathological back-ground of renal transplant pathology and important mile-stones of the Banff classification

Banff 1 Banff Pathological back-ground of renal transplant pathology and important mile-stones of the Banff classification Department of Nephrology, Japanese Red Cross Nagoya Daini Hospital Morozumi Kunio,