New perspectives on the link between nutrition and the immune system. Jurriaan Mes Wageningen UR - Food & Biobased Research

Size: px

Start display at page:

Download "New perspectives on the link between nutrition and the immune system. Jurriaan Mes Wageningen UR - Food & Biobased Research"

Charity Hancock
5 years ago
Views:

1 New perspectives on the link between nutrition and the immune system Jurriaan Mes Wageningen UR - Food & Biobased Research Jurriaan.mes@wur.nl

2 Current nutritions with immune health effects Nutritional factors that received an authorised health claims regarding immune function: Copper, Iron, Zinc, Selenium Folate Vitamin A Vitamin B12 Vitamin B6 Vitamin D Vitamin C (2x) contributes to the normal function of the immune system contributes to maintain the normal function of the immune system during and after intense physical exercise

3 Product launched with link to immune based on these vitamins and minerals

4 EFSA guidelines leading

5 Approved compounds on vaccination effect Savy M, et al Landscape analysis of interactions between nutrition and vaccine responses in children. J Nutr 139:2154S-218S. Evidence for definitive adjunctive effects of micronutrient supplementation at the time of vaccination is also weak. No evidence for an effect of Vitamin A supplementation on specific responses to diphtheria and tetanus, cholera, influenza, Haemophilus influenza type b and pneumococcal vaccines. Habib et al (2015) Zinc supplementation fails to increase the immunogenicity of oral poliovirus vaccine: a randomized controlled trial. 33(6): Many more examples

6 Some general designs Population: elderly Expected a more senescent immune system But very heterogeneous group Common vaccination model More appealing to the general community Often these studies are small <40 Analysis Often based on many markers pilot trial (need correction multiples testing) Low in confirmative trials one primary outcome (preferred by EFSA)

7 Study related to support vaccination PS

8 Study related to support vaccination Lb Akatsu H, et al Lactobacillus in jelly enhances the effect of influenza vaccination in elderly individuals. J Am Geriatr Soc Oct;61(10):

9 Study related to support vaccination Lb Roman BE, Beli E, Duriancik DM, Gardner EM Short-term supplementation with active hexose correlated compound improves the antibody response to influenza B vaccine. Nutr Res. 33(1):12-7.

Study related to immune support wolfberry milk-based wolfberry formulation (Lacto-Wolfberry) 150 Chinese elderly (65 70 years old) supplemented with Lacto-Wolfberry or placebo (13.

10 Study related to immune support wolfberry milk-based wolfberry formulation (Lacto-Wolfberry) 150 Chinese elderly (65 70 years old) supplemented with Lacto-Wolfberry or placebo (13.7 grams/day) IgG levels responded significantly different Not known effect to separate vaccines But no significant changes in many cellular parameters, DHT, inflammatory markers, symptoms Vidal et al (2012) Immunomodulatory effects of dietary supplementation with a milk-based wolfberry formulation in healthy elderly: a randomized, double-blind, placebocontrolled trial. Rejuvenation Res. 15(1):89-97.

Study related to immune support Lb Jespersen 2015.

11 Study related to immune support Lb Jespersen Am J Clin Nutr. 101(6): Reaching enough illness symptoms (checked by practitioner) requires large group and or long intervention period and or heavy challenge period.

12 Shift to other vaccine models? Mwanza-Lisulo M, Kelly P. Potential for use of retinoic acid as an oral vaccine adjuvant. Philos Trans R Soc Lond B Biol Sci Jun 19;370(1671).

13 Effect all-trans retinoic acid in oral typhoid vaccination Lisulo MM, et al. (2014) Adjuvant potential of low dose all-trans retinoic acid during oral typhoid vaccination in Zambian men. Clin Exp Immunol. 175(3): Whole gut lavage fluid (WGLF) local production need to flush out

14 Relation fruit & vegetable intake on vaccination History dependent response on IgG sab But not on tetanus Gibson et al Effect of fruit and vegetable consumption on immune function in older people: a randomized controlled trial. Am J Clin Nutr. 96(6):

15 Tips and tricks Subjets not exposed to vaccination model before? Or use memory cell population as new type of read out Select vaccine on potential mechanism T cell dependent/independent Th1/Th2 directed Use suboptimal doses Study dynamics of the response Window of improvement Preferable use vaccine with definitions of normal levels of antibody response and protected levels Make trial large and dedicated (if want to convince EFSA)

Gut innate immune system important Leaky gut syndrome is a hypothetical condition that might be related to chronical diseases (Metabolic Syndrome, T2D, lupus, Multiple Sclerosis, migraines, autism

16 Gut innate immune system important Leaky gut syndrome is a hypothetical condition that might be related to chronical diseases (Metabolic Syndrome, T2D, lupus, Multiple Sclerosis, migraines, autism etc). dysfunctional gut syndrome Malabsorption Abnormal hormonal signalling Mucosal barrier Local and systemic challenge by bacterial, endotoxins, PAMPs/MAMPs etc Local and systemic challenge by proteins/ epitopes trigger immune responses

Price et al (2013) Nuts 'n' guts: transport of food allergens across the intestinal epithelium.

17 Leaky is not only in between cells Ghoshal S, et al (2009) Chylomicrons promote intestinal absorption of lipopolysaccharides. J Lipid Res. 50(1):90-7. Price et al (2013) Nuts 'n' guts: transport of food allergens across the intestinal epithelium. Asia Pac Allergy. 3(4): Jialal I, Rajamani U. (2014) Endotoxemia of metabolic syndrome: a pivotal mediator of meta-inflammation. Metab Syndr Relat Disord. 12(9):454-6.

Markers to study gut/barrier function Potential markers to use Sugar probes - Sucrose, Lactulose, rhamnose, Sucralose, Erythritol Gut permeability Zonulin, ifabp, CLDNs Endotoxines levels - LPS, LBP,

18 Markers to study gut/barrier function Potential markers to use Sugar probes - Sucrose, Lactulose, rhamnose, Sucralose, Erythritol Gut permeability Zonulin, ifabp, CLDNs Endotoxines levels - LPS, LBP, CD14 PAMPs, bacterial DNA, flagella, peptidoglycans, etc Cholesterol metabolism - HDL/LDL/apoB Inflammatory markers hscrp, IL-6, TNF-α, calprotectin, α1- antitrypsin Food compounds e.g. peanut allergen Others for specific (metabolic) functions to develop

19 An example with Probiotic mixture Van Hemert et al (2013) Advances in Microbiology 3,

20 Some factors to keep in mind Sample collection can influence outcome Faecal samples random Urine moderate dynamics, 0-5h, 5-24h Serum overnight fasted or dynamics (area under the curve) Use of challenge models NSAIDs ibuprofen High fat, high sugar, or together (PhenFlex) Vary in type of fat (sat, mono-un, poly-un)

21 Future perspectives to study nutrition and immune support Need to understand personal immune status Need to identify key arkers

22 Personalized risk assessment model (+ nutrient based advices) Nutrients Age Gut function and microbiot a Systemic and Metabolic Related processes Stress and chronic inflammati on related challenges Physical Activity Immune status acute challenge Immune status risk assessment Castiglione et al. JMIR Res Protoc Oct 31;2(2):e44.

23 Thank you for the attention

The Role of Nutrition and Functional Medicine to Alleviate

The Role of Nutrition and Functional Medicine to Alleviate the Symptoms of Lupus Margaret A. Romero NP-C Ivy-league trained Board certified Nurse Practitioner Specializes in Integrative/Functional Medicine,