Publications (*corresponding author)

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1 Publications (*corresponding author) 1. Q. Ding and K.S. Tan* (2016). The danger signal extracellular ATP is an inducer of Fusobacterium nucleatum biofilm dispersal. Frontiers in Cellular and Infection Microbiology (Accepted). 2. Y. Zou, H.J. Tong, M. Li, K.S. Tan and T. Cao (2016). Telomere length is regulated by FGF-2 in human embryonic stem cells and affects the life span of its differentiated progenies. Biogerontology (Accepted). 3. Q. Ding, S.Y. Quah and K.S. Tan* (2016). Secreted ATP from A. actinomycetemcomitans triggers chemokine response. Molecular Oral Microbiology 31: G. Sriram, V.P. Natu, I. Islam, X. Fu, J.C. Seneviratne, K.S. Tan, T. Cao (2016). Innate immune response of human embryonic stem cell derived-fibroblasts and mesenchymal stem cells to periodontopathogens. Stem Cells International 2016: W. Guo, S.Y. Quah, K.C. Lim, V.S.H. Yu and K.S. Tan* (2016). Cysteamine enhances biofilm eradication efficacy of calcium hydroxide. Journal of Endodontics 42: X.J. Ooi and K.S. Tan* (2016). Reduced glutathione mediates resistance to H 2 S toxicity in oral streptococci. Applied and Environmental Microbiology 82(7): C.X. Tay, S.Y. Quah, J.N. Lui, V.S.H. Yu and K.S. Tan* (2015). MMP inhibitor as an antimicrobial agent to eradicate Enterococcus faecalis biofilm. Journal of Endodontics 41(6): DOI: /j.joen H.P. Lew, S.Y. Quah, J.N. Lui, G. Bergenholtz, V.S.H. Yu and K.S. Tan* (2015). Isolation of alkaline tolerant bacteria from primary infected root canals. Journal of Endodontics 41(4): DOI: /j.joen K.S. Tan*, V.S.H. Yu, S.Y. Quah and G. Bergenholtz (2015). Rapid method for the detection of root canal bacteria in endodontic therapy. Journal of Endodontics 41(4): Selected as top endodontic article published in April 2015 by the Scientific Advisory Board of Endolit]. 10. P. Lee and K.S. Tan* (2015). Effects of epigallocatechin gallate against Enterococcus faecalis biofilm and virulence. Archives of Oral Biology 60: C.Y. Tay, W. Fang, M.I. Setyawati, S.L. Chia, K.S. Tan, C.H.L. Hong and D. Leong (2014). Nanohydroxyapatite and nano-titanium dioxide exhibit different sub-cellular distribution and apoptotic profile in human oral epithelium. ACS Applied Materials & Interfaces DOI: /am501266a. 12. P. Lee and K.S. Tan* (2014). Fusobacterium nucleatum activates immune response through Retinoic Acid Inducible Gene I. Journal of Dental Research 93(2):

2 13. S.Y. Quah, G. Bergenholtz and K.S. Tan* (2014). Fusobacterium nucleatum induces cytokine production through toll-like receptor independent mechanism. International Endodontic Journal 47: F.K. Kidwai, D.S. Jokhun, M.M. Movahednia, J.F. Yeo, K.S. Tan, T. Cao (2013). Human embryonic stem cells derived keratinocyte as an in vitro research model for the study of immune response. Journal of Oral Pathology & Medicine 42: S.Y. Quah, S. Wu, J.N. Lui, C.P. Sum and K.S. Tan* (2012). N-acetylcysteine inhibits growth and eradicates biofilm of Enterococcus faecalis. Journal of Endodontics, 38(1): K.S. Tan, K.O. Lee, K.C. Low, A.M. Gamage, Y. Liu, G.Y.G. Tan, H.Q.V. Koh, S. Alonso, Y.H. Gan (2012). Glutathione deficiency in Type 2 diabetes impairs cytokine responses and control of intracellular bacteria. Journal of Clinical Investigation, 122: K.S. Tan, Y. Chen, Y.C. Lim, G.Y.G. Tan, Y. Liu, Y.T. Lim, P. MacAry and Y.H. Gan (2010). Inhibition of host innate immune response by Burkholderia pseudomallei through virulence factor TssM. Journal of Immunology, 184: I.E. Tchivileva, K.S. Tan, M. Gambarian, A. Medvedev, A.G. Nackley, S. Romanov, P.M. Flood, W. Maixner, S.S. Makarov and L.B. Diatchenko (2009). Signaling pathways mediating beta-3 adrenergic receptor-induced production of Interleukin-6 in adipocytes. Molecular Immunology, 46: K.S. Tan, A.G. Nackley, K. Satterfield, W. Maixner, L.B. Diatchenko and P.M. Flood (2007). Beta-2 adrenergic receptor activation stimulates pro-inflammatory cytokine production in macrophages via PKA- and NF-κB-independent mechanisms. Cellular Signaling 19: L. Qian, K.S. Tan, S.J. Wei, H.M. Wu, B. Wilson, J.S. Hong and P.M. Flood (2007). Microgliamediated neurotoxicity is inhibited by both levo- and dextro- forms of morphine through an ERKmediated reduction of NADPH oxidase activity. Journal of Immunology, 179: A.G. Nackley, K.S. Tan, K. Fecho, P. Flood, L. Diatchenko and W. Maixner (2007). Catechol-Omethyltransferase inhibition increases pain sensitivity through activation of both beta-2 and beta-3 adrenergic receptors. Pain, 128: K.S. Tan, L. Qian, R. Rosado, P.M. Flood and L.F. Cooper (2006). The role of titanium surface topography on J774A.1 macrophage inflammatory cytokines and nitric oxide production. Biomaterials, 27: K.S. Tan, G. Ong and K.P. Song (2005). Introns in the cytolethal distending toxin gene of Actinobacillus actinomycetemcomitans. Journal of Bacteriology, 187:

3 24. K.S. Tan, K.P. Song and G. Ong (2002). Cytolethal-distending toxin of Actinobacillus actinomycetemcomitans: Occurrence and association with periodontal disease. Journal of Periodontal Research, 37: K.S. Tan, K.P. Song and G. Ong (2001). Bacteroides forsythus prth genotype in periodontitis patients: Occurrence and association with periodontal disease. Journal of Periodontal Research, 36: K.S. Tan, C.H. Woo, G. Ong and K.P. Song (2001). Prevalence of Actinobacillus actinomycetemcomitans in an ethnic adult Chinese population. Journal of Clinical Periodontology, 28: K.S. Tan, B.Y. Wee and K.P. Song (2001). Evidence for holin-function of tcde gene in the pathogenesis of Clostridium difficile. Journal of Medical Microbiology, 50: Oral/Poster Presentations and Abstracts (*corresponding author) 1. K.S. Tan* and Q. Ding (2016). Feasibility of Himar1 tranposon mutagenesis in Aggregatibacter actinomycetemcomitans. International Association for Dental Research General Session, Seoul, Korea (Oral Presentation). 2. J.L. Mougeot, F.B. Mougeot, C.B. Stevens, M.T. Brennan, K.S. Tan, P.L. Tan, C.H. Hong CH (2016). Oral Microbiome Changes in Children Undergoing Conditioning Therapy for Hematopoietic Stem Cell Transplant. Multinational Association of Supportive Care in Caner, June, Adelaide, Australia (Poster Presentation). 3. K.S. Tan* and Q. Ding (2015). Bacterial extracellular ATP: A novel signaling molecule in periodontal disease. International Association for Dental Research-South East Asian Division, Bali. (Oral Presentation). 4. G.S. Lau, K.S. Tan, C.A. Lim, Y.H. Chan and L.P. Lim (2015). Serum Inflammatory biomarkers in chronic kidney disease patients with chronic periodontitis: An interventional trial. International Association for Dental Research-South East Asian Division, Bali. (Poster Presentation). 5. W.L. Tan, Y.H. Chan, K.S. Tan and L.P. Lim (2015). Changes in inflammatory mediators in the gingival crevicular fluid of renal patients with periodontitis. International Association for Dental Research-South East Asian Division, Bali. (Poster Presentation). 6. S. Tan, L.P. Lim, Y.H. Chan and K.S. Tan (2015). Salivary biomarkers in renal patients with periodontitis. International Association for Dental Research-South East Asian Division, Bali. (Poster Presentation). 3

4 7. X.E. Goh, K.S. Tan, C.A. Lim, Y.H. Chan and L.P. Lim (2015). Photodynamic Therapy During Supportive Periodontal Therapy: A Randomised Split-mouth Controlled Trial. International Association for Dental Research-South East Asian Division, Bali. (Oral Presentation). 8. C.H. Hong, K.S. Tan, K.S. Tang, H.J. Tong, von Bültzingslöwen I and M.T. Brennan (2015). Dental parameters and bacteremia in pediatric hematopoietic stem cell transplantations: clinical findings. Multinational Association of Supportive Care in Cancer, June, Copenhagen, Denmark (Poster Presentation). 9. K.S. Tan* and P. Lee (2015). Porphyromonas gingivalis suppresses immune response in periodontal fibroblast. Euro Perio 8, London. (Poster Presentation). 10. E.J. Chong, H.S.G. Tan, Y.R.I. Lim, Y.P.B. Loh and K.S. Tan* (2015). Low dose C-reactive protein on macrophage response to bacterial infection. Second Prize, Hatton Award (Junior Category), International Association for Dental Research General Session, Boston. 11. K.S. Tan* and P. Lee (2015). Effects of alkaline stress on Enterococcus faecalis biofilm formation and antimicrobial resistance. International Association for Dental Research General Session, Boston. (Poster Presentation). 12. Q. Ding and K.S. Tan* (2015). Extracellular ATP release by periodontal pathogen induces cytokine production in macrophages. International Association for Dental Research General Session, Boston. (Poster Presentation). 13. X.J. Ooi and K.S. Tan* (2015). Hydrogen sulfide activates camp signaling through extracellular ATP in periodontal ligament fibroblast. International Association for Dental Research General Session, Boston. (Poster Presentation). 14. E.J. Chong, Y.R.I. Lim, Y.P.B. Loh, H.S.G. Tan, and K.S. Tan* (2014). Low dose C-reactive protein on macrophage response to bacterial infection. First Prize, Hatton Divisional Award (Junior Category), International Association for Dental Research-South East Asian Division, Sarawak. 15. Q. Ding and K.S. Tan* (2014). Saturated free fatty acids modulate inflammatory responses of periodontal ligament fibroblasts. International Association for Dental Research-South East Asian Division, Sarawak. (Oral Presentation) 16. X.J. Ooi and K.S. Tan* (2014). Hydrogen sulfide modulates interleukin-8 transcript stability in periodontal ligament fibroblast. International Association for Dental Research-South East Asian Division, Sarawak. (Oral Presentation) 17. H.P. Lew, S.Y. Quah, V.S.H. Yu and K.S. Tan* (2014). Isolation of alkaline tolerant bacteria from primary infected root canals. International Association for Dental Research-South East Asian Division, Sarawak. (Oral Presentation) 4

5 18. C.X. Tay, S.Y. Quah, V.S.H. Yu and K.S. Tan* (2014). Eradicating Enterococcus faecalis Biofilm with Metal Chelator 1,10-Phenanthroline-5,6-dione. International Association for Dental Research- South East Asian Division, Sarawak. (Oral Presentation) 19. Y.R. Tan, Y. Sha, S.Y. Toh, M.S.E. Toh and K.S. Tan* (2013). Enhancing Antimicrobial Activity by Combining Antibiotics with N-Acetylcysteine: Potential application for biofilm-related infections. Participated in the IADR-SEA Division Joseph Lister Awards in Oral Disease Prevention Competition, 2 nd International Association for Dental-Asia Pacific Region, Bangkok. 20. X.J. Ooi and K.S. Tan* (2013). Volatile sulphur compound modulates inflammatory response in periodontal ligament fibroblasts. Participated in the IADR-SEA Unilever Divisional Travel Award Competition (Senior Category), 2 nd International Association for Dental Research-Asia Pacific Region, Bangkok. 21. P. Lee and K.S. Tan* (2013). Fusobacterium nucleatum activates pro-inflammatory response through RIG-I in human periodontal ligament fibroblasts. 2 nd International Association for Dental Research-Asia Pacific Region, Bangkok. (Poster Presentation) 22. A.L.H. Tay, X. Yuan, K.S. Tan* and J. Xie (2013). Silver nanoparticles enhance potency of cetylpyridinium chloride against Candida albicans. 2 nd International Association for Dental Research-Asia Pacific Region, Bangkok. (Oral Presentation) 23. L.H. Foo, K.S. Tan and L.P. Lim (2012). Effect of photodynamic therapy on matrix metalloproteinases-8 (MMP-8) in periodontitis patients. International Association for Dental Research-South East Asian Division, Hong Kong. (Poster Presentation) 24. J. Lu, K.S. Tan and L.P. Lim (2012). Effect of photodynamic therapy on subgingival microflora in periodontitis patients. International Association for Dental Research-South East Asian Division, Hong Kong. (Poster Presentation) 25. K.S. Tan, K.O. Lee and Y.H. Gan (2010). Factors contributing to increased susceptibility to Burkholderia pseudomallei infection in diabetic patients. 6 th World Melioidosis Congress, Townsville, Australia. (Oral Presentation) 26. K.S. Tan, K.O. Lee and Y.H. Gan (2010). Differential activation of innate immune response between diabetics and healthy individuals in response to a bacterial pathogen. 10th Nagasaki- Singapore Medical Symposium on Infectious Disease. (Oral Presentation) 27. K.S. Tan, Y.H. Chen and Y.H. Gan (2008). Interference with NFκB signalling pathways by Burkholderia pseudomallei. Keystone Symposia: Pathogenesis and Control of Emerging Infectious and Drug-Resistant Organism, Bangkok, Thailand. (Poster Presentation) 5

6 28. K.S. Tan, Y.H. Chen and Y.H. Gan (2007). Effect of hyperglycemia on B. pseudomallei type three secretion system gene expression following macrophage infection. World Melioidosis Congress, Khon Kaen, Thailand. (Poster Presentation) 29. P.F. Ong, T.S. Sim, K.S. Tan, G. Ong and K.P. Song (2006). Characterization of a novel 24 kda hemin-binding protein, HmuX, in Porphyromonas gingivalis W50. Louis Pasteur Conference for Infectious Disease, Paris, France. (Poster Presentation) 30. K.S. Tan, L.F. Cooper and P.M. Flood (2006). Effects of inflammatory mediators on OPG/OPGL in mesenchymal stem cells. American Association for Dental Research, Orlando, USA. (Poster) 31. A.G. Nackley, J.M. Faison, B.L. Lambeth, K.S. Tan, K. Fecho, P.M. Flood, L.B. Diatchenko and W. Maixner. (2005) Catechol-O-methyltransferase modulates pain behavior and cytokine production via β2/3-adrenergic receptor mechanisms. Society for Neuroscience, Washington DC, USA. (Poster Presentation) 32. K.S. Tan, K.P. Song and G.Ong (2004). Cytolethal-distending toxin gene of Actinobacillus actinomycetemcomitans: A self-splicing intron. Finalist, 82 nd International Association for Dental Research/Unilever Hatton Awards, Honolulu, Hawaii, USA. 33. K.S. Tan, K.P. Song and G. Ong (2003). Cytolethal-distending toxin gene of Actinobacillus actinomycetemcomitans: A self-splicing intron. First Prize, 18 th International Association for Dental Research-South East Asian Division Unilever Travel Award (Senior Category), Ho Chi Minh city, Vietnam. 34. K.S. Tan, K.P. Song and G. Ong (2003). Transcript analysis of the leukotoxin operon in highly and minimally leukotoxic Strains of Actinobacillus actinomycetemcomitans. 81 st International Association for Dental Research General Session, Gothenburg, Sweden. (Oral Presentation) 35. P. Yuan, K.S. Tan, K.P. Song and G. Ong (2003). Quantification of Actinobacillus actinomycetemcomitans in periodontal health and diseased in ethnic Chinese by real-time PCR. 81 st International Association for Dental Research General Session, Gothenburg, Sweden. (Poster Presentation) 36. K. S. Tan, K. P. Song and G. Ong (2001). Is the 16S rdna a suitable PCR gene target for detection of Bacteroides forsythus and Porphyromonas gingivalis? International Academy of Periodontology International Meeting, Auckland, New Zealand. (Poster Presentation) 37. K.S. Tan, C. H. Woo, G. Ong and K.P. Song (2000). Prevalence of Actinobacillus actinomycetemcomitans in Singapore Chinese adults. International Congress of the Confederation of Anaerobic Societies, Manchester, England. (Poster Presentation) 6

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