Klinik und Diagnostik bullöser Autoimmundermatosen Wenn die Schleimhaut nicht mehr heilen will

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1 Klinik und Diagnostik bullöser Autoimmundermatosen Wenn die Schleimhaut nicht mehr heilen will Ana Luiza Lima, Detlef Zillikens, Enno Schmidt Literatur Leserservice zm Nr. 08/2016, S Ahmed, A.R., Z. Spigelman, L.A. Cavacini, and M.R. Posner Treatment of pemphigus vulgaris with rituximab and intravenous immune globulin. N Engl J Med 355: Amagai, M., K. Tsunoda, D. Zillikens, T. Nagai, and T. Nishikawa The clinical phenotype of pemphigus is defined by the anti-desmoglein autoantibody profile. J Am Acad Dermatol 40: Anhalt, G.J Paraneoplastic pemphigus. J Investig Dermatol Symp Proc 9: Bernard, P., F. Antonicelli, C. Bedane, P. Joly, C. Le Roux-Villet, S. Duvert-Lehembre, P. Rousselle, and C. Prost-Squarcioni Prevalence and clinical significance of antilaminin 332 autoantibodies detected by a novel enzyme-linked immunosorbent assay in mucous membrane pemphigoid. JAMA Dermatol 149: Bernard, P., L. Vaillant, B. Labeille, C. Bedane, B. Arbeille, J.P. Denoeux, G. Lorette, J.M. Bonnetblanc, and C. Prost Incidence and distribution of subepidermal autoimmune bullous skin diseases in three French regions. Bullous Diseases French Study Group. Arch Dermatol 131: Bertram, F., E.B. Brocker, D. Zillikens, and E. Schmidt Prospective analysis of the incidence of autoimmune bullous disorders in Lower Franconia, Germany. J Dtsch Dermatol Ges 7: Blocker, I.M., C. Dahnrich, C. Probst, L. Komorowski, S. Saschenbrecker, W. Schlumberger, W. Stocker, D. Zillikens, and E. Schmidt Epitope mapping of BP230 leading to a novel enzyme-linked immunosorbent assay for autoantibodies in bullous pemphigoid. Br J Dermatol 166: Buijsrogge, J.J., G.F. Diercks, H.H. Pas, and M.F. Jonkman The many faces of epidermolysis bullosa acquisita after serration pattern analysis by direct immunofluorescence microscopy. Br J Dermatol 165:92 98.

2 Chan, L.S., A.R. Ahmed, G.J. Anhalt, W. Bernauer, K.D. Cooper, M.J. Elder, J.D. Fine, C.S. Foster, R. Ghohestani, T. Hashimoto, T. Hoang-Xuan, G. Kirtschig, N.J. Korman, S. Lightman, F. Lozada-Nur, M.P. Marinkovich, B.J. Mondino, C. Prost-Squarcioni, R.S. Rogers, 3rd, J.F. Setterfield, D.P. West, F. Wojnarowska, D.T. Woodley, K.B. Yancey, D. Zillikens, and J.J. Zone The first international consensus on mucous membrane pemphigoid: definition, diagnostic criteria, pathogenic factors, medical treatment, and prognostic indicators. Arch Dermatol 138: Charneux, J., J. Lorin, F. Vitry, F. Antonicelli, Z. Reguiai, C. Barbe, T. Tabary, F. Grange, and P. Bernard Usefulness of BP230 and BP180-NC16a enzyme-linked immunosorbent assays in the initial diagnosis of bullous pemphigoid: a retrospective study of 138 patients. Arch Dermatol 147: Dainichi, T., S. Kurono, B. Ohyama, N. Ishii, N. Sanzen, M. Hayashi, C. Shimono, Y. Taniguchi, H. Koga, T. Karashima, S. Yasumoto, D. Zillikens, K. Sekiguchi, and T. Hashimoto Anti-laminin gamma-1 pemphigoid. Proc Natl Acad Sci U S A 106: Egan, C.A., Z. Lazarova, T.N. Darling, C. Yee, T. Cote, and K.B. Yancey Antiepiligrin cicatricial pemphigoid and relative risk for cancer. Lancet 357: Eming, R., M. Sticherling, S.C. Hofmann, N. Hunzelmann, J.S. Kern, H. Kramer, C. Pfeiffer, V. Schuster, D. Zillikens, M. Goebeler, M. Hertl, A. Nast, H.D. Orzechowski, M. Sardy, E. Schmidt, C. Sitaru, B. Sporbeck, and M. Worm S2k guidelines for the treatment of pemphigus vulgaris/foliaceus and bullous pemphigoid. J Dtsch Dermatol Ges 13: Goletz, S., T. Hashimoto, D. Zillikens, and E. Schmidt Anti-p200 pemphigoid. J Am Acad Dermatol 71: Groth, S., A. Recke, K. Vafia, R.J. Ludwig, T. Hashimoto, D. Zillikens, and E. Schmidt Development of a simple enzyme-linked immunosorbent assay for the detection of autoantibodies in anti-p200 pemphigoid. Br J Dermatol 164: Hahn-Ristic, K., B. Rzany, M. Amagai, E.B. Brocker, and D. Zillikens Increased incidence of pemphigus vulgaris in southern Europeans living in Germany compared with native Germans. J Eur Acad Dermatol Venereol 16: Harman, K.E., P.T. Seed, M.J. Gratian, B.S. Bhogal, S.J. Challacombe, and M.M. Black The severity of cutaneous and oral pemphigus is related to desmoglein 1 and 3 antibody levels. Br J Dermatol 144:

3 Hertl, M., H. Jedlickova, S. Karpati, B. Marinovic, S. Uzun, S. Yayli, D. Mimouni, L. Borradori, C. Feliciani, D. Ioannides, P. Joly, C. Kowalewski, G. Zambruno, D. Zillikens, and M.F. Jonkman Pemphigus. S2 Guideline for diagnosis and treatment--guided by the European Dermatology Forum (EDF) in cooperation with the European Academy of Dermatology and Venereology (EADV). J Eur Acad Dermatol Venereol 29: Joly, P., S. Baricault, A. Sparsa, P. Bernard, C. Bedane, S. Duvert-Lehembre, P. Courville, P. Bravard, B. Remond, V. Doffoel-Hantz, and J. Benichou Incidence and mortality of bullous pemphigoid in France. J Invest Dermatol 132: Joly, P., H. Mouquet, J.C. Roujeau, M. D Incan, D. Gilbert, S. Jacquot, M.L. Gougeon, C. Bedane, R. Muller, B. Dreno, M.S. Doutre, E. Delaporte, C. Pauwels, N. Franck, F. Caux, C. Picard, E. Tancrede-Bohin, P. Bernard, F. Tron, M. Hertl, and P. Musette A single cycle of rituximab for the treatment of severe pemphigus. N Engl J Med 357: Kasperkiewicz, M., F. Schulze, M. Meier, N. van Beek, M. Nitschke, D. Zillikens, and E. Schmidt Treatment of bullous pemphigoid with adjuvant immunoadsorption: A case series. J Am Acad Dermatol 71: Kasperkiewicz, M., I. Shimanovich, R.J. Ludwig, C. Rose, D. Zillikens, and E. Schmidt Rituximab for treatment-refractory pemphigus and pemphigoid: a case series of 17 patients. J Am Acad Dermatol 65: Kasperkiewicz, M., I. Shimanovich, M. Meier, N. Schumacher, L. Westermann, J. Kramer, D. Zillikens, and E. Schmidt Treatment of severe pemphigus with a combination of immunoadsorption, rituximab, pulsed dexamethasone and azathioprine/mycophenolate mofetil: a pilot study of 23 patients. Br J Dermatol 166: Kim, J.H., Y.H. Kim, and S.C. Kim Epidermolysis bullosa acquisita: a retrospective clinical analysis of 30 cases. Acta Derm Venereol 91: Le Roux-Villet, C., C. Prost-Squarcioni, M. Alexandre, F. Caux, F. Pascal, S. Doan, M.D. Brette, I. Soued, E. Gabison, F. Aucouturier, R. Letestu, L. Laroche, and H. Bachelez Rituximab for patients with refractory mucous membrane pemphigoid. Arch Dermatol 147: Letko, E., E. Miserocchi, Y.J. Daoud, W. Christen, C.S. Foster, and A.R. Ahmed A nonrandomized comparison of the clinical outcome of ocular involvement in patients with mucous membrane (cicatricial) pemphigoid between conventional immunosuppressive and intravenous immunoglobulin therapies. Clin Immunol 111: Ludwig, R.J Clinical presentation, pathogenesis, diagnosis, and treatment of epidermolysis bullosa acquisita. ISRN Dermatol 2013:

4 Marazza, G., H.C. Pham, L. Scharer, P.P. Pedrazzetti, T. Hunziker, R.M. Trueb, D. Hohl, P. Itin, S. Lautenschlager, L. Naldi, and L. Borradori. 2009a. Incidence of bullous pemphigoid and pemphigus in Switzerland: a 2-year prospective study. Br J Dermatol 161: Marazza, G., H.C. Pham, L. Scharer, P.P. Pedrazzetti, T. Hunziker, R.M. Trueb, D. Hohl, P. Itin, S. Lautenschlager, L. Naldi, L. Borradori, and g. Autoimmune bullous disease Swiss study. 2009b. Incidence of bullous pemphigoid and pemphigus in Switzerland: a 2-year prospective study. Br J Dermatol 161: Martin, L.K., V. Werth, E. Villanueva, J. Segall, and D.F. Murrell Interventions for pemphigus vulgaris and pemphigus foliaceus. Cochrane Database Syst Rev CD Probst, C., W. Schlumberger, W. Stocker, A. Recke, E. Schmidt, T. Hashimoto, X.J. Zhu, D. Zillikens, and L. Komorowski Development of ELISA for the specific determination of autoantibodies against envoplakin and periplakin in paraneoplastic pemphigus. Clin Chim Acta 410: Sardy, M., S. Karpati, B. Merkl, M. Paulsson, and N. Smyth Epidermal transglutaminase (TGase 3) is the autoantigen of dermatitis herpetiformis. J Exp Med 195: Saw, V.P., and J.K. Dart Ocular mucous membrane pemphigoid: diagnosis and management strategies. Ocul Surf 6: Schmidt, E. 2015a. S2k Guidelines for diagnosis of pemphigus vulgaris/foliaceus and bullous pemphigoid. In J Dtsch Dermatol Ges Schmidt, E., L. Borradori, and P. Joly. 2015a. Epidemiology of autoimmune bullous diseases. In: Murrell D (Eds). Blistering diseases. 1st edition. Springer, Heidelberg Schmidt, E., Borradori, L., Joly, P b. Epidemiology of autoimmune bullous diseases. In Murrell D (Eds). Blistering diseases. Springer, Heidelberg Schmidt, E., C. Dahnrich, A. Rosemann, C. Probst, L. Komorowski, S. Saschenbrecker, W. Schlumberger, W. Stocker, T. Hashimoto, E.B. Brocker, A. Recke, C. Rose, and D. Zillikens Novel ELISA systems for antibodies to desmoglein 1 and 3: correlation of disease activity with serum autoantibody levels in individual pemphigus patients. Exp Dermatol 19: Schmidt, E., R. della Torre, and L. Borradori Clinical features and practical diagnosis of bullous pemphigoid. Immunol Allergy Clin North Am 32: , v. Schmidt, E., M. Goebeler, M. Hertl, M. Sardy, C. Sitaru, R. Eming, S.C. Hofmann, N. Hunzelmann, J.S. Kern, H. Kramer, H.D. Orzechowski, C. Pfeiffer, V. Schuster, B.

5 Sporbeck, M. Sticherling, M. Worm, D. Zillikens, and A. Nast. 2015b. S2k guideline for the diagnosis of pemphigus vulgaris/foliaceus and bullous pemphigoid. J Dtsch Dermatol Ges 13: Schmidt, E., M. Goebeler, and D. Zillikens Rituximab in severe pemphigus. Ann N Y Acad Sci 1173: Schmidt, E., K. Obe, E.B. Brocker, and D. Zillikens Serum levels of autoantibodies to BP180 correlate with disease activity in patients with bullous pemphigoid. Arch Dermatol 136: Schmidt, E., C. Skrobek, A. Kromminga, T. Hashimoto, G. Messer, E.B. Brocker, K.B. Yancey, and D. Zillikens Cicatricial pemphigoid: IgA and IgG autoantibodies target epitopes on both intra- and extracellular domains of bullous pemphigoid antigen 180. Br J Dermatol 145: Schmidt, E., and D. Zillikens Modern diagnosis of autoimmune blistering skin diseases. Autoimmun Rev 10: Schmidt, E., and D. Zillikens The diagnosis and treatment of autoimmune blistering skin diseases. Dtsch Arztebl Int 108: Schmidt, E., and D. Zillikens Pemphigoid diseases. Lancet 381: Schmidt und Zillikens,.Immunfluoreszenztechniken, In: Cerroni L, Garbe C, Metze D, Kutzner H, Kerl H (Hrsg.). Histopathologie der Haut. 2. Auflage. Springer, Heidelberg. Thorne, J.E., G.J. Anhalt, and D.A. Jabs Mucous membrane pemphigoid and pseudopemphigoid. Ophthalmology 111: van Beek, N., D. Knuth-Rehr, P. Altmeyer, C. Assaf, P. Babilas, C. Bayerl, S. Benoit, E. Dippel, I. Effendy, R. Eming, M. Fischer, T. Glaenz, R. Glaser, M. Goebeler, H. Gollnick, S. Gotze, G. Gross, E. Hadaschik, R. Herbst, B. Hermes, B. Homey, N. Hunzelmann, M. Junger, A. Kapp, J.S. Kern, A. Korber, T. Luger, D. Mechtel, M. Megahed, I. Moll, K.P. Peters, C. Pfeiffer, J. Ring, M. Rocken, M. Sardy, C.S. Seitz, R. Stadler, K. Steinbrink, M. Sticherling, R.M. Szeimies, M. Tronnier, J. Ulrich, T. Vogt, N. Wagner, J. Welzel, J. Wenzel, G. Wozel, C.C. Zouboulis, D. Zillikens, and E. Schmidt Diagnostics of autoimmune bullous diseases in German dermatology departments. J Dtsch Dermatol Ges 10: Wojnarowska, F., B.S. Bhogal, and M.M. Black Chronic bullous disease of childhood and linear IgA disease of adults are IgA1-mediated diseases. Br J Dermatol 131:

6 Woodley, D.T., R.A. Briggaman, E.J. O Keefe, A.O. Inman, L.L. Queen, and W.R. Gammon Identification of the skin basement-membrane autoantigen in epidermolysis bullosa acquisita. N Engl J Med 310: Zillikens, D., Y. Kawahara, A. Ishiko, H. Shimizu, J. Mayer, C.V. Rank, Z. Liu, G.J. Giudice, H.H. Tran, M.P. Marinkovich, E.B. Brocker, and T. Hashimoto A novel subepidermal blistering disease with autoantibodies to a 200-kDa antigen of the basement membrane zone. J Invest Dermatol 106: Zillikens, D., S. Wever, A. Roth, B. Weidenthaler-Barth, T. Hashimoto, and E.B. Brocker Incidence of autoimmune subepidermal blistering dermatoses in a region of central Germany. Arch Dermatol 131: Zimmermann, J., F. Bahmer, C. Rose, D. Zillikens, and E. Schmidt Clinical and immunopathological spectrum of paraneoplastic pemphigus. J Dtsch Dermatol Ges 8: