DERMAZELAN ACNE PILOSEBACEOUS FOLLICLE DISFUNCTION

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2 ACNE = PILOSEBACEOUS FOLLICLE DISFUNCTION

3 PATHOGENESIS FUNCTIONAL DISFUNCTIONS OF THE SEBACEOUS GLANDS

4 MULTIFACTORIAL ETHIOLOGY HYPERSEBORRHEA FOLICULAR HYPERKERATOSIS SAPROFITE MICROFLORA PROLIFERATION FREE RADICALS AND FATTY ACIDS PRODUCTION

5 INFLUENCING SKIN & MUCOSES INTERNAL ORGANS MIND THERE IS ALSO A PSYCHOLOGICAL ASPECT

6 VICIOUS CIRCLE

7 Ingestion of big amount high glycemic index food Decreases endogen retinoics efectivity on inhibition of follicle cells proliferation. + insuline Follicle hyperkeratinization + sebum Increases cell mitosis in all tissues Aviable Androgens + of androgens synthesis in gonades Precursors synthesis in the liver INFLUENCE OF THE OCCIDENTAL DIET ON ACNE APPEARANCE

8 4 CAUSES INCREASE OF THE CUTANEOUS SEBUM SECRETION ABNORMAL KERATINISATION OF THE HAIR FOLLICLE WALLS BACTERIAL INFECTIONS INFLAMMATION ANSWERS

9 SKIN STRUCTURE DERMAZELAN

10 HAIR FOLLICLE STRUCTURE Hair Skin surface sebum follicle Sebaceous gland

11 HYPERSEBORRHEA PUBERAL HORMONAL FLUCTUATIONS INCREASE OF THE ANDROGENIC SECRETION DILATED PORES OILY SKIN / PROACNEIC SKIN

12 ABNORMAL KERATINISATION HIGHER LEVELS OF ANDROGENS CORNEOCYTES MATURING PROCESS ALTERED DETATCHMENT OF CORNEOCYTES IN GROUPS HYPERSEBORRHOEA + CRNCT. = PORES OBSTRUCTED

13 BACTERIAL INFECTIONS MICRO-AIR ATMOSPHERE INSIDE THE SEBACEOUS GLANDS SAPROFITE BACTERIAS MICRO FLORA DEVELOPMENT LIPIDS HYDROLISIS BY BACTERIAL ENZYMES (LIPASES) FATTY ACIDS RELEASE IRRITATION / PROINFLAM.

14 INFLAMMATION ANSWERS TISSULAR CHEMIOTACTIC FACTORS + LEUCOCYTES MIGRATION TO THE ALTERED SEBACEOUS GLAND PUS & FREE RADICALS FORMATION MORE IMPORTANT INFLAMED LESIONS

15 Puberal increase of testosterone & dihydrotest. secretion Sebaceous gland hyperactivity Increase of sebum production Cell turn over increase Abnormal keratinization Comedones production Increase of P.A. bct Release of P.A. cell mb fragments Chymiotaxis Intense inflammation

16 COMEDONES EARLY INITIAL LESION OF THE PROACNEIC SKIN SEBUM ACCUMMULATION UNDER KERATINIC CAP DUCTAL HYPERCORNIFICATION + NON- INFLAMED LESION OF ACNE OPEN COMEDONE = BLACK HEAD CLOSED COMEDONE = WHITE HEAD

17 Closed comedone Open comedone Infected comedone Inflammed comedone

18 COMEDONE ALTERATION OF THE KERATINIZATION PROCESS QUANTITY & QUALITY CHANGES OF THE KERATIN INCREASING OF THE DUCTAL EPITELIUM TURN-OVER PRODUCTION OF A KERATIN CAP BLOCKAGE OF THE SEBUM PRODUCED

19 FOLLICULAR HYPERKERATOSIS Follicle duct full of keratin, sebum and bacterial micro-flora Keratinic epitelium that follows the upper epidermis Same type of ripening that epidermis Keratinization = cornification Quality & quantity alteration of the Keratinization Detachment of the corneocytes by an accumulative form

20 ABNORMAL KERATINIZATION DERMAZELAN

21 BACTERIAL MICRO-FLORA CHANGE Micro air atmosphere of the sebaceous glands Saprophyte micro-flora proliferation Propionilbacterium Acnes and other micro-organisms Increase of some bacterial enzymes production (lipases & proteases) Hydrolysis of the lipids by bacterial lipases fatty acids (F.A) F.A. with irritative and pro-inflammatory characteristics BCT INFECTIONS

22 CORNEOCYTES ACCUMMULATION + HYPERSEBORRHOEA COMEDONE CLOSED OPENED

23 INFLAMMATORY ANSWERS PUS FREE RADICALS INFLAMMATION FOLLICLE WALLS BREACKAGE BCTR SURROUN- DING TISSUES IN- FLAMMATION +++ PUS CELLULAR DETRITUS

24 CLINICAL MANIFESTATIONS NON INFLAMMATORY COMEDONES OPENED CLOSED PAPULES PUSTULES INFLAMMATORY NODES PILOSEBAC. UNIT CLOSED COMEDONE OPEN COMEDONE CISTES SCARS PÁPULE PUSTULE CISTES

25 ETHIOLOGY ( influencing factors ) HORMONES: puberty, menstrual cycles, hormonal fluctuations STRESS: hormonal repercussion, (suprarenal, hipotal./ hipofis.) DEAD CELLS ACCUMMULATION INSIDE THE GLANDS PORES BACTERIAL COLONISATION AND ALLERGIC ANSWERS STEROIDS DRUGS CLORATED COMPONENTS EXPOSITION ( cloroacne)

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27 Frequent septic manipulation Lesions get a severe stage Post acne scars

28 ANTIACNE TREATMENT Active ingredients group of chemical & natural nature The target of the ingredients are the 4 causes of acne Synergic & polyvalent answers, combining ingredients Non medical or cosmetic treatment is giving an immediate result Minor forms (comedones) have good results with an adequate cosmetic tr. Severe inflammatory forms may require medical treatment Cosmetic treatments are a good complement for the medical ones Sudden changes of the products can create irritative answers

29 ANTIACNE TREATMENT (Actions) SEBUM REGULATOR KERATOLITIC SAPROFITE MICRO- FLORA INHIBITOR PURIFIER & IMPURITIES REMOVER EXFOLIATOR PORES DESCA- LORER DESPIGMENTATOR MOISTURIZERER

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31 PRODUCT DESCRIPTION

32 DEGREASING SOLUTION MASK CLEANSING SOLUTION MAINTENANCE CREAM OCCASIONAL TREATMENT MOISTURIZING HEALING DEGREASING Urea Isopropanol Acetone aloe vera panthenol aloe vera aloe vera aloe vera Asian Centella Asian Centella CELL STIMULATOR SAPROF FLORA INHIB Alantoin Triclosan Alantoin Kójic ac Triclosan Azelaic ac T.tree oil Triclosan Triclosan Kójic ac. Azelaic ac. SEBUM REMOVER Cremophor RH 40 SEBUM ABSORBER KERATOLITIC SEBUM REGULATOR Aerosil & Caolín Salicílic ac. Resorcin Zinc Licorice extract Salicílic ac. Licorice extract Zinc Licorice extract Salicílic ac. Resorcin Zinc DEPIGMENTANT ANTI-INFLAMMATORY Kójic ac. Bisabolol Bisabolol Amonic Glicirinate Kójic ac. Bisabolol Amonic Glicirinate ANTIOXIDANT Kójic ac. Kójic ac. ALFA REDUCT INHIB ASTRINGENT UV-B PROTECTION Lignanes Lignanes Lignanes Hammamelis extract Hammamelis extract Metoxicinamate Octyl Metoxicinamate Octyl

33 APPLICATION PROTOCOL DERMAZELAN REMOVE SEBUM EXCESS WITH DEGREASING SOLUTION APPLY MASK DURING 3 TO 6 HOURS REMOVE MASK WITH SPONGES AND WATER APPLY MAINTENANCE CREAM MORNING AND NIGHT CLEANSE THE SKIN WITH FACIAL GEL CLEANSER DAILY DAILY APPLY ROLL-ON OCCASIONAL TRTMNT SEVERAL TIMES COMBINATION WITH SALYCILIC-PEEL 10% UNDER PROFS. CRITERIA COMBINATION WITH BLUE LIGHT PHOTOTHERAPIE OF PHOTOGEN S.

34 Thank you for your attention