Models of preventive care in clinical practice to achieve 25 by 25

Size: px

Start display at page:

Download "Models of preventive care in clinical practice to achieve 25 by 25"

Sharon Pope
5 years ago
Views:

1 Models of preventive care in clinical practice to achieve 25 by 25 Professor David A Wood Garfield Weston Professor of Cardiovascular Medicine International Centre for Circulatory Health Imperial College London United Kingdom

3 Guidelines Implementation Evaluation

Belgium Romania Hungary Spain Slovenia Greece Bulgaria Serbia

4 EUROASPIRE IV Ireland Netherlands Finland Russia Germany UK Latvia Sweden France Czech Republic Poland Lithuania Croatia Belgium Romania Hungary Spain Slovenia Greece Bulgaria Serbia Italy Cyprus Turkey Bosnia and Herzegovina Eur J Prevent Cardiol 2015 Ukraine

5 Prevalence of smoking, obesity* and central obesity** EUROASPIRE II EUROASPIRE III EUROASPIRE IV p=0.04 p=0.007 p=0.55 * BMI 30 kg/m²; **Waist circumference 88 cm for women and 102 cm for men

6 Prevalence of smoking by age and sex

Prevalence of raised BP*, elevated LDL-C** and diabetes*** P<0.

78 * SBP/DBP 140/90 mmhg ( 140/80 mmhg for patients with diabetes); LDL 1.

7 Prevalence of raised BP*, elevated LDL-C** and diabetes*** P< EUROASPIRE II EUROASPIRE III EUROASPIRE IV p=0.01 p= p=0.78 * SBP/DBP 140/90 mmhg ( 140/80 mmhg for patients with diabetes); LDL 1.8 mmol/l ( 70 mg/dl); ***Fasting glucose 7 mmol/l ( 126 mg/dl) for patients without history of diabetes

8 Cardiovascular protective drug therapies P< P< EUROASPIRE II EUROASPIRE III EUROASPIRE IV P< P<0.0001

9 Cardiopulmonary rehabilitation Cardiac rehabilitation is a branch of rehabilitation medicine dealing with optimizing physical function in patients with cardiac disease or recent cardiac surgeries Wickipedia March 25 th 2015

10 Randomised controlled trials of cardiac rehabilitation Cardiac rehab 95% CI Secondary prevention 95% CI Total mortality , , 0.94 CHD mortality , Myocardial re-infarction , , 0.94 Taylor R et al, Am J Med 2004; 116: Clark A M et al Annals of Internal Medicine 2005;143: Heran B S, et al Cochrane Database of Systematic Reviews 2011

Programme with no exercise Programme with exercise Randomised controlled trials of secondary prevention All cause mortality Treatment Control Relative Risk 95% CI 4598 4604 0.87 0.

11 Programme with no exercise Programme with exercise Randomised controlled trials of secondary prevention All cause mortality Treatment Control Relative Risk 95% CI , , 1.04 Exercise only , 0.95 Overall* , 0.94 *p=0.001 Clark A M et al Annals of Internal Medicine 2005;143:

12 Randomised controlled trials of secondary prevention Recurrent myocardial infarction Programme with no exercise Programme with exercise Treatment Control Relative Risk 95% CI , , 0.87 Exercise only , 1.01 Overall* , 0.94 *p=0.002 Clark A M et al Annals of Internal Medicine 2005;143:

13 Cardiac rehabilitation + Secondary prevention

14 Cardiac rehabilitation is a branch of rehabilitation medicine dealing with optimizing physical function in patients with cardiac disease. While the glue of cardiac rehabilitation is exercise, programmes are evolving to become comprehensive prevention centers where all aspects of care are delivered. Wickipedia March 25 th 2015

15 Comprehensive prevention centers where all aspects of care are delivered. Wickipedia March 25 th 2015

16 Lifestyle (smoking cessation, diet, physical activity) intervention, taking account of psychosocial factors, and using a behavioural approach Measuring, monitoring and managing other risk factors (blood pressure, lipids and glucose) to target Understanding of, and adherence with, cardioprotective drug therapies for life

17 SCORE: the European Risk Prediction System Total risk assessment 3rd Joint European Societies Task Force Data from: 12 European cohort studies wide geographic spread of countries at different levels of cardiovascular risks 3-million person-years of observation 7,934 fatal cardiovascular events 2004 European Society of Cardiology SCORE Score enabled HeartScore, an interactive tool

18 SCORE

SCORE: the European Risk Prediction System 1994 2003 1998 Total risk assessment 3rd Joint European Societies Task Force Data from: 12 European cohort studies wide geographic spread of countries at

19 SCORE: the European Risk Prediction System Total risk assessment 3rd Joint European Societies Task Force Data from: 12 European cohort studies wide geographic spread of countries at different levels of cardiovascular risks 3-million person-years of observation 7,934 fatal cardiovascular events 2004 European Society of Cardiology SCORE Total risk management Score enabled HeartScore, an interactive tool

20 Lifestyle (smoking cessation, diet, physical activity) intervention, taking account of psychosocial factors, and using a behavioural approach Measuring, monitoring and managing other risk factors (blood pressure, lipids and glucose) to target Understanding of, and adherence with, cardioprotective drug therapies for life

21 EUROACTION A European Society of Cardiology demonstration project: 8 countries and 24 hospital and general practice centres Lancet 2008; 371:

Pau Dr Antonio Salvador, Cristina Buigues, Ana Bonet,

22 General hospitals and general practices Dr Jorge Navarro and Gemma Medez Perez Centro de Salud de San Pau Dr Antonio Salvador, Cristina Buigues, Ana Bonet, Arancha Ruescas and Rosario Cuevas Hospital General de Dr. Peset

23 Ambulatory nurse-coordinated multidisciplinary approach The EUROACTION team in Boldrini Hospital, Thiene, Italy The EUROACTION nurse and the lead GP in Hoensbroek, The Netherlands

24 Healthy eating, Weight management Lifestyle change in families Smoking cessation Increasing Physical activity No smoking Saturated Fat: <10% total Energy Fruits and vegetables: >400g/day Fish: >20g/day Oily Fish: >3 times/week minutes of physical activity at 60 75% of the average maximum heart rate on four-five days of the week Weight reduction 5% Waist <94 cm in men and <80 cm in women

25 Family based lifestyle programme Sweden Poland

26 Health promotion workshops Gemona, Italy Valencia, Spain

27 Supervised hospital and home based physical activity programme Halmstad, Sweden Valencia, Spain Thiene, Italy

28 A CLUSTER RANDOMISED CONTROLLED TRIAL Randomisation INT UC Identification 2778 PATIENTS 1632 PARTNERS 2613 PATIENTS 1634 PARTNERS Initial assessment 2179 PATIENTS 910 PARTNERS 580 SUB-SAMPLE Intervention PROGRAMME 16 week hospital 1 year primary care One year assessment 1965 PATIENTS 626 PARTNERS 1999 PATIENTS 698 PARTNERS

29 EUROACTION: Hospital Smoking cessation at one year in coronary patients who were smokers in the month prior to their event + 10% ( - 0.3% to + 21%) p = 0.06

30 EUROACTION + Intensive Smoking Cessation with Varenicline UK Italy Netherlands Spain Eur Heart J 2014; 35:

Study Participants N=696 Eligible patients N=559 High-Risk patients N=137 Vascular patients EA+ ARM N=350 patients N=276 High-Risk patients N=74 Vascular patients USUAL CARE ARM N=346 patients N=283

31 Study Participants N=696 Eligible patients N=559 High-Risk patients N=137 Vascular patients EA+ ARM N=350 patients N=276 High-Risk patients N=74 Vascular patients USUAL CARE ARM N=346 patients N=283 High-Risk patients N=63 Vascular patients N=328 Baseline assessment N=313 Participated in EA+ N= % 16-weeks assessment N= % 16-weeks assessment N=346 Primary endpoint N=335 Primary endpoint

32 Smoking abstinence for last 7 days confirmed by CO in breath < 10 ppm PRIMARY ENDPOINT Odds Ratio (95% CI) = 4.52 (3.20 to 6.39)

33 EUROACTION A European Society of Cardiology demonstration project: 8 countries and 24 hospital and general practice centres Lancet 2008; 371:

34 Proportions of patients achieving the European targets for a healthy diet Hospital General Practice p = p = p = p = 0.91 p = 0.26 p = 0.04 p = 0.13 Intervention Usual Care

Practice p = 0.31 p = 0.002 p = 0.002 p = 0.98 p = 0.

35 Proportions of partners achieving the European targets for a healthy diet Hospital General Practice p = 0.31 p = p = p = 0.98 p = 0.42 p = 0.77 p = 0.09 Intervention Usual Care

36 Proportion of patients achieving European Guidelines for physical activity Hospital + 36% (+20% to + 51%) General Practice + 29% ( + 11% to + 48%) P = P = 0.001

37 Proportion of partners achieving European Guidelines for physical activity Hospital General Practice + 19% (- 0.6% to + 38%) + 27% (+ 4% to + 50%) P = 0.06 p = 0.03

38 Proportion of patients achieving the European target for blood pressure Hospital General Practice + 10% (+ 0.6% to + 20%) + 17% (+ 2% to + 32%) P = 0.04 p = 0.03 Intervention Usual Care

39 Proportion of patients achieving European target for blood pressure % Patients without diabetes + 17% (+ 0.5% to + 33%) Patients with diabetes + 19% (+ 1% to + 37%) p = 0.04* * random effects modelling p = 0.04*

Practice p=0.28 p=0.16 p=0.04 p=0.26 p=0.03 p=0.

40 Proportion of patients on cardiovascular protective drug therapy Hospital General Practice p=0.28 p=0.16 p=0.04 p=0.26 p=0.03 p= p=0.06 p=0.91 p=0.02 p=0.24 Intervention Usual Care

41 EUROACTION set a new standard for preventive cardiology in both secondary and primary prevention

42 Terminology Cardiac rehabilitation Cardiovascular rehabilitation Rehabilitation and secondary prevention Cardiac rehabilitation and prevention Cardiovascular prevention and rehabilitation

43 NICE Guideline: MI - secondary prevention Cardiac rehabilitation programme is defined as: Exercise Health education and information Psychology and social support

44 NICE Guideline: MI - secondary prevention Cardiac rehabilitation does NOT include: Lifestyle changes after MI: Smoking cessation Changing dietary regimen Alcohol consumption Weight management Drug therapy after MI

45 Terminology Cardiac rehabilitation Cardiovascular rehabilitation Rehabilitation and secondary prevention Cardiac rehabilitation and prevention Cardiovascular prevention and rehabilitation

46 Cardiac rehabilitation and secondary prevention for patients with established atherosclerotic disease + Primary prevention for asymptomatic individuals at high risk of developing CVD including patients with diabetes mellitus, CKD and other high risk diseases

47 Primary Prevention Secondary Prevention

48 Integrate secondary and primary prevention in one programme

EUROACTION A model for secondary and primary preventive care to achieve 25 by 25

EUROACTION A model for secondary and primary preventive care to achieve 25 by 25 Professor David A Wood Garfield Weston Professor of Cardiovascular Medicine International Centre for Circulatory Health