Radial Artery Hemostasis and Post procedure Management
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1 Radial Artery Hemostasis and Post procedure Management Samir B. Pancholy, MD, FACP, FACC, FSCAI Program Director, Cardiology Fellowship, Wright Center for Graduate Medical Center Associate Professor of Medicine, The Commonwealth Medical College, Scranton, PA
2 Radial hemostasis The easiest part of the procedure. The main reason for attractiveness of TRA
3 Radial artery hemostasis Radial artery lies on the flat portion of radius No major neurovascular structures Ulnar collateralization prevents ischemia Well tolerated
4 Distal forearm anatomy
5 Common Methods Sheath is removed and Hemoband / TR band is applied Patient can sit up immediately after the procedure Ambulation can occur as soon as patient steady.
6 Radial artery hemostasis Most significantly affects radial artery outcomes
7 Radial artery hemostasis Most significantly affecting radial artery outcomes Most CAD patients will need more than one procedure
8 Radial artery occlusion Asymptomatic (>95%) Symptomatic Inflammatory (radial arteritis) Ischemic (embolic) Limits future ipsilateral TRA
9 RAO HAPPENS 10.5% at 1 week follow up (Sanmartin et al) 7% at 4 weeks ( Pancholy et al) 6.8% at 4 6 months (Rathore et al) 7% at 4 8 weeks (Plante et al)
10 Radial Artery Occlusion Rates Early Late Pre Patent hemostasis % NR NR Sanmartin Rathore Plante Pancholy Anticoagulation UFH u/kg UFH 70 u/kg UFH 70 u/kg Or Bivalirudin UFH 50u/kg Coutesy of SV Rao, MD
11 Heparin and RAO Incidence of RAO (%) No Heparin I.U 5000 I.U 2000 I.U 5000 I.U Spaulding et al Bernat et al Incidence of RAO (%)
12 Radial artery Hemostasis PREVENTION OF RADIAL ARTERY OCCLUSION
13 Mechanism of RAO Flow cessation During procedure: Caused by hardware
14 Mechanism of RAO Flow cessation During procedure: Caused by hardware Caused by spasm
15 Mechanism of RAO Flow cessation During procedure: Caused by hardware Caused by spasm After procedure:
16 Mechanism of RAO Flow cessation During procedure: Caused by hardware Caused by spasm After procedure: Caused by compression
17 Mechanism of RAO Flow cessation During procedure: Caused by hardware Caused by spasm After procedure: Caused by compression Caused by residual spasm
18 Mechanism of RAO
19 Mechanism of RAO Thrombosis (acute) Rapid organization with fibrotic lumen obliteration
20 Mechanism of RAO
21 Mechanism of RAO
22 Mechanism of RAO
23 Mechanism of RAO
24 Mechanism of RAO
25 Mechanism of RAO Flow cessation During procedure: Caused by hardware Caused by spasm After procedure: Caused by compression Caused by residual spasm
26 Prevention of RAO During the procedure Use lowest profile hardware Systemic anticoagulation
27 Prevention of RAO Spaulding C et al. Cathet Cardiovasc Diagn Dec;39(4):
28 Prevention of RAO Bivalirudin as effective as Heparin
29 Does route of administration matter Pancholy S. Am J Cardiol Oct 15;104(8):1083 5
30 Radial artery hemostasis Absent radial flow Sanmartin et al CCI 2007; 70: 185 9
31 Radial artery hemostasis Interruption of radial flow highly predictive of subsequent radial artery occlusion. Sanmartin et al CCI 2007; 70: 185 9
32 Active radial hemostasis Attention to hemostasis Attention to radial artery patency Periodic monitoring of radial artery patency
33 Patent Hemostasis P < 0.05 % Pancholy S et al, CCI 2008;72:335 40
34 Patent Hemostasis
35 Patent Hemostasis
36 Patent Hemostasis
37 Patent Hemostasis
38 Patent Hemostasis
39 Patent Hemostasis
40 Patent Hemostasis
41 Patent Hemostasis
42 Ideal Hemostasis
43 Radio Ulnar circuit UA RA
44 Radio Ulnar circuit UA RA
45 Radio Ulnar circuit UA RA
46 Ulnar compression
47 Ulnar compression UA compressed UA released
48 Radial VTI with Ulnar compression * VTI (m.s 2 ) P < Baseline Ulnar compression N = 150
49 Larger the Ulnar higher the VTI increase Ulnar Diameter (mm) r=0.60, P < ) DVTI
50 Prevention of Radial artery Occlusion using Prophylactic Hyperperfusion Evaluation Trial (PROPHET II) 610 patients randomized to Group I: Patent Hemostasis Group II: Patent Hemostasis + Ulnar compression
51 PROPHET II Ulnar compression lowers RAO
52 PROPHET II STAY TUNED
53 Hemostasis Protocol Monitor radial patency every 15 min Adjust hemostatic pressure to maintain radial patency Remove pressure device in 2 hours. Apply light dressing (e.g Bandaid) Avoid compressive dressing.
54 Have we made a difference?
55 Radial Artery Occlusion Rates Early Late Pre Patent hemostasis Post Patent hemostasis % Anticoagulation 2 0 NR NR Sanmartin Rathore Plante Pancholy Cubero Bernat UFH u/kg UFH 70 u/kg UFH 70 u/kg Or Bivalirudin UFH 50u/kg UFH u/kg UFH 5000 u Patent hemostasis No No No Yes Yes Yes + Ulnar compression
56 Treatment of RAO Symptomatic treatment: Local cold pack, NSAIDS,? Systemic anticoagulants No need for endovascular/surgical therapy
57 Treatment of RAO Symptomatic treatment: Local cold pack, NSAIDS,? Systemic anticoagulants No need for endovascular/surgical therapy EMBOLIZATION
58 Summary Use lowest profile hardware Use systemic anticoagulation Use patent hemostasis technique New ideas?
59 Thank you
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