Clinical Outcomes of Pedal Artery Angioplasty for Patients with Ischemic Wounds Result from the Multicenter RENDEZVOUS Registry
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1 Clinical Outcomes of Pedal Artery Angioplasty for Patients with Ischemic Wounds Result from the Multicenter RENDEZVOUS Registry Tatsuya Nakama 1 Nozomi Watanabe¹ Takuya Haraguchi² Hiroshi Sakamoto³ Daisuke Kamoi⁴ Yoshinori Tsubakimoto⁵ Kenji Ogata¹ Katsuhiko Satoh² Kazushi Urasawa² Hiroshi Andoh³ Hiroshi Fujita⁵ and Yoshisato Shibata¹ on behalf of the RENDEZVOUS registry investigators ¹Miyazaki Medical Association Hospital, Cardiovascular Center, Miyazaki ²Cardiovascular Center, Tokeidai Memorial Hospital, Sapporo ³Department of Cardiology, Kasukabe Chuo General Hospital, Saitama ⁴Department of Cardiology, Nagoya Kyoritsu Hospital, Nagoya ⁵Department of Cardiology, Japanses Red Cross Kyoto Daini Hospital, Kyoto
2 Disclosure Speaker name: Tatsuya Nakama MD.... I have the following potential conflicts of interest to report: Consulting: Abbot Vascular, Boston Scientific Employment in industry: None Stockholder of a healthcare company: None Owner of a healthcare company: None Other(s): Honoraria recieved from Abbot Vascular, Boston Scientific, COOK, Medtronic
3 Experience of Pedal revascularization Nakama T, et al. EJEVS Extra, 2014; 27: e7-e9
4 Pioneer of pedal intervention Palena LM, Manzi M, et al. JEVT 2012; 19: Palena LM, Manzi M, et al. CCI 2014; 83:123-9
5 Key issue of aggressive strategy What are the clinical implications of pedal artery intervention?
6 Result of Pedal artery angioplasty Nakama et al. Oral presentation, JCS (2015) Nakama et al, J Endovasc Ther 23: (2016)
7 Hypothesis development Adjunctive pedal intervention Improve the rate of wound healing
8 Result from single center study PAA(+) 92.9% PAA(-) 59.7% p value= 0.05 Time to wound-healing PAA(+): 86.0 ± 18.7 days (IQR: ) PAA(-): ± 60.2 days (IQR: ) P=0.05 Months PAA(+) at risk % PAA(-) at risk % Nakama et al. Oral presentation, JCS (2015) Nakama et al, J Endovasc Ther 23: (2016)
9 Tsubakimoto Y. Japanese Red Cross Kyoto Daini HP, Kyoto Miyazaki Medical Association HP, Miyazaki Kamoi D. Nagoya Kyoritsu HP, Nagoya Urasawa K. Tokeidai Memorial HP, Sapporo Ando H. Kasukabe Chuou Genera HP, Kasukabe Nakama T, et al. J Am Coll Cardiol Intv 2017; 10: 79-90
10 Study synopsis Study type Retrospective, multi-center Number of patients 257 patients (257 limbs, R5 and 6) Comparison group study PAA group vs Non-PAA group Nakama T, et al. J Am Coll Cardiol Intv 2017; 10: 79-90
11 Outcomes Primary outcome Rate of wound (& time to wound healing) Specify the indication of PAA Delayed wound healing score (DH-Score) Nakama T, et al. J Am Coll Cardiol Intv 2017; 10: 79-90
12 Backgrounds of patients Overall PAA group Non-PAA group P value Age, years 73.2 ± ± ± Male, n (%) 175 (68.1) 96 (68.6) 79 (67.5) % Non-ambulatory status, n (%) Diabetes 132 (51.4) 64 (45.7) 68 (58.1) BMI<18, n (%) 40 (15.6) 18 (12.9) 22 (18.8) Hypertension, n (%) 186 (72.4) 96 (68.6) 90 (76.9) Dyslipidemia, n (%) 76 (29.6) 44 (31.4) 32 (27.4) Diabetes mellitus, n (%) % Daily 187 (72.8) hemodialysis 101 (72.1) 86 (73.5) Smoking history, n (%) 111 (43.2) 67 (47.9) 44 (37.6) Regular hemodialysis, n (%) 160 (62.3) 89 (63.6) 71 (60.7) History of IHD, n (%) 148 (57.6) 88 (62.9) 60 (51.3) Previous stroke, n (%) % Nonambulatory 69 (26.8) 34 (24.3) 35 (29.9) Albumin< 3g/dL, n (%) 51 (19.8) 24 (47.1) 27 (23.1) Nakama T, et al. J Am Coll Cardiol Intv 2017; 10: 79-90
13 Target limbs status Overall PAA group Non-PAA group P value 20 Wound Classification % Rutherford class 6 Rutherford 6, n (%) 57 (22.2) 34 (24.3) 23 (19.7) University of Texas grade 2, n (%) 119 (46.3) 71 (50.7) 48 (41.0) SVS WIfI 60 classification WIfI Clinical Stage 4 (high % risk), n (%) 163 (63.4) 96 (68.6) 67 (57.3) WiFI Clinical stage 4 WIfI composite score 5.5 ± ± ± WIfI composite score 5, n (%) 173 (67.3) 98 (70.0) 75 (64.1) Wound location Forefoot wounds, n (%) % Pressure 190 (73.9) 104 are (74.3) wounds 86 (73.5) Pressure area wounds, n (%) 40 (15.6) 21 (15.0) 19 (16.2) Nakama T, et al. J Am Coll Cardiol Intv 2017; 10: 79-90
14 Rate of wound healing P = % 211 days P= % 365 days Nakama T, et al. J Am Coll Cardiol Intv 2017; 10: 79-90
15 Factors of Wound healing Positive influence Nonambulatory HR: 2.02 ( ) Depth of wounds HR: 3.24 ( ) Daily hemodialysis HR: 2.89 ( ) HR: 0.43 ( ) Negative influence Pedal angioplasty Nakama T, et al. J Am Coll Cardiol Intv 2017; 10: 79-90
16 Risk-stratification: DH-score Delayed wound healing score (DH-score) was evaluated Non-ambulatory Depth of wound Daily hemodialysis DH-score 0 Low-risk population (n=28) DH-score 1-2 Moderate-risk population (n=196) DH-score 3 High-risk population (n=33) Nakama T, et al. J Am Coll Cardiol Intv 2017; 10: 79-90
17 WHR in low-risk population 93.3% P= % Nakama T, et al. J Am Coll Cardiol Intv 2017; 10: 79-90
18 WHR in moderate-risk population P= % 33.9% Nakama T, et al. J Am Coll Cardiol Intv 2017; 10: 79-90
19 WHR in high-risk population P= % 29.4% Nakama T, et al. J Am Coll Cardiol Intv 2017; 10: 79-90
20 Summary of RENDEZVOUS registry PAA showed its positive effect on wound-healing PAA is recommended in the moderate-risk population However, in the high-risk population, PAA could not show its efficacy. Nakama T, et al. J Am Coll Cardiol Intv 2017; 10: 79-90
21 Take home message
22 Let us remember the past
23 Let us continue the challenges
24 experiences will become evidences
25 Let us imagine the future
26 Trailblazing effort will open the Door of the future of CLI treatment
27 Clinical Outcomes of Pedal Artery Angioplasty for Patients with Ischemic Wounds Result from the Multicenter RENDEZVOUS Registry Tatsuya Nakama 1 Nozomi Watanabe¹ Takuya Haraguchi² Hiroshi Sakamoto³ Daisuke Kamoi⁴ Yoshinori Tsubakimoto⁵ Kenji Ogata¹ Katsuhiko Satoh² Kazushi Urasawa² Hiroshi Andoh³ Hiroshi Fujita⁵ and Yoshisato Shibata¹ on behalf of the RENDEZVOUS registry investigators ¹Miyazaki Medical Association Hospital, Cardiovascular Center, Miyazaki ²Cardiovascular Center, Tokeidai Memorial Hospital, Sapporo ³Department of Cardiology, Kasukabe Chuo General Hospital, Saitama ⁴Department of Cardiology, Nagoya Kyoritsu Hospital, Nagoya ⁵Department of Cardiology, Japanses Red Cross Kyoto Daini Hospital, Kyoto
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