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1 The Journal of Qazvin Univ. of Med. Sci. No. 35, Summer CRP **** **** *** ** * Comparing plasma level of CRP, factor VII, fibrinogen; platelet counts, systolic and diastolic blood pressure in smokers with opium addicted smokers G. Naderi S. Asgary M. Sadeghi Z. Sabetnezhad M. Tansaz Abstract Background: The observational and experimental studies show that there are more cases of cardiovascular disease especially myocardial infarction (MI) among addicts who are referred to hospitals compared with non-addicts. Objective: To determine some of cardiovascular risk factors in addict subjects. Methods: A total of 70 subjects aged (35 smokers with opium addiction who were addict at least for last three years as case group and 35 smokers as control group) were selected. The plasma levels of factor VII, CRP, fibrinogen and blood platelet counts were determined for both groups. Also, the systolic and diastolic blood pressure was measured. Findings: The mean activity percent of plasma level for factor VII was significantly higher in opium addict men than control. The mean plasma level of fibrinogen in case group was lower than control but not significant. Also, no significant difference was observed between blood platelet counts among two groups. Mean plasma level of CRP was also significantly lower in addict group than the control group. Systolic and diastolic blood pressure was significantly lower in case group compared with control group (P<0.05). Conclusion: The data found in our study showed that the blood factors such as plasma levels of factor VII and fibrinogen, as two cardiovascular risk factors, and also blood pressure were affected by opium addiction. It seems that one of the causes of higher numbers of MI among addict subjects to be likely associated with significantly greater values for factor VII activity seen in this population. Keywords: Narcotic Dependence, Heart Block, Fibrinogen, Blood Pressure - :. CRP :. ). - : (. CRP. t. :.. CRP..(p</) :. : ** * **** *** - : GH_Naderi@crc.mui.ac.ir Page (3)
2 /... CRP (MDA) (6). 20 (7). (8). HbA1C. CRP. : : (1).. (Opium) Papaverum Somniferum Popy. 20 : () 3 (2) ) HDL ( (3). SGPT SGOT (4) VLDL LDL (5). HDL
3 (F Vll deficient) PT SPSS9. t. : CRP..(1 ) CRP CRP. CRP.. CellCounter -1 () ( 35) 3/54 ± 0/ ± 39/4 280/2 ± 131/5 119/7 ± 68/5 122/5 ± 17/7 81/4 ± 10/4 ( 35) 3/11 ± 0/ ± 50/8 263/4 ± /9 ± /4 ± 12/4 73/4 ± 7/9 *( ) CRP * * *. 0/05 *
4 /... CRP (8). (9).. (10) () (35) ( 35) VII ) ( < > 300 < 70 * VII > 130 (%). p<0/05 * : CRP. (CRP).... CRP
5 of the narcotic alkaloids, cocaine and codeine on nonenzymatic lipid peroxidation in rat brain mitochondria. Biochem Med Metab Biol 1987 Apr; 37(2): Di Bello MG, Masini E, Ioannides C, Fomusi Ndisang J, Links S, Bani Sacchi T, Mannaioni PF. Histamine release from rat mast cells induced by the metabolic activation of drugs of abuse into free radicals. Inflamm Res 1998 Mar; 47(3): Goldstein DE, Little RR. Glycated hemoglobin methodologies and clinical applications. Clin Chem 1986; 32110(13): Marck mann P, Bladbjerg E M, Jespersen J. Diet and blood coagulation factor VII-a key protein in arterial thrombosis Eur J Clin Nutr 1995; 52: Brodin E, Borvik T, Sandest PM, Bonaa KH Nordoy A, etal. Coagulation activation in young Survivors of myocardial infarction (MI)-apopulation-based Case-Control study. Thrimb Haemost 2004 Jul 92(1): Inan S, Tallarida RJ. Morphine potentiotes dextromethorphan - induced vasodilation in rat superior mesenteric artery. Eur J Pharmacol 2004 Feb; 486(1): : Kaplan Harold I, Sadock Benjamin J. Opioid related disorders. In: Kaplan and Sadocks, (eds). Synopsis of psychiatry. 1994; Maccari S, Bassi C, Zanoni P, Plancher Ac. Plasma cholesterol and triglycerides in heroin addicts. Drug Alcohol Depend 1991 Dec 31; 29 (2): Brayant HU, Story JA, Yim GK. Morphine-induced alteration in plasma and tissue cholesterol levels. Life Sci 1987 Aug 3; 41 (5); Das NP, Ratty AK. Studies on the effects
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