Surgical Approach To An Unsuccessful Device Closure of Atrial Septal Defect. U Yetkin, B Özpak,? Yürekli, K Ergüne?, N Eren, O Ergene, A Gürbüz

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1 ISPUB.COM The Internet Journal of Thoracic and Cardiovascular Surgery Volume 11 Number 2 Surgical Approach To An Unsuccessful Device Closure of Atrial Septal Defect U Yetkin, B Özpak,? Yürekli, K Ergüne?, N Eren, O Ergene, A Gürbüz Citation U Yetkin, B Özpak,? Yürekli, K Ergüne?, N Eren, O Ergene, A Gürbüz. Surgical Approach To An Unsuccessful Device Closure of Atrial Septal Defect. The Internet Journal of Thoracic and Cardiovascular Surgery Volume 11 Number 2. Abstract Atrial septal defect (ASD) is the second most frequent congenital heart defect seen among grownups after bicuspid aortic valve. This defect must be closed due to morbid and mortal complications seen particularly in 4th or 5th decades; such as heart failure, systemic or pulmonary emboli. There have been many reports of excellent early follow up results after device closure of ASD.This method is an effective and fairly safe alternative to surgery with minimal periprocedural complications. In this study, we aimed to present a case with ASD under the light of the literature who had undergone primary surgical repair due to thrombus formation on the tip of occluding device during an unsuccessful attempt of device closure. INTRODUCTION Secundum atrial septal defect (ASD) is a common congenital heart disease and accounts for approximately 6% to 10% of all congenital cardiac defects( 1, 2 ). Since 1976, when King and associates attempted the first transcatheter closure of a secundum ASD in humans, device closure has evolved significantly( 1 ). Surgical closure of ASD has a low perioperative mortality and morbidity, it is still associated with a cosmetic disadvantage and a longer hospital stay compared with device closure( 1, 3 ). The alleged advantages of percutaneous closure over surgical closure as shown by some studies in older children and adults include avoidance of cardiopulmonary bypass, decreased complication rates, shorter hospital stays and greater cost-effectiveness( 1, 3, 4 ). The Amplatzer Septal Occluder (ASO) is the first and only device to receive full approval for clinical use in patients with secundum atrial septal defect (ASD) from the United States Food and Drug Administration( 5 ). Interventional ASD closure is now widely practised and has replaced surgical ASD closure in many centres( 6, 7 ). Improvements in design have made the devices retrievable, and reduction in the size of the introduction systems allows interventional treatment even in young patients( 7 ). dyspnea,tachycardia and increasing fatigue. The transthoracic echocardiography (TTE) which was performed in admittance to our institution, showed a dropout image in interatrial septum compatible with ASD and dilatation of right-sided structures of the heart (diameter of right atrium: 52 millimeters, diameter of right ventricle: 44 millimeters). Transesophageal echocardiography (TEE) revealed a secundum ASD of 2.3 centimeters in diameter at the region corresponding to foramen ovale. She was then hospitalized by Department of Cardiology for percutaneous closure of ASD. Before the attempt for closure, the defect's diameter was measured as 2.5 centimeters by the sizing balloon (Figure 1). CASE PRESENTATION Our case was a 37-years-old woman. She was admitted to our Cardiology Outpatient Clinic with complaints of 1 of 5

2 Figure 1 Figure 1: Sizing procedure using the sizing balloon Figure 2 Figure 2: View of thrombus formed on the tip of ASO device Afterwards, the procedure was continued with a 26-mm ASO. But, the device was then removed since it did not catch the rim and it was considered that the defect could be larger than 25 millimeters. Therefore, a 32-mm ASO device was inserted into left atrium under the guidance of TEE. Due to the tendency to coagulation, routine dose of 5000 IU of unfractioned heparin was completed to IU. Nevertheless, during TEE examination a suspicious image compatible with thrombus material was seen. Therefore, the device was then removed carefully and a thombus material was observed on the tip of the device (Figure 2). She was then transferred to our clinic for surgical repair after this unsuccessful attempt.she was operated under endotracheal general anesthesia and in supine position.following a median sternotomy,pericardium was opened longitudinally. After heparinization, extra-corporeal circulation is established between the venae cavae and the ascending aorta. A cross clamp was placed on aorta and by antegrade intermittant isothermic blood cardioplegia from aortic root,cardiac arrest was established.hypothermia was moderate (30ºc).A vent was placed via the right superior pulmonary vein. Standart right atriotomy was made. ASD was evaluated regarding its localization, size, other related cardiac structures and possible associated abnormalities (Figure 3). Figure 3 Figure 3: Perioperative view of ASD. 2 of 5

3 It was determined that primary closure of the defect would not have caused any tension on the septum and the defect was closed primarily by 4/0 polyproylene suture material. Right atriotomy was closed in a standard fashion. Postoperative rhythm was sinusal. She didn't required inotropic support during weaning from cardiopulmonary bypass and early postoperative period. The volume of blood transfused was one unit. The quantity of mediastinal drainage was 300 cc.she was extubated after an intubation duration of 7 hours and stayed in the intensive care for 2 days. The hospital stay was 7 days.postoperatively an echocardiographic investigation was revealed no residual shunt for the repaired ASD. She was followed at our outpatient clinic without additional problem. DISCUSSION ASD transcatheter occlusion techniques have become alternative to surgical procedures. A number of different devices are available for transcatheter ASD closure( 8 ).In study of Lisignoli et al.,for 98 consecutive patients (mean age /- 13 years, 61 women),indications of percutaneous closure of a patent foramen ovale (PFO) included recurrent transient ischaemic attack (47%), cryptogenic stroke (34%), peripheral embolism (11%), disabling migraine with aura (4%), professional scuba diving (1 pt) and severe platypnea-orthodeoxia syndrome (1 patient).in same study; major complications included heparin-induced thrombocytopenia in 1 patient and device dislodgement in 1 patient; minor complications were mostly related to the catheter introduction site (2 patients) and mild immediate shunt (2 patients)(9). The type and incidence of complications depend partially upon different devices( 8 ).In study of Gao et al., transcatheter closure of ASD with Amplatzer septal occluder (ASO) was performed in 119 patients. The immediate, one month and one year complete occlusion rates were 93.8% (105/112), 97.3% (109/112) and 98.2% (110/112), respectively. Residual shunt remained in 2 cases( 8 ). Risk of complications do not seem to occur more frequently than after closure of smaller defects if one adheres to certain sizing and implantation measures. The incidence of transient atrial tachyarrhythmias seems to be low( 10 ). If the diameter of ASD is over 36 mm, the device choice should depend on the maximum diameter of ASD determined with echocardiography. It is very important to avoid air embolism and atrial perforation during the procedure( 8 ). The self centring Amplatzer septal occluder offers a different approach by stenting the interatrial communication( 7, 11 ). This unique technique makes it possible to close even large defects (up to 38 mm), while the inability to close such large defects remains a limitation of the patch type devices( 6, 7, 12 ). The device can obstruct the orifice of the right pulmonary veins in rare cases with a more superior and posterior defect location( 7 ). TTE and TEE have proved to be very important tools for the exact anatomical delineation of the defect within the atrial septum. As it is difficult to examine defects in older patients using TTE, inspection of the exact nature of the septal rim near to other cardiac structures like the atrioventricular valves, the right pulmonary veins, or the inferior caval vein must be carried out with TEE before catheterisation. TEE is also very important to ensure the correct positioning of the device before and after its release( 7 ). Device embolization risk was reported to be about 1.1%( 1, 13 ). Diab et al. believe that more experience in using the ASO device in young infants will make this technical complication less frequent( 1 ). In conclusion; although atrial septal defects are mostly asymptomatic, they should be occluded with appropriate techniques due to such potentially morbid and mortal late complications as arrhythmias, heart failure and paradoxic embolism if remained open. CORRESPONDENCE TO Doç. Dr. Ufuk YETKİN 1379 Sok. No: 9,Burç Apt. D: , Alsancak İZMİR / TURKEY Tel: Fax: ufuk_yetkin@yahoo.fr References 1. Diab KA, Cao QL, Bacha EA, Hijazi ZM. Device closure of atrial septal defects with the Amplatzer septal occluder: safety and outcome in infants. J Thorac Cardiovasc Surg. 2007;134(4): Dickinson DF,Arnold R,Wilkinson JL. Congenital heart disease among 160,480 live-born children in Liverpool 1960 to 1969 Implications for surgical treatment.br Heart J 1981;46 : Du ZD,Hijazi ZM,Kleinman CS,Silverman NH,Larntz K. Amplatzer Investigators, Comparison between transcatheter and surgical closure of secundum atrial septal defect in children and adults: results of a multicenter nonrandomized trial. J Am Coll Cardiol 2002;39: Kim JJ, Hijazi ZM. Clinical outcomes and costs of Amplatzer transcatheter closure as compared with surgical closure of ostium secundum atrial septal defects. Med Sci Monit 2002;8: Lin MC, Fu YC, Jan SL, Lin WW, Chu KH, Ting CT, Chen YT, Chi CS. Transcatheter closure of secundum atrial 3 of 5

4 septal defect using the Amplatzer Septal Occluder: initial results of a single medical center in Taiwan. Acta Paediatr Taiwan 2005;46(1): Berger F, Ewert P, Bjornstad PG, et al. Transcatheter closure as standard treatment for most interatrial defects: experience in 200 patients treated with the Amplatzer septal occluder. Cardiol Young 1999;9: Fischer G, Stieh J, Uebing A, Hoffmann U, Morf G, Kramer HH. Experience with transcatheter closure of secundum atrial septal defects using the Amplatzer septal occluder: a single centre study in 236 consecutive patients.heart 2003;89(2): Gao W, Zhou AQ, Yu ZQ, Li F, Zhang YQ, Sun K, Zhong YM. Transcatheter closure of secundum atrial septal defect in children. Zhonghua Er Ke Za Zhi 2004;42(4): Lisignoli V, Lanzone AM, Zavalloni D, Pagnotta P, Presbitero P. Closure of patent foramen ovale: when and how? Curr Vasc Pharmacol 2007;5(4): Berger F, Ewert P, Dähnert I, Stiller B, Nürnberg JH, Vogel M, von der Beek J, Kretschmar O, Lange PE. Interventional occlusion of atrial septum defects larter than 20 mm in diameter. Z Kardiol 2000;89(12): Sharafuddin MJA, Gu X, Titus J, et al. Transvenous closure of secundum atrial septal defects: preliminary results with a new self-expanding nitinol prosthesis in a swine model. Circulation 1997;95: Carminati M, Giusti S, Hausdorf G, et al. A European multicentric experience using the CardioSEAL and STARFlex double umbrella devices to close interatrial communications holes within the oval fossa. Cardiol Young 2000;10: Masura J,Gavora P,Formanek A, Hijazi JM. Transcatheter closure of secundum atrial septal defects using the new self-centering Amplatzer septal occluder: initial human experience, Cathet Cardiovasc Diagn 1997;42: of 5

5 Author Information Ufuk Yetkin, M.D. Deputy Chief, Department of Cardiovascular Surgery, İzmir Atatürk Training and Research Hospital Berkan Özpak, M.D. Assistant, Department of Cardiovascular Surgery, İzmir Atatürk Training and Research Hospital?smail Yürekli, M.D. Specialist, Department of Cardiovascular Surgery, İzmir Atatürk Training and Research Hospital Kaz?m Ergüne?, M.D. Specialist, Department of Cardiovascular Surgery, İzmir Atatürk Training and Research Hospital Nihan Kahya Eren, M.D. Specialist, Department of II.Cardiology, İzmir Atatürk Training and Research Hospital OKtay Ergene, M.D. Clinic Chief, Department of II.Cardiology, İzmir Atatürk Training and Research Hospital Ali Gürbüz, M.D. Clinic Chief, Department of Cardiovascular Surgery, İzmir Atatürk Training and Research Hospital 5 of 5