Supplemental Table 1. Standardized Serum Creatinine Measurements. Supplemental Table 3. Sensitivity Analyses with Additional Mortality Outcomes.
|
|
- Annis Owens
- 6 years ago
- Views:
Transcription
1 SUPPLEMENTAL MATERIAL Supplemental Table 1. Standardized Serum Creatinine Measurements Supplemental Table 2. List of ICD 9 and ICD 10 Billing Codes Supplemental Table 3. Sensitivity Analyses with Additional Mortality Outcomes. Supplemental Table 4. Sensitivity Analyses by Revascularization Status. Supplemental Figure 1. Creation of the Stage 3 through 5 Sunnybrook Chronic Kidney Disease Cohort. Supplemental Figure 2. Rates of Hospitalization for Interim Cardiovascular Events. Supplemental Figure 3. Time of ESRD or ACM prior to ESRD After Interim Cardiovascular Event Supplemental Figure 4. Rates of Competing Outcomes by Revascularization Status. Supplemental Figure 5. Rates of Competing Outcomes after Interim Heart Failure, Myocardial Infarction and Stroke Events. Supplemental Figure 6. Adjusted Risk of Competing Outcomes After Revascularized Interim CV Events Supplemental Figure 7. Adjusted Risk of Competing Outcomes After Interim Heart Failure, Myocardial Infarction and Stroke Events. S1#
2 Supplemental Figure 8. Adjusted Risk of Competing Outcomes After Revascularized Interim Heart Failure and Myocardial Infarction Events Supplemental Figure 9. Rates of Hospitalization for Interim Cardiovascular Events Either Before or After Progression toesrd. Supplemental Figure 10. Rates of All-Cause Mortality, Either Prior to or After ESRD, Subsequent to Hospitalization Heart Failure, Myocardial Infarction and Stroke. Supplemental Figure 11. Adjusted Risk of All-Cause Mortality, Either Prior to or after ESRD, Subsequent to Interim Cardiovascular Events. S2#
3 Laboratory N* Years Assay type Reference(s) Analyzer(s) IDMS traceable SRM Sunnybrook Modified (kinetic) Jaffe 1-3 Hitachi 911, Hitachi 917,Roche Modular P Yes SRM 914, SRM 967 Gamma Enzymatic -- Kodak Vitros 950 Yes SRM 914 Dynacare TM Gamma Dynacare TM 2008 Modified (kinetic) Jaffe 3-5 Roche Modular Analyzer Yes SRM 914 Canadian Medical Laboratiories TM 514 Prior to 2008 Modified (kinetic) Jaffe 6 Beckman LX20 Yes SRM 914 LifeLabs TM 430 Prior to 2008 Other/unknown** 412 Prior to 2008 Enzymatic -- Ortho No Supplemental Table 1. Standardized Serum Creatinine Measurements. The table provides a summary of the laboratories that provided baseline creatinine values to the Sunnybrook CKD cohort and the assay methodology employed. *N = the number of subjects whose baseline creatinine value was measured by a given laboratory for the time intervals listed. **Other/unknown = 123 creatinine determinations in which a laboratory provider was not listed in the clinical record and 289 values from twelve other community laboratories. IDMS = isotope dilution mass spectrometry, SRM = standard reference material number. S3#
4 Outcome Source Type ICD version Code(s) Validity Ref Heart Failure Myocardial Infarction Stroke, non subarachnoid hemorrhage or infarction FSC Diag DAD Diag Sens: 77%, PPV: 88% DAD Diag 10 I50 Sens: 86%, PPV: 86% FSC Diag DAD Diag 9 410,411 Sens: 89%, PPV: 89% DAD Diag 10 I21 - I23 Sens: 89%, PPV: 87% FSC Diag , , 432.9, 434- DAD Diag , 436 Sens: 92%, PPV: 71% Sens: 75-81%, PPV: 69-87% DAD Diag 10 I61 - I64 E650, E655, E679, E682, G262, G263, Revasc. FSC Proc -- G298, G509, R700, Z434, Z442, Z743, Z744, Z759, Z780, Z781, Z788 All Cause Mortality End-stage Renal Disease ,11 11, RPDB Vital Status Field Sens: 94%, PPV: 100% FSC Proc -- G863, G866, G865, G864, G862, G861, G860, G099, R852, R853, R840, R851, R827, S Supplemental Table 2. List of ICD 9 and ICD 10 Billing Codes. Revasc coronary revascularization codes (angiography, percutaneous coronary interventions or coronary artery bypass grafting); FSC Fee for Service Code; DAD Discharge Abstract Database; Diag Diagnostic code; Proc Procedural Code; RPDB Registered Persons Database; Sens Sensitivity; PPV Positive Predictive Value; Ref reference number. S4#
5 Any CV Event ESRD All Cause Mortality CV-Related Death Non-CV-Related Death ## ## ## ## Main Analysis 5.33 (3.74, 7.58) 4.15 (3.30, 5.23) (8.30, 18.45) 2.13 (1.57, 2.87) Main#Analysis#with#Baseline#Covariates# within#90#days#of#index#date*# 5.32 (3.69, 7.65) 4.27 (3.38, 5.39) (8.46, 19.02) 2.20 (1.63, 2.98) Main#Analysis#with#Age#as#the#Time#Scale**# 4.69 (3.30, 6.67) 4.26 (3.41, 5.32) (7.60, 16.32) 2.30 (1.73, 3.07) Main Analysis in Complete Cases 5.74 (3.82, 8.62) 4.48 (3.22, 6.23) (9.37, 32.06) 2.03(1.32, 3.13) Adjusted#for#Baseline#Traditional#Risk# Factors # Adjusted for Baseline Extended Comorbidity List Main Analysis Within Alternative Interim CV Event and CV-Related Death Definition 5.22 (3.65, 7.46) 4.14 (3.29, 5.21) (8.30, 18.46) 2.12 (1.57, 2.87) 5.31 (3.70, 7.61) 4.18 (3.32, 5.27) (8.17, 18.27) 2.15 (1.59, 2.91) 3.88 (2.51, 5.99) 3.56 (2.76, 4.58) (8.81, 27.68) 2.41 (1.80, 3.22) Supplemental Table 3. Sensitivity Analyses with Additional Mortality Outcomes. The hazard ratios and 95% confidence intervals of competing outcomes when an interim cardiovascular event is analyzed in a time-dependent Cox proportional hazards model are presented. The main analysis is adjusted for baseline age, gender, glomerular filtration rate, albuminuria, calcium, phosphate, albumin, bicarbonate, hemoglobin, heart failure, occlusive cardiovascular disease, hypertension, and diabetes history. Sensitivity analysis included: *restricting to patient with baseline covariates available within 90 days of the index date (n=2942) **age as the time-scale rather than time-on-study, complete cases (n=1620), #after adjustment for heavily imputed traditional risk factors such as body-mass index, systolic blood pressure, high-density lipoprotein, and total cholesterol, after adjustment for an extended list of baseline comorbid conditions including history of cancer (n=1162), chronic obstructive pulmonary disease (n=453), dementia (n=164), and S5#
6 after restricting interim CV events to hospitalizations in which the primary diagnosis was heart failure, myocardial infarction or stroke (n=271) and restricting CV-related death to mortality in hospital or within 30 days of a hospitalization in which the primary diagnosis was a CV event (n=75). CV - cardiovascular; ESRD - end-stage renal disease. S6#
7 Any CV Event ESRD ACM Prior to ESRD Revascularized Not Revascularized Revascularized Not Revascularized ## ## ## ## Main Analysis 9.04 (4.10, 19.93) 5.04 (3.49, 7.29) 3.78 (2.22, 6.43) 4.19 (3.30, 5.32) Main#Analysis#with#Baseline#Covariates# within#90#days#of#index#date*# (4.32, 25.24) 5.00 (3.42, 7.30) 3.41 (1.80, 6.44) 4.35 (3.42, 5.53) Main#Analysis#with#Age#as#the#Time#Scale**# 7.60 (3.43, 16.82) 4.46 (3.08, 6.45) 4.02 (2.34, 6.89) 4.28 (3.40, 5.40) Main Analysis in Complete Cases 9.76 (3.02, 31.50) 5.49 (3.62, 8.33) 3.38 (1.56, 7.32) 4.62 (3.29, 6.47) Adjusted#for#Baseline#Traditional#Risk# Factors # Adjusted for Baseline Extended Comorbidity List Main Analysis Within Alternative Interim CV Event Definition 9.67 (4.36, 21.43) 4.91 (3.38, 7.13) 3.77 (2.23, 6.37) 4.18 (3.29, 5.31) 8.97 (4.02, 20.02) 5.03 (3.45, 7.32) 3.79 (2.18, 6.59) 4.22 (3.32, 5.36) 6.09 (2.38, 15.56) 3.68 (2.32, 5.83) 3.04 (1.69, 5.48) 3.61 (2.77, 4.72) Supplemental Table 4. Sensitivity Analyses by Revascularization Status. The hazard ratios and 95% confidence intervals of competing outcomes when an interim cardiovascular event is analyzed in a time-dependent Cox proportional hazards model are presented. The main analysis is adjusted for baseline age, gender, glomerular filtration rate, albuminuria, calcium, phosphate, albumin, bicarbonate, hemoglobin, heart failure, occlusive cardiovascular disease, hypertension, and diabetes history. Sensitivity analysis included: *restricting to patient with baseline covariates available within 90 days of the index date (n=2942) **age as the time-scale rather than time-on-study, complete cases (n=1620), #after adjustment for heavily imputed traditional risk factors such as body-mass index, systolic blood pressure, high-density lipoprotein, and total cholesterol, after adjustment for an extended list of baseline co- S7#
8 morbid conditions including history of cancer (n=1162), chronic obstructive pulmonary disease (n=453), dementia (n=164), and after restricting interim CV events to hospitalizations in which the primary diagnosis was heart failure, myocardial infarction or stroke (n=271). ACM- all-cause mortality, CV - cardiovascular; ESRD - end-stage renal disease. S8#
9 Supplemental Figure 1. Creation of the Stage 3 through 5 Sunnybrook Chronic Kidney Disease Cohort. See text for details. S9#
10 (A) # # S10#
11 (B)" " S11#
12 # Supplemental Figure 2. Rates of Hospitalization for Interim Cardiovascular Events. (A) The time-to-hospitalization for cardiovascular events are depicted as incidence functions using the method of Kaplan and Meier, which may overestimate incidence in the presence of competing risks such as death and end-stage renal disease. However, this analysis is congruent with crude rates (presented below) and cause-specific hazard modelling. The number at risk is shown below the plot. (B) The unadjusted crude rates of hospitalization for interim cardiovascular events with 95% confidence intervals are depicted. Note that the numbers of specific events do not sum to 447 because of the possibility of more than one CV event type during a follow-up or hospitalization. Any cardiovascular event: black, heart failure: red, myocardial infarction: blue, stroke: green. Rates are presented per 100 person-time-years with 95% confidence intervals. CV: Cardiovascular, ESRD: End-Stage Renal Disease; N: number of patients. S12#
13 Supplemental Figure 3. Time of ESRD or ACM prior to ESRD After an Interim Cardiovascular Event. The proportion of patients who developed ESRD or suffered ACM prior to ESRD grouped by the time period in which the competing event occurred after the interim CV event is depicted. There were 447 interim CV events. Seventy-six of these patients developed ESRD of which 40 S13#
14 (53%) occurred 90 days after the interim CV event. Similarly, 167 patients with an interim CV event suffered ACM prior to ESRD, of which 134 (80%) occurred 90 days after the interim CV event. CV- cardiovascular; ACM all cause mortality; ESRD End-Stage Renal Disease S14#
15 S15#
16 Supplemental Figure 4. Rates of Competing Outcomes by Revascularization Status. The unadjusted rates of ESRD and all-cause mortality prior to ESRD after revascularized CV events, non-revascularized CV events and without CV events is depicted. Rates are presented per 100 person-time-years with 95% confidence intervals. ACM- all-cause mortality; ESRD - end-stage renal disease S16#
17 S17#
18 Supplemental Figure 5. Rates of Competing Outcomes After Hospitalization Heart Failure, Myocardial Infarction and Stroke. The unadjusted rates of ESRD, all-cause mortality, CV-related death prior to ESRD and non-cv-related death prior to ESRD with and without a heart failure, myocardial infarction or stroke event. Rates are presented per 100 person-time-years with 95% confidence intervals. CV cardiovascular; ESRD - end-stage renal disease S18#
19 S19#
20 Supplemental Figure 6. Adjusted Risk of Competing Outcomes After Revascularized Interim CV Events. Forrest plots depict hazard ratios and 95% confidence intervals for the competing outcomes when a CV event analyzed as a time-dependent covariate in a Cox proportional hazards model. Interim events were partitioned based on revascularization occurring during the interim hospitalization or within 14 days of discharge. The referent group are patients not experiencing an interim event during the study period. The models are adjusted for baseline age, gender, glomerular filtration rate, albuminuria, calcium, phosphate, albumin, bicarbonate, hemoglobin, heart failure, occlusive cardiovascular disease, hypertension, and diabetes history. HF: heart failure, MI: myocardial infarction, ESRD: End-Stage Renal Disease, HR: hazard ratio S20#
21 Supplemental Figure 7. Adjusted Risk of Competing Outcomes After Interim Heart Failure, Myocardial Infarction and Stroke Events. Forrest plots depict hazard ratios and 95% confidence intervals for the competing outcomes when an interim heart S21#
22 failure, myocardial infarction, and stroke event is analyzed as a time-dependent covariate in a Cox proportional hazards model. The referent group are patients not experiencing an interim event during the study period. The models are adjusted for baseline age, gender, glomerular filtration rate, albuminuria, calcium, phosphate, albumin, bicarbonate, hemoglobin, heart failure, occlusive cardiovascular disease, hypertension, and diabetes history. HF: heart failure, MI: myocardial infarction, ESRD: End-Stage Renal Disease, HR: hazard ratio. S22#
23 S23#
24 Supplemental Figure 8. Adjusted Risk of Competing Outcomes After Revascularized Interim Heart Failure and Myocardial Infarction Events. Forrest plots depict hazard ratios and 95% confidence intervals for the competing outcomes when an interim heart failure and myocardial infarction event analyzed as a time-dependent covariate in a Cox proportional hazards model. Interim events were partitioned based on revascularization occurring during the interim hospitalization or within 14 days of discharge. The referent group are patients not experiencing an interim event during the study period. Stroke events were not analyzed due to small number of events. The p-value for difference between ESRD vs ACM prior to ESRD for revascularized and non-revascularized heart failure events was P=0.73 and P=0.33, respectively. The p-value for difference between ESRD vs ACM prior to ESRD for revascularized and non-revascularized myocardial infarction events was P=0.06 and P=0.99, respectively. The models are adjusted for baseline age, gender, glomerular filtration rate, albuminuria, calcium, phosphate, albumin, bicarbonate, hemoglobin, heart failure, occlusive cardiovascular disease, hypertension, and diabetes history. HF: heart failure, MI: myocardial infarction, ESRD: End-Stage Renal Disease, HR: hazard ratio. S24#
25 (A) S25#
26 (B) S26#
27 Supplemental Figure 9. Rates of Hospitalization for Interim Cardiovascular Events Before or After ESRD. (A) The time-tohospitalization for cardiovascular events are depicted as incidence functions using the method of Kaplan and Meier, which may overestimate incidence in the presence of the competing risk of death. However, this analysis is congruent with crude rates (presented below) and cause-specific hazard modelling. The number at risk is shown below the plot. (B) The unadjusted rates of hospitalization for cardiovascular events with 95% confidence intervals are depicted. Note that the numbers of specific events do not sum to because of the possibility of more than one CV event type during a follow-up or hospitalization. Any cardiovascular event: black, heart failure: red, myocardial infarction: blue, stroke: green. Rates are presented per 100 person-time-years with 95% confidence intervals. CV cardiovascular; ESRD - end-stage renal disease; N - number of patients; CHF congestive heart failure; HF heart failure; MI myocardial infarction. S27#
28 S28#
29 Supplemental Figure 10. Rates of All-Cause Mortality After Hospitalization Heart Failure, Myocardial Infarction and Stroke. The unadjusted rates all-cause mortality either before or after ESRD and 95% confidence intervals are depicted in patients with and without an interim CV, heart failure, myocardial infarction or stroke event. Rates are presented per 100 person-time-years with 95% confidence intervals. CV cardiovascular; ESRD - end-stage renal disease; HF - heart failure; MI - myocardial infarction. S29#
30 Supplemental Figure 11. Adjusted Risk of All-Cause Mortality After Interim Cardiovascular Events. Forrest plots depict hazard ratios and 95% confidence intervals for all-cause mortality before or after end-stage renal disease (ESRD) when an interim cardiovascular (CV), heart failure, myocardial infarction or stroke event is analyzed as a time-dependent covariate in a Cox proportional hazards model. The referent group are patients not experiencing an interim event during the study period. The models are adjusted for baseline age, gender, glomerular filtration rate, albuminuria, calcium, phosphate, albumin, bicarbonate, hemoglobin, heart S30#
31 failure, occlusive cardiovascular disease, hypertension, diabetes history and ESRD (modeled as a time-dependent covariate). CV cardiovascular; ESRD - end-stage renal disease; HR - hazard ratio; ACM - all-cause mortality. S31#
32 SUPPLEMENTAL REFERENCES 1.$ Jaffé$M.$Über$den$Niederschlag,$welchen$Pikrinsäure$in$normalem$Harn$erzeugt$und$über$eine$ neue$reaktion$des$kreatinins.$z"eitschrift"fur"physiologische"chemie."1886;10:391m400.$ 2.$ Fabiny$DL,$Ertingshausen$G.$Automated$reactionMrate$method$for$determination$of$serum$ creatinine$with$the$centrifichem.$clin"chem."aug$1971;17(8):696m700.$ 3.$ Bartels$H,$Bohmer$M.$[MicroMdetermination$of$creatinine].$Clin"Chim"Acta."Mar$1971;32(1):81M 85.$ 4.$ Siekmann$L.$Measurement$of$creatinine$in$human$serum$by$isotope$dilution$mass$spectrometry.$ J"Clin"Chem"Clin"Biochem."1985;23:137M144.$ 5.$ Seelig$HP.$Zeitschrift$fur$klinische$Chemie$und$klinische$Biochemie$1969;7(6):581M585.$ 6.$ Heinegard$D,$Tiderstrom$G.$Determination$of$serum$creatinine$by$a$direct$colorimetric$method.$ Clin"Chim"Acta."Feb$12$1973;43(3):305M310.$ 7.$ Quan$H,$Parsons$GA,$Ghali$WA.$Validity$of$information$on$comorbidity$derived$rom$ICDM9MCCM$ administrative$data.$med"care."aug$2002;40(8):675m685.$ 8.$ Deyo$RA,$Cherkin$DC,$Ciol$MA.$Adapting$a$clinical$comorbidity$index$for$use$with$ICDM9MCM$ administrative$databases.$j"clin"epidemiol."jun$1992;45(6):613m619.$ 9.$ Henderson$T,$Shepheard$J,$Sundararajan$V.$Quality$of$diagnosis$and$procedure$coding$in$ICDM10$ administrative$data.$med"care."nov$2006;44(11):1011m1019.$ 10.$ Austin$PC,$Daly$PA,$Tu$JV.$A$multicenter$study$of$the$coding$accuracy$of$hospital$discharge$ administrative$data$for$patients$admitted$to$cardiac$care$units$in$ontario.$am"heart"j."aug$ 2002;144(2):290M296.$ 11.$ Juurlink$DN,$Prevra$C,$Croxford$R.$Canadian"Institute"for"Health"Information"Discharge"Abstract" Database:"a"validation"study.$Toronto,$On.2006.$ 12.$ Fisher$ES,$Whaley$FS,$Krushat$WM,$et$al.$The$accuracy$of$Medicare's$hospital$claims$data:$ progress$has$been$made,$but$problems$remain.$am"j"public"health."feb$1992;82(2):243m248.$ 13.$ Jha$P,$Deboer$D,$Sykora$K,$Naylor$CD$Characteristics$and$Mortality$Outcomes$of$Thrombolysis$ Trial$Participants$and$Nonparticipants:$a$PopulationMBased$Comparison.$J$Am$Coll$Cardiol.$1996;$ 27:$1335M42.$ S32$
Supplement materials:
Supplement materials: Table S1: ICD-9 codes used to define prevalent comorbid conditions and incident conditions Comorbid condition ICD-9 code Hypertension 401-405 Diabetes mellitus 250.x Myocardial infarction
More informationegfr > 50 (n = 13,916)
Saxagliptin and Cardiovascular Risk in Patients with Type 2 Diabetes Mellitus and Moderate or Severe Renal Impairment: Observations from the SAVOR-TIMI 53 Trial Supplementary Table 1. Characteristics according
More informationSupplementary Online Content
Supplementary Online Content Tangri N, Stevens LA, Griffith J, et al. A predictive model for progression of chronic kidney disease to kidney failure. JAMA. 2011;305(15):1553-1559. eequation. Applying the
More informationChapter 2: Identification and Care of Patients With Chronic Kidney Disease
Chapter 2: Identification and Care of Patients With Chronic Kidney Disease Introduction The examination of care in patients with chronic kidney disease (CKD) is a significant challenge, as most large datasets
More informationSUPPLEMENTARY DATA. Supplementary Figure S1. Cohort definition flow chart.
Supplementary Figure S1. Cohort definition flow chart. Supplementary Table S1. Baseline characteristics of study population grouped according to having developed incident CKD during the follow-up or not
More informationTable S1: Diagnosis and Procedure Codes Used to Ascertain Incident Hip Fracture
Technical Appendix Table S1: Diagnosis and Procedure Codes Used to Ascertain Incident Hip Fracture and Associated Surgical Treatment ICD 9 Code Descriptions Hip Fracture 820.XX Fracture neck of femur 821.XX
More informationAHA Clinical Science Special Report: November 10, 2015
www.canheart.ca High-density lipoprotein cholesterol and cause-specific mortality: A population-based study of more than 630,000 individuals without prior cardiovascular conditions Dennis T. Ko, MD, MSc;
More informationSupplementary Appendix
Supplementary Appendix This appendix has been provided by the authors to give readers additional information about their work. Supplement to: Wanner C, Inzucchi SE, Lachin JM, et al. Empagliflozin and
More informationChapter 4: Cardiovascular Disease in Patients With CKD
Chapter 4: Cardiovascular Disease in Patients With CKD Introduction Cardiovascular disease is an important comorbidity for patients with chronic kidney disease (CKD). CKD patients are at high-risk for
More informationSupplementary Appendix
Supplementary Appendix This appendix has been provided by the authors to give readers additional information about their work. Supplement to: Bucholz EM, Butala NM, Ma S, Normand S-LT, Krumholz HM. Life
More informationDECLARATION OF CONFLICT OF INTEREST
DECLARATION OF CONFLICT OF INTEREST Is there a mortality risk associated with aspirin use in heart failure? Results from a large community based cohort Margaret Bermingham, Mary-Kate Shanahan, Saki Miwa,
More informationBeta-blockers in Patients with Mid-range Left Ventricular Ejection Fraction after AMI Improved Clinical Outcomes
Beta-blockers in Patients with Mid-range Left Ventricular Ejection Fraction after AMI Improved Clinical Outcomes Seung-Jae Joo and other KAMIR-NIH investigators Department of Cardiology, Jeju National
More informationTable 1 Baseline characteristics of 60 hemodialysis patients with atrial fibrillation and warfarin use
Table 1 Baseline characteristics of 60 hemodialysis patients with atrial fibrillation and warfarin use Baseline characteristics Users (n = 28) Non-users (n = 32) P value Age (years) 67.8 (9.4) 68.4 (8.5)
More informationUSRDS UNITED STATES RENAL DATA SYSTEM
USRDS UNITED STATES RENAL DATA SYSTEM Chapter 2: Identification and Care of Patients With CKD Over half of patients from the Medicare 5 percent sample have either a diagnosis of chronic kidney disease
More informationThis clinical study synopsis is provided in line with Boehringer Ingelheim s Policy on Transparency and Publication of Clinical Study Data.
abcd Clinical Study Synopsis for Public Disclosure This clinical study synopsis is provided in line with s Policy on Transparency and Publication of Clinical Study Data. The synopsis which is part of the
More informationA: Epidemiology update. Evidence that LDL-C and CRP identify different high-risk groups
A: Epidemiology update Evidence that LDL-C and CRP identify different high-risk groups Women (n = 27,939; mean age 54.7 years) who were free of symptomatic cardiovascular (CV) disease at baseline were
More informationSupplementary Online Content
1 Supplementary Online Content Friedman DJ, Piccini JP, Wang T, et al. Association between left atrial appendage occlusion and readmission for thromboembolism among patients with atrial fibrillation undergoing
More informationSecular Trends in Cardiovascular Disease in Kidney Transplant Recipients: 1994 to 2009
Western University Scholarship@Western Electronic Thesis and Dissertation Repository June 2015 Secular Trends in Cardiovascular Disease in Kidney Transplant Recipients: 1994 to 2009 Ngan Lam The University
More informationWhat oral antiplatelet therapy would you choose? a) ASA alone b) ASA + Clopidogrel c) ASA + Prasugrel d) ASA + Ticagrelor
76 year old female Prior Hypertension, Hyperlipidemia, Smoking On Hydrochlorothiazide, Atorvastatin New onset chest discomfort; 2 episodes in past 24 hours Heart rate 122/min; BP 170/92 mm Hg, Killip Class
More informationChapter 4: Cardiovascular Disease in Patients With CKD
Chapter 4: Cardiovascular Disease in Patients With CKD The prevalence of cardiovascular disease is 68.8% among patients aged 66 and older who have CKD, compared to 34.1% among those who do not have CKD
More informationSurgical Outcomes: A synopsis & commentary on the Cardiac Care Quality Indicators Report. May 2018
Surgical Outcomes: A synopsis & commentary on the Cardiac Care Quality Indicators Report May 2018 Prepared by the Canadian Cardiovascular Society (CCS)/Canadian Society of Cardiac Surgeons (CSCS) Cardiac
More information4. Which survey program does your facility use to get your program designated by the state?
STEMI SURVEY Please complete one survey for each TCD designation you have in your facility. There would be a maximum of three surveys completed if your facility was designated as a trauma, stroke and STEMI
More informationGALECTIN-3 PREDICTS LONG TERM CARDIOVASCULAR DEATH IN HIGH-RISK CORONARY ARTERY DISEASE PATIENTS
GALECTIN-3 PREDICTS LONG TERM CARDIOVASCULAR DEATH IN HIGH-RISK CORONARY ARTERY DISEASE PATIENTS Table of Contents List of authors pag 2 Supplemental figure I pag 3 Supplemental figure II pag 4 Supplemental
More informationSupplementary Online Content
Supplementary Online Content Leibowitz M, Karpati T, Cohen-Stavi CJ, et al. Association between achieved low-density lipoprotein levels and major adverse cardiac events in patients with stable ischemic
More informationSupplementary Online Content
Supplementary Online Content Khera R, Dharmarajan K, Wang Y, et al. Association of the hospital readmissions reduction program with mortality during and after hospitalization for acute myocardial infarction,
More informationAntihypertensive Trial Design ALLHAT
1 U.S. Department of Health and Human Services Major Outcomes in High Risk Hypertensive Patients Randomized to Angiotensin-Converting Enzyme Inhibitor or Calcium Channel Blocker vs Diuretic National Institutes
More informationCVD risk assessment using risk scores in primary and secondary prevention
CVD risk assessment using risk scores in primary and secondary prevention Raul D. Santos MD, PhD Heart Institute-InCor University of Sao Paulo Brazil Disclosure Honoraria for consulting and speaker activities
More informationMalmö Preventive Project. Cardiovascular Endpoints
Malmö Preventive Project Department of Clinical Sciences Skåne University Hospital, Malmö Lund University Malmö Preventive Project Cardiovascular Endpoints End of follow-up: 31 December Report: 9 March
More informationSupplementary Online Content
Supplementary Online Content Inohara T, Manandhar P, Kosinski A, et al. Association of renin-angiotensin inhibitor treatment with mortality and heart failure readmission in patients with transcatheter
More informationHYPERTENSION GUIDELINES WHERE ARE WE IN 2014
HYPERTENSION GUIDELINES WHERE ARE WE IN 2014 Donald J. DiPette MD FACP Special Assistant to the Provost for Health Affairs Distinguished Health Sciences Professor University of South Carolina University
More informationImpaired Chronotropic Response to Exercise Stress Testing in Patients with Diabetes Predicts Future Cardiovascular Events
Diabetes Care Publish Ahead of Print, published online May 28, 2008 Chronotropic response in patients with diabetes Impaired Chronotropic Response to Exercise Stress Testing in Patients with Diabetes Predicts
More informationRace Original cohort Clean cohort HR 95%CI P HR 95%CI P. <8.5 White Black
Appendix Table 1: Hazard Ratios of the association between CSCs and all-cause mortality from original cohort and the clean cohort excluding CHD/strokes. CSC categories Race Original cohort Clean cohort
More informationEffectiveness of statins in chronic kidney disease
Q J Med 2012; 105:641 648 doi:10.1093/qjmed/hcs031 Advance Access Publication 29 February 2012 Effectiveness of statins in chronic kidney disease X. SHENG 1, M.J. MURPHY 2, T.M. MACDONALD 1 and L. WEI
More informationSupplementary Online Content
Supplementary Online Content Shurraw S, Hemmelgarn B, Lin M, et al. Association between glycemic control and adverse outcomes in people with diabetes mellitus and chronic kidney disease: a population-based
More informationPatient characteristics Intervention Comparison Length of followup
ISCHAEMIA TESTING CHAPTER TESTING FOR MYCOCARDIAL ISCHAEMIA VERSUS NOT TESTING FOR MYOCARDIAL ISCHAEMIA Ref ID: 4154 Reference Wienbergen H, Kai GA, Schiele R et al. Actual clinical practice exercise ing
More informationImpact of coronary atherosclerotic burden on clinical presentation and prognosis of patients with coronary artery disease
Impact of coronary atherosclerotic burden on clinical presentation and prognosis of patients with coronary artery disease Gjin Ndrepepa, Tomohisa Tada, Massimiliano Fusaro, Lamin King, Martin Hadamitzky,
More informationTwo: Chronic kidney disease identified in the claims data. Chapter
Two: Chronic kidney disease identified in the claims data Though leaves are many, the root is one; Through all the lying days of my youth swayed my leaves and flowers in the sun; Now may wither into the
More informationJNC Evidence-Based Guidelines for the Management of High Blood Pressure in Adults
JNC 8 2014 Evidence-Based Guidelines for the Management of High Blood Pressure in Adults Table of Contents Why Do We Treat Hypertension? Blood Pressure Treatment Goals Initial Therapy Strength of Recommendation
More informationManaging Chronic Kidney Disease: Reducing Risk for CKD Progression
Managing Chronic Kidney Disease: Reducing Risk for CKD Progression Arasu Gopinath, MD Clinical Nephrologist, Medical Director, Jordan Landing Dialysis Center Objectives: Identify the most important risks
More informationSupplement Table 1. Definitions for Causes of Death
Supplement Table 1. Definitions for Causes of Death 3. Cause of Death: To record the primary cause of death. Record only one answer. Classify cause of death as one of the following: 3.1 Cardiac: Death
More informationSUPPLEMENTAL MATERIALS
SUPPLEMENTAL MATERIALS Table S1: Variables included in the propensity-score matching Table S1.1: Components of the CHA 2DS 2Vasc score Table S2: Crude event rates in the compared AF patient cohorts Table
More informationANNEX FORM TO EXAMINE THE CAUSES OF ESRD I IDENTIFICATION. 1 Record number (patient chart) Name. 1.1 Date of birth / / 1.2 Sex:
Supplementary Material from Prevalence of clinically validated primary causes of end-stage renal disease (ESRD) in a State Capital in Northeastern Brazil ANNEX FORM TO EXAMINE THE CAUSES OF ESRD I IDENTIFICATION
More informationZhao Y Y et al. Ann Intern Med 2012;156:
Zhao Y Y et al. Ann Intern Med 2012;156:560-569 Introduction Fibrates are commonly prescribed to treat dyslipidemia An increase in serum creatinine level after use has been observed in randomized, placebocontrolled
More informationMedicare and Medicaid Payments
and Payments The following table includes information about payments made by and for the 17 medical conditions/surgical procedures included in this Hospital Performance Report. This analysis is based on
More informationThe Prognostic Importance of Comorbidity for Mortality in Patients With Stable Coronary Artery Disease
Journal of the American College of Cardiology Vol. 43, No. 4, 2004 2004 by the American College of Cardiology Foundation ISSN 0735-1097/04/$30.00 Published by Elsevier Inc. doi:10.1016/j.jacc.2003.10.031
More informationLucia Cea Soriano 1, Saga Johansson 2, Bergur Stefansson 2 and Luis A García Rodríguez 1*
Cea Soriano et al. Cardiovascular Diabetology (2015) 14:38 DOI 10.1186/s12933-015-0204-5 CARDIO VASCULAR DIABETOLOGY ORIGINAL INVESTIGATION Open Access Cardiovascular events and all-cause mortality in
More informationSoo LIM, MD, PHD Internal Medicine Seoul National University Bundang Hospital
Soo LIM, MD, PHD Internal Medicine Seoul National University Bundang Hospital Agenda Association between Cardiovascular Disease and Type 2 Diabetes Importance of HbA1c Management esp. High risk patients
More informationSupplementary Online Content
Supplementary Online Content Dharmarajan K, Wang Y, Lin Z, et al. Association of changing hospital readmission rates with mortality rates after hospital discharge. JAMA. doi:10.1001/jama.2017.8444 etable
More informationAPPENDIX EXHIBITS. Appendix Exhibit A2: Patient Comorbidity Codes Used To Risk- Standardize Hospital Mortality and Readmission Rates page 10
Ross JS, Bernheim SM, Lin Z, Drye EE, Chen J, Normand ST, et al. Based on key measures, care quality for Medicare enrollees at safety-net and non-safety-net hospitals was almost equal. Health Aff (Millwood).
More informationLnformation Coverage Guidance
Lnformation Coverage Guidance Coverage Indications, Limitations, and/or Medical Necessity Abstract: B-type natriuretic peptide (BNP) is a cardiac neurohormone produced mainly in the left ventricle. It
More information1. Albuminuria an early sign of glomerular damage and renal disease. albuminuria
1. Albuminuria an early sign of glomerular damage and renal disease albuminuria Cardio-renal continuum REGRESS Target organ damage Asymptomatic CKD New risk factors Atherosclerosis Target organ damage
More informationSupplementary Online Content
Supplementary Online Content Melgaard L, Gorst-Rasmussen A, Lane DA, Rasmussen LH, Larsen TB, Lip GYH. Assessment of the CHA 2 DS 2 -VASc score in predicting ischemic stroke, thromboembolism, and death
More informationGSK Medicine: Study Number: Title: Rationale: Phase: Study Period: Study Design: Centres: Indication: Treatment: Objectives:
The study listed may include approved and non-approved uses, formulations or treatment regimens. The results reported in any single study may not reflect the overall results obtained on studies of a product.
More informationBlood Pressure Monitoring in Chronic Kidney Disease
Blood Pressure Monitoring in Chronic Kidney Disease Aldo J. Peixoto, MD FASN FASH Associate Professor of Medicine (Nephrology), YSM Associate Chief of Medicine, VACT Director of Hypertension, VACT American
More informationMalmö Diet and Cancer Study incl. CV-cohort. Cardiovascular Endpoints
The Malmö Diet and Cancer Study Department of Clinical Sciences Skåne University Hospital, Malmö Lund University Malmö Diet and Cancer Study incl. CV-cohort Cardiovascular Endpoints End of follow-up: 31
More informationThe University of Mississippi School of Pharmacy
LONG TERM PERSISTENCE WITH ACEI/ARB THERAPY AFTER ACUTE MYOCARDIAL INFARCTION: AN ANALYSIS OF THE 2006-2007 MEDICARE 5% NATIONAL SAMPLE DATA Lokhandwala T. MS, Yang Y. PhD, Thumula V. MS, Bentley J.P.
More informationHaemodiafiltration - the case against. Prof Peter G Kerr Professor/Director of Nephrology Monash Health
Haemodiafiltration - the case against Prof Peter G Kerr Professor/Director of Nephrology Monash Health Know your opposition.. Haemodiafiltration NB: pre or post-dilution What is HDF how is it different
More informationESM1 for Glucose, blood pressure and cholesterol levels and their relationships to clinical outcomes in type 2 diabetes: a retrospective cohort study
ESM1 for Glucose, blood pressure and cholesterol levels and their relationships to clinical outcomes in type 2 diabetes: a retrospective cohort study Statistical modelling details We used Cox proportional-hazards
More informationSupplementary Online Content
Supplementary Online Content Nikolova AP, Hitzeman TC, Baum R, et al. Association of a novel diagnostic biomarker, the plasma cardiac bridging integrator 1 score, with heart failure with preserved ejection
More informationSeung Hyeok Han, MD, PhD Department of Internal Medicine Yonsei University College of Medicine
Seung Hyeok Han, MD, PhD Department of Internal Medicine Yonsei University College of Medicine The Scope of Optimal BP BP Reduction CV outcomes & mortality CKD progression - Albuminuria - egfr decline
More informationHEART AND SOUL STUDY OUTCOME EVENT - MORBIDITY REVIEW FORM
REVIEW DATE REVIEWER'S ID HEART AND SOUL STUDY OUTCOME EVENT - MORBIDITY REVIEW FORM : DISCHARGE DATE: RECORDS FROM: Hospitalization ER Please check all that may apply: Myocardial Infarction Pages 2, 3,
More informationCoronary Artery Stenosis. Insight from MAIN-COMPARE Study
PCI for Unprotected Left Main Coronary Artery Stenosis Insight from MAIN-COMPARE Study Young-Hak Kim, MD, PhD Cardiac Center, University of Ulsan College of Medicine, Asan Medical Center Current Practice
More informationEffects of Kidney Disease on Cardiovascular Morbidity and Mortality
Effects of Kidney Disease on Cardiovascular Morbidity and Mortality Joachim H. Ix, MD, MAS Assistant Professor in Residence Division of Nephrology University of California San Diego, and Veterans Affairs
More informationUSRDS UNITED STATES RENAL DATA SYSTEM
USRDS UNITED STATES RENAL DATA SYSTEM Chapter 9: Cardiovascular Disease in Patients With ESRD Cardiovascular disease is common in ESRD patients, with atherosclerotic heart disease and congestive heart
More informationChapter 3: Morbidity and Mortality
Chapter 3: Morbidity and Mortality Introduction In this chapter we evaluate the morbidity and mortality of chronic kidney disease (CKD) patients continuously enrolled in Medicare. Each year s analysis
More informationNATIONAL INSTITUTE FOR HEALTH AND CARE EXCELLENCE General practice Indicators for the NICE menu
NATIONAL INSTITUTE FOR HEALTH AND CARE EXCELLENCE General practice Indicators for the NICE menu Indicator area: Pulse rhythm assessment for AF Indicator: NM146 Date: June 2017 Introduction There is evidence
More informationChapter Two Renal function measures in the adolescent NHANES population
0 Chapter Two Renal function measures in the adolescent NHANES population In youth acquire that which may restore the damage of old age; and if you are mindful that old age has wisdom for its food, you
More informationBlood Pressure Targets in Diabetes
Stockholm, 29 th August 2010 ESC Meeting Blood Pressure Targets in Diabetes Peter M Nilsson, MD, PhD Department of Clinical Sciences University Hospital, Malmö Sweden Studies on BP in DM2 ADVANCE RCT (Lancet
More informationProton Pump Inhibitors increase Cardiovascular risk in patient taking Clopidogrel
Proton Pump Inhibitors increase Cardiovascular risk in patient taking Clopidogrel Dr.A.K.M. Aminul Hoque Assoc. Prof. of Medicine. Dhaka Medical College. Clopidogrel Metabolism Clopidogrel is an inactive
More informationChapter 9: Cardiovascular Disease in Patients With ESRD
Chapter 9: Cardiovascular Disease in Patients With ESRD Cardiovascular disease is common in adult ESRD patients, with atherosclerotic heart disease and congestive heart failure being the most common conditions
More informationSupplementary Online Content
Supplementary Online Content Pincus D, Ravi B, Wasserstein D. Association between wait time and 30-day mortality in adults undergoing hip fracture surgery. JAMA. doi: 10.1001/jama.2017.17606 eappendix
More informationThe MAIN-COMPARE Study
Long-Term Outcomes of Coronary Stent Implantation versus Bypass Surgery for the Treatment of Unprotected Left Main Coronary Artery Disease Revascularization for Unprotected Left MAIN Coronary Artery Stenosis:
More informationCLINICAL PROCESS IMPROVEMENT INITIATIVE (CPII) EFFICIENCY REPORT EXPLANATION January 4, 2016
CLINICAL PROCESS IMPROVEMENT INITIATIVE (CPII) EFFICIENCY REPORT EXPLANATION January 4, 2016 WHAT IS AN EPISODE OF CARE? An episode of care is a grouping of a patient s health care claims for a unique
More informationQuality Measures MIPS CV Specific
Quality Measures MIPS CV Specific MEASURE NAME Atrial Fibrillation and Atrial Flutter: Chronic Anticoagulation Therapy CAHPS for MIPS Clinician/Group Survey Cardiac Rehabilitation Patient Referral from
More informationSurvival comorbidity. Mrs Retha Steenkamp Senior Statistician UK Renal Registry. UK Renal Registry 2011 Annual Audit Meeting
Survival comorbidity Mrs Retha Steenkamp Senior Statistician UK Renal Registry UK Renal Registry 2011 Annual Audit Meeting Importance of co-morbidities in survival Co-morbidities collected by the Renal
More informationCentral pressures and prediction of cardiovascular events in erectile dysfunction patients
Central pressures and prediction of cardiovascular events in erectile dysfunction patients N. Ioakeimidis, K. Rokkas, A. Angelis, Z. Kratiras, M. Abdelrasoul, C. Georgakopoulos, D. Terentes-Printzios,
More informationEvidence-Based Management of CAD: Last Decade Trials and Updated Guidelines
Evidence-Based Management of CAD: Last Decade Trials and Updated Guidelines Enrico Ferrari, MD Cardiac Surgery Unit Cardiocentro Ticino Foundation Lugano, Switzerland Conflict of Interests No conflict
More informationRevascularization after Drug-Eluting Stent Implantation or Coronary Artery Bypass Surgery for Multivessel Coronary Disease
Impact of Angiographic Complete Revascularization after Drug-Eluting Stent Implantation or Coronary Artery Bypass Surgery for Multivessel Coronary Disease Young-Hak Kim, Duk-Woo Park, Jong-Young Lee, Won-Jang
More informationEffect of upstream clopidogrel treatment in patients with ST-segment elevation myocardial infarction undergoing primary PCI
Effect of upstream clopidogrel treatment in patients with ST-segment elevation myocardial infarction undergoing primary PCI Dr Sasha Koul, MD Dept of Cardiology, Lund University Hospital, Lund, Sweden
More informationFaculty/Presenter Disclosure
Faculty/Presenter Disclosure Faculty: Andre Lamy Relationships with commercial interests: Grants/Research Support: None Speakers Bureau/Honoraria: None Consulting Fees: None Other: None CORONARY: The Coronary
More informationSupplementary Appendix
Supplementary Appendix This appendix has been provided by the authors to give readers additional information about their work. Supplement to: Rawshani Aidin, Rawshani Araz, Franzén S, et al. Risk factors,
More informationCondition/Procedure Measure Compliance Criteria Reference Attribution Method
Premium Specialty: Cardiology Credentialed Specialties include: Cardiac Diagnostic, Cardiology, Cardiovascular Disease, Clinical Cardiac Electrophysiology, and Interventional Cardiology This document is
More informationMortality following acute myocardial infarction (AMI) in
In-Hospital Mortality Among Patients With Type 2 Diabetes Mellitus and Acute Myocardial Infarction: Results From the National Inpatient Sample, 2000 2010 Bina Ahmed, MD; Herbert T. Davis, PhD; Warren K.
More informationOsler Journal Club Outcomes Research
Osler Journal Club Outcomes Research Malenka DJ, et al. Outcomes Following Coronary Stenting in the Era of Bare-Metal vs. the Era of Drug- Eluting Stents. JAMA 2008; 299(24):2868-2876 Mentor: Dr. Boulware
More informationDefinitions of chronic conditions used to define the number of serious comorbidities in the study.
Supplementary Table 1 Definitions of chronic conditions used to define the number of serious comorbidities in the study. Comorbidity ICD-9 Code Description CAD/MI 410.x Acute myocardial infarction 411.x
More informationISCHEMIC VASCULAR DISEASE (IVD) MEASURES GROUP OVERVIEW
ISCHEMIC VASCULAR DISEASE (IVD) MEASURES GROUP OVERVIEW 2014 PQRS OPTIONS F MEASURES GROUPS: 2014 PQRS MEASURES IN ISCHEMIC VASCULAR DISEASE (IVD) MEASURES GROUP: #204. Ischemic Vascular Disease (IVD):
More informationSupplementary Appendix
Supplementary Appendix This appendix has been provided by the authors to give readers additional information about their work. Supplement to: Weintraub WS, Grau-Sepulveda MV, Weiss JM, et al. Comparative
More informationLEADER Liraglutide and cardiovascular outcomes in type 2 diabetes
LEADER Liraglutide and cardiovascular outcomes in type 2 diabetes Presented at DSBS seminar on mediation analysis August 18 th Søren Rasmussen, Novo Nordisk. LEADER CV outcome study To determine the effect
More informationSupplementary Online Content
Supplementary Online Content Kavousi M, Leening MJG, Nanchen D, et al. Comparison of application of the ACC/AHA guidelines, Adult Treatment Panel III guidelines, and European Society of Cardiology guidelines
More informationTrial to Reduce. Aranesp* Therapy. Cardiovascular Events with
Trial to Reduce Cardiovascular Events with Aranesp* Therapy John J.V. McMurray, Hajime Uno, Petr Jarolim, Akshay S. Desai, Dick de Zeeuw, Kai-Uwe Eckardt, Peter Ivanovich, Andrew S. Levey, Eldrin F. Lewis,
More informationNQF-ENDORSED VOLUNTARY CONSENSUS STANDARD FOR HOSPITAL CARE. Measure Information Form Collected For: CMS Outcome Measures (Claims Based)
Last Updated: Version 4.3 NQF-ENDORSED VOLUNTARY CONSENSUS STANDARD FOR HOSPITAL CARE Measure Information Form Collected For: CMS Outcome Measures (Claims Based) Measure Set: CMS Readmission Measures Set
More informationWhat s new in cardiovascular disease risk assessment and management for primary care clinicians
Cardiovascular system What s new in cardiovascular disease risk assessment and management for primary care clinicians The recently released 2018 Cardiovascular Disease Risk Assessment and Management for
More informationUNIVERSITY OF CALGARY. diabetes mellitus. Vinay Deved A THESIS SUBMITTED TO THE FACULTY OF GRADUATE STUDIES
UNIVERSITY OF CALGARY Quality of care and outcomes for First Nations People and non-first Nations People with diabetes mellitus by Vinay Deved A THESIS SUBMITTED TO THE FACULTY OF GRADUATE STUDIES IN PARTIAL
More informationDUKECATHR Dataset Dictionary
DUKECATHR Dataset Dictionary Version of DUKECATH dataset for educational use that has been modified to be unsuitable for clinical research or publication (Created Date and Time: 28OCT16 14:35) Table of
More informationChapter 4: Cardiovascular Disease in Patients with CKD
Chapter 4: Cardiovascular Disease in Patients with CKD The prevalence of cardiovascular disease (CVD) was 65.8% among patients aged 66 and older who had chronic kidney disease (CKD), compared to 31.9%
More informationWhy is co-morbidity important for cancer patients? Michael Chapman Research Programme Manager
Why is co-morbidity important for cancer patients? Michael Chapman Research Programme Manager Co-morbidity in cancer Definition:- Co-morbidity is a disease or illness affecting a cancer patient in addition
More informationWhy is co-morbidity important for cancer patients? Di Riley Associate Director Clinical Outcomes Programme
Why is co-morbidity important for cancer patients? Di Riley Associate Director Clinical Outcomes Programme Co-morbidity in cancer Definition:- Co-morbidity is a disease or illness affecting a cancer patient
More informationThe MAIN-COMPARE Registry
Long-Term Outcomes of Coronary Stent Implantation versus Bypass Surgery for the Treatment of Unprotected Left Main Coronary Artery Disease Revascularization for Unprotected Left MAIN Coronary Artery Stenosis:
More informationLIVE KIDNEY DONOR RISK PREDICTION ; NEW PARADIGM, NEW CALCULATORS PEDRAM AHMADPOOR MD
LIVE KIDNEY DONOR RISK PREDICTION ; NEW PARADIGM, NEW CALCULATORS PEDRAM AHMADPOOR MD Outline: PART 1 : Update on safety of nephrectomy for living donor candidate PART 2 : Latest guideline recommendation
More information