COMBAT SYNDROME X, Y, AND Z, THE UNIFYING DISEASE CONCEPT OF THE METABOLIC SYNDROME AND THEIR MANAGEMENT

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1 COMBAT SYNDROME X, Y, AND Z, THE UNIFYING DISEASE CONCEPT OF THE METABOLIC SYNDROME AND THEIR MANAGEMENT Stephen Holt M.D., LLD(Hon), MRCP(UK), FRCP(C), FACG, FACP, FACN, FACAM

2 SUPER-SIZING AMERICA Americans exude complacency about their overweight status Obesity is part of a metabolic syndrome Syndrome X is under diagnosed and often mistreated by conventional and integrative medicine

3 Accepted Facts About Weight Control There is not a diet described in the history of medicine that has resulted in sustained weight control Atkins Diet Revolution was a step in the right direction, but Robert Atkins was addressing the important issues of insulin resistance and the Metabolic Syndrome X with its excessive morbidity and mortality Atkins was not preoccupied with cosmetic issues

4 Accepted Facts About Weight Control Weight control programs must involve calorie controlled diets, behavior modification, exercise, and adjunctive therapies (eg evidence based dietary supplements or drugs) Regulations do not permit stand-alone weight loss claims for dietary supplements

5 Evidence Base For Weight Control With Dietary Supplements Ephedra was effective for weight control, but it had dangerous side effects when misused. Some people who took Ephedra had CVS and stroke risk, probably as a consequence of the presence of the Metabolic Syndrome X. The industry is cutting the fat from many weight loss claims which must be evidence based.

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7 CARDINAL FEATURES OF SYNDROME X Abdominal Obesity. Waist M > 100, F > 88cm Hypertriglyceridemia > 150mg/dL Low HDL, M < 40mg/dL, F < 50 mg/dl Hypertension > 130/85 mmhg High fasting blood glucose > 110mg/dL

8 REDEFINING SYNDROME X Classic Definition: Obesity, Hypercholesterolemia, High Blood Pressure, Linked by Insulin Resistance. Syndrome X, Y and Z.., an expanded definition incorporating a novel unifying concept of common diseases

9 SYNDROME X,Y AND Z S.Holt MD expanded Reaven s concept to Syndrome X,Y and Z to define the global health threat of Syndrome X which causes : Cardiovascular Disease, Diabetes Mellitus, Thrombosis, Female Endocrine Disorders, Acne, Infertility (PCOS), Impaired Immunity, Inflammation and Cancer etc. STUDIES DESCRIBE MANY DISEASES ASSOCIATED WITH SYNDROME X

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12 SYNDROME X NUTRITIONAL FACTORS OBESITY: Hoodia, fiber, green coffee bean extract, starch blocker, chromium, fat blockers HYPERTENSION: fiber, botanicals unpredictable OXIDATIVE STRESS: alpha lipoic acid, AGES, redox balanced, hydrophilic and lipophilic HOMOCYSTEINE: B6, B12, folate, TMG INSULIN RESISTANCE: fish oil(epa), alpha lipoic acid, vitamin and mineral support BLOOD LIPID: soy, fish oil, guggul, garlic etc. INFLAMMATION: EPA, curcumin, C etc.

13 SYNDROME X : NUTRITION WATCH MACRONUTRIENTS CHO, FAT, PROTEIN HEALTHY FAT (EPA) SALT RESTRICTION FIBER INTAKE LOW CALORIE, nutrient dense TOXIC FOOD, ratios/components

14 A LIFESTYLE PROGRAM FOR METABOLIC SYNDROME X EDUTHERAPY LIFESTYLE CHANGE NUTRITION BEHAVIOR MODIFICATION EXERCISE NUTRITIONAL/HERBAL/BOTANICAL

15 SYNDROME X NUTRITIONAL FACTORS A healthy blood glucose level A healthy blood cholesterol level A healthy blood homocysteine level Healthy immune function Healthy digestive function Antioxidant function Calorie control by induction of satiety Inhibition of fat and sugar absorption

16 WHAT IS HOODIA GORDONII?

17 THE SAN BUSHMEN

18 REPORTED EFFECTS OF HOODIA Hunger and thirst suppression Energizing effects Aphrodisiac effects Suppression of gastric acid Contention effective as extract containing steroidal glycosides or effective as a dietary supplement?

19 EMERGING CONCEPTS Sleeplessness causes obesity Average sleep duration fallen Study, December 7, 2004, Ann. Int. Med Decrease leptin, increased ghrelin Carbohydrate craving with sleep loss The Sleep Naturally Plan A new innovation in weight loss

20 CONCLUSION Weight control is a serious public health initiative. Hoodia gordonii will ignite the industry in Low carb diets interventions alone invariably fail. Low carb diets require facilitation with lifestyle change, modification and the right supplements, with a primary focus on overcoming insulin resistance in many but not all people. Calorie control, key step, HOODIA.