bmismart Clinical Research Summary

Transcription

1 bmismart Clinical Research Summary

2 -week study: The benefit of fat binding on weight loss and body shaping A human clinical trial was conducted to test the effectiveness of, the patented complex in bmismart I-REMOVE Fat Binder on weight loss for overweight and obese individuals. This clinical trial was a double-blind, randomized, placebo-controlled trial with a -week run in period. The results of this study were published in the respected journal, Obesity. Reduction in Body Fat 9 I-REMOVE Fat Binder with InQpharm s proprietary complex has its origins in opuntia ficus-indica, a cactus also known as prickly pear. Through patented technologies, InQpharm creates a proprietary fiber complex with standardized lipophilic activity. The resulting plant-based compound reduces dietary fat absorption through gastrointestinal fat binding, and has been shown to bind dietary fat at a level previously only achieved by prescription drugs, but without the undesirable side effects. Week Mean Reduction in Body Fat (lbs) Week Reduction in Waist Circumference. Reduction in Body Mass Index. Mean Reduction of Waist Size (inches) Week Mean Reduction of Fat Mass (lbs).... Week Citation: Grube B, et al.,. A natural Fiber Complex Reduces Body Weight in the Overweight and Obese: A Double-blind, Randomized, -controlled Study. Obesity. Vol (). doi:./oby..

3 Long-Term Weight Maintenance Study: -month human clinical trial on weight maintenance Because the ability to maintain weight loss is a critical component of healthy weight loss, InQpharm conducted a separate study on the ability of to help participants maintain their weight loss for a period of six months. This study was a double-blind, randomized, placebo-controlled study with 9 participant results. After the -month trial period: Amount of weight lost or gained during -month trial Weight - - Months Percentage of participants who maintained previous weight loss Weight Maintenance percentage 9 Months Citation: Grube B, et al.,. Weight Maintenance with (IQP-G-AS): A -Week Double-Blind, Randomized, -Controlled Study. Obesity, Mechanism of action study: Fat binding decreased the amount of fat absorbed works by using a combination of insoluble and soluble fibers to bind and eliminate the fat. The insoluble fibers in are responsible for binding the dietary fats in the meal, in the upper part of the stomach through lipophilic interactions (the ability of being dissolved or attached to lipids). This action creates fat-fiber complexes that are too large to be absorbed and are naturally expelled as waste. The soluble fibers in are a non-starch, mucilage type of polysaccharide, which absorb water and swell to form a gel. InQpharm conducted a human clinical study, which measured exactly how much additional fat was excreted in fecal matter, as compared to a placebo. This study showed that participants taking excreted significantly more dietary fat than the placebo group. Percentage of dietary fat excreted Percentage 9 Citation: Uebelhack, R. et al,. Effects of Cactus Fiber on the Excretion of Dietary Fat in Healthy Subjects: A Double Blind Randomized, -Controlled, Crossover Clinical Investigation. Current Therapeutic Research vol. pp 9-.

4 -week study: The benefit of fat binding on weight loss and body shaping A human clinical trial was conducted to test the effectiveness of, the patented complex in bmismart I-BLOCK Carb & Sugar Blocker on weight loss for overweight and obese individuals. This clinical trial was a double-blind, randomized, placebocontrolled trial with a -week run in period. The results of this study were published in the respected journal, Evidence-based Complementary and Alternative Medicine. Reduction in Body Fat Content I-BLOCK Carb & Sugar Blocker with InQpharm s proprietary complex is formulated with a unique blend of L-arabinose, a naturally occurring pentose, and grape marc extract. L-Arabinose works by inhibiting the hydrolysis of sugar to glucose and fructose by intestinal sucrase, thus reducing glucose absorption in the intestine. Grape marc extract contains tannins that form complexes with carbohydrate-digesting enzymes, such as alpha-amylase and alpha-glucosidase, and a fat-digesting enzyme, lipase. This reduces the breakdown of complex carbohydrates, disaccharides and fats, which in turn reduces absorption of carbohydrate-derived and fat-derived calories. Results on a -week weight loss study using to inhibit digestive enzyme function are shown below (-week run-in period). Week Reduction in Fat Mass % Reduction in Body Fat Content Week Mean Reduction of Fat Mass (lbs) Week Citation: Grube, B, et al.. IQP-VV-, a Novel Proprietary Composition for Weight Reduction: A Double- Blind Randomized Clinical Trial for Evaluation of Efficacy and Safety. Evidence-Based Complementary and Alternative Medicine,

5 -week clinical study: The benefit of appetite reduction on weight loss A human clinical trial was conducted to test the effectiveness of, the patented complex in bmismart I-CONTROL Appetite Reducer on weight loss for overweight and obese individuals. This clinical trial was a double-blind, randomized, placebo-controlled trial with a -week run in period. The results of this study were published in the respected journal, Advancement in Medical Plant Research. Fat Loss Reduction in Waist Circumference. I-CONTROL Appetite Reducer with InQpharm s is a patent-pending fiber complex based on glucomannan, carrageenan and xanthan gum. Designed to reduce appetite, swells in the stomach, filling up to % of the volume, helping individuals feel fuller for longer. As food exits the stomach more slowly, the complex may delay the intestine s absorption of glucose, helping to reduce appetite and sustain feelings of satiety. technology has been clinically studied and shown to help individuals lose weight significantly. Mean Reduction of Fat (lbs) Week Mean Reduction of Waist Size (inches) Week Week Week Week Citation: Bongartz, U. et al.,. Double-blind, randomized, placebo-controlled, bicentric clinical investigation to evaluate the benefit and tolerability of IQP-AK- in reducing body weight in overweight and obese subjects. Advancement in Medicinal Plant Research Vol. () pp. -.