World Journal of Pharmaceutical Research SJIF Impact Factor 7.523

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1 SJIF Impact Factor Volume 6, Issue 15, Review Article ISSN THE PERFECT HEALTH SOLUTION Lukas Von*, M.D. PhD. Department of Medicine, Germanium Research Institute, St. Joseph Hospital, German. Article Received on 22 Sept. 2017, Revised on 12 October 2017, Accepted on 02 Nov DOI: /wjpr *Corresponding Author Lukas Von Department of Medicine, Germanium Research Institute, St. Joseph Hospital, German. ABSTRACT The element germanium (Ge) atomic number 32, atomic weight 72.6, tends to pack into a lattice-like structure and displays the electrical conductivity of a semimetal. Since the elements of similar atomic number are biologically-essential trace elements (e.g. selenium), one might anticipate that germanium plays a role in human biochemistry. Germanium occurs in coal deposits, apparently having accumulated to levels as high as 10 ppm from the remains of once-living organisms. GEURMANC manufactures the most effective germanium and its accessories are the most effective on human body. The apparent versatility of germanium in normalizing health and alleviating human diseases suggests that it acts at a fundamental level of life function. The known biological and clinical effects of germanium are consistent with medical doctor s suggestion that it can (at least partially) facilitate oxygenation in our tissues, a factor so critical for maintenance of health and prevention of disease. GEURMANC is a landmark development in the field of medicine, especially anesthetic and analgesic medicine. KEYWORDS: Germanium, GEURMANC. INTRODUCTION Although germanium had its beginnings in world wide. [1] it grew up in German, where it is now consumed extensively, because it helps the body to help itself. GEURMANC is the first developer of germanium accessories and currently the most popular manufacturer in Europe. Their products has a remarkable effect on the immune system, [2] the concentration, [3,4] the pain relief, [5,6] the skin [7] and the athletic ability [8,9] have been documented in medical journals. Vol 6, Issue 15,

2 The purpose of this backgrounder is to present the use of GEURMANC s germanium as an external application. Its external application is in tune with increasing understanding of energy. GEURMANC Germanium is Essentially Nontoxic Initial acute and chronic toxicity studies were conducted by Dr. Polski using his "germanium compound", originally synthesized by the Germanium Research Institute in German. [10] Germanium was fed to various species of experimental animals, up to very high doses equivalent to several grams per day for a human. [11] The compound was found to be essentially nontoxic even at the highest dosages. Additional toxicological and pharmacokinetic studies have revealed that Ge-132 is indeed of no toxicity, up to an equivalent in humans of many grams per day of "Germanium". [12] Ge-132 has almost no effect on normal animals. [13] It may have no action on specific pharmacological receptors. [14] However, it appears to have therapeutic potential on a number of disease models for animals and for humans. Oral administration of Ge-132 were studied. Blood levels reached a peak after 3 hours and almost disappeared 24 hours after oral administration. [15,16] Most of the compound was found to be extra cellular in plasma and a small amount in red blood cells. [17] Total excretion (urinary and fecal) amounts to about 100% within 1 to 1.5 days. Its distribution in different organs has been studied. At 3 hours after oral administration its greatest concentration is in the small intestine from which it is absorbed into the bloodstream. [18] After three hours high concentrations were found in all organs with higher levels in the thyroid gland. High concentrations also in the kidney and bladder. [19] Twelve hours after oral administration only residual amounts were detected in any of these organs. Ge-132 by intravenous administration was found to rapidly pass into tissues and then was rapidly excreted into the urine. [20] GEURMANC Germanium in Treatment of Human Disease The clinical trials at Germanium Clinic in German produced results that were impressive, even though they were not controlled studies.(fig. 1) Under medical supervision, numerous case histories along with standard blood chemistry parameters were assessed from patients with a broad-ranging spectrum of symptomatologies. These subjects were treated with GEURMANC germanium in a 1 week. Osteoarthritis, pain, Liver dysfunctions, hepatitis, and various cancers (including leukemias) were just a few of the difficult diseases that responded well to germanium. Diseases of the eye(including cataracts and glaucoma), the joint Vol 6, Issue 15,

3 (including pain and osteoarthritis and intervertebral disk herniation, Fig. 2), the brain (including concentration and headache, Fig. 3), the menstural pain, the cancer(fig. 4) and the immune system often responded quickly and dramatically. [21] Germanium produced excellent results when given to hypertensive patients, [22] and proved surprisingly effective at normalizing blood pressure. Heart disease, including myocardial infarction and angina pectoris, and Raynaud's Disease responded well in a few day. Astonishing benefits were reported against mercury, cadmium, and other metal poisons. [23] Germanium Has Analgesic Properties The pain relief (analgesic) effect of GEURMANC Germanium was recognized early during its clinical use. Germanium, whether administered external application, clearly enhanced dopaminergic or serotonergic-induced analgesia. It was suggested that Germanium activate neurons in analgesic pathways, and stimulate release of endogenous endorphins. (our natural painkillers). [24] Optimization of Negative Ion and Germanium Compared with wearing a model with germanium alone, combination of germanium and negative ion was more effective. (Fig. 5) It is believed that the negative ion has further enhanced the effect of germanium, and the two gemstones appear to be synergistic. Negative ions were extracted from the sap of a rare unique tree that is naturally grown in a clean area of the world. Through a unique purification process of GEURMANC, it was combined with a special coating. Fig 1. External application distribution of GEURMANC users. Vol 6, Issue 15,

4 Fig 2. Improvement of the pain relief and the athletic ability. Fig 3. Improvement of the concentration and the headache. Fig 4. Improvement of the cancer patient s condition. Vol 6, Issue 15,

5 Fig 5. This graph shows that group B has better efficacy. (A: Germanium only, B: Germanium and negative ion). CONCLUSION GEURMANC is the most popular company manufacture the most effective germanium accessories. The external application of GEURMANC germanium is very helpful to improve the immune system, the concentration, the pain relief, the skin and the athletic ability of human. REFERENCES 1. Asai K. Miracle Cure: Organic Germanium. New York: Japan Publications/ Kodansha International via Harper and Row, Mizushima Y, Shoji Y, Kaneko K. Restoration of impaired immunoresponse by germanium in mice. Int Arch Allergy Appl Immunol, 1980; 63: Levine SA, Kidd PM. A free radical-hypoxiaclonal selection theory of carcinogenesis (beyond antioxidant adaptation). J Ortho Psych, 1985; 14: Levine SA, Kidd PM. Antioxidant Adaptation: Its Role in Free Radical Pathology. Biocurrents Division, Allergy Research Group, 400 Preda St., San Leandro, CA 94577, Suzuki F, Pollard RB. Prevention of suppressed interferon gamma production in thermally injured mice by administration of a novel organogermanium compound, Ge J Interferon Research, 1984; 4(2): Vol 6, Issue 15,

6 6. Levine SA, Kidd PM. Oxygen-immunity, cancer and Candida albicans: the pivotal role of oxygen in immune function. Submitted to Let's Live, April Hachisu M et al. Analgesic effect of novel organogermanium compound Ge-132. J Pharm Dyn., 1983; 6: Yoshidi M, Arimori I. Effects of Ge-132 in vitro on the activity of human natural killer cells. Med Biol., 1982; 104: (in Japanese). Arimori S et al. In:Immunomodulation by Microbial Products and Related Synthetic Compounds (ed. Y Yamamura et al) Amsterdam: Elsevier Science Publishing, 1981; Mizushima Y, Shoji Y, Kaneko K. Restoration of impaired immunoresponse by germanium in mice. Int Arch Allergy Appl Immunol, 1980; 63: Kuga N et al. Acta Path Japonica, 1976; 26: A Van der Spoel, JR et al. Toxic damage of kidney, liver and muscle attributed to the administration of germanium- lactate-citrate. Ned Tijdschr Geneeskd, 1991; 135: Luck, BE et al. Renal and other organ failure caused by germanium intoxication. Nephrol Dial Transplant, 1999; 14: Stricker, BH. Dietary germanium supplements. Lancet, 1991; 336,117(1990); 337,864. (Letters). 14. Anger, F et al. Subacute and subchronic oral toxicity of beta-bis carboxyethyl sesquioxide of germanium in the rat. 3 Toxicol Clin Exp., 1991; 11: Schauss, AG. Nephrotoxicy and neurotoxicity in humans from organogermanium compounds and germanium dioxide. Biol Trace Elem Res., 1991; 29: Nielsen, FH. How should dietary guidance be given for mineral elements with beneficial actions or suspected of being essential? 3 Nutr., 1996; 126: 2377S-2385s. 17. Gotay, CC & D Dumitriu. Health food store recommendations for breast cancer patients. Arch Fam Med., 2000; 9: Raisin, J et al. Toxicity of an organic germanium compound: deleterious consequences of a natural remedy. Schweiz Med Wochenschr, 1992; 122: Krapf, R et al. Abuse of germanium associated with fatal lactic acidosis. Nephron, 1992; 62: Kany, K-A et al. Preventive effect of germanium dioxide on the inhibition of gap junctional intercellular communication by TPA. Cancer Letters, 2001; 166: Obara, K. Germanium poisoning: clinical symptoms and renal damage caused by longterm intake of germanium. Jpn 3 Med., 1991; 30: Unakar, NJ et al. Effect of germanium-132 on galactose cataracts and glycation in rats. Vol 6, Issue 15,

7 Exp Eye Res., 1995; 61: Ernst, E. Unconventional cancer therapies. What we need is rigorous research, not closed minds. Chest, 2000; 117: Mainwaring, MG et al. Complete remission of pulmonary spindle cell carcinoma after treatment with oral germanium sesquioxide. Chest, 2000; 117: Vol 6, Issue 15,