PREMIUM QUALITY FEED-ENHANCER SPECIES GENEX SOW PIGS. Supporting the reproductive cycle

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1 PREMIUM QUALITY FEED-ENHANCER SPECIES PIGS Supporting the reproductive cycle

2 Background Today s farming production systems are more intensive and much more is expected from farm animals. The modern sow is a totally different animal to that of 25-3 years ago. Genetic improvements have led to highly prolific sows with the ability to produce greater numbers of piglets each cycle. Every aspect of a sow s management must be correct in order to obtain the maximum number of piglets. These piglets need to be healthy, viable and have good birth weights in order to achieve maximum profitability. Farmers must manage the bacterial challenge from the environment to safeguard their profits. Common threats to a farm s profitability are E. coli and other pathogens. Genex Sow protects against these harmful bacteria which are often consumed via the feed. Genex Sow uses a unique blend of organic acids, essential oils and plants extracts, which means that the effect of Genex Sow is not via a simple ph reduction effect. Organic acids are used to control potentially pathogenic bacteria. Genex Sow is formulated using a unique blend of organic acids combined with a stable carrier. It s the types of acids used in Genex Sow that make the difference. ESSENTIALS OILS ORGANIC ACIDS GENEX PLANT EXTRACTS Phyllosilicates What does do? Multiple synergistic associations: bacteriostatic and bactericide effect in feed. Protects intestinal mucosa and villi from harmful bacterial consumed via the feed. Helps the animal achieve the optimal intestinal microbial balance by reducing exposure to contaminated feed. Supports animal health and digestive function. Phyllosilicate carrier known to adsorb mycotoxins and endotoxins. Phyllosilicate carrier enables slow release of active components The benefits of reducing pathogenic infection: GESTATION Increased litter size Increased birth weight Improved conception rates/less returns Decreased birth weight variability Less runts LACTATION Better early performance Increased weaning weights Decreased variation in weaning weights By combining all of these components, Genex Sow provides excellent protection against feed borne pathogens. This unique blend of active ingredients used in Genex Sow is born of intensive R&D. It is not just the ingredients themselves that gives the product its unique properties. It is the ratio of those ingredients and balance between them which combine to achieve the optimal synergistic effect. By examining the potential of each material and considering how it may enhance the efficacy of the other components, the researchers at Optivite designed the ultimate formulation that makes Genex Sow so effective.

3 : The Science HOW DOES WORK? The essential oils in Genex Stimulate feed intake Damage microorganism cell wall structure - Cell contents lost - Disrupts cell homeostasis/genetic material replication - Allows more organic acid into cell Prevent flagella formation - Limits movement - Limits growth & multiplication The pathogenic challenge Bacteria such as E. coli are a major threat to sows and their piglets. There are many possible sources of infection of which feed can be a main route. Organic acids The effect of Genex Sow is not a simple ph reduction by the acids. Genex Sow is formulated using a unique blend of organic acids combined with a stable carrier that make a difference. Organic acids their effect on Gramnegative enterobacteria e.g. E. coli: Organic acids (AH) consist of two components, negatively charged anions (A-) and positively charged hydrogen ions or cations (H+). Organic acids Their effect on lactobacilli bacteria A similar process also takes place in lactic acid producing bacteria lactobacilli. However, our acids target the harmful bacteria not the beneficial bacteria that contribute to a healthy gut. Untreated cells (control) (Afetr Burt & Reinders, Letters in Applied Microbiology (23) 36: ) Cells damaged after treatment with essential oil Intestinal wall microvilli, microscopic cellular membrane protrusions that are responsible for a wide variety of functions including absorption of nutrients, can be seriously damaged by E. coli and other pathogens. This can lead to the malabsorption of nutrients reducing the efficiency of digestion and inhibiting animal performance. Why use organic acids? Organic acids are used to control potentially pathogenic bacteria because of their ability to penetrate the bacterial cell wall of Gram-negative bacteria. Once the cell has been compromised the organic acids catastrophically disrupt cell metabolism, thus killing the bacteria. STEP 1 The acid penetrates the cell wall AH move into the cell & split up acidifying the internal cell environment. In order to maintain the neutrality of the internal environment, the cell moves to step 2. STEP 1 The acid penetrates the cell wall Lactobacilli are acid tolerant, so are able to cope with a greater ph shift. The plant extracts in Genex Natural surfactants - Coats bacteria - Damages bacterial cell wall - Cell contents lost - Allows more organic acid into cell - Enhances essential oil effect By combining all of these components, Genex Sow provides excellent protection against pathogens, including E. coli. STEP 2 Removal of cations The cell uses energy to power the proton pumps which move H+ out of the cell. STEP 2 Removal of cations Less energy used in moving H+ out of the cell. Genex Sow vs. E. coli in finished feed Healthy microvilli 2 15 Challenged microvilli STEP 3 Cell dies As the cell is using all of its available energy moving H+ out of the cell normal cell function is impaired. Inhibition of DNA replacement occurs leading to cell death. STEP 3 Cell survives The energy expended is low meaning more energy is available for normal cell function and viability. COUNT PER GRAM OF SAMPLE 1 5 E. coli adheres to the intestinal mucosa causing the destruction of intestinal microvilli (After Dr David Dean, Institute of Cell & Molecular Biosciences, University of Newcastle, UK) = Anions (Negatively charged) KEY: = Hydrogen/Cations (Positively charged) CONTROL HOURS 4 GENEX

4 Using To control bacterial levels (in particular E. coli) in feed as part of an overall reduction strategy offers a number of benefits. By using Genex Sow in feed as part of an overall bacterial control strategy, the following has been observed. Effects on numbers born alive 8 Leads to increased birth weight, reducing piglet mortality 7 Improving weaning weights No. OF TRIALS 1 CONTROL No. PIGS BORN ALIVE 11.9 No. PIGS BORN ALIVE (No) +.44 POST WEANING GAIN (g/d) MORTALITY (%) 7 6o o >1.8 BIRTH WEIGHT (kg) (Broekman,85) Improved weaning weights improves post weaning gain DAY 25 WEIGHT (kg) DAYS: BIRTH TO SLAUGHTER WEANING WEIGHT (kg) BIRTH WEIGHT (kg) (Cole & Varley, 2) Faster to slaughter Effect on birth weight BIRTH WEIGHT (kg) COEFFICIENT OF VARIATION (%) WEANING WEIGHT (kg) COEFFICIENT OF VARIATION (%) BEFORE Effect on weaning weight Inclusion rates DRY / GESTATING SOWS 4kg/t BEFORE Benefits of Increased piglets per litter LACTATING SOWS 4kg/t Reduces microbial challenge from feed which can give Heavier weaning weights P VALUE < P VALUE <.1.49 WHEN ENCOUNTERING A SEVERE CHALLENGE PLEASE CONSULT YOUR OPTIVITE NUTRITIONIST (Bilkei, 99) WEANING WEIGHT (kg) DAILY LIVE WEIGHT GAIN POST WEANING (g/d) (Cole & Varley, 2) Increased birth weight Faster piglet growth Improved litter uniformity More productive sows

5 : The Support Optivite provides cutting-edge, science based products plus the support you need. Optivite s nutritionists and animal husbandry specialists are available with expert advice, service and product knowledge, with regional sales and technical support people on-hand to assist with day-to-day challenges. What s more, our global distributor network is here to guide you to the right product choices wherever you are in the world. Optivite distributor countries Contact Optivite Manton Wood Enterprise Park Worksop, S8 2RS, UK info@optivite.com international@optivite.com t: +44 () f: +44 ()