TOWARDS OPTIMAL USE OF GUT HEALTH SUPPORTING FEED ADDITIVES. Dr. Daniel Ramirez

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1 TOWARDS OPTIMAL USE OF GUT HEALTH SUPPORTING FEED ADDITIVES Dr. Daniel Ramirez

2 Defining gut health Gut health is important for maximizing the health, welfare, and performance of poultry. Gut health could be defined as the correct interactions among these physiological functions. Diet - Macro micro nutrient - Additives - Antinutritional factor - Indigestible fractions Effective digestion & absorption - Nutritional status - Absorption of feed water, minerals. - Fecal consistency Gut mucosa Gut health = Performance - Mucus layer - Epithelium - GALT Microbiota Homeostasis - Normal physiological function Effective Immune system - GI Barrier - Mucus production - HDP production - IgA activity - Complex composition - Activity (exc)

3 Functional feed additives can improve intestinal development and function FFA positively affect microbiota, maximizing poultry health, and growth whilst enhancing the efficiency of feed conversion. Among feed additives alternatives Precision Delivery Coated Butyrate (PDCB) and some Phytogenic Components (PC) probably represent the best potential to approach the balance of the gut health ecosystem.

4 What is butyrate? salt of naturally occurring short-chain fatty acid many beneficial effects in the gut

5 How does butyrate mediate all these effects? animal host cell (e.g. gut epith. cell, immune cell,...) bacterium (e.g. Salmonella)

6 Functional feed additives can improve intestinal development and function increased secretion of digestive fluids energy source for liver villi development gut empowerment; intestinal barrier reduction of inflammation triggers enteric endocrine system energy source for colonic cells prevention of colonisation by pathogens better absorption of water dryer faeces

7 Phytogenic feed additives: the secret is in selecting the best molecules aiming at several targets, as good as possible feed intake digestion antibacterial anti-oxidation Quorum Sensing

8 Phytogenic feed additives: the secret is in selecting the best molecules aiming at several targets, as good as possible Selection of efficacious anti-oxidative compounds via literature study and database analysis Mode of action: antibacterial effect 1E+07 Ec O149 Ec O157 Lb pl Lb casei 1E+06 1E+05 1E+04 1E+03 1E+02 1E+01 1E+00 Neg. ctrl AGP APEX

9 Phytogenic feed additives: Mode of action: Quorum Sensing A form of bacterial communication dependent on population-density

10 Phytogenic feed additives: Mode of action: Quorum Sensing 2 QS signal systems tested (with Univ. of Ghent) bioactive components from botanicals: tested separately and in mixes, at concentrations well-below MIC strength of QS signal 1 (%) strength of QS signal 2 (%) no botanical added no EO no EO + botanical 1 + EO 1 + EO 1 + botanical 2 + EO 2 + EO 2 + botanical 3 + EO 3 + EO 3... PC + EO core PC components shuts down QS! p <

11 Performance effect of precision delivery coated butyrate ( PDCB) and Phytobiotics 784 day-old male Cobb 500 chicks, 4 treatment groups 7 replicates of 28 birds. Effect of different concentrations of PDCB 0.25, 0.5, 1 kg/ton Effect of PDCB + Phytobiotics in the grower and finisher rations, on top of adding PDCB in the starter feed. Zootechnical parameters measured at: 21,35, 42 days

12 Material & Mthods Group Phases Pre-starter Starter Growth withdrawal 1 AGP + AA AGP + AA AGP + AA AGP 2 AA AA AA 3 PDCB 1 kg/t + AA PDCB 1 kg/t + AA PDCB 0,5 kg/t + AA PDCB 0,25 kg/t 4 PDCB 1 kg/t + AA PDCB 1 kg/t + AA PC 0,15 kg/t + AA PC 0,15 kg/t AA - anticoccidiostat AGP - Growth promoter

13 Facilities Material & Mthods

14 Experiment 1 - Figure 1 Technical parameters - PDCB levels in starter at 21 day feed intake (FI) FCR Weight (AW) P = 0.04 P = 0.05 P = (d) (d) (d) NC PDCB 0, PDCB 0, PDCB 1,00-0-0

15 Experiment 2 - Figure 2 Technical parameters - PDCB levels in starter at 42 day feed intake (FI) FCR Weight (AW) P = (d) (d) (d) NC PDCB 0, PDCB 0, PDCB 1,00-0-0

16 Experiment 2 - Figure 3 Performance at day 21 - PDCB+BO in grower feed intake (FI) 21 d FCR (corrected) 21d Weight (AW) 21 d P = 0.05 b a ab a (d) (d) (d) 999 Control AGP PDCB PDCB+BO

17 Experiment 2 - Figure 4 Performance at day 21 - PDCB+BO in grower feed intake (FI) 42 d FCR (Corrected) 42 d Weight (AW) 42 d ab b ab a b ab a a (d) (d) (d) Control AGP PDCB PDCB+BO

18 Conclusions An improvement of feed intake at day 42 (p=0.01) With increasing PDCB inclusion levels, we found an improvement in feed intake (FI) (p=0.04), body weight (BW) (p=0.08) and feed efficiency (FCR) (p=0.05) at day 21, Better weight gain (p=0.05) at the end of the trial (42d). The best result on final weight was observed for the treatment combining PDCB in the starter feed with PC in the grower and finisher rations.

19 Integral program to prevent and control disease Management Nutrition Microbiome control Veterinary medicine Hygiene Particle size Inmune response Biosecurity Vaccination Digestibility macro & micro nutrients Intestinal integrity Diagnostics Prevention (vaccination) AF programs Mycotoxin control Increase in HDP Programas AF AB reduction in phases i. 20% ii. 40% iii. 60% Nutrients maximization (enzymes) Intestinal health Growth promoters Nutrition Prevention Veterinary medicine Challenges