LinkAsia Partners Building Bridges to Asia Pacific

Transcription

1 LinkAsia Partners Building Bridges to Asia Pacific

2 Welcome to LinkAsia Partners Satellite Symposium

3 Featuring

4 Today s Program Welcome - David Saunders: LinkAsia Partners Probiotics in Sow Lactation Feeds: Dr. Johann Hammerer - Schaumann HiZox as an Alternative to Pharmacological Levels of Zinc Oxide in Piglet Diets Stephane Durosoy - Animine 3pm - Coffee Eubiotic Fibre - A New Tool for Sow Management Paul Hubilla - PLH Nutrition Panel Discussion

5 Probiotic Use in Sow Lactation Feeds

6 SCHAUMANN On a Path of Rapid Expansion Production facilities:! 3 plants for mineral feeds (2 in Germany and 1 in Austria)! 1 plant for complete feed (UNA- HAKRA in Germany)! 1 biotechnological plant (LACTOSAN in Austria)! 1 plant for acids (LIGRANA in Germany) Subsidiaries in:! Austria, Czech Republic, Slovakia, Poland, Russia, France, Hungary, Croatia, Ukraine, China, Italy and Switzerland Distributors in:! Albania, Belarus, Belgium, Bosnia, Bulgaria, Denmark, Estonia, Finland, Greece, Georgia, Great Britain, Lebanon, Lithuania, Latvia, Luxembourg, Macedonia, Netherlands, Portugal, Romania, Serbia, Slovenia, Spain, South Africa, Taiwan

7 SCHAUMANN Key Figures Annual turnover: 400 Mio. Euro Employees: 1200 Total production: tons Export business : 25 %

8 Schaumann is Committed to R & D IS FORSCHUNG in Wahlstedt, Germany Laboratories, fundamental research LACTOSAN in Kapfenberg, Austria Highly specialized research activities in the field of lactic acid bacteria (Bonsilage, Bonvital, Provita LE) Farm HÜLSENBERG in Hülsenberg, Germany Additionally Dairy herd and biogas plant; field tests, on-road tests Partnerships and collaborations with national and international universities and research institutions

9 Setting the Stage The industry is increasingly focused on sow efficiency Sow management Feeding programs Key challenges Feed intake during lactation Rebreeding efficiency In-feed probiotic use: sow efficiency benefiting from eubiotic gut management

10 Probiotic Use in Sows Probiotics - Overview The gastrointestinal tract and its microflora Mode of Action of Probiotic feed additives BONVITAL - efficacy trial results Schaumann Research Center - Hülsenberg External Research

11 Probiotics - Overview Wikipedia Probiotics are defined to be non-pathogenic organisms that are incorporated into the diet to: modify gut microbial ecology, leading to beneficial structural and functional changes in the gut. carry out metabolic functions such as helping the fermentation of nondigestible fibres storing energy in the form of short-chain fatty acids Probiotics serve as a barrier for the colonization of pathogens to: prevent disease enhance the immune system. The Good Bifidobacteria Lactobacilli The Bad Staphylococci Clostridia

12 Therapy of Gastroenteritis with a Lactobacilli Preparation in Children 100 Incidence Aqueous Diarrhea (%) p<0,07 Group 1 (L.GG ferm.milk) n= 24 Group 2 (L.GG powder) n = 23 Group 3 (control) n = 24 p<0,001 p<0,02 0 day 1 day 2 day 3 day 4 day 5 Isolauri E et al. Pediatrics 88: 90-97, 1991 LGG: Lactobacillus casei strain GG

13 Probiotics in Animal Nutrition Probiotics are live microbial additives which affect the gut flora in a way that is beneficial to the host animal. This also referred to as improving the intestinal microbial balance (Fuller, 1992) Common synonyms -Bioregulators -Gut flora stabilisers -DFM (direct fed microbial)

14 Interactions between Host and Intestinal Flora digestible feed components Feed indigestible feed components Host endogenous substrates Intestinal Flora intestinal function health composition activity

15 Co-habitation and Synergism Host Pig Constant Temperature Regulation of ph value Provision of nutrients Removal of waste products Intestinal Flora Protection against extraneous microbes Antagonistic effect against extraneous microbes Maturation and stimulation of the immune system Digestion of nutrients

16 A matter of balance Colonisation of Intestine by Section acc. Gedek, 1991 Section CFU / ml Stomach < 1000 Duodenum < Small Intestine < 100 Million Large Intestine < 1000 Billion

17 Microflora of the GI tract 100 trillion microorganisms composed of bacteria, protozoa and fungi comprised of some species. Dominant flora > 90% Bifidobacteria, Lactobacilli, Bacteroides, Eubacteria Secondary flora about 1% -Enterococci, E.coli, Residual flora about 0.01% -Proteus, Staphylococci, Pseudomonas

18 Eubiosis - Dysbiosis Eubiosis Steady state Healthy coexistence for mutual benefit Dominant flora, secondary flora and residual flora - Ratio > 90 : 1: 0.01 Dysbiosis unbalanced microbial population The secondary and residual flora increase to as much as 40 % of the total. Example: Increase in E. coli in the small intestine.

19 Eubiosis Stasis Challenges Diet Feeding errors and change in diet Poor quality feed components Poor feed hygiene Host animal Digestive secretions Immune substances Intestinal peristalsis

20 Protective or Potentially Pathogen Protective Effect Pathogen Effect

21 The intestine the largest organ of the immune system The gut-associated immune system is the body s largest immune system organ. The intestine is colonized by good and bad microbes. Numerous immunologically active tissues and cells ensure an adequate immune response. The defensive functions of the gut are reinforced by microorganisms colonizing the intestinal mucosa.

22 Competitive exclusion Formation of a biofilm Structure of a natural gut surface. BONVITAL organisms in the intestinal lumen. BONVITAL organisms begin to adhere to the intestinal mucosa. A protective biofilm is formed. BONVITAL organisms colonise the gut surface. Pathogenic bacteria are suppressed and prevented from propagating.

23 Introducing BONVITAL Specifications Enterococcus faecium protected by microencapsulation Concentration Available: 1 X CFU/gram Recommended Dosages Inclusion Rate (g/ton) CFU / kg feed Piglets 50 5 X 10 8 Sows 50 5 X 10 8 Growing and Finishing 20 2 X 10 8 Formulate into premix for best mixability Shelf life: 18 months

24 Target Benefits of BONVITAL Sow Management Litter size Litter weight Daily weight gain Health status of sow and piglets Reduced Incidence of Scours Reduction in Medication costs Piglet Management Grower - Finisher Weight Gain Feed Consumption Feed Conversion

25 BONVITAL Performance Improvement in piglet production Schaumann Research Centre Number of Sows: 35 Feeding of Bonvital - 90th day of gestation to insemination Sow Parturitions before trial: Control + 6 % % 24.8 BONVITAL 5X10 5 BONVITAL 5X10 6 Reared Piglets / Sow / Year

26 BONVITAL Performance Improvement in piglet production Trial Conducted: 2004 Number of Sows: 33 1st Parity Dosage in Treatment Group: * 5 X days of Gestation to Weaning at 28 days % + 13 % -7,5 % Control BONVITAL % losses of piglets during lactation g/ Piglet/ Day Prestarter intake Live Weight loss (g/ Sow/ weaned piglet)

27 BONVITAL Improvements of health in piglet production Incidence of Treatment of Sows Control BONVITAL % 6 8 0

28 BONVITAL in Sows with Downstream Benefits Schaumann Research Centre Control group: 10 sows fed normal rations without BONVITAL Two litters with piglets Trial group: 10 sows fed normal rations plus 50g BONVITAL / t feed (= 5x10 8 CFU/kg feed) Two litters with piglets

29 BONVITAL IN SOWS: Design of the trial Schaumann Research Centre Measurement Parameters Sows Live weight Feed Intake Health Status Milk Composition Piglets Live weight Feed intake Health status Microbiological Analysis of Feces Fertility Microbiological Analysis of Feces

30 BONVITAL Reduces Weight Losses in Sows During Lactation Schaumann Research Centre Weight Loss (kg) Influence of BONVITAL on the weight losses of sows after the 1 st and 2 nd litter (data per animal and 28-day suckling period) b -10 a -4 b Control BONVITAL -20 a Litter 1 Litter 2 ab values with different letters show a significant difference (p<0,05)

31 Summary of BONVITAL Trial in Sows Schaumann Research Centre Supplementation of BONVITAL : significant lower live weight losses in both lactation periods Feed intake of the sows was about 1.2% and 2.7% higher in the 1st and 2nd lactation than in the sows of the control group Ingested 4780 kcal ME and kcal ME more during the 1st and 2nd lactation period than the Sows without BONVITAL

32 BONVITAL in Sows: Reduction in Non-Productive Days Schaumann Research Centre Influence of BONVITAL in lactation diets on return to estrus and dry period after the 1 st and 2 nd litter. (data per animal) Control 16 BONVITAL 14.9 Days st Litter 2nd Litter 1st Litter 2nd Litter Weaning to Estrus Dry Period

33 BONVITAL in Lactation Feeds Schaumann Research Centre Summary of Trial Results: Reduction in sow weight loss during lactation Time to return to heat reduced Dry period was decreased

34 BONVITAL in Lactation Diets Improves Piglet Performance Schaumann Research Centre Influence of BONVITAL in lactation diets on the weight gain of the piglets in the 1 st and 2 nd litter (data per animal and 28-day suckling period) Weight Gain (kg) Control 6.45 BONVITAL st Litter 2nd Litter

35 Impact of BONVITAL in Lactation Feed on Piglets Schaumann Research Centre Summary of Results for 1st Parity Sows BONVITAL in sows lactation feed resulted in: Piglet weight gain was 5% higher Mortality of piglets was 21.8% lower Piglet feed intake was 11.1% higher

36 Impact of BONVITAL in Lactation Feed on Piglets Schaumann Research Centre Summary of Results for 2nd Parity Sows BONVITAL in sows lactation feed resulted in: Piglet weight gain was 2.3% higher No difference in mortality of piglets between groups Piglet feed intake was 12.9% higher

37 BONVITAL in Lactation Diets Increases Crude Protein Content in Sow s Milk Schaumann Research Centre Influence of BONVITAL in rations for sows on the crude protein content in the sow s milk (at the 14 th day of lactation) Crude Protein of Sow Milk (%) a Control 1st Litter 63.2 ab values with different letters show a significant difference (p<0,05) b BONVITAL 49 2nd Litter 50.7

38 BONVITAL in Lactation Diets Increases FAT Content in Sow s Milk Schaumann Research Centre Influence of BONVITAL in rations for sows on the content fat in the sow s milk (at the 14 th day of lactation) Fat Content of Sow Milk (%) a Control st Litter ab values with different letters show a significant difference (p<0,05) b BONVITAL nd Litter 83.5

39 Impact of BONVITAL in Lactation Feed on Sows Schaumann Research Centre Summary of Results for 1st Parity Sows BONVITAL in sows lactation feed resulted in: Higher levels of fat and crude protein in milk Calculated gross energy of milk from BONVITAL fed sows was 11.1% (5.46 MJ/l vs 4.74 MJ/l) No Significant differences in 2nd Parity milk quality

40 BONVITAL in Lactation Diets Impacts Intestinal Flora Influence of BONVITAL in lactation diets on the quantity of intestinal bacteria in the sow s faeces after the 1 st litter (at the 14 th day of lactation) 11 log CFU per kg faeces Bioburden Gram-Positive (Total) Enterobacteria Enterococci Control BONVITAL

41 BONVITAL in Lactation Diets Impacts Intestinal Flora Influence of BONVITAL in lactation diets on the quantity of intestinal bacteria in the sow s faeces after the 2nd litter (at the 14 th day of lactation) 10 log CFU per kg faeces Bioburden Gram-Positive (Total) Enterobacteria Enterococci Control BONVITAL

42 Impact of BONVITAL in Lactation Feed on Sows Schaumann Research Centre Summary of Results for 1st Parity Sows BONVITAL in sows lactation feed resulted in: Higher bacterial counts compared to control Higher levels of gram positive and Enterococci Lower levels of enterobacterials Similar results on 2nd parity sows

43 BONVITAL in Lactation Diets Impacts Intestinal Flora Influence of BONVITAL in lactation diets on the quantity of intestinal bacteria in the piglet s faeces after the 1 st litter (at the 14 th day of lactation) 10 log CFU per kg faeces Bioburden Gram-Positive (Total) Enterobacteria Enterococci Control BONVITAL

44 BONVITAL in Lactation Diets Impacts Intestinal Flora Influence of BONVITAL in lactation diets on the quantity of intestinal bacteria in the piglet s faeces after the 2nd litter (at the 14 th day of lactation) log CFU per kg faeces Bioburden Gram-Positive (Total) Enterobacteria Enterococci Control BONVITAL

45 Target Benefits of BONVITAL Sow Management Litter size Litter weight Daily weight gain Health status of sow and piglets Reduced Incidence of Scours Reduction in Medication costs Piglet Management Grower - Finisher Weight Gain Feed Consumption Feed Conversion

46 Thank you