Ryan P. Mulligan, MD Samuel B. Adams, MD Mark E. Easley, MD James K. DeOrio, MD James A. Nunley, MD

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1 Comparison of the posterior Achilles tendonsplitting approach and intramedullary nailing versus lateral transfibular approach with fixed-angle plating for tibiotalocalcaneal arthrodesis Ryan P. Mulligan, MD Samuel B. Adams, MD Mark E. Easley, MD James K. DeOrio, MD James A. Nunley, MD Department of Orthopaedic Surgery, Duke University Medical Center Durham, NC

2 None Disclosures

3 Tibiotalocalcaneal (TTC) Arthrodesis Complex operation; salvage procedure for many indications Post-traumatic arthritis Inflammatory arthropathy Charcot neuroarthropathy Acquired or neuromuscular deformity Talus AVN Nonunion of prior arthrodesis Failed TAA

4 TTC Arthrodesis Operative Techniques Approaches Lateral, transfibular Posterior, Achilles tendon splitting Anterior + sinus tarsi Medial Posterolateral Posteromedial Primary Fixation Intramedullary nail Locking plate Anatomic Blade plate Screws External fixator

5 Purpose Many case series reporting outcomes no comparative studies Compare the results of TTC arthrodesis between the PATS and IM nailing versus the LTF approach and lateral, fixed-angle plating Union Symptomatic union with revision Complications

6 Methods Retrospective review, Minimum 1 year clinical/radiographic followup PATS/IM nail and LTF/fixed-angle plate only Union defined radiographically XR: Bridging bone in three of four cortices on orthogonal images CT (44%): Bridging trabecular bone on more than fifty percent of surface at arthrodesis site

7 Results 66 patients; 38 PATS/IM nail, 28 LTF/fixed-angle plate Overall PATS / IM nail (38) LTF / Fixed-angle plating (28) p Age (years) 58.9 (30-86) 58.8 (30-86) 59.2 (41-78) 0.89 BMI 33.6 ( ) Follow-up (months) 73.4 (12-123) 62.1 (12-72) 88.4 (12-123) 0.01 Gender 29 M / 37 L 16 M / 22 F 13 M / 15 F 0.80 Laterality 40 R / 26 L 22 R / 16 L 18 R / 10 L 0.62 Overall PATS / IM nail (38) LTF / Fixed-angle plating (28) p Diabetes mellitus 16 (24%) 5 (13%) 11 (39%) 0.02 Tobacco use 10 (15%) 6 (16%) 4 (14%) 1.00 Peripheral vascular disease 7 (11%) 4 (11%) 3 (11%) 1.00 Chronic corticosteroid use 9 (14%) 3 (8%) 6 (21%) 0.15 Presence of ulcer 4 (6%) 1 (3%) 3 (11%) 0.30 Overall PATS / IM nail (38) LTF / Fixed-angle plating (28) p Supplementary fixation (any) 46 (70%) 20 (53%) 26 (93%) <0.01 Screws 42 (64%) 16 (42%) 26 (93%) <0.01 Plates 9 (14%) 4 (11%) 5 (18%) 0.48 Supplementary graft material (any) 64 (97%) 37 (97%) 27 (96%) 1.00 Allograft 55 (83%) 34 (89%) 21 (75%) 0.18 Femoral head 20 (30%) 18 (47%) 2 (7%) <0.01 Orthobiologics 49 (74%) 28 (74%) 21 (75%) 1.00

8 Results 71 % union rate 76% PATS/IM nail, 64% LTF/fixed-angle plate (p =.41) PATS/IM nail nonunion: 7 TT, 2 TT/ST LTF/fixed-angle plate nonunion: 6 TT, 1 ST, 3 TC 12% revision rate for symptomatic nonunion 16% PATS/IM nail, 7% LTF/fixed-angle plate (p=.45) Stage 4 flatfoot 4 (6%) Prior nonunion 16 (24%) Indications Talus AVN 7 (10%) Posttraumatic 11 (17%) Endstage arthritis 11 (17%) Neuroart hropathy 8 (12%) Failed TAA 9 (14%)

9 Results PATS/IM nail 4 superficial wound complications No nerve injury 2 stress fractures (non-op) 3 elective HWR 1 amputation LTF/fixed-angle plate 4 superficial wound complications 1 sural nerve irritation 2 stress fractures (non-op) 5 elective HWR 1 amputation No significant difference with any complication

10 Conclusion Acceptable union rates and similar complication rates with either technique in a complex patient population Prior incisions, preexisting hardware or deformity may preclude techniques, but other strategies can be executed with similar success rates Future studies should evaluate coronal deformity correction, functional outcomes, and cost

11 References Acosta R, Ushiba J, Cracchiolo A. The results of a primary and staged pantalar arthrodesis and tibiotalocalcaneal arthrodesis in adult patients. Foot Ankle Int. 2000;21(3): doi: / Ahmad J, Pour AE, Raikin SM. The modified use of a proximal humeral locking plate for tibiotalocalcaneal arthrodesis. Foot Ankle Int Sep;28(9): Alfahd U, Roth SE, Stephen D, Whyne CM. Biomechanical comparison of intramedullary nail and blade plate fixation for tibiotalocalcaneal arthrodesis. J Orthop Trauma Nov-Dec;19(10): Attinger CE, Evans KK, Bulan E, Blume P, Cooper P. Angiosomes of the foot and ankle and clinical implications for limb salvage: reconstruction, incisions, and revascularization. Plast Reconstr Surg. 2006;117(suppl):261S-293S. doi: /01.prs Bibbo C, PatelDV, Haskell MD. Recombinant bone morphogenetic protein-2 (rhbmp-2) in high-risk ankle and hindfoot fusions. Foot Ankle Int 30(7): , Boer R, Mader K, Pennig D, Verheyen CC. 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Tibiotalocalcaneal arthrodesis: a biomechanical analysis of the rotational stability of the Biomet Ankle Arthrodesis Nail. Foot Ankle Int Sep;22(9): Means KR, Parks BG, Nguyen A, Schon LC. Intramedullary nail fixation with posterior-to-anterior compared to transverse distal screw placement for tibiotalocalcaneal arthrodesis: a biomechanical investigation. Foot Ankle Int Dec;27(12): Mendicino RW, Catanzariti AR, Saltrick KR, Dombek MF, Tullis BL, Statler TK, Johnson BM. Tibiotalocalcaneal arthrodesis with retrograde intramedullary nailing. J Foot Ankle Surg Mar-Apr;43(2):82-6. Millett PJ, O'Malley MJ, Tolo ET, Gallina J, Fealy S, Helfet DL. Tibiotalocalcaneal fusion with a retrograde intramedullary nail: clinical and functional outcomes. Am J Orthop (Belle Mead NJ) Sep;31(9): Mückley T, Klos K, Drechsel T, Beimel C, Gras F, Hofmann GO. Short-term outcome of retrograde tibiotalocalcaneal arthrodesis with a curved intramedullary nail. 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