Lower Extremity Alignment: Genu Varum / Valgum

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1 Lower Extremity Alignment: Genu Varum / Valgum Arthur B Meyers, MD Nemours Children s Hospital & Health System Associate Professor of Radiology, University of Central Florida Clinical Associate Professor of Pediatric Radiology, Florida State University

2 Disclosures Author/editor for Amirsys/Elsevier, receiving royalties

3 Outline Definitions Normal knee alignment during development Genu Varum Genu Valgum

4 Outline Definitions Normal knee alignment during development Genu Varum Genu Valgum

5 Varus Valgus

6 Varus Distal to angulation Valgus Distal to angulation

7 Varus Distal to angulation Apex of angulation Valgus Distal to angulation Apex of angulation

8 Varus Distal to angulation Apex of angulation Valgus Distal to angulation Apex of angulation Midline Right Left

9 Varus Distal to angulation Apex of angulation Valgus Distal to angulation Apex of angulation Midline Right Left

10 Varus Distal to angulation deviates to midline Apex of angulation Valgus Distal to angulation Apex of angulation Midline Right Left

11 Varus Distal to angulation deviates to midline Apex of angulation points from midline Valgus Distal to angulation Apex of angulation Midline Right Left

12 Varus Distal to angulation deviates to midline Apex of angulation points from midline Valgus Distal to angulation Apex of angulation Midline Right Left

13 Varus Distal to angulation deviates to midline Apex of angulation points from midline Valgus Distal to angulation Apex of angulation Midline Right Left

14 Varus Distal to angulation deviates to midline Apex of angulation points from midline Valgus Distal to angulation deviates from midline Apex of angulation Midline Right Left

15 Varus Distal to angulation deviates to midline Apex of angulation points from midline Valgus Distal to angulation deviates from midline Apex of angulation points to midline Midline Right Left

16 Normal Knee Alignment

17 Tibiofemoral angle

18 Tibiofemoral angle On standing radiograph

19 Tibiofemoral angle On standing radiograph Angle between lines parallel to: Mid femoral diaphysis Mid tibial diaphysis

20 Tibiofemoral angle Salenius P, et al. Development of the tibiofemoral angle in children. J Bone Joint Surg Am Mar;57(2):

21 Tibiofemoral angle 0-1 yr varus Salenius P, et al. Development of the tibiofemoral angle in children. J Bone Joint Surg Am Mar;57(2):

22 Tibiofemoral angle 0-1 yr varus 1-2 yrs 0-10 varus Salenius P, et al. Development of the tibiofemoral angle in children. J Bone Joint Surg Am Mar;57(2):

23 Tibiofemoral angle 0-1 yr varus 1-2 yrs 0-10 varus 2-3 yrs 0-10 valgus Salenius P, et al. Development of the tibiofemoral angle in children. J Bone Joint Surg Am Mar;57(2):

24 Tibiofemoral angle 0-1 yr varus 1-2 yrs 0-10 varus 2-3 yrs 0-10 valgus 3-4 yrs 8-12 valgus Salenius P, et al. Development of the tibiofemoral angle in children. J Bone Joint Surg Am Mar;57(2):

25 Tibiofemoral angle 0-1 yr varus 1-2 yrs 0-10 varus 2-3 yrs 0-10 valgus 3-4 yrs 8-12 valgus 4-13 yrs ~6 valgus Salenius P, et al. Development of the tibiofemoral angle in children. J Bone Joint Surg Am Mar;57(2):

26 Developmental changes 1-year-old 3-year-old 13-year-old

27 Developmental changes 1-year-old 3-year-old 13-year-old Varus

28 Developmental changes 1-year-old 3-year-old 13-year-old Varus Valgus

29 Developmental changes 1-year-old 3-year-old 13-year-old Varus Valgus Mild Valgus

30 Genu varum

31 Genu varum / Bowing Angular deformity at the knee Apex of the deformity points away from the midline. Leg (below knee) deviates toward the midline. Common referral to orthopedic clinics Up-to-date, 2017

32 Genu varum / Bowing Angular deformity at the knee Apex of the deformity points away from the midline. Leg (below knee) deviates toward the midline. Common referral to orthopedic clinics Up-to-date, 2017

33 Genu varum / Bowing Differential diagnosis: Exaggerated physiologic bowing Blount disease Abnormal bones Metabolic bone disease Skeletal dysplasias Physeal/metaphyseal injury Up-to-date, 2017

34 Genu varum / Bowing Differential diagnosis: Exaggerated physiologic bowing Blount disease Abnormal bones Metabolic bone disease Skeletal dysplasias Physeal/metaphyseal injury Up-to-date, 2017

35 Exaggerated Physiologic Bowing

36 Exaggerated Physiologic Bowing Exaggeration of the normal age-related bowing Birth 2yrs Bilateral & symmetric Normal stature <2 sd of mean height for age & sex

37 Exaggerated Physiologic Bowing Radiographs 23-month-old

38 Exaggerated Physiologic Bowing Radiographs Varus angulation 20 varus 1-2 years nl = 0-10 varus 23-month-old

39 Exaggerated Physiologic Bowing Radiographs Varus angulation Medial tibial metaphysis Mild enlargement / depression Mild beaking No fragmentation 23-month-old

40 Exaggerated Physiologic Bowing Radiographs Varus angulation Medial tibial metaphysis Mild enlargement / depression Mild beaking No fragmentation

41 Exaggerated Physiologic Bowing Radiographs Varus angulation Medial tibial metaphysis Mild enlargement / depression Mild beaking No fragmentation Mild thickening of the medial tibal cortex

42 Exaggerated Physiologic Bowing Radiographs Varus angulation Medial tibial metaphysis Mild enlargement / depression Mild beaking No fragmentation Mild thickening of the medial tibal cortex Normal metaphysealdiaphyseal angle

43 Metaphyseal Diaphyseal Angle MDA the angle between:

44 Metaphyseal Diaphyseal Angle MDA the angle between: Line drawn along the proximal tibial metaphysis

45 Metaphyseal Diaphyseal Angle MDA the angle between: Line drawn along the proximal tibial metaphysis Line perpendicular to the long axis of the tibia 10

46 Metaphyseal Diaphyseal Angle MDA the angle between: Line drawn along the proximal tibial metaphysis Line perpendicular to the long axis of the tibia MDA values Physiologic bowing MDA typically < 11 Blount disease MDA typically > 11 Borderline

47 Exaggerated Physiologic Bowing Initial 7 months later

48 Blount Disease

49 Blount Disease (Tibia Vara) Developmental disorder with disrupted endochondral ossification of the medial proximal tibial physis Abnormal development of the proximal, medial tibial epiphysis/metaphysis

50 Blount Disease (Tibia Vara) Developmental disorder with disrupted endochondral ossification of the medial proximal tibial physis Abnormal development of the proximal, medial tibial epiphysis/metaphysis Angular deformites: Genu varum Procurvatum Internal rotation of the tibia

51 Blount Disease (Tibia Vara) Developmental disorder with disrupted endochondral ossification of the medial proximal tibial physis Abnormal development of the proximal, medial tibial epiphysis/metaphysis Angular deformites: Genu varum Procurvatum Internal rotation of the tibia Limb shortening Leg length discrepancy if asymmetric or unilateral

52 Blount Disease Risk factors: Early ambulation Obesity African or Scandinavian descent

53 Blount Disease Risk factors: Early ambulation Obesity African or Scandinavian descent Etiology: unknown (likely multifactorial) Risk factors of early ambulation & obesity suggest biomechanical component

54 Blount Disease Risk factors: Early ambulation Obesity African or Scandinavian descent Etiology: unknown (likely multifactorial) Risk factors of early ambulation & obesity suggest biomechanical component Two forms: Infantile or early onset < 4 years Late onset >4 yrs Juvenile 4-10 yrs Adolescent >10 yrs

55 Langenskiöld Classification of Early Onset Blount Disease Sabharwal S. Blount Disease. J Bone Joint Surg Am, 2009 Jul 01; 91 (7):

56 Radiographic findings

57 Radiographic findings Standing AP radiograph

58 Radiographic findings Standing AP radiograph Genu Varum 15-month-old

59 Radiographic findings Standing AP radiograph Genu Varum Tibiofemoral angles ~ years nl = 0-10 varus 15-month-old

60 Radiographic findings Genu Varum (Standing AP radiograph) Increased metaphysealdiaphyseal angle (MDA) Physiologic bowing MDA typically < 11 Blount disease MDA typically > 11 Borderline

61 Radiographic findings Genu Varum (Standing AP radiograph) Increased metaphysealdiaphyseal angle (MDA) Physiologic bowing MDA typically < 11 Blount disease MDA typically > 11 Borderline

62 Radiographic findings Genu Varum (Standing AP radiograph) Increased metaphyseal-diaphyseal angle (MDA) 1 year later

63 Radiographic findings Genu Varum (Standing AP radiograph) Increased metaphyseal-diaphyseal angle (MDA) Widened medial tibial physis Medial tibial metaphysis Depression Beaked Irregular / fragmented

64 Radiographic findings Genu Varum (Standing AP radiograph) Increased metaphyseal-diaphyseal angle (MDA) Widened medial tibial physis Medial tibial metaphysis Depression Beaked Irregular / fragmented

65 Radiographic findings Genu Varum (Standing AP radiograph) Increased metaphyseal-diaphyseal angle (MDA) Widened medial tibial physis Medial tibial metaphysis Depression Beaked Irregular / fragmented

66 Radiographic findings Genu Varum (Standing AP radiograph) Increased metaphyseal-diaphyseal angle (MDA) Widened medial tibial physis Medial tibial metaphysis Depression Beaked Irregular / fragmented

67 Radiographic findings Genu Varum (Standing AP radiograph) Increased metaphyseal-diaphyseal angle (MDA) Widened medial tibial physis Medial tibial metaphysis Depression Beaked Irregular / fragmented

68 Radiographic findings Genu Varum (Standing AP radiograph) Increased metaphyseal-diaphyseal angle (MDA) Widened medial tibial physis Medial tibial metaphysis Depression Beaked Irregular / fragmented

69 Radiographic findings Genu Varum (Standing AP radiograph) Increased metaphyseal-diaphyseal angle (MDA) Widened medial tibial physis Medial tibial metaphysis Depression Beaked Irregular / fragmented Medial tibial epiphysis Abnormal/delayed ossification

70 Radiographic findings Angular deformities: Genu varum Lateral subluxation of the tibia Procurvatum

71 Radiographic findings Angular deformities: Genu varum Lateral subluxation of the tibia Procurvatum

72 Radiographic findings Angular deformities: Genu varum Lateral subluxation of the tibia Procurvatum Lateral radiograph 10 year old

73 Radiographic findings Angular deformities: Genu varum Lateral subluxation of the tibia Procurvatum Lateral radiograph

74 Radiographic findings Angular deformities: Genu varum Lateral subluxation of the tibia Procurvatum Lateral radiograph

75 MRI Findings

76 MRI Findings Medial Proximal Tibia

77 MRI Findings Medial Proximal Tibia Physis / metaphysis Physeal widening

78 MRI Findings Medial Proximal Tibia Physis / metaphysis Physeal widening Downsloping / irregularity

79 MRI Findings Medial Proximal Tibia Physis / metaphysis Physeal widening Downsloping / irregularity

80 MRI Findings Medial Proximal Tibia Physis / metaphysis Physeal widening Downsloping / irregularity Physeal Bridge

81 MRI Findings Medial Proximal Tibia Physis / metaphysis Physeal widening Downsloping / irregularity Physeal Bridge

82 MRI Findings Medial Proximal Tibia Physis / metaphysis Physeal widening Downsloping / irregularity Physeal Bridge Epiphyseal cartilage Far medial thick Central medial - thin Increased joint space

83 MRI Findings Medial Proximal Tibia Physis / metaphysis Physeal widening Downsloping / irregularity Physeal Bridge Epiphyseal cartilage Far medial thick Central medial - thin Increased joint space

84 MRI Findings Medial Proximal Tibia Physis / metaphysis Physeal widening Downsloping / irregularity Physeal Bridge Epiphyseal cartilage Far medial thick Central medial - thin Increased joint space Ho-Fung V, et al. Pediatr Radiol (2013)

85 MRI Findings Medial Proximal Tibia Physis / metaphysis Physeal widening Downsloping / irregularity Physeal Bridge Epiphyseal cartilage Far medial thick Central medial - thin Increased joint space Ho-Fung V, et al. Pediatr Radiol (2013)

86 MRI Findings Medial Proximal Tibia Physis / metaphysis Physeal widening Downsloping / irregularity Physeal Bridge Epiphyseal cartilage Far medial thick Central medial - thin Increased joint space Medial Meniscus Thickened +/- abnormal signal

87 MRI Findings Medial Proximal Tibia Physis / metaphysis Physeal widening Downsloping / irregularity Physeal Bridge Epiphyseal cartilage Far medial thick Central medial - thin Increased joint space Medial Meniscus Thickened +/- abnormal signal

88 MRI Findings Medial Proximal Tibia Physis / metaphysis Physeal widening Downsloping / irregularity Physeal Bridge Epiphyseal cartilage Far medial thick Central medial - thin Increased joint space Medial Meniscus Thickened +/- abnormal signal

89 MRI Findings Medial Proximal Tibia Physis / metaphysis Physeal widening Downsloping / irregularity Physeal Bridge Epiphyseal cartilage Far medial thick Central medial - thin Increased joint space Medial Meniscus Thickened +/- abnormal signal Angular deformities Medial and posterior downsloping

90 MRI Findings Other findings:

91 MRI Findings Other findings: Lateral proximal tibia Physis - widened/irregular Metaphysis

92 MRI Findings Other findings: Lateral proximal tibia Physis - widened/irregular Metaphysis

93 MRI Findings Other findings: Lateral proximal tibia Physis Metaphysis - irregular

94 MRI Findings Other findings: Lateral proximal tibia Physis Metaphysis Femur Epiphysis Metaphysis Physis

95 MRI Findings Other findings: Lateral proximal tibia Physis Metaphysis Femur Epiphysis Metaphysis Physis Ho-Fung V, et al. Pediatr Radiol (2013)

96 MRI Findings Other findings: Lateral proximal tibia Physis Metaphysis Femur Epiphysis Metaphysis Physis Ho-Fung V, et al. Pediatr Radiol (2013)

97 MRI Findings Other findings: Lateral proximal tibia Physis Metaphysis Femur Epiphysis Metaphysis Physis Soft tissues Perichondral menbrane Thickened ACL - laxity Ho-Fung V, et al. Pediatr Radiol (2013)

98 Treatment of Blount Disease

99 Treatment Conservative Observation Orthosis

100 Treatment Conservative Observation Orthosis Surgery Lateral hemiepiphyseodesis Resection of a physeal bar Realignment osteotomy

101 Treatment Conservative Observation Orthosis Surgery Lateral hemiepiphyseodesis Resection of a physeal bar Realignment osteotomy

102 Treatment Conservative Observation Orthosis Surgery Lateral hemiepiphyseodesis Resection of a physeal bar Realignment osteotomy

103 Treatment Conservative Observation Orthosis Surgery Lateral hemiepiphyseodesis Resection of a physeal bar Realignment osteotomy

104 Genu varum / Bowing Differential diagnosis: Exaggerated physiologic Blount disease Abnormal bones Metabolic bone disease Skeletal dysplasias Physeal/metaphyseal injury

105 Genu varum / Bowing Differential diagnosis: Exaggerated physiologic Blount disease Abnormal bones Metabolic bone disease Skeletal dysplasias Physeal/metaphyseal injury

106 Genu varum / Bowing Differential diagnosis: Exaggerated physiologic Blount disease Abnormal bones Metabolic bone disease Rickets Skeletal dysplasias Physeal/metaphyseal injury 3-year-old girl with rickets

107 Genu varum / Bowing Differential diagnosis: Exaggerated physiologic Blount disease Abnormal bones Metabolic bone disease Rickets Skeletal dysplasias Physeal/metaphyseal injury 3-year-old girl with rickets

108 Genu varum / Bowing Differential diagnosis: Exaggerated physiologic Blount disease Abnormal bones Metabolic bone disease Skeletal dysplasias Achondroplasia Physeal/metaphyseal injury 4-year-old boy with achondroplasia

109 Genu varum / Bowing Differential diagnosis: Exaggerated physiologic Blount disease Abnormal bones Metabolic bone disease Skeletal dysplasias Achondroplasia Physeal/metaphyseal injury 5-year-old boy with achondroplasia

110 Genu varum / Bowing Differential diagnosis: Exaggerated physiologic Blount disease Abnormal bones Metabolic bone disease Skeletal dysplasias Physeal/metaphyseal injury

111 Physeal/metaphyseal injury Chronic repetitive (overuse) injuries Physeal injury -> Bridge

112 Physeal/metaphyseal injury Chronic repetitive (overuse) injuries Physeal injury -> Bridge Can cause genu varum or valgum Depending on location of injury

113 Physeal/metaphyseal injury Chronic repetitive (overuse) injuries Physeal injury -> Bridge

114 Physeal/metaphyseal injury Chronic repetitive (overuse) injuries > Disruption of metaphyseal blood supply > Disruption of endochondral ossification 14-year-old competitive soccer player

115 Physeal/metaphyseal injury Chronic repetitive (overuse) injuries > Disruption of metaphyseal blood supply > Disruption of endochondral ossification 14-year-old competitive soccer player

116

117 2-month follow up after rest

118 Physeal/metaphyseal injury 11 years Laor T. et. al. Physeal Widening in the Knee Due to Stress Injury in Child Athletes. AJR 2006

119 Physeal/metaphyseal injury 11 years Laor T. et. al. Physeal Widening in the Knee Due to Stress Injury in Child Athletes. AJR 2006

120 Physeal/metaphyseal injury 11 years 2 year follow up Laor T. et. al. Physeal Widening in the Knee Due to Stress Injury in Child Athletes. AJR 2006

121 Physeal/metaphyseal injury 11 years 17 years Laor T. et. al. Physeal Widening in the Knee Due to Stress Injury in Child Athletes. AJR 2006

122 Genu valgum

123 Genu Valgum / Knock Knees Angular deformity at the knee Apex of the deformity points toward the midline. Leg (below knee) deviates away from the midline. Common referral to orthopedic clinics Up-to-date, 2017

124 Genu Valgum / Knock Knees Angular deformity at the knee Apex of the deformity points toward the midline. Leg (below knee) deviates away from the midline. Common referral to orthopedic clinics Up-to-date, 2017

125 Genu Valgum Differential diagnosis: Exaggerated physiologic Physeal/metaphyseal injuries Abnormal bones Tumors Up-to-date, 2017

126 Genu Valgum Differential diagnosis: Exaggerated physiologic Physeal/metaphyseal injuries Abnormal bones Tumors Up-to-date, 2017

127 Exaggerated Physiologic Valgum Exaggeration of the normal age-related valgus Age: 3-5 yrs Bilateral & symmetric Normal stature Absent or mild symptoms 3-years

128 Exaggerated Physiologic Valgum Exaggeration of the normal age-related valgus Age: 3-5 yrs Bilateral & symmetric Normal stature Absent or mild symptoms Valgus 3-4 yrs nl = 8-12

129 Exaggerated Physiologic Valgum Exaggeration of the normal age-related valgus Age: 3-5 yrs Bilateral & symmetric Normal stature Absent or mild symptoms 3-years 9-years

130 Genu Valgum Differential diagnosis: Exaggerated physiologic Physeal/metaphyseal injuries Chronic repetitive (overuse) injuries Physeal injury -> Bridge Cozen Phenomenon Abnormal bones Tumors

131 Physeal Injury -> Bridge Causes Trauma most common cause Other causes: Infection Radiation Medications Tumors

132 Risk Factors of Bridge Formation Severity of injury Growth potential Younger / less skeletal maturity Anatomic site Contour of the physis & growth rate

133 Risk Factors of Bridge Formation Anatomic site:

134 Risk Factors of Bridge Formation Anatomic site: Distal radius Distal femur

135 Risk Factors of Bridge Formation Anatomic site: Distal radius Distal femur

136 Risk Factors of Bridge Formation Anatomic site: Distal radius smooth, uniplanar Distal femur

137 Risk Factors of Bridge Formation Anatomic site: Distal radius smooth, uniplanar Distal femur - undulating, multiplanar physis

138 Risk Factors of Bridge Formation Anatomic site: Distal radius smooth, uniplanar Distal femur - undulating, multiplanar physis

139 Risk Factors of Bridge Formation Anatomic site: Distal radius smooth, uniplanar Distal femur - undulating, multiplanar physis Physeal fx: Radius >>> Femur % -> Bridges : Femur >>> Radius

140 10 year old girl

141 9 month follow up 10-year-old girl with history of a distal femur fracture

142 Imaging Physeal Bridges Radiographs Directly visualized Indirect evidence Narrowing of the physis Growth recovery lines 10-year-old girl with history of a distal femur fracture

143 Imaging Physeal Bridges Radiographs Directly visualized Indirect evidence Narrowing of the physis Growth recovery lines 10-year-old girl with history of a distal femur fracture

144 Imaging Physeal Bridges Radiographs Directly visualized Indirect evidence Narrowing of the physis Growth recovery lines 10-year-old girl with history of a distal femur fracture

145 Imaging Physeal Bridges Radiographs Directly visualized Indirect evidence Narrowing of the physis Growth recovery lines Normal - parallel physis 10-year-old girl with history of a distal femur fracture

146 Imaging Physeal Bridges Radiographs Directly visualized Indirect evidence Narrowing of the physis Growth recovery lines Normal - parallel physis 10-year-old girl with history of a distal femur fracture

147 Imaging Physeal Bridges Radiographs Directly visualized Indirect evidence Narrowing of the physis Growth recovery lines Normal - parallel physis Abnormal Oblique, converge at physeal bridge 10-year-old girl with history of a distal femur fracture

148 Imaging Physeal Bridges Radiographs Directly visualized Indirect evidence Narrowing of the physis Growth recovery lines Normal - parallel physis Abnormal Oblique, converge at physeal bridge 10-year-old girl with history of a distal femur fracture

149 Imaging Physeal Bridges Radiographs Directly visualized Indirect evidence Narrowing of the physis Growth recovery lines Normal - parallel physis Abnormal Oblique, converge at physeal bridge 10-year-old girl with history of a distal femur fracture

150 Treatment of Physeal Bridges Resection

151 Treatment of Physeal Bridges Resection considered if: Existing or developing deformity

152 Treatment of Physeal Bridges Resection considered if: Existing or developing deformity > 2 years or 2 cm of remaining growth

153 Treatment of Physeal Bridges Resection considered if: Existing or developing deformity > 2 years or 2 cm of remaining growth Bridge occupies < 50% of the physeal area GRE

154 Treatment of Physeal Bridges Resection considered if: Existing or developing deformity > 2 years or 2 cm of remaining growth Bridge occupies < 50% of the physeal area GRE

155 Treatment of Physeal Bridges Resection considered if: Existing or developing deformity > 2 years or 2 cm of remaining growth Bridge occupies < 50% of the physeal area GRE

156 Treatment of Physeal Bridges Resection considered if: Existing or developing deformity > 2 years or 2 cm of remaining growth Bridge occupies < 50% of the physeal area Total Area of Physis

157 Treatment of Physeal Bridges Resection considered if: Existing or developing deformity > 2 years or 2 cm of remaining growth Bridge occupies < 50% of the physeal area Area of Bridge _ Total Area of Physis

158 Treatment of Physeal Bridges Resection considered if: Existing or developing deformity > 2 years or 2 cm of remaining growth Bridge occupies < 50% of the physeal area Area of Bridge _ Total Area of Physis = % of Physis Occupied by Bridge

159 Physeal Bridge Treatment options: Bridge resection Osteotomy to correct angular deformities

160 Physeal Bridge Treatment options: Bridge resection Osteotomy to correct angular deformities Contralateral epiphysiodesis

161

162

163

164

165

166

167

168 Genu Valgum Differential diagnosis: Exaggerated physiologic Physeal/metaphyseal injuries Chronic repetitive (overuse) injuries Physeal injury -> Bridge Cozen Phenomenon Abnormal bones Tumors

169 Genu Valgum Differential diagnosis: Exaggerated physiologic Physeal/metaphyseal injuries Chronic repetitive (overuse) injuries Physeal injury -> Bridge Cozen Phenomenon Valgus deformity s/p proximal tibial fx Despite good alignment at fx site Burton A, et al. Cozen's phenomenon revisited. J Pediatr Orthop B Nov;25(6):

170 Genu Valgum Differential diagnosis: Exaggerated physiologic Physeal/metaphyseal injuries Chronic repetitive (overuse) injuries Physeal injury -> Bridge Cozen Phenomenon Valgus deformity s/p proximal tibial fx Despite good alignment at fx site Burton A, et al. Cozen's phenomenon revisited. J Pediatr Orthop B Nov;25(6):

171 Genu Valgum Differential diagnosis: Exaggerated physiologic Physeal/metaphyseal injuries Chronic repetitive (overuse) injuries Physeal injury -> Bridge Cozen Phenomenon Valgus deformity s/p proximal tibial fx Despite good alignment at fx site Burton A, et al. Cozen's phenomenon revisited. J Pediatr Orthop B Nov;25(6):

172 Genu Valgum Differential diagnosis: Exaggerated physiologic Physeal/metaphyseal injuries Chronic repetitive (overuse) injuries Physeal injury -> Bridge Cozen Phenomenon Valgus deformity s/p proximal tibial fx Despite good alignment at fx site Burton A, et al. Cozen's phenomenon revisited. J Pediatr Orthop B Nov;25(6):

173 Genu Valgum Differential diagnosis: Exaggerated Physiologic Physeal/metaphyseal injuries Chronic repetitive (overuse) injuries Physeal injury -> Bridge Cozen Phenomenon Most accepted theory Fx -> vascularity -> medial metaphyseal overgrowth Burton A, et al. Cozen's phenomenon revisited. J Pediatr Orthop B Nov;25(6):

174 Genu Valgum Differential diagnosis: Exaggerated Physiologic Physeal/metaphyseal injuries Abnormal bones Tumors

175 Genu Valgum Differential diagnosis: Exaggerated Physiologic Physeal/metaphyseal injuries Abnormal bones Metabolic bone disease Rickets 5-year-old boy with rickets

176 Genu Valgum Differential diagnosis: Exaggerated Physiologic Physeal/metaphyseal injuries Abnormal bones Metabolic bone disease Rickets 5-year-old boy with rickets

177 Genu Valgum Differential diagnosis: Exaggerated Physiologic Physeal/metaphyseal injuries Abnormal bones Metabolic bone disease Rickets 5-year-old boy with rickets

178 Genu Valgum Differential diagnosis: Exaggerated Physiologic Physeal/metaphyseal injuries Abnormal bones Metabolic bone disease Lysosomal storage disease Mucopolysaccharidosis IV (Morquio syndrome) Mucopolysaccharidosis IV

179 Genu Valgum Differential diagnosis: Exaggerated Physiologic Physeal/metaphyseal injuries Abnormal bones Metabolic bone disease Lysosomal storage disease Mucopolysaccharidosis IV (Morquio syndrome) Mucopolysaccharidosis IV

180 Genu Valgum Differential diagnosis: Exaggerated Physiologic Physeal/metaphyseal injuries Abnormal bones Metabolic bone disease Lysosomal storage disease Mucopolysaccharidosis IV (Morquio syndrome) Mucopolysaccharidosis IV

181 Genu Valgum Differential diagnosis: Exaggerated Physiologic Physeal/metaphyseal injuries Abnormal bones Metabolic bone disease Lysosomal storage disease Skeletal dysplasias Chondroectodermal dysplasia (Ellisvan Crevald) Ellis-van Crevald

182 Genu Valgum Differential diagnosis: Exaggerated Physiologic Physeal/metaphyseal injuries Abnormal bones Metabolic bone disease Lysosomal storage disease Skeletal dysplasias Chondroectodermal dysplasia (Ellisvan Crevald) Ellis-van Crevald

183 Genu Valgum Differential diagnosis: Exaggerated Physiologic Physeal/metaphyseal injuries Abnormal bones Metabolic bone disease Lysosomal storage disease Skeletal dysplasias Chondroectodermal dysplasia (Ellisvan Crevald) Ellis-van Crevald

184 Genu Valgum Differential diagnosis: Exaggerated Physiologic Physeal/metaphyseal injuries Abnormal bones Tumors Osteochondromas / Mutliple hereditary exostosis

185 Genu Valgum Differential diagnosis: Exaggerated Physiologic Physeal/metaphyseal injuries Abnormal bones Tumors Osteochondromas / Mutliple hereditary exostosis

186 Summary

187 Summary Normal developmental changes at the knee 1-year-old 3-year-old Varus Valgus

188 Summary Genu Varum Exaggerated Physiologic Blount Abnormal Bones Injuries Genu Valgum Exaggerated Physiologic Physeal/metaphyseal injuries Abnormal bones Tumors Physiologic Morquio Blount Osteochondromas

189 References Salenius P, et al. Development of the tibiofemoral angle in children. J Bone Joint Surg Am Mar;57(2): Sabharwal S. Blount disease. J Bone Joint Surg Am Jul;91(7): Ho-Fung V, et al. MRI evaluation of the knee in children with infantile Blount disease: tibial and extra-tibial findings. Pediatr Radiol Oct;43(10): Burton A, et al. Cozen's phenomenon revisited. J Pediatr Orthop B Nov;25(6): Laor T, et al. Physeal widening in the knee due to stress injury in child athletes. AJR Am J Roentgenol May;186(5):

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