IS A TEAM SPORT. The Promise of Multimodal Imaging and Cross-Institutional Collaborations. January 26, :30am 4:00pm

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January 26, 2018 7:30am 4:00pm T. Boone Pickens Auditorium, NG3.

1 January 26, :30am 4:00pm T. Boone Pickens Auditorium, NG3.112 Neuroimaging IS A TEAM SPORT The Promise of Multimodal Imaging and Cross-Institutional Collaborations

2 Neuroimaging IS A TEAM SPORT UTSW North Campus UTD Campus

3 Welcome Neuroimaging IS A TEAM SPORT This symposium will share the results of successful neuroimaging research projects that have evolved between researchers at The University of Texas Southwestern Medical Center and The University of Texas at Dallas. As the symposium title suggests, neuroimaging is a team sport that requires collaborations across a diverse set of disciplines, including bioengineering, cognitive neuroscience, neurology, neuropsychology, neurological surgery, psychiatry, and radiology. The joint usage of the Advanced Imaging Research Center by researchers at the two universities has led naturally to the development of cross-institutional projects. These collaborations are critical for unleashing the potential that neuroimaging research has to remediate human suffering as well as to provide an understanding of nature s most complex creation the human brain. We are hopeful that this symposium will lay the groundwork for significant future successes. We welcome all of you to this symposium and celebrate the collaborative spirit of the neuroimaging community at UTSW and. Thank you for joining us! The Conference Organizers Denise C. Park, PhD The University of Texas at Dallas Joseph Madjian, MD The University of Texas Southwestern Medical Center Rathan Subramaniam, MD, PhD The University of Texas Southwestern Medical Center

4 Program 7:30 REGISTRATION AND BREAKFAST INTRODUCTION 8:00 Daniel K. Podolsky, MD, President, The University of Texas Southwestern Medical Center Richard C. Benson, PhD, President, The University of Texas at Dallas SESSION I. COLLABORATIVE PROJECTS THAT WORK Session Chair: Rathan Subramaniam, MD, PhD, Conference Organizer 8:20 Effects of Marijuana Use on Brain Structure and Function Speaker: Francesca Filbey, PhD,, Partner: Bryon Adinoff, MD, Department of Psychiatry, UTSW 8:35 Intracranial Recordings from the Hippocampus: A Collaboration of Neurosurgery and Cognitive Neuroscience Speaker: Bradley Lega, MD, Department of Neurological Surgery, UTSW Partner: Michael Rugg, PhD,, 8:50 Hippocampal Function and Mild Cognitive Impairment Speaker: Michael Rugg, PhD,, Partner: C. Munro Cullum, MD, Department of Psychology, UTSW 9:05 Reclassifying Diagnostic Categories of Mental Illness: Neuroimaging and Data Driven Approaches Speaker: Elena Ivleva, MD, Department of Psychiatry, UTSW Partner: Michael Rugg, PhD,, 9:20 New Approaches to Brain Stimulation for Clinical Purposes Speaker: John Hart, Jr., MD, Department of Neurology and Neurotherapeutics, UTSW &, 9:35 Multiple Sclerosis and Cognition Speaker: Bart Rypma, PhD,, Partner: Darin Okuda, MD, Department of Neurology and Neurotherapeutics, UTSW 9:50 Deep Learning Approaches to Large Data Sets Speaker: Albert Montillo, PhD, Department of Bioinformatics, UTSW Partner: Denise Park, PhD,, 10:05 Large-Scale Brain Network Dysfunction as a Biomarker of Depression Sub-Types Speaker: Gagan Wig, PhD,, Partner: Madhukar Trivedi, MD, Department of Psychiatry, UTSW 10:20 Break

5 Program SESSION II. AMYLOID AND TAU IMAGING Session Chair: Joseph Maldjian, MD, Conference Organizer 10:30 Tau PET and Alzheimer s Disease: Possible Promise and Pitfalls Speaker: Marc Diamond, MD, Department of Neurology and Neurotherapeutics, UTSW 11:00 What is Normal Cognitive Aging and What Does Amyloid and Tau Imaging Tell Us About It? Speaker: Denise Park, PhD,, 11:30 KEYNOTE SPEAKER Amyloid, Tau and Models of Preclinical Alzheimer s Disease: Urgent Questions for Future Research Speaker: Clifford Jack, MD, Department of Radiology, Mayo Clinic 12:30 Break for Lunch SESSION III. RESOURCES FOR THE IMAGING COMMUNITY Session Chair: Denise Park, PhD, Conference Organizer 1:30 The NIA Alzheimer s Disease Center Speaker: Marc Diamond, MD, Department of Neurology and Neurotherapeutics, UTSW 1:40 Imaging Resources Available at the Advanced Imaging Research Center Speaker: A. Dean Sherry, PhD, Advanced Imaging Research Center, UTSW & Department of Chemistry & Biochemistry, 1:50 The Cyclotron and Molecular Neuroimaging Resources Speaker: Rathan Subramaniam, MD, PhD, Department of Radiology, UTSW 2:00 Bioengineering: A Collaborative Model Speaker: Robert Rennaker, PhD, Department of Bioengineering, 2:10 Bioinformatics Initiative at UTSW Speaker: Gaudenz Danuser, PhD, Department of Bioinformatics, UTSW 2:20 The Center for Vital Longevity Speaker: Michael Rugg, PhD, Center for Vital Longevity, 2:30 The ANSIR Lab: Developing Big Data Image Analysis Pipelines Speaker: Joseph Maldjian, MD, Department of Radiology, UTSW 2:40 The Psychiatry Clinical Research Infrastructure Speaker: Carol Tamminga, MD, Department of Psychiatry, UTSW 2:50 The Dallas Lifespan Study Data Repository Speaker: Denise Park, PhD, Center for Vital Longevity, CLOSING REMARKS 3:00 Looking to the Future Hobson Wildenthal, PhD, Executive Vice President, Christopher Madden, MD, Executive Clinical Director, Peter O Donnell Jr. Brain Institute, UTSW 3:30 Reception on the 14th floor of the Pickens Building, ND14

Medicine Doris and Bryan Wildenthal Distinguished Chair in Medical Sciences Christopher

Southwestern Medical Center Richard Benson, PhD President, The University of Texas at

Mechanical Engineering Hobson Wildenthal Executive Vice President, The University of

Green Distinguished Chair of Academic Leadership Professor of Physics KEYNOTE SPEAKER

Alzheimer s Disease Research Mayo Clinic Rochester Gaudenz Danuser, PhD Professor &

Haggerty Distinguished Chair in Basic Biomedical Science CPRIT Scholar in Cancer

Director, Center for Alzheimer s and Neurodegenerative Diseases John Hart, Jr.

School of Behavioral and Brian Sciences Distinguished Chair in Neuroscience Elena I.

6 Speakers Daniel K. Podolsky, MD President, The University of Texas Southwestern Medical Center Philip O Bryan Montgomery, Jr., M.D. Distinguished Presidential Chair in Academic Administration Professor of Internal Medicine Doris and Bryan Wildenthal Distinguished Chair in Medical Sciences Christopher J. Madden, MD Associate Vice President Clinical Executive Director of Neurosciences Peter O Donnell Jr. Brain Institute Professor, Department of Neurological Surgery The University of Texas Southwestern Medical Center Richard Benson, PhD President, The University of Texas at Dallas Eugene McDermott Distinguished University Chair of Leadership Professor of Mechanical Engineering Hobson Wildenthal Executive Vice President, The University of Texas at Dallas Cecil H. Green Distinguished Chair of Academic Leadership Professor of Physics KEYNOTE SPEAKER Clifford Jack, MD Professor of Diagnostic Radiology The Alexander Family Professor of Alzheimer s Disease Research Mayo Clinic Rochester Gaudenz Danuser, PhD Professor & Chair Lyda Hill Department of Bioinformatics Patrick E. Haggerty Distinguished Chair in Basic Biomedical Science CPRIT Scholar in Cancer Research Marc Diamond, MD Professor Department of Neurology & Neurotherapeutics Director, Center for Alzheimer s and Neurodegenerative Diseases John Hart, Jr., MD Professor Department of Neurology & Neurotherapeutics and Psychiatry Professor School of Behavioral and Brian Sciences Distinguished Chair in Neuroscience Elena I. Ivleva, MD, PhD Assistant Professor Department of Psychiatry Division of Translational Neuroscience Research in Schizophrenia Francesca Filbey, PhD Associate Professor Bert Moore Chair in BrainHealth Center for BrainHealth Head, Cognition and Neuroscience Doctoral Program Bradley Lega, MD Assistant Professor Department of Neurological Surgery and Department of Neurology & Neurotherapeutics Adjunct Professor Department of Bioengineering

Speakers Joseph Maldjian, MD Conference Organizer Professor & Chief of

Research Core Bart Rypma, PhD Professor Meadows Foundation Chair Center for

Assistant Professor Lyda Hill Department of Bioinformatics Department of

Biochemistry Denise Park, PhD Conference Organizer Professor & Distinguished

Vital Longevity Adjunct Professor, Department of Psychiatry Rathan Subramaniam,

Molecular Imaging Program Robert Rennaker, PhD Professor & Head Department of

7 Speakers Joseph Maldjian, MD Conference Organizer Professor & Chief of Neuroradiology Department of Radiology Director, Advanced Neuroscience Imaging Research Core Bart Rypma, PhD Professor Meadows Foundation Chair Center for BrainHealth Adjunct Professor Department of Psychiatry Albert Montillo, PhD Assistant Professor Lyda Hill Department of Bioinformatics Department of Radiology and Advanced Imaging Research Center Adjunct Assistant Professor School of Engineering and Computer Science A. Dean Sherry, PhD Professor, Department of Radiology Director, Advanced Imaging Research Center Professor & Cecil H. and Ida Green Distinguished Chair in Systems Biology Department of Chemistry and Biochemistry Denise Park, PhD Conference Organizer Professor & Distinguished University Chair UT Regents Research Scholar Director of Research, Center for Vital Longevity Adjunct Professor, Department of Psychiatry Rathan Subramaniam, MD, PhD Conference Organizer Professor & Chief Division of Nuclear Medicine Robert W. Parkey MD Distinguished Professor in Radiology Medical Director, Cyclotron & Molecular Imaging Program Robert Rennaker, PhD Professor & Head Department of Bioengineering Texas Instruments Distinguished Chair in Bioengineering Director, Texas Biomedical Device Center Carol A. Tamminga, MD Professor & Chair Department of Psychiatry Lou and Ellen McGinley Distinguished Chair in Psychiatric Research McKenzie Chair in Psychiatry Michael Rugg, PhD Professor & Distinguished Chair Director, Center for Vital Longevity Adjunct Professor Department of Psychiatry Gagan Wig, PhD Assistant Professor Center for Vital Longevity

8 Thank You We would like to express our gratitude to the many people that came together to make the symposium happen. Special thanks to the symposium speakers for such thoughtful and stimulating presentations. We are particularly grateful to Cliff Jack of the Mayo Clinic for his challenging, forward-leaning keynote address and for his consistent generosity in contributing both his intellect and time to the UTSW/UTD imaging community. The symposium was jointly organized by staff at the UTSW Peter O Donnell Jr. Brain Institute and the Center for Vital Longevity (CVL). Great leadership and a strong collaborative spirit on the part of Teresa Fain at UTSW, and Alex Lyda and Lisa Ball at UTD made working on the project a pleasure. Important contributions were additionally made by Julie Kirchem (UTSW), Sol Jerome (UTD), and Ashley Kuvet (UTD). We are deeply appreciative of the terrific effort extended by Cary Delmark and Janice Scribner to design a working conference web site for us virtually overnight. Finally, a special word of thanks to Chris Madden, Hobson Wildenthal, Inga Musselman and Joe Pancrazio for unflagging support of this effort. Denise Park, Ph.D, Joseph Maldjian, MD, and Rathan Subramanium, MD Conference Organizers

Postdoctoral and research scientist positions

Postdoctoral and research scientist positions Postdoctoral Positions 1. Brain Injury in Contact Sports 2. Imaging Genetics 3. Multi-parametric Tumor Quantification 4. Deep Learning for Neuroimaging 5.