Management Issues in Hypoglossal Stimulation for OSA. A Sleep Medicine view of surgery
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1 Management Issues in Hypoglossal Stimulation for OSA Kingman P Strohl M.D. Professor of Medicine, Physiology & Biophysicis, and Oncology Center for sleep Disorders Reseach Case Western Reserve University, Cleveland OH, USA A Sleep Medicine view of surgery Senstivity of the ventilatory control system loop gain Pharyngeal muscle activation (low gain and reflex response) Anatomy (small, collapsible upper airway) CPAP Oral Appliance, etc. Anatomic Surgery Sleep (low arousal threshold) Obstructive Sleep Apnea Hypopnea Syndrome Decker et al
2 Inspire Medical Disclosures Site PI for the STAR Trial, and Inspire Post Approval and Registry Studies Consultant on FDA application NIH and VA research Awards on Causes and Consequences of Sleep Apnea Galvani Bioelectronics (Consultant) Sommetrics (Consultant and Research Support) Summary Hypoglossal Stimulation is a somewhat predictable treatment option for some. Who: Have moderate to severe OSA Struggle to get consistent benefit from CPAP Have a compatible airway anatomy profile Have a body mass index (BMI) <35, ideally <32 A team is best to determine if this invasive, non-anatomic therapy is right at this time for any given patient. Success is dependent upon its action to reduce the closing pressure of upper airway. In our hands, best success is when it opens the retropharyngeal space. 4 2
3 Process Assessment Implant Follow Up Routine Follow-ups CPAP Profile Anatomy check Sleep Study Profile DISE (Drug-Induced Sleep Endoscopy) Typically outpatient activation optimization Follow up Assessment for Neural Stimulation Senstivity of the ventilatory control system <25% Central or Mixed Apneas Pharyngeal muscle activation (low gain and reflex response) Rx: Neurostimulation Anatomy Office and DISE examination do not appear to be limiting factors.?? Sleep????? Insomnia and OSA (low arousal threshold) Obstructive Sleep Apnea Hypopnea Consequences (AHI 20 60) Decker et al
4 Insurance/Cost Considerations Inspire therapy is FDA approved. Currently, the therapy is being reviewed by insurance companies on a patient-bypatient basis. The first step is to see if a patient qualifies for the therapy and then the work with the patient and/or an insurance company on the Inspire implant. UAS Process Assessment Implant Follow Up Routine Follow-ups CPAP Profile Anatomy check Sleep Study Profile ENT and DISE (Drug-Induced Sleep Endoscopy) activation optimization Follow up 4
5 Sleep Medicine Inclusion/exclusion criteria needs CPAP/oral appliance and documentation of attempts, reasons, and face validity of non use (HNS is not a choice therapy).. then Explanation of the purpose and manner of therapy including follow up Restate the patient goals and assess committment Include some documentation by the patient of why they need it. Post Implant Management Implant Activation Phase Titration Phase Long term Post op 1 week 1 month post op 2 month post op Thresholds Office Visit: Stimulation Thresholds Home Use: Acclimatization * In lab tuning PSG 2 6 months Stimulation Across states and positions 6 months and Annually* Office Visit: Battery Usage Thresholds Adjustment HST in many cases are considered 5
6 Final Thoughts: Patient Cost, Physician Roles, Volume Assessment Implant Follow Up Routine Follow-ups Eligibility visit (1 of 5 move forward) Anatomy visit* Sleep Study Profile Typically Outpatient * activation optimization Follow up DISE* (Drug-Induced Sleep Endoscopy) Often a stopping point Checklist for a Center: Build a Team OSA Common Knowledge Sleep Incidence/ prevalence/demographics Disease pathophysiology Outcomes of untreated OSA Inspire Mechanisms of Action Inspire vs. Alternative Therapies Efficacy Safety profiles Patient selection Patient preference Clinical Evidence Reduction AHI/ODI (%) Safety Profile Effect on Co-morbidities/mortality QOL/ADL Health Economics Cost of Inspire vs. alternate therapies Cost vs. non-treatment Hospital economics Physician economics Reimbursement Coding Assessment and Implant Surgical techniques Device follow-up and programming Post operative complications Practice & Patient Mgmt Patient selection Clinical trials - best practices Medical management after implant Psychological issues 6
7 Question 1 What is the operational need to establish upper airway stimulation as on option for OSA? 1. A committed surgeon 2. A sleep laboratory that can focus on higher levels of recording and analysis 3. Research level sleep medicine group 4. Both 1 and 2 5. All factors Question 1 What is the operational need to establish upper airway stimulation as on option for OSA? 1. A committed surgeon 2. A sleep laboratory that can focus on higher levels of recording and analysis 3. Research level sleep medicine group 4. Both 1 and 2 5. All factors 7
8 Question 2 What is the hardest issue in the assessment of a patient who really wants hypoglossal stimulation? 1. Cost 2. Defining CPAP failure 3. Organizing DISE 4. Scoring the PSG for eligibility 5. Physical examination Question 2 What is the hardest issue in the assessment of a patient who really wants hypoglossal stimulation? 1. Cost 2. Defining CPAP failure 3. Organizing DISE 4. Scoring the PSG for eligibility 5. Physical examination 8
9 Question 3 What statement about management planning is true? 1. The hospital will not be worried about the cost. 2. The cost to the patient is more than they ever expected. 3. The routines in the ENT and Sleep Medicine sections for this therapy will mesh perfectly. Question 3 What statement about management planning is true? 1. The hospital will not be worried about the cost. 2. The cost to the patient is more than they ever expected. 3. The routines in the ENT and Sleep Medicine sections for this therapy will mesh perfectly. 9
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