PHRM H2001: Principles of Pharmacology

Transcription

1 Short Title: Full Title: Principles of APPROVED Principles of Module Code: PHRM H2001 Credits: 5 NFQ Level: 6 Field of Study: Combined Life Science Module Delivered in 2 programme(s) Reviewed By: KIERAN COLLINS Module Author: KIERAN COLLINS Module Description: This module seeks to introduce students to the principles of pharmacology and in particular the application of these principles to the area of health. Students will be provided with a thorough understanding of the fate of drugs in a mammalian system by providing a detailed insight into selected topics including; routes of administration of drugs, phases of drug metabolism and pharmacokinetics. The relevance of this topic will be developed in relation to pharmacokinetics, drug metabolism and elimination. The analysis of drugs and their metabolites will be examined in relation to physiological enhancement in health and performance in sports science. Learning Outcomes On successful completion of this module the learner will be able to: LO1 LO2 LO3 LO4 LO5 LO6 LO7 Describe the principles of pharmacology and their application to health. Describe the process of drug absorption and distribution. Identify the key factors affecting drug absorption and distribution. Describe the process of drug metabolism and resultant metabolites. Identify the most likely route(s) of drug elimination; Identify some of the key organs/systems affected by drugs. Describe how drugs may be utilized to enhance performance or treat disease. Pre-requisite learning Co-requisite Modules No Co-requisite modules listed

2 Module Content & Content (The percentage workload breakdown is inidcative and subject to change) % General Principles of What is pharmacology, What is a drug?, What is Medicine?, Origins and Antecedents, and the 21st Century Principles of Drug Action The general principles of drug action, How drugs act, Agonists and Antagonists, General Overview, Binding of drug molecules to cells, Drug antagonism, Quantitative aspects of drug-receptor interactions, The nature of drug effects, Affinity and Efficacy Molecular Aspects of Drug Action Binding of drug molecules to cells, Drug targets, Targets for drug action, Receptor proteins, Ion channels as drug targets, Control of receptor expression, Receptors and disease. Absorption and Distribution of Drugs Routes of administration, Drug/Medicine foumulations, Absorption of drugs, Body fluid compartments, Movement of drugs across cellular barriers, Diffusion through lipid, carrier mediated transport, partition into body fat and other tissues, binding to plasma proteins, Phases of drug deposition, ph and Ionisation, Distribution and Bioavailability of drugs Drug Elimination and Pharmacokinetics Overview, Introduction to drug elimination, Drug metabolism, The Stages of Drug metabolism - Phase I and II, First pass metabolism; Clinincal relevance of drug metabolism, Extretion - Renal excretion of drugs and drug metabolites; Biliary excretion and enterohepatic circulation, Drug-drug interactions, Overview of Pharmacokinetics Drugs Affecting Major Organ Systems Pharmacological alteration of Organ/System function in Health, The nervous system and pharmacology, neurotransmitter cehmistry of the autonomic nervous system (ANS), Drug targets in cholinergic transmission, Drug targets in adenergic transmission, Drugs and the circulatory system, The heart, Circulation, vascular- neural and humoral control 5.00% 25.00% 10.00% Breakdown % Course Work 30.00% End of Module Formal Examination 70.00% Course Work Type Description Outcome addressed % of total Date Continuous Continuous Continuous One (CA 1) - Multiple Choice Questions (MCQ) negative marking. Continuous Two (CA 2) - Multiple Choice Questions (MCQ) negative marking. 1,2, Week 6 4,5,6, Week 11 End of Module Formal Examination Type Description Outcome addressed % of total Date Formal Exam End-of-Semester Final Examination 1,2,3,4,5,6, End-of-Semester Reassessment Requirement Repeat examination Reassessment of this module will consist of a repeat examination. It is possible that there will also be a requirement to be reassessed in a coursework element. IT Tallaght reserves the right to alter the nature and timings of assessment

3 Module Workload Workload: Full Time Workload Type Workload Description Hours Frequency Average Weekly Learner Workload Lecture Lecture series based on syllabus content 3.00 Every Week Independent Learning Student Independent Learning 3.00 Every Week Total Weekly Learner Workload 6.00 Total Weekly Contact Hours 3.00 This module has no Part Time workload.

4 Module Resources Required Book Resources Humphrey P. Rang, and Maureen M. Dale 2011, Rang & Dale's PHARMACOLOGY, 7th Edition Ed., Churchill Livingstone [ISBN: ] Recommended Book Resources James M. Ritter... [et al.] 2008, A Textbook of Clinical and Therapeutics, Hodder Arnold London [ISBN: ] Bertram Katzung, Anthony Trevor, Susan Masters, 2009, Basic and Clinical, 11th Edition Ed., Lange Basic Science [ISBN: ] Required Article/Paper Resources Selected relevant articles from TIPS, British Journal of, Toxicology This module does not have any other resources

5 Module Delivered in Programme Code Programme Semester Delivery TA_SASCH_B Bachelor of Science (Hons) in Sports Science and Health 3 Mandatory TA_SASCH_D Bachelor of Science in Sports Science and Health 3 Mandatory