See how you can guide the path her cancer takes
|
|
- Delilah Gordon
- 5 years ago
- Views:
Transcription
1 See how you can guide the path her cancer takes
2 The need for improved diagnostics At the advanced edge of oncology, rapid access to accurate data on disease state is vital. Current technologies such as digital PCR and NGS are complex, require a lot of hands-on time and are often difficult to implement in the lab. 1 3 The limitations of these technologies delay the delivery of fast, standardized results, preventing rapid initiation of correct therapy and thereby losing precious time Rapid access to data about relevant cancer mutations and treatment resistance creates the opportunity for disease interception changing the course of a patient s cancer. 4,5
3 The next level in disease interception The Idylla system is the first and only diagnostic system that combines: 1,6 10 Ease of use Fully automated sample processing Speed Short preparation and turnaround time The Idylla system can be used with multiple sample types including liquid (Idylla ctbraf Mutation Assay*) and tissue biopsies (Idylla BRAF Mutation Test). This flexibility allows use of the system for diagnosis and potential future monitoring applications. The Idylla system can simultaneously detect all clinically relevant BRAF V600 mutations, in just one BRAF or ctbraf cartridge. 3,9 The Idylla ctbraf Mutation Assay* is the first of several planned liquid biopsy assays. Accuracy High sensitivity Multiplexing Detection of all relevant mutations in one cartridge Connectivity Remote assistance, monitoring and upgrading *Research use only (RUO), not for use in diagnostic procedures.
4 The power of a fully automated system The Idylla system provides fully automated, high precision PCR: 1,3,7,10 Can be used in any laboratory setting Requires less than 2 minutes hands-on time From sample preparation to result in minutes Allows on-demand access (no need for batching) Doesn t require pre-processing FFPE and plasma samples can be loaded directly into the cartridge Eliminates the risk of PCR contamination (due to the closed nature of PCR cartridges)
5 The fast, straightforward workflow The Idylla system in combination with the Idylla ctbraf Mutation Assay * has the potential to streamline the diagnostic and monitoring process. Comparative workflows Manual interventions 15 MINS 85 MINS Blood draw Sample loading Automated processing & analysis MINS Conventional PCR/ Digital droplet PCR 6 1 DAY BEAMing technology 10 3 DAYS NGS DAYS *Research use only (RUO), not for use in diagnostic procedures.
6 The bright future of liquid biopsy testing Liquid biopsies are less invasive, more cost-effective and provide a more genetically heterogeneous sample of tumour DNA compared to tissue biopsies. 4,5,11,12 Liquid biopsy-based technology has the potential to improve the way disease is intercepted in oncology, allowing you to: 4,5,8,11,13,14 Accurately detect and screen for mutations Continually monitor treatment response Detect treatment resistance early Measure disease burden Detect disease recurrence early How could Idylla help you to change the course of your patients cancer?
7 The accuracy you can rely on Liquid biopsy analysis of BRAF V600 mutation 15 Raw PCR Curves V600E V600K WT The Idylla ctbraf Mutation Assay* shows high sensitivity, detecting down to 60 mutant BRAF V600E copies/ml in a wild-type background (0.06%) Fluorescence Cycles *Research use only (RUO), not for use in diagnostic procedures.
8 The confidence that comes with high concordance Both the Idylla ctbraf Mutation Assay * and the Idylla BRAF Mutation Test are proven to have high concordance with routine PCR diagnostic tests and CLIA-certified methods. 1,8,16 % concordance Idylla ctbraf Mutation Assay (liquid) FFPE CLIA-certified methods (tissue) 88% 100% of concordance with ddpcr and BEAMing in liquid vs. tissue discordant results % concordance Idylla BRAF Mutation Test (tissue) Miseq, Cobas, CLIA-certified methods (tissue) >96% *Research use only (RUO), not for use in diagnostic procedures. Data was obtained with a prototype assay.
9 The innovative approach to cancer monitoring BRAF V600 mutation load as detected by Idylla ctbraf Mutation Assay * 14 BRAF V600 mutation detected in tissue CT scan Partial response % BRAF mutant ctdna CT scan Progressive disease Detection of the BRAF mutant ctdna load in a patient s blood could become a fast, easy and accurate method to see if the patient is responding well to therapy 14 Start BRAF/MEK inhibitor treatment % BRAF mutant ctdna days An increase in BRAF mutant ctdna might give an earlier indication of resistance to therapy compared to CT scan /08/ /09/ /10/ /11/ /12/ /01/ /02/2015 dabra 300mg + trame 2mg dabra 300mg + trame 1mg Figure adapted from Schreuer M et al., *Research use only (RUO), not for use in diagnostic procedures. Data was obtained with a prototype assay.
10 The assessment of overall patient survival 100 Overall survival in patients with BRAF V600 mutation 8 BRAF V600 2% >2% n=160 Measuring the fraction of mutated BRAF ctdna in liquid biopsies to assess overall survival could be another potential application of liquid biopsy Overall survival % Cancer patients with 2% BRAF V600 mutations before start of treatment had a longer overall survival vs. patients with >2% BRAF V600 mutations Time (months) Figure adapted from Janku F et al., 2015.
11 Guide the path their cancer takes The Idylla system can be used with both liquid and tissue biopsies. When used with liquid biopsies, the Idylla system is the first and only fully automated system that combines: 1,6 10 Ease of use Less than 1 minute hands-on time Speed Short preparation and turnaround time Accuracy High sensitivity of 0.06% Multiplexing All relevant BRAF mutations detected in one cartridge Connectivity Remote assistance, monitoring and upgrading The right diagnosis and monitoring system is vital for baseline mutation detection and assessment of future disease monitoring opportunities. With first-time-right results, you can create the opportunity for disease interception changing the course of your patients cancer. Join the investigation of disease interception
12 The future of diagnosis & monitoring Current & future Idylla assays Tissue Liquid Melanoma BRAF ctbraf* ( * ) Lung EGFR** ctegfr** Colorectal KRAS NRAS-BRAF-EGFR S492R* NRAS-BRAF** ctkras** ctnras-braf** MSI** * Research use only (RUO), not for use in diagonostic procedures. ** Idylla ctbraf, NRAS-BRAF, ctkras, ctnras-braf, MSI, EGFR and ctegfr tests are currently under development. Idylla assays are not for sale in the US and Canada.
13 References 1. Janku F et al. Oncotarget. 2015; 6(29): Sam SS et al. Pathol Res Pract pii: jclinpath Colling R et al. J Clin Pathol pii: jclinpath Bratzman SV et al. Expert Rev Mol Diagn. 2015; 15(6): Siravegna G and Bardelli A. Genome Biol. 2014; 15(8): Vandebroucke I et al. Presented at AACR Melchior L et al. Exp Mol Pathol. 2015; 99(3): Janku F et al. Proceedings of the 106th Annual Meeting of the American Association for Cancer Research (#2413), 4/ Jacobs B et al. Poster presented at World CDx Idylla Fully-automated molecular diagnostics system. Product brochure. 11. Gray ES et al. Oncotarget. 2015; 6(39): Janku F et al. Oncotarget. 2015; 6(14): Tsao SC et al. Sci Rep. 2015; 5: Schreuer M et al. Melanoma Res. 2016; 26(2): Biocartis, Data on File. 16. Huang HJ et al. Abstract Presented AACR Annual Meeting DA EN
See how you can guide the path her cancer takes
See how you can guide the path her cancer takes 1 Idylla : easy, rapid and accurate molecular medicine for every patient Paola Valente Strategic Marketing Biocartis 6th meeting on external quality assessment
More informationY L L NOTHING BUT THIS. NOTHING IS SIMPLE IN ONCOLOGY.
ID Y L L NOTHING BUT THIS. A NOTHING IS SIMPLE IN ONCOLOGY. WHAT DOES IDYLLA TM M E AN FOR CANCER PATIENTS? High Precision Diagnostics for Personalized Medicine RAPID TREATMENT INITIATION 1 Test results
More informationLiquid Biopsy Applications on the Idylla Fully Integrated Sample-to-Result MDx System
Liquid Biopsy Applications on the Idylla Fully Integrated Sample-to-Result MDx System Erwin Sablon, Head of R&D, Biocartis NV World CDx, Boston, September 10 th 2015 0 About Biocartis Innovative molecular
More informationctbraf Mutation Assay
The first and only fully automated liquid biopsy assay ctbraf Idylla ctbraf Mutation Assay The easiest solution to implement liquid biopsy testing The potential of liquid biopsy The use of liquid biopsies
More informationGuide the path her cancer takes
Guide the path her cancer takes Direct access to same-day-results Fully Automated Molecular Diagnostics Fully Automated Molecular Diagnostics 24/7 FAST ACCURATE EASY ACCESSIBLE We at Biocartis aim to provide
More informationSee how you can guide the path her cancer takes
See how you can guide the path her cancer takes Direct access to same-day-results Fully automated Molecular Diagnostics www.biocartis.com We at Biocartis aim to provide direct access to personalized medicine
More informationSee how you can guide the path her cancer takes
See how you can guide the path her cancer takes Direct access to same-day-results Fully Automated Molecular Diagnostics 24/7 FAST ACCURATE EASY ACCESSIBLE We at Biocartis aim to provide direct access to
More informationNOTHING BUT THIS. NOTHING IS SIMPLE IN ONCOLOGY.
ID Y L L NOTHING BUT THIS. A NOTHING IS SIMPLE IN ONCOLOGY. Idylla TM A revolutionary, fully automated system that makes molecular testing convenient and exceptionally fast. Suitable for any lab. 2 Biocartis
More informationDisruptive innovation in molecular diagnostics. Hilde Windels CEO Biocartis 25 March 2017
Disruptive innovation in molecular diagnostics Hilde Windels CEO Biocartis 25 March 2017 1 One of the key innovations in healthcare in the last decade PERSONALISED MEDICINE or HIGH PRECISION MEDICINE From
More informationIdylla A fully automated, highly accurate, easy to use MDx platform: Too much to ask for?
GOING MOLECULAR HAS NEVER BEEN EASIER Idylla A fully automated, highly accurate, easy to use MDx platform: Too much to ask for? October 18 th, 2017 NOTICES AND WARNINGS This presentation has been prepared
More informationMUTATION TEST CE IVD. ctnras-braf FEATURES
ctnras-braf CE IVD TECHNICAL SHEET IDYLLA ctnras-braf MUTATION TEST The Idylla ctnras-braf Mutation Test, performed on the Biocartis Idylla System, is an in vitro diagnostic test for the qualitative detection
More informationThe OncoBEAM RAS liquid biopsy experience in real-world clinical practice Frederick S. Jones, Ph.D., Global Director, Medical Scientific
The OncoBEAM RAS liquid biopsy experience in real-world clinical practice Frederick S. Jones, Ph.D., Global Director, Medical Scientific Affairs,Sysmex 2 OncoBEAM liquid biopsy: circulating tumor DNA (ctdna)
More informationLa biopsia liquida. Aldo Scarpa. Anatomia Patologica e ARC-NET Centro di Ricerca Applicata sul Cancro
La biopsia liquida Aldo Scarpa Anatomia Patologica e ARC-NET Centro di Ricerca Applicata sul Cancro Azienda Ospedaliera Universitaria Integrata di Verona Obstacles to precision oncology Genomic heterogeneity
More informationClinical molecular profiling to detect targetable alterations in archival tumor tissue and cell-free DNA from patients with Erdheim-Chester disease
ECD International Medical Symposium Paris, France September 15, 2016 Clinical molecular profiling to detect targetable alterations in archival tumor tissue and cell-free DNA from patients with Erdheim-Chester
More informationAVENIO ctdna Analysis Kits The complete NGS liquid biopsy solution EMPOWER YOUR LAB
Analysis Kits The complete NGS liquid biopsy solution EMPOWER YOUR LAB Analysis Kits Next-generation performance in liquid biopsies 2 Accelerating clinical research From liquid biopsy to next-generation
More informationLiquid Biopsy. Jesus Garcia-Foncillas MD PhD. Director
Liquid Biopsy Jesus Garcia-Foncillas MD PhD Director Main issues about liquid biopsies New paradigm: Precision Medicine Heterogeneity & Dynamics Surrogate mirror for the tumor CTCs in colon cancer ctdna:
More informationLiquid biopsy in lung cancer: The EGFR paradigm
Liquid biopsy in lung cancer: The EGFR paradigm Lynette M. Sholl, M.D. Brigham and Women s Hospital Dana Farber Cancer Institute Department of Pathology Boston, MA Disclosure of Relevant Financial Relationships
More informationIntroduction to liquid biopsies. Rachel Butler All Wales Genetics Laboratory
Introduction to liquid biopsies Rachel Butler All Wales Genetics Laboratory What is cell free DNA? Non-Invasive Prenatal Testing (NIPT) Extract DNA Genetic alterations detectable in circulating cell-free
More informationTransforming Oncology With Precision Medicine Solutions. Company Overview January 2017
Transforming Oncology With Precision Medicine Solutions Company Overview January 2017 FORWARD-LOOKING STATEMENTS Statements in this presentation about the Company's expectations, applications of its technology,
More informationRobert Beer
Robert Beer Robert.beer@wales.nhs.uk All Wales Medical Genetics Service Genetic Technologist Training Day 22 nd November 2017 Contents Stratified Medicine NHS EGFR Diagnostic Testing Services Cell free
More informationUtility of liquid biopsies EQA Program Naples, IT Sidney A. Scudder, MD Director, Clinical Science 13 May, 2017
Utility of liquid biopsies EQA Program Naples, IT Sidney A. Scudder, MD Director, Clinical Science 13 May, 2017 picture placeholder Agenda cobas EGFR Mutation Test v2 Ring Trial SQI Semi Quantitative Index
More informationBiocartis Corporate Presentation. September 2017
Biocartis Corporate Presentation September 2017 NOTICES AND WARNINGS This presentation has been prepared by the management of Biocartis Group NV (the "Company"). It does not constitute or form part of,
More informationUrinary ctdna Platform for Diagnosis and Cancer Treatment Monitoring. Summit August 19,2015
Urinary ctdna Platform for Diagnosis and Cancer Treatment Monitoring Mark G. Erlander, Ph.D., CSO CHI Next Generation Summit August 19,2015 Circulating Tumor DNA (ctdna) Tumor cells Main Advantages of
More informationCirculating Tumor DNA in GIST and its Implications on Treatment
Circulating Tumor DNA in GIST and its Implications on Treatment October 2 nd 2017 Dr. Ciara Kelly Assistant Attending Physician Sarcoma Medical Oncology Service Objectives Background Liquid biopsy & ctdna
More informationClinical molecular profiling of archival tumor tissue and cell-free DNA from patients with Erdheim-Chester disease
ECD International Medical Symposium New York City October 26, 2017 Clinical molecular profiling of archival tumor tissue and cell-free DNA from patients with Erdheim-Chester disease Filip Janku, Eli Diamond,
More informationQué hemos aprendido hasta hoy? What have we learned so far?
Qué hemos aprendido hasta hoy? What have we learned so far? Luís Costa Hospital de Santa Maria & Instituto de Medicina Molecular Faculdade de Medicina de Lisboa Disclosures Research Grants: Amgen; Novartis;
More informationTissue or Liquid Biopsy? ~For Diagnosis, Monitoring and Early detection of Resistance~
16 th Dec. 2016. ESMO Preceptorship Program Non-Small-Cell Lung Cancer @Singapore Tissue or Liquid Biopsy? ~For Diagnosis, Monitoring and Early detection of Resistance~ Research Institute for Disease of
More informationBiocartis Corporate Presentation. November 2017
Biocartis Corporate Presentation November 2017 NOTICES AND WARNINGS This presentation has been prepared by the management of Biocartis Group NV (the "Company"). It does not constitute or form part of,
More informationTransform genomic data into real-life results
CLINICAL SUMMARY Transform genomic data into real-life results Biomarker testing and targeted therapies can drive improved outcomes in clinical practice New FDA-Approved Broad Companion Diagnostic for
More informationMolecular Testing Updates. Karen Rasmussen, PhD, FACMG Clinical Molecular Genetics Spectrum Medical Group, Pathology Division Portland, Maine
Molecular Testing Updates Karen Rasmussen, PhD, FACMG Clinical Molecular Genetics Spectrum Medical Group, Pathology Division Portland, Maine Keeping Up with Predictive Molecular Testing in Oncology: Technical
More informationCDx in oncology Prof. Christophe Le Tourneau, MD, PhD FEAM Geneva September 27, 2018
CDx in oncology Prof. Christophe Le Tourneau, MD, PhD Institut Curie Paris & Saint-Cloud France Head, Department of Drug Development and Innovation (D 3 i) INSERM U900 Research unit Versailles Saint-Quentin-en-Yvelines
More informationNGS in tissue and liquid biopsy
NGS in tissue and liquid biopsy Ana Vivancos, PhD Referencias So, why NGS in the clinics? 2000 Sanger Sequencing (1977-) 2016 NGS (2006-) ABIPrism (Applied Biosystems) Up to 2304 per day (96 sequences
More informationLa biopsia liquida dei tumori: il viaggio. Paola Gazzaniga Liquid Biopsy Unit Dept. Molecular Medicine Sapienza University of Rome
La biopsia liquida dei tumori: il viaggio Paola Gazzaniga Liquid Biopsy Unit Dept. Molecular Medicine Sapienza University of Rome Must Know Necessary Travel Tips There is lack of drugs to treat all the
More informationAVENIO family of NGS oncology assays ctdna and Tumor Tissue Analysis Kits
AVENIO family of NGS oncology assays ctdna and Tumor Tissue Analysis Kits Accelerating clinical research Next-generation sequencing (NGS) has the ability to interrogate many different genes and detect
More informationQIAGEN Complete Solutions for Liquid Biopsy Molecular Testing
QIAGEN Complete Solutions for Liquid Biopsy Molecular Testing Christopher Swagell, PhD Market Development Manager, Advanced Molecular Pathology QIAGEN 1 Agenda QIAGEN Solid Tumor Testing and Liquid Biopsy
More informationIntroduction to liquid biopsy in a Specialized Cancer Center
Introduction to liquid biopsy in a Specialized Cancer Center Dr. Antonio Cubillo Head, Medical OncologyDepartment HM-CIOCC In collaboration with OUTLINE Need Liquid Biopsy: Definition and techniques Sensitivity
More informationThe OncoBEAM Platform: The Use of a High Sensitive Technology for Liquid Biopsies in Clinical Practice
The OncoBEAM Platform: The Use of a High Sensitive Technology for Liquid Biopsies in Clinical Practice Sysmex Inostics Dr. Friederike Lehmann Head of CRO Marketing Sysmex Corporation Kobe 2 Sysmex Corporation
More informationCLIA Laboratory Testing of Urinary BRAF V600E DNA mutations: Application in the Management of Patients with Histiocytic Diseases
CLIA Laboratory Testing of Urinary BRAF V600E DNA mutations: Application in the Management of Patients with Histiocytic Diseases Adriana Muniz 1, Mariko Matsutani 1, Karena Kosco 1, John Spinosa 1, Cecile
More informationLukas Bubendorf Pathologie. Liquid biopsies
Lukas Bubendorf Pathologie Liquid biopsies Liquid biopsies 1. Circulating cell-free tumor-dna (ctdna) 2. Circulating tumor cells (CTC) Source: Sysmex CTCs ctdna ctrna exosomes Quantification Protein RNA
More informationClinical Utility of Droplet ddpcr, moving to diagnostics. Koen De Gelas, PhD, CRIG ddpcr mini symposium, 15/05/2018
1 Clinical Utility of Droplet ddpcr, moving to diagnostics 2 Koen De Gelas, PhD, CRIG ddpcr mini symposium, 15/05/2018 Disclaimer Disclaimer: all consumables, instruments, applications and software covered
More informationWat is de potentiële waarde van ctdna? PLCRC - MEDOCC
Wat is de potentiële waarde van ctdna? PLCRC - MEDOCC Translational Gastrointestinal Oncology Remond Fijneman r.fijneman@nki.nl Department of Pathology, Amsterdam, NL Wat is de potentiële waarde van ctdna?
More informationFuture directions of Liquid Biopsy in monitoring of melanoma patients
Future directions of Liquid Biopsy in monitoring of melanoma patients Verena Haselmann, MD PhD Institute for Clinical Chemistry University of Mannheim, Germany verena.haselmann@umm.de Circulating tumor
More informationEGFR ctdna Testing. Andrew Wallace 21/09/2015 Genomic Diagnostics Laboratory St. Mary s Hospital, Manchester
EGFR ctdna Testing Andrew Wallace 21/09/2015 Genomic Diagnostics Laboratory St. Mary s Hospital, Manchester ctdna & EGFR Testing in NSCLC EGFR ctdna testing Non-invasive - patients too sick/biopsy or cytology
More informationCURRENT STANDARD OF CARE OF COLORECTAL CANCER: THE EVOLUTION OF ESMO CLINICAL PRACTICE GUIDELINES
CURRENT STANDARD OF CARE OF COLORECTAL CANCER: THE EVOLUTION OF ESMO CLINICAL PRACTICE GUIDELINES Fortunato Ciardiello ESMO Past-President 2018-2019 Dipartimento di Medicina di Precisione Università degli
More informationBiocartis Corporate Presentation. April 2018
Biocartis Corporate Presentation April 2018 NOTICES AND WARNINGS This presentation has been prepared by the management of Biocartis Group NV (the "Company"). It does not constitute or form part of, and
More informationDiagnostic with alternative sample types (liquid biopsy)
MOLECULAR DIAGNOSTICS OF EGFR AND T790M MUTATIONS CHALLENGES AND SOLUTIONS Diagnostic with alternative sample types (liquid biopsy) James CH Yang, MD, PhD Director, Professor, Graduate Institute of Oncology
More informationUpdated Molecular Testing Guideline for the Selection of Lung Cancer Patients for Treatment with Targeted Tyrosine Kinase Inhibitors
Q: How is the strength of recommendation determined in the new molecular testing guideline? A: The strength of recommendation is determined by the strength of the available data (evidence). Strong Recommendation:
More informationCTC in clinical studies: Latest reports on GI cancers
CTC in clinical studies: Latest reports on GI cancers François-Clément Bidard, MD PhD GI cancers are characterized by Multimodal treatment strategies Treatments are adapted to tumor burden & prognosis
More informationPlasma ctdna RAS/RAF mutations analysis for monitoring overall survival (OS) and heterogeneity in metastatic colorectal cancer patients (mcrc)
Plasma ctdna RAS/RAF mutations analysis for monitoring overall survival (OS) and heterogeneity in metastatic colorectal cancer patients (mcrc) Authors: Andrea Petricca Mancuso, Veronica Varchetta, Fabrizio
More informationEnterprise Interest No
Enterprise Interest No SY-05 Pulmonary Pathology: Options for targeted therapy in lung cancer Liquid biopsy in thoracic oncology Where are we now? Paul Hofman Laboratory of Clinical and Experimental Pathology
More informationREVIEW ON THE ESMO CONSENSUS CONFERENCE ON ADVANCED COLORECTAL CANCER
ESMO Preceptorship Programme Colorectal Cancer Barcelona November, 25-26, 2016 REVIEW ON THE ESMO CONSENSUS CONFERENCE ON ADVANCED COLORECTAL CANCER Andrés Cervantes Professor of Medicine Strategic changes
More informationPersonalized Healthcare Update
Dr. Kai - Oliver Wesche Market Development Manager, Personalized Healthcare QIAGEN Personalized Healthcare Update Pioneering Personalized Medicine through Partnering TOMTOVOK BKM120 Zelboraf QIAGEN partners:
More informationRegulatory Landscape for Precision Medicine
Regulatory Landscape for Precision Medicine Adam C. Berger, Ph.D. Office of In Vitro Diagnostics and Radiological Health, FDA FOCR-Alexandria A Blueprint for Breakthrough Meeting September 13, 2017 1 What
More informationBiocartis Corporate Presentation. 3 December 2018
Biocartis Corporate Presentation 3 December 2018 NOTICES AND WARNINGS This presentation has been prepared by the management of Biocartis Group NV (the "Company"). It does not constitute or form part of,
More informationExosome DNA Extraction Kits
Exosome DNA Extraction Kits Summary Section 5 Introduction 40 EXO-DNAc 41 EXO-DNA 43 Introduction Genomic DNA Extractiom Kits Ordering informations Products can be purchased directly in our on-line shop:
More informationA better clinical pathway for cancer monitoring. Antonius Schuh, Ph.D. Chief Executive Officer December 2013
A better clinical pathway for cancer monitoring Antonius Schuh, Ph.D. Chief Executive Officer December 2013 DISCLAIMER Forward-Looking Statements Statements in this presentation about the Company's expectations,
More informationBiocartis Corporate Presentation. 7 January 2019
Biocartis Corporate Presentation 7 January 2019 NOTICES AND WARNINGS This presentation has been prepared by the management of Biocartis Group NV (the "Company"). It does not constitute or form part of,
More informationColorectal cancer: pathology
UK NEQAS for Molecular Pathology Colorectal cancer: pathology Nick West Pathology & Tumour Biology May 2013 Colorectal cancer (CRC) 40,695 new cases in 2010 15,708 deaths Management of CRC Surgery Main
More informationColorectal Cancer - Working in Partnership. David Baty Genetics, Ninewells Hospital
Colorectal Cancer - Working in Partnership David Baty Genetics, Ninewells Hospital Genetics and Pathology National initiatives Colorectal cancer Inherited CRC Sporadic CRC The Liquid Biopsy The future?
More informationPatient Leader Education Summit. Precision Medicine: Today and Tomorrow March 31, 2017
Patient Leader Education Summit Precision Medicine: Today and Tomorrow March 31, 2017 Precision Medicine: Presentation Outline Agenda What is a Precision Medicine What is its clinical value Overview of
More informationLiquid biopsy: the experience of real life case studies
Liquid biopsy: the experience of real life case studies 10 th September 2018 Beatriz Bellosillo Servicio de Anatomía Patológica Hospital del Mar, Barcelona Agenda Introduction Experience in colorectal
More informationECMC cfdna consensus meeting
ECMC cfdna consensus meeting State of the art for cfdna technologies 24 th November 2014 Applications of ctdna analysis for drug development Potential of ctdna analysis to: Identify the right patients
More informationEnabling Personalized
Molecular Enabling Personalized Diagnostics Medicine- Targeted Sequencing: NGS-based solutions Silvia Dorn Roel Reinders- Andreas Diplas Friday, 19.06.2015 Company Overview Founded in April 2011 Development
More informationDisclosure. Summary. Circulating DNA and NGS technology 3/27/2017. Disclosure of Relevant Financial Relationships. JS Reis-Filho, MD, PhD, FRCPath
Circulating DNA and NGS technology JS Reis-Filho, MD, PhD, FRCPath Director of Experimental Pathology, Department of Pathology Affiliate Member, Human Oncology and Pathogenesis Program Disclosure of Relevant
More informationNext generation diagnostics Bringing high-throughput sequencing into clinical application
Next generation diagnostics Bringing high-throughput sequencing into clinical application Leonardo A. Meza-Zepeda, PhD Translational Genomics Group Institute for Cancer Research Leonardo.Meza-Zepeda@rr-research.no
More informationDevelopment of Circulating Tumor DNA
Development of Circulating Tumor DNA Title of presentation Arial Bold 30pt in White Biomarkers Secondary title 22pt using Arial Next in White Generation Sequencing Brian Dougherty PhD, MBA Translational
More informationPRECISION INSIGHTS. Liquid GPS. Blood-based tumor profiling and quantitative monitoring. Reveal more with cfdna + cfrna.
PRECISION INSIGHTS Liquid GPS Blood-based tumor profiling and quantitative monitoring Reveal more with cfdna + cfrna www.nanthealth.com Why Blood-Based Tumor Profiling? Although tissue-based molecular
More informationThe feasibility of circulating tumour DNA as an alternative to biopsy for mutational characterization in Stage III melanoma patients
The feasibility of circulating tumour DNA as an alternative to biopsy for mutational characterization in Stage III melanoma patients ASSC Scientific Meeting 13 th October 2016 Prof Andrew Barbour UQ SOM
More informationColon cancer: practical molecular diagnostics. Wade S. Samowitz, M.D. University of Utah and ARUP
Colon cancer: practical molecular diagnostics Wade S. Samowitz, M.D. University of Utah and ARUP Disclosure Dr. Samowitz may receive royalties in the future related to the Ventana BRAF V600E antibody.
More informationQIAGEN's Growing Immuno-Oncology Testing Portfolio
QIAGEN's Growing Immuno-Oncology Testing Portfolio QIAGEN Your Partner in Translational Medicine Current Biomarkers of Immuno-Oncology Focus: Immuno-Oncology Testing Portfolio Tumor mutation burden (TMB)
More informationValidation of QClamp as Next Generation Liquid Biopsy Technique for Colorectal Cancer He James Zhu M.D. Ph.D
Validation of QClamp as Next Generation Liquid Biopsy Technique for Colorectal Cancer He James Zhu M.D. Ph.D Department of Radiation Oncology University of Florida College of Medicine Outline Objective
More informationCell-free tumor DNA for cancer monitoring
Learning objectives Cell-free tumor DNA for cancer monitoring Christina Lockwood, PhD, DABCC, DABMGG Department of Laboratory Medicine 1. Define circulating, cell-free tumor DNA (ctdna) 2. Understand the
More informationReview of the ESMO consensus conference on metastatic CRC Basis strategies ad groups (RAS, BRAF, etc) Michel Ducreux
Review of the ESMO consensus conference on metastatic CRC Basis strategies ad groups (RAS, BRAF, etc) Michel Ducreux 2 ESMO consensus on mcrc 2016 Chairs: Co-Chairs of working groups E Van Cutsem A Sobrero
More informationMETASTATIC COLORECTAL CANCER: TUMOR MUTATIONAL ANALYSIS AND ITS IMPACT ON CHEMOTHERAPY SUMA SATTI, MD
METASTATIC COLORECTAL CANCER: TUMOR MUTATIONAL ANALYSIS AND ITS IMPACT ON CHEMOTHERAPY SUMA SATTI, MD INTRODUCTION Second leading cause of cancer related death in the United States. 136,830 cases in 2014
More informationBiopsia Líquida: Oncología en Tiempo Real. Federico Rojo Fundación Jiménez Díaz
Biopsia Líquida: Oncología en Tiempo Real Federico Rojo Fundación Jiménez Díaz Liquid Biopsy in Cancer Liquid Biopsy in Cancer Publication Date: April 5, 2016 Blood Tests replace Surgical Biopsies to create
More informationANTI-EGFR IN MCRC? Assoc. Prof. Gerald Prager, Medical University of Vienna, Austria
IS IT TIME TO RE-CHALLENGE ANTI-EGFR IN MCRC? Assoc. Prof. Gerald Prager, Medical University of Vienna, Austria Dr. Andrea Sartore-Bianchi, Oncologia Clinica Molecolare, Niguarda Cancer Center, Milano,
More informationUpdate on Exact Sciences Molecular CRC Screening Test. November 16 th, 2011
Update on Exact Sciences Molecular CRC Screening Test November 16 th, 2011 0 Safe Harbor Statement Certain matters contained in this presentation, other than historical information, consist of forward-looking
More informationDr Yvonne Wallis Consultant Clinical Scientist West Midlands Regional Genetics Laboratory
Dr Yvonne Wallis Consultant Clinical Scientist West Midlands Regional Genetics Laboratory Personalised Therapy/Precision Medicine Selection of a therapeutic drug based on the presence or absence of a specific
More informationMolecular biology of colorectal cancer
Molecular biology of colorectal cancer Phil Quirke Yorkshire Cancer Research Centenary Professor of Pathology University of Leeds, UK Rapid pace of molecular change Sequencing changes 2012 1,000 genomes
More informationAndreas Wicki. University Hospital Basel Switzerland
Andreas Wicki University Hospital Basel Switzerland Disclosures Funding of research projects: Piqur Therapeutics Consultancy: Actelion Pharmaceuticals Predictive Biomarkers for Targeted Therapy in Oncology
More informationBowel Disease Research Foundation
Research Project Annual Report Lead investigator Dr Ricky Sharma Institution Department of Oncology, University of Oxford Project Title Making radiotherapy for rectal cancer more effective by identifying
More informationRadiation Oncology. The conf ident path to treatment Philips Radiation Oncology Solutions
Radiation Oncology The conf ident path to treatment Philips Radiation Oncology Solutions The confident path to treatment Philips Radiation Oncology Solutions Imaging Image registration Contouring Treatment
More informationccfdna Webinar Series: The Basics and Beyond
ccfdna Webinar Series: The Basics and Beyond Part I Maxwell RSC ccfdna Plasma Kit and Maxwell RSC instrument are For Research Use Only. Not for Use in Diagnostic Procedures. Introduction to Circulating,
More informationIf multiple KRAS mutation tests have been performed, refer to the most recent test results.
Measure #452 (NQF 1860): Patients with Metastatic Colorectal Cancer and KRAS Gene Mutation Spared Treatment with Anti-epidermal Growth Factor Receptor (EGFR) Monoclonal Antibodies National Quality Strategy
More informationBetter Cancer Monitoring with Circulating Tumor DNA. March 2016
Better Cancer Monitoring with Circulating Tumor DNA March 2016 Forward-Looking Statements Statements in this presentation about the Company's expectations, applications of its technology, markets, launch
More informationMET skipping mutation, EGFR
New NSCLC biomarkers in clinical research: detection of MET skipping mutation, EGFR T790M, and other important biomarkers Fernando López-Ríos Laboratorio de Dianas Terapéuticas Hospital Universitario HM
More informationConsensus statement between CM-Path, CRUK and the PHG Foundation following on from the Liquid Biopsy workshop on the 8th March 2018
Consensus statement between CM-Path, CRUK and the PHG Foundation following on from the Liquid Biopsy workshop on the 8th March 2018 Summary: This document follows on from the findings of the CM-Path The
More informationAmoyDx TM BRAF V600E Mutation Detection Kit
AmoyDx TM BRAF V600E Mutation Detection Kit Detection of V600E mutation in the BRAF oncogene Instructions For Use Instructions Version: B3.1 Date of Revision: April 2012 Store at -20±2 o C 1/5 Background
More informationClinical Grade Genomic Profiling: The Time Has Come
Clinical Grade Genomic Profiling: The Time Has Come Gary Palmer, MD, JD, MBA, MPH Senior Vice President, Medical Affairs Foundation Medicine, Inc. Oct. 22, 2013 1 Why We Are Here A Shared Vision At Foundation
More informationResponse and resistance in melanoma. Helen Rizos
Response and resistance in melanoma Helen Rizos RESISTANCE: Kinase inhibitors PI3K only 5% MAPK+PI3K 20% Unknown 38% MAPK 37% BRAF amplification 15% 111 pati ents 100 BRA F inhibitor 11 BRAF+MEK inhibitor
More informationNGS IN ONCOLOGY: FDA S PERSPECTIVE
NGS IN ONCOLOGY: FDA S PERSPECTIVE ASQ Biomed/Biotech SIG Event April 26, 2018 Gaithersburg, MD You Li, Ph.D. Division of Molecular Genetics and Pathology Food and Drug Administration (FDA) Center for
More informationEconomic Value Lab Efficiencies Safety Clinical Outcomes. Visit BD Booth AACC/ASCLS 2009 Annual Meeting
Economic Value Lab Efficiencies Safety Clinical Outcomes Visit BD Booth 1225 AACC/ASCLS 2009 Annual Meeting BD Events & Co-Promotions Join us this year at booth #1225 to discover the full spectrum of solutions
More informationThe Cancer Research UK Stratified Medicine Programme: Phases One and Two Dr Emily Shaw
The Cancer Research UK Stratified Medicine Programme: Phases One and Two Dr Emily Shaw Introduction The CRUK Stratified Medicine Programme: SMP1 rationale, design and implementation The role of the cellular
More informationSimple, rapid, and reliable RNA sequencing
Simple, rapid, and reliable RNA sequencing RNA sequencing applications RNA sequencing provides fundamental insights into how genomes are organized and regulated, giving us valuable information about the
More informationValidated and promising predictive factors in mcrc: Recent updates on RAS testing Fotios Loupakis, MD PhD
Validated and promising predictive factors in mcrc: Recent updates on RAS testing Fotios Loupakis, MD PhD U.O. Oncologia 2 Universitaria Azienda Ospedaliero-Universitaria Pisana Pisa, Italy Learning Objectives
More informationPlateform of Somatic Oncology INSERM LNC-UMR 1231 University Hospital of Dijon, France
Plateform of Somatic Oncology INSERM LNC-UMR 1231 University Hospital of Dijon, France The liquid biopsy in oncology Crowley E, Di Nicolantonio F, Loupakis F, Bardelli A. Nat Rev Clin Oncol. 2013 1. Setting
More informationBiomarker for Response and Resistance in Ovarian Cancer
2016 대한부인종양학회제 31 차춘계학술대회 New Trends in Translational Research Biomarker for Response and Resistance in Ovarian Cancer Shin-Wha Lee, M.D., Ph.D. Department of Obstetrics and Gynecology ASAN Medical Center
More informationMonitoring the effect of first line treatment in RAS/RAF mutated metastatic colorectal cancer by serial analysis of tumor specific DNA in plasma
Thomsen et al. Journal of Experimental & Clinical Cancer Research (2018) 37:55 https://doi.org/10.1186/s13046-018-0723-5 RESEARCH Monitoring the effect of first line treatment in RAS/RAF mutated metastatic
More informationA complete next-generation sequencing workfl ow for circulating cell-free DNA isolation and analysis
APPLICATION NOTE Cell-Free DNA Isolation Kit A complete next-generation sequencing workfl ow for circulating cell-free DNA isolation and analysis Abstract Circulating cell-free DNA (cfdna) has been shown
More informationIntroduction of an NGS gene panel into the Haemato-Oncology MPN service
Introduction of an NGS gene panel into the Haemato-Oncology MPN service Dr. Anna Skowronska, Dr Jane Bryon, Dr Samuel Clokie, Dr Yvonne Wallis and Professor Mike Griffiths West Midlands Regional Genetics
More information