Goitre prevalence (%) Grade 1. Grade 2. TGP < >300 <100 Median Mean. * National: PW: Total F NS

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1 Last Updated: TGP < >300 <00 Median Mean N 003 National: SAC: Total B National: PW: Total F NS SAC by region: Blagoevgrad B SAC by region: Dobrich B SAC by region: Gabrovo B SAC by region: Lovech B SAC by region: Pazardjik B SAC by region: Pleven B SAC by region: Smolian B SAC by region: Sofia-city B SAC by region: Sofia-region B SAC by region: Vratsa B PW by region: Blagoevgrad F NS PW by region: Dobrich F NS PW by region: Gabrovo F NS PW by region: Lovech F NS PW by region: Pazardjik F NS PW by region: Pleven F NS PW by region: Smolian F NS PW by region: Vrata F NS National: SAC: Total B SAC by sex F SAC by sex M SAC by sex and age F SAC by sex and age F SAC by sex and age F SAC by sex and age F SAC by sex and age F SAC by sex and age M SAC by sex and age M SAC by sex and age M SAC by sex and age M SAC by sex and age M SAC by region: Blagoevgrad B SAC by region: Dobrich B SAC by region: Gabrovo B SAC by region: Lovech B SAC by region: Pazardjik B

2 Last Updated: TGP < >300 <00 Median Mean N 003 SAC by region: Pleven B SAC by region: Smolian B SAC by region: Sofia-city B SAC by region: Sofia-region B SAC by region: Vraca B L 00 Sofia city: SAC B Sofia city: SAC B N 999 National: Pre-SAC B R regions: SAC: Total B SAC by sex F SAC by sex M SAC by age B SAC by age B SAC by age B SAC by age B SAC by region: Bladoevgard B SAC by region: Gabrovo B SAC by region: Kardjali B SAC by region: Kyustendil B SAC by region: Lovetch B SAC by region: Pazardjik B SAC by region: Pernik B SAC by region: Plovdiv B SAC by region: Sliven B SAC by region: Smolyan B SAC by region: Sofia B SAC by region: Sofia-Capital B SAC by region: Vidin B SAC by region: Vratza B N 996 National: SAC: Total B SAC by regions: 8 endemic regions B SAC by regions: 5 non endemic regions B S 995 Smoljan region: Adolescents B

3 Last Updated: TGP < >300 <00 Median Mean S 995 Smoljan region: PW F Smoljan region: Adolescents B Adolescents by sex F Adolescents by sex M S 994 Plovdiv and Kjustendil regions: SAC B L South Mountains: villages: Total B NS All by sex F NS All by sex M NS Pre-SAC B SAC by age B SAC by age B Adults by age B Adults by age B Adults by age B Adults by age B Adults by age B Elderly by age B Elderly by age B NS Pre-SAC by sex F SAC by sex and age F SAC by sex and age F Women by age F Women by age F Women by age F Women by age F Women by age F Elderly females by age F Elderly females by age F NS Pre-SAC by sex M SAC by sex and age M SAC by sex and age M Men by age M Men by age M Men by age M Men by age M Men by age M

4 Last Updated: TGP < >300 <00 Median Mean L Elderly males by age M Elderly males by age M NS 46.0

5 NOTES no 4857 : comprised of SAC and PW (nd and 3rd trimester); SAC selected from 0 regions, which were purposely selected as 8 regions with known iodine deficiency and without; in each region 0 schools randomly selected (5 from the regional city and 5 from other locations including at least from villages); PW selected from 8 regions; urinary iodine measured in subsample - every 5th child; goitre investigated by ultrasonography, values not included in the database; summary data reported in reference No note note note 3 note 4 note 5 note 6 note 7 note 8 note 9 note 0 note note Non endemic region. Non endemic region UI <50 µg/l: 0.8% Mean age: 6 ±5 years. UI <50 µg/l: 0.8% no 306 : Cross-sectional study Sofia city 6 years after the introduction of universal salt iodization; sample comprised SAC from 0 schools randomly selected; prevalence of goitre investigated by ultrasonography, values not included in the database. no 34 : Two-stage cluster sampling; cross-sectional survey of institutionalized socially deprived children; 8 institutions randomly selected from 3 social institutions in Bulgaria; the sample is national representative for institutionalized socially deprived children; additional information in reference No no 086 : comprised SAC from 6 towns and village schools randomly selected from 4 endemic regions; according to author results obtained not reliable for Smolyan region (TGR 00%) and selected municipalities of Blagoevgrad and Pazardjik regions. note 3 An error in reference No. 086 in TGP for the 4 endemic regions corrected in accordance with correspondence from the Ministry of Health to data as shown. no 307 : Cross-sectional national survey of school children in 8 endemic and 5 non endemic regions; survey performed two years after introduction of universal salt iodization in Bulgaria. no 304 : selected by cluster method from endemic settlements of Smoljan's region; prevalance of goitre investigated by ultrasonography, values not reported in the database. no 308 : Cross-sectional survey carried out before introduction of salt iodization in the endemic regions of Plovdiv and Kjustendil. no 64 : Survey re-examining 0 villages surveyed in 956 and 974; the villages surveyed were: Delcheveo, Klisura, Momina Klisura, Moskovec, Musomiste, Pastra, Simeonovo, Stob, Stoletovo, Techovo, Golemo Belovo; prevalence of cretinism determined, values not included in the database.

6 R E F E R E N C E S Timtcheva T. Information on IDD situation in Bulgaria [unpublished report]. Sofia, Ministry of Health, 999. Hubaveshki S, Powles J, Lozanov B. Prevalence of goitre in the southern mountainous regions of Bulgaria, Central European Journal of Public Health, 997, 5 : Lozanov B, Hubaveshki ST, Kovatcheva R, Ivanova R, Kirilov G, Apostolova E. The early effects of adequate iodine supplementation on the indicators of iodine deficiency in Smoljan's endemic area (south Bulgaria) [in Bulgarian]. Endocrinologia, 996, : Kovatcheva R, Ivanova R, Lozanov B, Vassileva B, Kurtev A, Kazakova K, Stefanova E, Iliev D, Vukov M. Thyroid volume and urinary iodine in Bulgarian school children from Sofia's region [in Bulgarian]. Endocrinologia, 00, 6 Ivanova L, Lozanov B, Timcheva Zv, Vukov M, Boeva B. Urinary iodine in IDD monitoring in Bulgaria. In: Geertman RM, ed. 8th World Salt Symposium. Volume ; 000 May 7-; The Hague, Netherlands. Amsterdam, Elsevier, Ivanova L. Monitoring of the Efficiency of the IDD Program in Bulgaria [report]. National Centre of Hygiene, Medical Ecology and Nutrition, 00. Ivanova L et al. Ioduria in the monitoring efficiency of IDD prevention: 7 National Symposium "Acad. Ivan Penchev". Endocrinologia, 00, 6 Ministry of Health, Bulgaria, National Center for Hygiene, Medical Ecology and Nutrition-Sofia. Report on the results of the national representative survey on endemic goiter and iodine status in Bulgaria Sofia, Ministry of Health, 003.

7 ADDITIONAL REFERENCES Pencev I, Papasov G, Varbanov V, Staykov T. Distribution and Salient Features of Endemic Goiter in Bulgaria. In: Delange F et al., eds. Iodine deficiency in Europe. A continuing concern. New York, Plenum Press, 965 : Vassileva B, Peneva L. Epidemiology of the schoolchildren goiter in Bulgaria [in Russian]. Pediatriia, 989, 8 :3-37. Lozanov BS, Hubaveshki S, Vassilevski M, Staikov T, Koev D. The long-term epidemiological observation on the endemic goitre in the presence of sufficient iodine prophylaxis. In: Hellenic Endocrine Society. Satellite Symposium International on Iodine & The Thyroid; 990 Sept 4-6; Athens, Greece. Athens, Hellenic Endocrine Society, 990 :6. Peneva L, Losanov B, Koev D. Status of iodine nutrition in Bulgaria. In: Delange F et al., eds. Iodine deficiency in Europe. A continuing concern. New York, Plenum Press, 993 : Petrova M. Diseases of the thyroid during pregnancy and post pregnancy [dissertation]. Varna, Medical University of Varna, 00. Ivanova RB, Kirilov, Ivanova LB, Lozanov BS. Evaluation of thyroid status in pregnant women under supplementation with iodized table salt [in Bulgarian]. Endocrinologia, 003, 8 : van der Haar F, van Ingen JWF, Laurberg PM. Review of progress towards sustained optimal iodine nutrition in Bulgaria, 6 April - 5 May 005. Bulgaria, Network for Sustained Elimination of Iodine Deficiency, 005. Gatseva P, Argirova M, Vladeva S. Status of iodine nutrition in Bulgarian schoolchildren- results from strategies for prevention and control of iodine deficiency disorders. Trace Element and Electrolytes, 006, 3 :58-6.

Rabies eradication programme: Role of hunters

Rabies eradication programme: Role of hunters Directorate ANIMAL HEALTH AND WELFARE AND FEED CONTROL, Bulgarian Food Safety Agency, : 02 915 98 69; e-mail: g_chobanov@bfsa.bg Pravetz, 18-19.12.2017 г.