7 Ways to Improve Your Liposuction Results. Karen Cronholm Product Manager April 21, 2011

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1 7 Ways to Improve Your Liposuction Results Karen Cronholm Product Manager April 21, 2011

2 What value does Smartlipo TriPlex add to my practice? There are 7 Ways.

3 Reason #1 Smartlipo s unique technology improves patient outcomes

4 Data courtesy of Gordon Sasaki, MD Presented ASPS October 2009 Reduced Pain, Less Downtime Patients back to work 50% faster and experienced less pain compared to liposuction alone

5 Laser Lipolysis by Smartlipo The first of it s kind! Unique technology tighten tissue through coagulation rupture fat cells for easier aspiration of fat Over 9 years of experience in Europe, Asia, Middle East and South America More than 45 Clinical Studies Proven to perform technology Offers patients a more appealing option that just liposuction alone

6 Smartlipo Clinical Indications Rupturing of adipocytes - localized fat Coagulation of small blood vessels Less bleeding, trauma, swelling, pain and quicker recovery Promotes tissue coagulation resulting in tissue tightening Ideal for areas of high flaccidity-neck, etc Useful tool for fibrous areas/corrections

7 Smartlipo Procedure Performed under local anesthesia Adjunct to liposuction Tumescent solution is applied to the area (Lactate Ringers, epinephrine, lidocaine) Very small incisions made Fiber is threaded through cannula 1-2 mm Adipocytes are ruptured with laser Subdermal Layer is treated for tissue tightening - through coagulation Aspiration is required for best results

8 Smartlipo Procedure

9 Reason #2 Bring Patients in the Door

10 Smartlipo Brand Name Recognition Smartlipo voted #1 Best of All Aesthetic Procedures in 2010 for the third year in a row!* *AmericanHealthandBeauty.com

11 Proven to Drive Patients to Your Practice Smartlipo is the most sought after procedure in the aesthetic industry Voted #1 Body Contouring Brand* Smartlipo has featured on over 400 local news stations and many big media outlets E! Television New York Times People Magazine 94% patient satisfaction rating *by AmericanHealthandBeauty.com based on patient requests

12 Cynosure can help increase your referrals from the web Social Media Facebook and Twitter initiatives Partnerships Liposuction.com The Patient s Guide MD Connect Patient website Smartlipocynosure.com

13 Reason #3 Tissue Tightening - Treat areas that are difficult with traditional Liposuction alone

14 Results - Neck

15 Results - Abdomen

16 Results - Arms

17 Does it Last? 1 year Result

18 For Proven Tissue Tightening Blend 1064nm and 1320nm Produces a uniform thermal profile for proven tissue coagulation and tightening Tissue tightens 57% more than liposuction alone Evidence of new collagen production after Smartlipo treatments

19 Does Smartlipo MPX really tighten skin (tisssue)? Yes! 10-20% improved skin area shrinkage Up to 57% improved elasticity or tightening index 4 studies by Drs. DiBernardo, Katz and Sasaki

20 4 Peer Review Studies to Prove It!

21 Tissue Tightening Video

22 Reason #4 Reduce complications Less touch ups Less side effects

23 Clinical Evidence of Efficacy and Safety Complication Rates Complication Rate of 0.93% Botox is 0.1-1%* Touch up Rates Touch up rate of 3.5 % Compared to 12% for standard liposuction Local Anesthesia for less risk Study by Bruce Katz, MD and Jason McBean, MD *

24 Reason #5 ThermaGuide Intelligent Delivery Improved Patient Safety and More Control

25 Intelligent Delivery Systems Improving Clinical Outcomes New technologies make Smartlipo Easier to Use SmartSense ThermaGuide Groundbreaking Thermal Sensing Products: Provide more precise and controlled body contouring Achieve a higher level of safety Best possible skin tightening results* Available only from Cynosure *through tissue coagulation

26 ThermaGuide Technology Development Epidermal necrosis & collaginous change 1 Occurance of necrosis Epidermal necrosis & collaginous change Surface Temprature (oc) Clinical Temperature Study-DiBenardo Handheld Infrared Thermometer ThermaGuide Subdermal Thermal Sensing

27 Clinical Implications of Temperature Groundbreaking study is the 1 st to correlate subdermal temperature rise with tissue damage Exceed these temperatures and cause epidermal and dermal injury: Skin surface - 47ºC Journal of Cosmetic and Laser Therapy Study DiBenardo Tissue at 5mm deep ºC Collagen changes found in tissue heated, but not damaged Temperature for best skin tightening determined

28 Occurance of necrosis Surface Temperature Epidermal necrosis & collaginous change Yes1 Necrosis threshold (47 o C) Epidermal necrosis & collaginous change No Surface Temprature (oc) Surface temperature vs. Histological finding of epidermal necrosis and collaginous change

29 ThermaGuide ThermaGuide is a temperature sensing cannula Continuously monitors subdermal tissue temperature Interacts with the Smartlipo MPX workstation

30 ThermaGuide ThermaGuide cannula contains a temperature sensor 1cm from the distal fiber tip Max cross section approximately 2 mm Heatshrink Cannula Kerf recess Temp sensor

31 ThermaGuide Smartlipo displays temperature on the screen Laser energy delivered to reach target temperature Safer and more uniform treatment Adjust temperature - recommendations for each treatment area or type

32 ThermaGuide Case Study Dr. Stephen Mulholland Neck Treatment 50 yr. old woman Smartlipo Settings: 6W 1064nm/6W 1320nm ThermaGuide Settings: Low: 40ºC High: 45ºC ThermaGuide was used to determine endpoint Results: Consistent, safe subdermal and epidermal temperature of 40 C More precise and refined control of laser energy delivery achieved while increasing patient safety

33 Reason #6 Smartlipo more than just liposuction

34 Emerging Indications Hyperhidrosis & Lipomoas Subdermal Nd-YAG Laser for Auxiliary Hyperhydrosis Alberto Goldman M.D. and Uwe Wollina, M.D. 17 Patients 88.% reported good-excellent results Treatment of Lipomas Eradication of fibrous lipomas, usually excised Minimally invasive, no scarring, quick recovery

35 Smartlifting Application SmartLifting: A Technological Innovation for Facial Rejuvenation Richard Gentile M. D. 200 Patients Benefits-Speed, less bleeding, skin tightening, downtime

36 New SmartLook Application Minimally invasive LaserFacialSculpting Tighten tissue (skin) subdermally Apply laser energy where it is more effective Reduce volume (only if needed) Accomplish with ThermaGuide it s safer and easier

37 SmartLook Results Excellent results Less Bruising and bleeding Less Downtime (1-2 days) Addresses the jowl area very well

38 SmartLook Results

39 Reason #7 Only Cynosure offers the fastest and most versatile laser system

40 Laser Lipolysis Redefined

41 New Smartlipo Triplex Laser 1440, 1320, 1064 nm wavelengths Smartlipo delivery system New look, GUI and display Most effective laser lipolysis SmartSense enabled Improved ThermaGuide

42 New Smartlipo TriPlex Delivered by multiplex and intelligent delivery Smartlipo TriPlex now offers 3 wavelengths 1064nm 1320nm 1440nm

43 Constantly Redefining Laser Body Sculpting MultiPlexing TriPlex 11/06 5/07 11/07 5/08 5/09 11/09 01/11 6W 10W 12W 18W 20W 30W 46W 40W, 24W, 15W 1064nm, 1320nm, 1440nm Blue handpiece SmartSense ThermaGuide New ThermaGuide 300 m fiber 600 m fiber 1000 m fiber New RFID fiber

44 Why add 1440nm? 1440nm has 40X greater absorption in fatty tissue than diode lasers (924nm and 980nm) Greater absorption = 50% faster treatments for improved ROI Blend with 1064nm for hemostasis

45 980nm Diode CW Treatment 15W treatment in actual human fatty tissue

46 Smartlipo TriPLex 1440 nm Treatment 15W treatment in actual human fatty tissue

47 Smartlipo TriPlex Specifications System Type Nd:YAG Individual Wavelength Options Wavelength 1064nm 1320nm 1440nm Pulse Width (Max) 500µs 1000µs 1000µs Power Output Options 40W 24W 15W Max Rep Rate 40Hz 40Hz 25Hz Multiplexing Options Wavelength 1064nm and 1320nm 1064nm and 1440nm Pulse Width (Max) 500µs and 1000µs 500µs and 1000µs Power Output Options 32W 20W Max Rep Rate 40Hz 40 Hz and 25Hz Aiming Beam Red Electrical 230 VAC/16A Requirements Size (HxWxD) 37.4 x 19.7 x 25.6 (95cm x 50cm x 65cm) Weight 220 lbs (100kg)

48 Data courtesy of Barry DiBernardo, MD Optimizing Your Treatments Recent clinical studies, demonstrates faster treatment times and use of less energy

49 More Fat is Disrupted Using Less Energy with 1440nm Heated Area Disrupted Area Heated Area Disrupted area Subcutaneous fatty tissue 1 week after 4W 1440nm Rx Less Power Need for a larger disrupted area Subcutaneous fatty tissue 1 week after 20W 1320nm Rx Larger heated area more ideal for tissue tightening

50 Smartlipo - High Definition Results

51 TriPlex Means High-Def Capability 1440nm allows for easier subdermal release Treatment is fasterrequired for a lengthy procedure Adds another patient population

52 Smartlipo Graphic User Interface

53 Smarter GUI Features New Look and Feel Benefits Simpler Navigation 2X Larger display and font New Angle Effortlessly read critical parameters Tracks Fiber Life with RFID logic For safe, precise and accurate treatment

54 New RFID Fiber Technology New Smartlipo TriPlex laser recognizes fiber How it works: RFID tag in fiber RFID reader inside laser 20 connects for enhanced safety, optimized energy delivery Sold Non-sterile 5 packs 600 and 1000 micron (orange, green)

55 Smartlipo TriPlex: Offers the right combination of wavelength for optimum results in a wide variety of patients More effective laser lipolysis Proven tissue coagulation resulting in tightening Faster treatment time Less Downtime High-definition sculpting capabilities

56 Cynosure has Continued to Define Future of Laser Body Sculpting Continued Innovation Unmatched Delivery Systems with ThermaGuide Added additional power and wavelengths Larger Fibers Proven to Perform The most clinical studies Proven to be Profitable Brand Awareness Expanded Patient Base Treat New Applications Facial Treatments Corrections/Scar tissue Cellulite Elastosis/skin laxity Hyperhidrosis 9 years of use Globally #1 Choice amongst patients

57 Summary Smartlipo s popular brand name provides customers with a huge revenue making opportunity Smartlipo TriPlex has become the standard of care for laser lipolysis around the world Treat all patients body contouring concerns

58

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