#26 made by: Lina Abdullah corrected by: sarah awaisheh date:

Transcription

1 #26 made by: Lina Abdullah corrected by: sarah awaisheh date: *slides are not included in this sheet

2 Review Infected adult males in mumps can get infertility, because the virus destroy the blood testis barrier so srerm exposed lymphocytes and it might produce sperm antibody this one mechanism sterelity of male infected with mumps virus. Attenuated viral vaccine used for mumps measles and rubeola (MMR) Slide 67 Measles Rubeola : normal measles. Rubella : german measles. very contagious معد ة بشكل كب ر خصوصا لألطفال spots" theبمع main sign in measles is "koplik على الجلد حمراء Exanthemطفح- -SSPE is a complication process through measles, it,s not necessary to occur all infected person. -also the same vaccine, MMR : Mumps Measles Rubeola Slide 69 bullet shaped مثل شكل الرصاصة نتمل عن طر ك الح وانات الكلب وفصائله مثل الذئاب onest of symptoms depends on site of infection if the infected site close to CNS, the symptoms appear rapidly but if not like (end of leg) the symptoms need more time to show.

3 -This infection is characterized by 3 stages: 1- prodomal : بدا ة ظهور االعراض tingling sensations تنم ل 2- Furious: تظهر االعراض بشكل سر ع وتكون لو ة hydrophobia: رهاب) خوف (من الماء 3- Dumb: االعراض بشكل خط ر و واضحة جدا -Rabies virus exists in salivate infected person. Slide 72 Negri body: من العالمات المميزة لداء الكلب وجود intracellular inclusion ( giant cell) خل ة موجود ف ها الف روس بشكل كب ر Negri body special sign in nervous tissue. Treatment : they give the infected person immune globulin that is specific for this virus, because our body cant form specific immune globulin in start period of time, in addition to vaccin that is given before getting infceted ofcourse for those who work in plentiful places of dogs(a preventive way mostly) strays: المشردة الكالب quarantine: الحجر صح

4 Slide 73 -spikes have spaces on their envelops -corona viruses infect upper or lower respiratory tract. SARS might lead to death. المرض معدي بشكل كب ر و ا ضا له المدرة على البماء لفترة طو لة خارج الجسم الح أي مكنه االنتمال عن طر ك ال Objects( not human) If someone sneezes and his hand is contaminated by droplet and then he touch the door, he might get the viruse مثل اذا شخص ما عطس و ده وتلوثت بالرذاذ ثم لمس باب واذا شخص لمس نفس المكان بالتال لد صاب بالف روس, Slide 74 It differs from measles by color of rash and itchy Congenital rubella: Duringه 1st trimester مرحلة من مراحل الحمل نتمل ف ها الف روس للجن ن خالل ال 3 شهور االولى -The rash during rubella starts from the face then to the chest and so on. Slide 76 Example of this group is hepatitis virus Heptitis may occur either with RNA or Dna virus - RNA virus (haptitis C and E) also called non A and non B

5 (C E) and الفرق ب نهم بطر مة االنتمال -DNA virus (haptitis B) D,B,C : is transmitted by blood A,E : is transmitted by oral fecal interferon : chemical inflamnatory meditors are produced by viral infected cell to protect the adjacent cell from being infected by this virus or another virus. so interferon is not viral specific but it is species specific. ه عبارة عن مواد تفرزها الخال ا المصابه بف روس مع ن لتحم الخال ا المجاورة من االصابة بنفس الف روس او ف روس آخر. Also interferon is very expensive and it use for antoimmune disease like (AIDs) species specific: عن interferon المعزول من االنسان عطى لالنسان والمعزول من الح وانات مثل الكلب والمطط عطى للح وانات من نفس النوع. interferon has start life time (it is bad point) Slide 77 HIV from chimpanzee virus or African monkey Encode reverse transcriptase enzyme: حتو ي على انز م االستنساخ العكس اي ان الف روس س تحول منRNA الى DNA عن طر ك هذا االنز م. coreceptor: to make binding between virus and surface more strong.

6 CD4 exists in various cells (dendrtic cell, Epitheia skin or in microvillial) but the most cell contain CD4 is T helper cell which is the target cell. T helper is the base of immune system which help all cells of the body (lymphocyte or microve, cytotoxic)so if T helper disbiling all immune system will depressed. من اول الفحوصات الت عملها المتبرعون بالدم ه HIV والفحوصات المتعلمة باالمراض الجنس ة و hepatitic B وحال اC. hepatitic All fluids in our bodies can transport the virus in few cases the virus is transmitted to baby by breast feeding. Slide 78 The spike of this virus consists of GP-120 and GP-41 mv another GP but these the most important. GP: glyco protein The binging process and white blood cell Slide 79 of this PG to thecd4 needs coreceptor Name of phagocytes depends on the site where it is located: -skin: dendritic -liver: kupffer cell -blood, monocyte. -tissue: macrophage -CNS: microgia cell

7 Slide 80 ssdna: single strand DNA. dsdna: double strand DNA. the virus enters to the test cell by CD4 or coreceptor (organe: ssrna, circle: reverse transcripatase) by transcripatase the ssrna molecules convert to early ssdna then to complete ssdna then to complete ssdna then to complete dsdna which is binding to DNA of last cell then transcription, transilation these process lead to copy RNA virus and copy for all component (spikes, protase) Slide 81 اعدادWBC leukopeniaللة : اعدادWBC : leukocytosisز ادة

8 lymphocytes in particular means T lymphocytes. : syncytiaالمدمج الخلوي fusiong between T lymphocytes to form against cell has nucleus, this process facilitae the virus to spread. Slide 82 symptoms of HIV infiction depends on the extent of the damage to T lymphocyte. (avg.10) : means the average 10 gears to appear syptoms. the virus lies in intracellular during activation, the virus move from intra to extracellular. لذلن اذا فحصوا الدم ف فترة عدم ظهور االعراض تكون النت جة negative الن الف روس obligute intracellular لذلن تعتبر هذه مشكله طب ه وتم عمد مؤتمر لمنالشة طرق عمل activation للف روس حتى ظهر. Don t stress Do your best Forget about the rest

9