RICONOSCIMENTO DELL Ag DA PARTE DELL IMMUNITA ADATTATIVA
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1 RICONOSCIMENTO DELL Ag DA PARTE DELL IMMUNITA ADATTATIVA T B TCR BCR
2 IMMUNOGLOBULINE QuickTime e un decompressore TIFF (Non compresso) sono necessari per visualizzare quest'immagine.
3 Struttura delle Immunoglobuline 1 QuickTime e un decompressore TIFF (Non compresso) sono necessari per visualizzare quest'immagine.
4 Struttura delle Immunoglobuline 2 QuickTime e un decompressore TIFF (Non compresso) sono necessari per visualizzare quest'immagine.
5 CHI PRODUCE LE IMMUNOGLOBULINE QuickTime e un decompressore TIFF (Non compresso) sono necessari per visualizzare quest'immagine.
6 Dissezione enzimatica delle Ig 1. PM 150 kda 2. Light chain 25kDa 3. Heavy chain 50kDa QuickTime e un decompressore TIFF (Non compresso) sono necessari per visualizzare quest'immagine.
7 5 Classi di Ig QuickTime e un decompressore TIFF (Non compresso) sono necessari per visualizzare quest'immagine.
8 Light Chain Structural Organization QuickTime e un decompressore TIFF (Non compresso) sono necessari per visualizzare quest'immagine.
9 REGIONI IPERVARIABILI QuickTime e un decompressore TIFF (Non compresso) sono necessari per visualizzare quest'immagine.
10 EPITOPO CONFORMAZIONALE AGRETOPO SITO DI LEGAME DELL ANTIGENE EPITOPO LINEARE QuickTime e un decompressore TIFF (Non compresso) sono necessari per visualizzare quest'immagine.
11 mab
12 mabs Clinic use 1. Against human Chorionic gonadotropin (HCG) Pregnancy test (ELISA 2. AIDS (ELISA) 3. Radioterapy, Radioimmunodetection 4. Bacteria Strain typing 5. OKT3 as immunosuppressive durg in transplanted patients
13 Drayer Bennet hypothesis: Tonegawa demonstration exp 1976 QuickTime and a TIFF (Uncompressed) decompressor are needed to see this picture. QuickTime and a TIFF (Uncompressed) decompressor are needed to see this picture.
14 GENETICA DELLE IMMUNOGLOBULINE QuickTime e un decompressore TIFF (Non compresso) sono necessari per visualizzare quest'immagine.
15 RICOMBINAZIONI SOMATICHE QuickTime e un decompressore TIFF (Non compresso) sono necessari per visualizzare quest'immagine.
16 COME AUMENTARE LA VARIABILITA 1 QuickTime e un decompressore TIFF (Non compresso) sono necessari per visualizzare quest'immagine.
17 Sequenza segnale di ricombinazione (RSS) RSS QuickTime e un decompressore TIFF (Non compresso) sono necessari per visualizzare quest'immagine.
18 RIARRANGIAMENTO 12/23 QuickTime e un decompressore TIFF (Non compresso) sono necessari per visualizzare quest'immagine.
19 COME AUMENTARE LA VARIABILITA 2 QuickTime e un decompressore TIFF (Non compresso) sono necessari per visualizzare quest'immagine. Aggiunta Nucleotidi P ed N Nei siti giunzionali
20 COMPLESSI ENZIMATICI V(D)J RECOMBINASI RAG1 RAG2 DNA ligasi IV TdT Desossinucleotidil transferasi terminale DNA PK
21 SWITCH ISOTIPICO QuickTime e un decompressore TIFF (Non compresso) sono necessari per visualizzare quest'immagine.
22 OMOLOGIE TRA Ig e TCR TCR like this portion of Ab Antibody Structure Complement Binding Site Phagocyte Receptor Binding Site
23 T Cell Receptor Antigen Recognition TCR per Lymphocyte α β T cell Membrane
24 All T cells are Antigen specific Mediated by T cell receptor TCR Surface molecule homologous to part of Ab Diversity is generated by rearrangement of TCR gene locus
25 Generation of TCR Diversity Variable-region (V) Genes Diversity (D) Gene Joining (J) Genes β Constant Domain Germline DNA Somatic Recombination Transcription DNA in T cell Splicing Translation Message TCR β Chain
26 Generation of TCR Diversity Variable-region (V) Genes Joining (J) Genes α Constant Domain Somatic Recombination Germline DNA Transcription DNA in T cell Splicing Message Translation TCR α Chain
27 Annual Review of Biophysics and Biomolecular Structure Vol. 31: Rudolph M et al TCR α β/γ δ
28 TCR associate with CD3 QuickTime e un decompressore TIFF (LZW) sono necessari per visualizzare quest'immagine. Call ME, Wucherpfennig KW. Molecular mechanisms for the assembly of the T cell receptor-cd3 complex. Mol Immunol Apr;40(18): Review.
29 CD3 STABILIZZA L ESPRESSIONE IN MEMBRANA DEL TCR
30 THE CD3 TCR ASSEMBLING PROCESS I
31 THE CD3 TCR ASSEMBLING PROCESS II
32 INTERAZIONI ED ORIENTAMENTO TRA TCR E MHC Annual Review of Biophysics and Biomolecular Structure
33 CO-RECEPTORS QuickTime e un decompressore TIFF (Non compresso) sono necessari per visualizzare quest'immagine.
34 TCR CO-RECEPTOR RECOGNITION QuickTime e un decompressore TIFF (Non compresso) sono necessari per visualizzare quest'immagine.
35 T cells T cell receptors (TCR) Ag specific Glycoproteins CD4 (helper T cells) or CD8 (cytotoxic T cells) CD4 CD8 TCR TCR CD4 T cell or helper T cell CD8 T cell or cytotoxic T cell
36 CD4+ T cells Helper T cells involved in Ab production Recognition of exogenous Ag Bacteria Extracellular Ag Recognize MHC class II molecule Present on antigen presenting cells = APC e.g. Macrophages, Dendritic Cells, B cells
37 APC = e.g., Macrophage Peptide Antigen TCR MHC Class II CD4 CD4 T Cell
38 TCR Recognizes its Epitope Only in the Context of MHC CD4 TCR peptide/mhc Class II CD8 TCR peptide/mhc Class I
39 APC Peptide Antigen TCR MHC Class II CD4 Cytokines CD4 T Cell
40 Bacteria Activation of CD4 Helper T Cell Y Cytokines Activate Macrophages - Boost Performance Y Y Y MHC Class II Cytokines Ag Binding to Ab on B cell & TCR Cytokines from T cells Activates B cell Proliferates Undergoes Class-switch Becomes Plasma Cells that secretes Ab Leads to formation of Memory B cells Increased affinity of Ab produced APC CD4 Peptide Cytokines T Cell is Activated Proliferates Produces Cytokines
41 B Cells are Antigen Presenting Cells (APC) too CD4 T cell B cell
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