Cent Gardes Conference: HIV Vaccines. Organized by Fondation Mérieux «Les Pensières» Fondation Mérieux Conference Center Veyrier du Lac - France
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1 Cent Gardes Conference: HIV Vaccines Organized by Fondation Mérieux «Les Pensières» Fondation Mérieux Conference Center Veyrier du Lac - October 6 to 8, 2017
2 Steering Committee Members Françoise Barré-Sinoussi François Dabis Jean-François Delfraissy Yves Levy Benoît Miribel Giuseppe Pantaleo Institutions 2008 Nobel Prize in Medicine and Physiology ANRS, Recherche Nord & Sud Sida-hiv Hépatites Comité consultatif national d'éthique CEA/INSERM/Université Paris Sud INSERM Fondation Mérieux Centre Hospitalier Universitaire Vaudois Switzerland Scientific Advisory Board Members Marcus Altfeld Constance Delaugerre Serge Eholié Gunilla Karlsson Hedestam Michel Nussenzweig Giuseppe Pantaleo Gabriella Scarlatti Olivier Schwartz Georgia Tomaras Carolyn Williamson Linqi Zhang Institutions HPI Hamburg Germany CHU Saint-Louis AP-HP University Félix Houphouet-Boigny Yvory Coast Karolinska Institutet Sweden CEA/INSERM/Université Paris Sud The Rockefeller University USA Centre Hospitalier Universitaire Vaudois Switzerland San Raffaele Scientific Institute Italia Institut Pasteur Duke University Medical Center USA University of Cape Town South Africa Tsinghua University China
3 Organizing Committee Members Guiseppe Pantaleo Cindy Grasso Valentina Picot Institutions CEA/INSERM/Université Paris Sud Centre Hospitalier Universitaire Vaudois Switzerland Fondation Mérieux Fondation Mérieux
4 Scientific Programme Friday, October 6 th h00-13h30 Registration 13h30-14h00 Welcome addresses Benoît Miribel Jean-François Delfraissy François Dabis Giuseppe Pantaleo Session 1 Regulation of induction of protective immune responses in natural infection and following vaccination Chair: Andrew McMichael 14h00-14h25 Presentation 1 Antonio Lanzavecchia 14h25-14h50 B Cell Activation Induces a Switch from Canonical to non-canonical Autophagy that Shapes B Cell Fate Facundo Batista Session 2 Update on HIV prevention: what are we learning from the clinic (immune correlates, vaccine, other interventions (PrEp) Chair: Robin Shattock 14h50-15h15 T cell responses and vaccine protection in prophylactic vaccines Julie McElrath 15h15-15h40 Presentation 2 Georgia Tomaras 15h40-16h05 Presentation 3 Larry Corey 16h05-16h30 Presentation 4 Sheena McCormack 16h30-16h55 Control of HIV infection by T cells Persephone Borrow 16h55-17h20 19h00 Dinner
5 Saturday, October 7th 2017 Role of antibodies in HIV Prevention and Therapy 8h30-9h15 Keynote lecture: B cell biology and germinal center formation Michel Nussenzweig Session 3 Advances in the development of bnabs and non-bnabs (antigen design and preclinical models ) Chair: John Moore & Carolyn Williamson 9h15-9h40 Presentation 1 Anthony Moody 9h40-10h05 Presentation 2 William Schief 10h05-10h30 10h30-11h00 11h00-11h25 11h25-11h50 11h50-12h15 Native-like HIV-1 envelope trimers that activate germline precursors of broadly neutralizing antibody precursors in vivo Coffee Break Structure-Based Elicitation of Fusion Peptide-Directed Antibodies that Neutralize Diverse Strains of HIV Structure-based design of improved antibodies against HIV Recapitulation of HIV-1 Envelope-Antibody Coevolution in Rhesus Macaques Leading to Neutralization Breadth Rogier Sanders Peter Kwong Pamela Bjorkman George Shaw 12h15-12h40 Presentation 7 Leo Stamatatos 12h40-14h00 Lunch
6 Session 4 Advances in the development of bnabs and non-bnabs (antigen design and preclinical models ) Chair: Susan Zolla-Pazner 14h00-14h25 Presentation 1 Dennis Burton 14h25-14h50 Presentation 2 Barton Haynes 14h50-15h15 15h15-15h40 15h40-16h10 16h10-16h40 HIV-1 Envelope Modifications that Permit Neutralization by Germline and Early Intermediates of CD4bs Broadly Neutralizing Antibodies Targeting productively and latently infected cells with antibodies Coffee Break David Montefiori Olivier Schwartz Session 5 bnabs and non-bnabs in prevention and therapy Chair: Linqi Zhang 16h40-17h05 17h05-17h30 17h30-17h55 Clinical Evaluation of anti-hiv Broadly Neutralizing Antibodies Antibody-mediated prevention of HIV-1 Infection Using anti-hiv 1 bnabs for Treatment and Prevention Marina Caskey John Mascola Malcom Martin 17h55-18h20 Presentation 4 Carolyn Williamson 18h20-18h50 19h00 Dinner
7 Sunday, October 8 th 2017 Mechanisms of transmission and mucosal immunity Session 6 Mechanisms of transmission and mucosal immunity Chair: Jake Estes 8h30-8h55 Presentation 1 Hugo Mouquet 8h55-9h20 Presentation 2 Robin Shattock 9h20-9h45 9h45-10h15 10h15-10h45 Early viral replication and dissemination dynamics following vaginal infection of a molecularly tagged SIV in rhesus macaques Coffee Break Brandon F. Keele HIV Functional Cure Session 7 HIV persistence and cell reservoir (molecular mechanisms, cell reservoir in blood and tissue cell populations) Chair: Olivier Lambotte and Jean-Daniel Lelièvre 10h45-11h10 Presentation 1 Jake Estes 11h10-11h35 Presentation 2 Warner Greene 11h35-12h00 Presentation 3 Giuseppe Pantaleo 12h00-13h30 Lunch 13h30-13h55 Presentation 4 Monsef Benkirane 13h55-14h20 Presentation 5 Thumbi Ndungu 14h20-14h50
8 Session 8 Immune-based interventions Chair: François Dabis 14h50-15h15 Immune-based interventions for HIV cure: lessons from NHP models Guido Silvestri 15h15-15h40 Presentation 2 Asier Saez-Cirion 15h40-16h05 Presentation 3 Yves Levy 16h05-16h35 16h35-17h00 17h00 Conclusions End of Meeting Giuseppe Pantaleo
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