BIO DATA OF THE INVESTIGATOR(S) 1. Name (Dr./Kum./Smt./Shri) : Sujatha Narayanan First Name(s) Surname. 6. Discipline : Immunology & Molecular Biology

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1 BIO DATA OF THE INVESTIGATOR(S) 1. Name (Dr./Kum./Smt./Shri) : Sujatha Narayanan First Name(s) Surname 2. Designation : Scientist G 3. Date of Birth : Date of joining : July Date of joining present post: Sept Discipline : Immunology & Molecular Biology 7. Complete Postal Address : Department of Immunology National Institute for Research In Tuberculosis 1, Mayor Sathyamurthy Road Chetput, Chennai E.mail: sujatha.sujatha36@gmail.com Tel. No.: Address : New No 7, Deivasigamani Road, Residence Royepettah, Chennai Phone Educational Qualification Degrees obtained (Begin with MBBS): Degree Institution Field(s) Year Ph.D. University of Madras, India Biochemistry 1985 Diploma University of Wisconsin, Cytotechnology 1977 Madison, WI M.Sc., University of Madras, India Biochemistry 1975 B Sc., University of Madras, India Chemistry 1973 P.U.C University of Madras, India Physics, Chemistry 1970 Natural Science

2 9. Research/Training Experience (apart from Thesis) Duration Institution Particulars of the work done Tuberculosis Research Centre Asst. Res. Officer, Dept. of Imm do- Research Officer, -do do- Sr. Res. Officer, -do do- Assistant Director, -do do- Dy. Director, -do National Institute for Research in Dy. Director (Sr.Gr.)/Scientist F present tuberculosis Scientist G 10. Molecular Biology,2. Molecular Epidemiology 3. and Host pathogen interaction. Research interests a. Functional genomics of Serine Threonine Kinases & cell wall proteins of M.tuberculosis b. Genotyping and understanding the transmission of M.tuberculosis. c. Gene regulation and Host pathogen interaction Special committies Life member of Indian Immunology society American society of clinical pathology ( ASCP) 11. Fellowships & Awards Fellow, LVD/NIAID/NIH, Bethesda, Maryland, USA Indo-UK DFID fellowship, Medical Research Council (MRC)/NIMR-London, UK 2002 & 2004 WHO Fellow, Division of Infectious Diseases and Geographic Medicine, Stanford University Medical School, Stanford, California, USA Principal Investigator (India) AITRP programme with AECOM, USA Principal Investigator INSERM /ICMR project 1. High resolution genotyping M. tuberculosis IS6110 low-copy number strains combining novel molecular approaches for global detection of tuberculosis 2

3 2. High resolution molecular markers as tools for evaluation of tuberculosis control programs in two Indian regions Principal Investigator (India ) RO3 grant NIH Comparative genomics of M. tuberculosis Co-investigator DBT project - Profiling of heterogeneity of field strains of M. tuberculosis Principle investigator from NIRT on DBT collaborative Project Bioprospecting Lichens for antimycobacterial compounds Network of Lichens - Bioprospecting secondary compounds for antimycobacterial compounds 2005& Best poster awards and oral presentation awards for our work Indian Immunology Society, Lucknow, our poster presentation got best poster award Microbiology conference at Ethiraj college for Women, Chennai HIV /TB conference Dr MGR Medical University and International conference in Infectious Diseases best oral presentation award for our work. Total number of publications: 75; Chapter in books 3; Patent filed 1: Patent applied: 1 Invited lectures given in conferences total Teaching Experience: Guidance for PhD students at the University of Madras Ten students have got their PhD degree and eight more are registered. Co-guidance for Ph.D. students: Co-mentor for more than ten students registered for the Ph.D. degree at the University of Madras and the Tamil Nadu Dr. MGR Medical University 8. Recent publications (last 5 years, with titles and references), 1. Kumar D, Hanna LE, Narayanan S. PknE, a Serine/Threonine protein kinase of Mycobacterium tuberculosis Initiates survival crosstalk that also impacts HIV coinfection PLOS ONE.2014;9(1):e Makeshkumar V, Madhavan R, Narayanan S. Polymerase chain reaction targeting insertion sequence for the diagnosis of extrapulmonary tuberculosis. Indian J Med Res.2014;139: Makeshkumar V, Madhavan R, Narayanan S, Lakshmi R. katg Gene as a 3

4 surrogate molecular marker leading to cause resistance in Mycobacterium tuberculosis Isolates. American J Infect Dis Microbiol.2013;1(5): Kumar D, Narayanan S. Cell death paradigms in the pathogenesis of Mycobacteriumtuberculosis infection. Front Cell Infect Microbiol.2014;4 (31): Makeshkumar V, Madhavan R, Narayanan S. Prevalence of drug resistance in Mycobacterium tuberculosis in a teaching hospital of Kanchipuram District, Tamilnadu, south India. American J Microbiol Res.2014;2(1): Balaji S, Kannan P, Arunkumar V, Narayanan S. Expression, purification and functional characterization of AmiA of acetamidase operon of Mycobacterium smegmatis. Microbiol Res in press. 7. Suba S, Narayanan S. The lpqs knockout mutant of Mycobacterium tuberculosis is attenuated in Macrophages. Microbiol Res.2013;168(7): Narayanan S, Deshpande U. Whole-Genome sequences of four clinical isolates of Mycobacterium tuberculosis from Tamil Nadu, South India. Genome Announc.2013; 1(3):1. 9. Kumar D, Kannan P, Challu VK, Kumar P, Narayanan S. PknE, a serine/threonine protein kinase from Mycobacterium tuberculosis has a role in adaptive responses. Arch Microbiol.2013;195(1): Bourai N, Jacobs WR Jr, Narayanan S. Deletion and overexpression studies on DacB2, a putative low molecular mass penicillin binding protein from Mycobacterium tuberculosis H 37 Rv. Microb Pathog.2012;52(2): Aparna JC, Karthika KD, Dhandapaani G, Kannan P, Gupta UD, Gupta P, Ignacimuthu S, Narayanan S. Epitope based recombinant BCG vaccine elicits specific Th1 polarized immune responses in BALB/c mice. Vaccine.2012;30(7): Kumar D, Narayanan S. pkne, a serine / threonine kinase of Mycobacterium tuberculosis modulates multiple apoptotic paradigms. Infect Genet Evol.2012;12(4): Kannan P, Malini V, Narayanan S. Characterization of Ffh of Mycobacterium tuberculosis and its interaction with 4.5S RNA. Microbiol Res.2012;167(9):

5 14. Refaya AK, Sivakumar S, Sundararaman B, Narayanan S. Polymorphism in the RD1 locus and its effect on downstream genes among South Indian clinical isolates of Mycobacterium tuberculosis. J Med Microbiol.2012;61 (Pt 10): Sivakumar S, Selvakumar N, Narayanan S. Drug resistance among different genotypes of Mycobacterium tuberculosis isolated from patients from Tiruvallur, south India. Infect Genet Evol.2011;11(5): Thangappah RBP, Paramasivan CN, Narayanan S. Evaluating PCR, culture & histopathology in the diagnosis of female genital tuberculosis. Indian J Med Res.2011;134: Natarajan PL, Narayanan S. Mitogen-activated protein kinases mediate the production of B-cell lymphoma 2 protein by Mycobacterium tuberculosis in monocytes. Biochemistry (Moscow);2011;76(8): Natarajan P, Ponnuraja C, Narayanan S. Mitogen activated protein kinase Influence the immune response of a prevalent Mycobacterium tuberculosis clinical strain of the Indo-Oceanic Clade. J Infect Dis Imm.2011;3(10): Jayakumar D, Jacobs WR Jr, Narayanan S. Protein kinase E of Mycobacterium tuberculosis has a role in the nitric oxide stress response and apoptosis in a human macrophage model of infection. Cell Microbiol.2008;10: Unissa AN, Suganthi C, Narayanan S, Selvakumar N. Detection of isoniazid-resistant clinical isolates of Mycobacterium tuberculosis from India using Ser315Thr marker by comparison of molecular methods. Int J Mol Clin Microbiol.2011;1(2): Unissa AN, Narayanan S, Selvakumar N. Virulence in isoniazid-resistant clinical isolates of Mycobacterium tuberculosis from south India. Int J Mol Clin Microbiol.2011;1(2): Narayanan S, Swaminathan S, Supply P, Shanmugam S, Narendran G, Hari L, Ramachandran R, Locht C, Jawahar MS, Narayanan PR. Impact of HIV infection on the recurrence of tuberculosis in south India. J Infect Dis.2010;201: Lakshminarayan H, Rajaram A, Narayanan S. Involvement of serine threonine protein kinase, PknL, from Mycobacterium tuberculosis H 37 Rv in starvation response of mycobacteria. J Microb Biochem Tech.2009;1:

SCIENTIST PROFILE. Phone: FAX : E.Mail : i) ii)

SCIENTIST PROFILE. Phone: FAX : E.Mail : i) ii) SCIENTIST PROFILE 1. Name : Dr. P. SELVARAJ 2. Designation : Scientist F (Deputy Director Sr.Gr.) 3. Date of Birth : 03-04-1953 4. Date of joining : 19-10-1984 5. Date of joining present post : 01-09-2011