Various interventions for controlling sexually transmitted infections have proven effective, including the syndromic

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1 levels, as understaffing is a chronic issue in all the countries that are scaling up male circumcision. Current achievements notwithstanding, it is necessary to reinforce and strengthen national political support for male circumcision scale-up, reach out to traditional providers and community leaders to promote buy-in and uptake, and accelerate the pace of service delivery roll-out. As services are scaled up, it is critical to closely monitor the implications of male circumcision for women and mitigate against any adverse societal effects that might negatively impinge on their health Prevention and management of sexually transmitted infections The rapid identification and treatment of infections is a key element in controlling the spread of HIV, as infections synergistically increase the risk of HIV transmission (57). Scientific evidence suggests that infections increase HIV shedding in the genital tract of HIV-positive individuals (thereby boosting infectiousness) and disrupt mucosal barriers, leading to increased susceptibility to HIV in HIV-negative individuals. 1 Various interventions for controlling infections have proven effective, including the syndromic 1 In low-level or concentrated HIV epidemics, particularly where the prevalence of infections is high and their control is poor, treatment of curable infections is likely to have a considerable impact on HIV incidence at the population level. In generalized HIV epidemics with a stable or declining prevalence of HIV infection, the effect of treatment of curable infections on HIV incidence at the population level is not measurable. management of genital ulcer disease and urethral discharge, testing pregnant women and individuals diagnosed with other infections for syphilis, treating male partners of patients with trichomoniasis, providing brief counselling about risk reduction for HIV and sexually transmitted infections, and treating partners of patients with gonococcal, chlamydial and syphilis infections. These interventions have resulted in a decline in the prevalence of infections such as chancroid, syphilis and gonorrhoea in many parts of the world. The control of infections may have also contributed to the gradual decline in HIV prevalence in several lowand middle-income countries (58). The most recent global estimates of the incidence and prevalence of sexually transmitted infections are from Unfortunately, the global burden of infections remains high in most regions of the world (Box 3.9) (59). Services for infections are a critical component of comprehensive HIV prevention programmes. In addition to addressing issues specific to sexually transmitted infections, they provide an opportunity to offer provider-initiated testing and counselling for HIV, and can serve as entry points to HIV care and treatment interventions. Data on infections can also assist in interpreting the epidemiological patterns of HIV. For example, syphilis infection rates among antenatal care attendees can provide an early warning of changes in risk behaviour associated with HIV transmission in the general population. Acute infections such as gonorrhoea and primary and secondary syphilis Box 3.9. Global estimates of the incidence and prevalence of infections caused by Chlamydia trachomatis, Neisseria gonorrhoeae, Treponema pallidum, and Trichomonas vaginalis In 2005, there were over 448 million new infections: 101 million new cases of chlamydial infection, 88 million new cases of gonorrhoea, 11 million new cases of syphilis, and 248 million new cases of trichomoniasis (59). Number of new infections in adult males and females between the ages of 15 and 49 years, 2005 (in millions) Treponema pallidum Chlamydia trachomatis Neisseria gonorrhoeae WHO Region (syphilis) Trichomonas vaginalis Total African Region Region of the Americas Eastern Mediterranean Region European Region South-East Asia Region Western Pacific Region Total At any point in 2005, there were 318 million prevalent cases of the four infections; some 98 million adults were infected with Chlamydia trachomatis, 31 million with Neisseria gonorrhoeae, 36 million with Treponema pallidum, and 153 million with Trichomonas vaginalis. These infections, however, are only four of the over 30 infections that can be transmitted sexually. Furthermore, it has been estimated that there were over 23.6 million new cases of herpes simplex virus-2 in Although these estimates are based on limited data from surveillance and special studies, they indicate that the global burden of infections remains high. More accurate estimates require higher-quality data collection on sexually transmitted infections at the country and regional levels. 39

2 towards universal also serve as biomarkers of HIV and can indicate the effectiveness of programmes for infections (Box 3.10). While broad-based services are well suited to address general population needs, in areas with high levels of stigma or legal barriers, dedicated services for groups at higher risk for HIV acquisition, such as sex workers and men who have sex with men, may need to be offered to ensure adequate levels of access to the necessary health interventions. Two indicators related to infection were part of the 2010 reporting process. Fifty-one and 77 of 193 Member States data, respectively, on the (i) number of targeted for sex workers where, per 1000 sex workers, and (ii) on the prevalence of syphilis attendees (see Annex 2). The overall median among reporting countries was 1.3 targeted clinics per 1000 sex workers in 2009, but this figure masks important regional variations. Availability of targeted clinics per 1000 sex workers was highest in sub-saharan Africa, with 2.0 targeted clinics per 1000 sex workers (Table 3.9). The lowest median figure, at 0.5, was found in Eastern Europe and Central Asia. While an important indicator of access, these data may underestimate true coverage, as sex workers may also receive services for infections in non-targeted clinics. Box Assessing the impact of HIV prevention interventions among female sex workers in Karnataka state, India: the Avahan Project The Avahan Project is a large-scale HIV prevention programme focused on most-at-risk groups in the six Indian states with the highest HIV prevalence. Launched in 2003, the Project supports a diverse package of interventions that includes behaviour change communication to promote condom use, regular screening for infections, establishment of dedicated sexual health services for sex workers and their partners, identification and syndromic case management of infections, routine speculum examination, periodic presumptive treatment every three to six months for chlamydial infection and gonorrhoea, screening and treatment for syphilis, and HIV counselling and testing. Women found to be HIV-positive are support and counselling, and referred for care. In order to assess the impact of these interventions on prevalence rates of HIV and infections, condom use and programme coverage, baseline (7 19 months after programme initiation) and follow up (28 37 months after programme initiation) integrated biological and behavioural surveys were conducted among randomly selected female sex workers in five districts in Karnataka state between 2004 and 2009 (60). Among the 4712 sex workers who participated in the study, over 85% reported contact by a peer educator and having visited a project clinic for infection. Comparing baseline and follow-up figures, the assessment found a statistically significant reduction in the prevalence rates of HIV, from 19.6% to 16.4%; high-titre syphilis, from 5.9% to 3.4%; and chlamydial infection and/or gonorrhoea, from 8.9% to 7.0%. Reported condom use with repeat clients increased, from 66.1% to 84.1%. The Avahan HIV prevention programme combined sexual risk reduction strategies with improved access to sexual health services, resulting in important reductions in the prevalence rates of both HIV and infections. It is an example of how it is possible to successfully integrate service provision for HIV and infections to most-at-risk groups. Table 3.9. services for infection are, and prevalence of syphilis attendees a Region Number of countries reporting b Median number of targeted for sex workers where services for sexually transmitted infection are Number of countries reporting b Median prevalence of syphilis attendees Eastern Europe and Central Asia % East, South, and South-East Asia % Latin America and Caribbean % North Africa and the Middle East 2 4 North America 0 0 Sub-Saharan Africa % Western and Central Europe 1 2 Global total % a Regional medians are not if fewer than five countries data. b Number of countries requested to report: 193. See Annex 2 for country data. 40 TOWARDS UNIVERSAL ACCESS: Scaling up priority HIV/AIDS interventions in the health sector

3 The median reported prevalence of syphilis among antenatal care attendees was 0.7%, with a high of 1.5% in sub-saharan Africa and a low of 0.1% in Eastern Europe and Central Asia. These averages, however, hide marked differences in prevalence rates across countries. For example, in Madagascar, syphilis prevalence was 7.7%, and Central African Republic, Chad, Fiji, Ghana, Grenada, Kiribati, Mozambique, Papua New Guinea, and Zambia all have prevalences above 5%. It is not possible at this time to assess trends over time due to the lack of reporting of longitudinal data to WHO; yet, as the breadth and robustness of monitoring and evaluation systems improve and more countries contribute data, it is expected that future surveys will generate more and better-quality information on services and interventions for infection Blood safety The WHO Global Database on Blood Safety (GDBS) was established in 1998 to address global concerns about the availability, safety and accessibility of blood for transfusion. The objective of this activity is to collect and analyse data from all countries on blood and blood product safety as the basis for effective action to improve blood transfusion services globally. A questionnaire, which has been developed as a standardized tool for the collection of data, is sent to national health authorities for completion. The questionnaire is based on the WHO Aide-mémoire for national health programmes: blood safety, which covers the four major components of the integrated strategy for blood safety advocated by WHO (61). 1 Data obtained through the questionnaire are supplemented by information collected by experts during on-site visits to ministries of health and blood transfusion services. As part of ongoing activities, and to supplement more comprehensive data collection using the standardized GDBS questionnaire, a list of blood safety indicators and a simplified data collection tool have been developed to collect information on 20 key quantitative indicators on blood safety. Blood safety indicators have been collected on an annual basis since The data collected through the GDBS questionnaire and the blood safety indicators are analysed and the reports are published on the WHO website (62). This is updated with the availability of the latest global data. The focus of the analysis is to provide information on the current status of blood transfusion services, assess country needs for improving blood safety, formulate strategic recommendations to countries, plan and implement activities, and evaluate progress. 1 These include: (i) establishment of a nationally coordinated blood transfusion service, (ii) collection of blood only from voluntary non-remunerated blood donors from low-risk populations, (iii) testing of all donated blood, including screening for transfusion-transmissible infections, blood grouping and compatibility testing, and (iv) reduction in unnecessary transfusions through the effective clinical use of blood, including the use of simple alternatives to transfusion (crystalloids and colloids), wherever possible. An estimated 93 million blood donations are given globally every year. 2 About half are collected in high-income countries and the remaining half in low- and middle-income countries. While important progress was made in the past decade in improving the supply of quality-assured blood and blood products worldwide, the availability and safety of blood supplies for transfusion remain issues of concern in multiple settings, especially in low-income countries. Blood shortages not only lead to serious health consequences such as death from postpartum haemorrhage but also contribute to an increased risk of HIV and hepatitis because an inadequate stock of blood forces a reliance on unsafe family or paid donors and increases pressure to issue blood without testing. Decreasing the incidence of HIV due to unsafe blood transfusion requires the implementation of an integrated strategy with a nationally coordinated blood transfusion service; collecting blood from voluntary, unpaid donors; screening all donated blood for transfusiontransmissible infections such as HIV; and ensuring adequate training and follow up of health-care providers. The generally accepted minimum level of donation required to meet a country s most basic requirements for blood is estimated at 1% of the total population. These requirements are higher in countries with more advanced health-care systems. The availability of blood, as measured by the ratio of donations per 1000 population, varies widely and the lowest levels of availability are found in low- and middle-income countries. Indeed, blood donation rates are more than 13 times higher in developed countries than in developing countries: the mean number of donations per 1000 population is 45.4 (range ) in high-income countries, 10.1 (range ) in middle-income countries and 3.6 (range ) in low-income countries. In , 46 countries, including 42 low- and middleincome countries, reported a more than 10% increase in voluntary donations in comparison with the previous year s figures, while 15 reported a more than 10% drop during the same period. Among the 173 countries reporting data in , 45 collected less than 25% of their blood supplies from voluntary non-remunerated blood donors and a sizeable amount of the blood supplies in these countries was still dependent on family/replacement and paid blood donors. Among 98 low- and middle-income countries for which comparable data are available from WHO surveys (62) conducted in , and , the number of countries reporting more than 50% of voluntary nonremunerated blood donations steadily increased. 2 Based on data from the 2008 Global Database on Blood Safety (130 countries) and on 2007 data reported directly to WHO (43 countries). An annual survey is conducted by the WHO Blood Transfusion Safety Programme on 20 key quantitative blood safety indicators. More comprehensive data collection is done triennially, based on a set and subset of about 150 questions. The objectives are: to assess the global situation on blood safety; to obtain the best available information on blood transfusion services in each Member State; to identify problems and needs in order to provide appropriate technical support; to identify countries for priority assistance; and to monitor progress and trends in blood safety. 41

4 towards universal Annex 2. Reported number of targeted sexually transmitted and prevalence of syphilis, by country, 2009 a Number of countries reporting Afghanistan % Antigua and Barbuda 0.72% Argentina 1.40% Bangladesh % Belarus % Benin % Bolivia (Plurinational State of) 0.60 Botswana 1.31% Brazil 1.60% Burkina Faso % Burundi 1.37% Cambodia % Cameroon 0.56% Central African Republic 5.88% Chad 7.30% Chile % China 0.54% Colombia 1.14% Comoros 4.00 Costa Rica 0.14 Côte d'ivoire % Cuba 0.77% Czech Republic % Democratic Republic of the Congo 1.98% Djibouti % Dominica 0.42% Dominican Republic % Ecuador 2.50 El Salvador % Estonia 0.50 Fiji 5.15% Gabon 0.94% Germany % Ghana 6.15% Grenada 5.25% Guatemala % Guinea % Guyana 0.17% Honduras % Hungary 6.25 India % Indonesia % Jordan % Kazakhstan 1.76 Kiribati % Kyrgyzstan % Lao People's Democratic Republic % Lithuania 0.40 Madagascar 7.70% Malawi 1.12% Malaysia % Maldives 0.00% Mali % Mauritius % Mexico 0.27% Mongolia % Mozambique 6.93% Myanmar % Namibia 2.32% Nepal 0.96 Nicaragua % Niger % Nigeria 1.50% Oman 0.04% Panama 1.00 Papua New Guinea 5.78% Paraguay 3.43% Peru % Philippines % Republic of Moldova 0.26% Romania 1.62% Rwanda 1.57% Sao Tome and Principe % Saudi Arabia 0.06% Sierra Leone 0.36% 112 Towards UNIVERSAL ACCESS: Scaling up priority HIV/AIDS interventions in the health sector

5 South Africa 3.91% Sri Lanka % Sudan 3.49% Swaziland 4.75% United Republic of Tanzania 4.40% Thailand % The former Yugoslav Republic of Macedonia 0.33 Togo % Trinidad and Tobago % Tunisia United Kingdom 0.17% Uruguay 9.33 Uzbekistan % Viet Nam % Zambia 5.10% Zimbabwe 0.59%... Data not available or not applicable. a Data are reported for 2009, but actual data collection period may vary. Data should be interpreted with caution as data may not be nationally representative, and methodology among countries varied (Annex 7). 113