HUMAN IMMUNODEFICIENCY VIRUS
|
|
|
- Chrystal Jackson
- 5 years ago
- Views:
Transcription
1 Futuro promisorio de la terapia antirretroviral: Nuevos blancos terapéuticos. María José Míguez, M.D., PhD., Universidad de Miami, EE.UU. HUMAN IMMUNODEFICIENCY VIRUS
2
3 REVERSE TRANSCRIPTASA
4 REPLICATION The protective shell and the helper and anchor proteins. TRANCRIPTION
5 The proteins are cut into usable pieces and packaged with the RNA. synthesis of three polyproteins: oenv gp containing gp 120 and gp 41 ogag p55 - containing MA (matrix), CA (capsid), and NC (nucleocapsid protein) ogag-pol p containing MA (matrix), CA (capsid), PR (proteinase), (RT) reverse transcriptase, and INT (integrase) op55 and p160 are generated from the same mrna strand by the process of ribosome frame shifting. The env (gp160) proteins pass through the E.R. and Golgi apparatus to be processed into gp120 and gp41 HIV envelope proteins. During movement through the Golgi apparatus, glycosylation of gp120 occurs.
6 The gag and gag-pol polyproteins associate with the inner surface of the plasma membrane and interact with gp41 present in the plasma membrane. Some of the 9 kb viral RNA interacts with the nucleocapsid portion of p55. As p55 and p160 accumulate on the inner surface of the plasma membrane, they aggregate and commence assembly to form the viron. the viral proteinase in p160 becomes active, resulting in the cleavage of p160 and p56 into the various subunits and generating the mature form of HIV. This processing of p160 and p56 by the viral proteinase is essential for the generation of infectious virus.
7 Cellular Receptors Immunoglobulin Superfamily CD4 Chemokine (Seven-transmembrane) Receptor Superfamily CXCR4 (also known as Fusin; LESTR; NPY3R) CCR5 (also known as CKR-5; CMKRB5) CCR3 (also known as CC-CKR-3; CKR-3; CMKBR3) Intracellular Targets Cellular Enzymes N-myristoyltransferase Glycosylation Enzymes gp-160 Processing Enzymes Ribonucleotide Reductase Polyamine Biosynthesis Cellular Transcription Factors Sp1 NF-kB
8 CONFORMATIONAL CHANGES HIV V3 domain of gp 120 Fusogenic domain of gp41 High affinity binding affinity CD4 CD26
9 Two heptad repeat sequences ( HR1 and HR2) Hairpin, formerly called a coiled-coil bundle. Brings the virus and cell membrane close together, Fusion of the membranes and entry of the virus core.
10 CD4 BINDING ADVANTAGES 1. The soluble form of CD4, rscd4 block viral binding in vitro 2. Had minimal toxicity DISADVANTAGES 1. But had no demonstrated antiviral effect in vivo. [11] 2. Most primary virus strains are relatively resistant to rscd4 inhibition [12,13] CD4 BINDING HOPE A tetravalent form of CD4 linked to IgG appears to neutralize a broad range of primary HIV strains 90% inhibition of HIV infection in vitro. [14]
11 CXCR4 INHIBITORS AMD3100 ADVANTAGES 1. Phase 2 trials, oral formulation. 2. Outstanding CXCR4 inhibition properties. CXCR4 INHIBITORS AMD3100 DISADVANTAGES 1. Cardiac arrhythmias 2. Adequate efficacy was not demonstrated CXCR4 INHIBITION 1. CONCERNS ABOUT CLASS OF INHIBITION 1. CXCR4 is important for vascularization and organogenesis. [18] 2. Blocking chemokine receptor pathways.
12 INHIBITION OF CCR5 SCH-C BENEFITS 1. Inhibit chemotaxis induced by MIP-1 beta. 2. Block the calcium flux induced by chemokines. 3. In vitro inhibit of HIV isolates that use CCR5. INHIBITION OF CCR5 SCH-C DISADVANTAGES 1. It does not block infection through CXCR4. 2. Some HIV strains exhibit high-level resistance. INHIBITION OF CCR5 SCH-C clinical trials Heart conduction abnormalities (prolonged QTc intervals). Virus population may shift to one that uses CXCR4 Syncytium-inducing (SI) more rapid CD4+ cell count depletion and clinical progression.
13
MedChem 401~ Retroviridae. Retroviridae
MedChem 401~ Retroviridae Retroviruses plus-sense RNA genome (!8-10 kb) protein capsid lipid envelop envelope glycoproteins reverse transcriptase enzyme integrase enzyme protease enzyme Retroviridae The
October 26, Lecture Readings. Vesicular Trafficking, Secretory Pathway, HIV Assembly and Exit from Cell
October 26, 2006 Vesicular Trafficking, Secretory Pathway, HIV Assembly and Exit from Cell 1. Secretory pathway a. Formation of coated vesicles b. SNAREs and vesicle targeting 2. Membrane fusion a. SNAREs
Human Immunodeficiency Virus
Human Immunodeficiency Virus Virion Genome Genes and proteins Viruses and hosts Diseases Distinctive characteristics Viruses and hosts Lentivirus from Latin lentis (slow), for slow progression of disease
Fayth K. Yoshimura, Ph.D. September 7, of 7 HIV - BASIC PROPERTIES
1 of 7 I. Viral Origin. A. Retrovirus - animal lentiviruses. HIV - BASIC PROPERTIES 1. HIV is a member of the Retrovirus family and more specifically it is a member of the Lentivirus genus of this family.
Julianne Edwards. Retroviruses. Spring 2010
Retroviruses Spring 2010 A retrovirus can simply be referred to as an infectious particle which replicates backwards even though there are many different types of retroviruses. More specifically, a retrovirus
Under the Radar Screen: How Bugs Trick Our Immune Defenses
Under the Radar Screen: How Bugs Trick Our Immune Defenses Session 7: Cytokines Marie-Eve Paquet and Gijsbert Grotenbreg Whitehead Institute for Biomedical Research HHV-8 Discovered in the 1980 s at the
Section 6. Junaid Malek, M.D.
Section 6 Junaid Malek, M.D. The Golgi and gp160 gp160 transported from ER to the Golgi in coated vesicles These coated vesicles fuse to the cis portion of the Golgi and deposit their cargo in the cisternae
HIV INFECTION: An Overview
HIV INFECTION: An Overview UNIVERSITY OF PAPUA NEW GUINEA SCHOOL OF MEDICINE AND HEALTH SCIENCES DIVISION OF BASIC MEDICAL SCIENCES DISCIPLINE OF BIOCHEMISTRY & MOLECULAR BIOLOGY PBL MBBS II SEMINAR VJ
Coronaviruses. Virion. Genome. Genes and proteins. Viruses and hosts. Diseases. Distinctive characteristics
Coronaviruses Virion Genome Genes and proteins Viruses and hosts Diseases Distinctive characteristics Virion Spherical enveloped particles studded with clubbed spikes Diameter 120-160 nm Coiled helical
There are approximately 30,000 proteasomes in a typical human cell Each proteasome is approximately 700 kda in size The proteasome is made up of 3
Proteasomes Proteasomes Proteasomes are responsible for degrading proteins that have been damaged, assembled improperly, or that are of no profitable use to the cell. The unwanted protein is literally
LESSON 4.4 WORKBOOK. How viruses make us sick: Viral Replication
DEFINITIONS OF TERMS Eukaryotic: Non-bacterial cell type (bacteria are prokaryotes).. LESSON 4.4 WORKBOOK How viruses make us sick: Viral Replication This lesson extends the principles we learned in Unit
HIV & AIDS: Overview
HIV & AIDS: Overview UNIVERSITY OF PAPUA NEW GUINEA SCHOOL OF MEDICINE AND HEALTH SCIENCES DIVISION OF BASIC MEDICAL SCIENCES DISCIPLINE OF BIOCHEMISTRY & MOLECULAR BIOLOGY PBL SEMINAR VJ TEMPLE 1 What
Fig. 1: Schematic diagram of basic structure of HIV
UNIVERSITY OF PAPUA NEW GUINEA SCHOOL OF MEDICINE AND HEALTH SCIENCES DIVISION OF BASIC MEDICAL SCIENCES DISCIPLINE OF BIOCHEMISTRY & MOLECULAR BIOLOGY PBL SEMINAR HIV & AIDS: An Overview What is HIV?
19 Viruses BIOLOGY. Outline. Structural Features and Characteristics. The Good the Bad and the Ugly. Structural Features and Characteristics
9 Viruses CAMPBELL BIOLOGY TENTH EDITION Reece Urry Cain Wasserman Minorsky Jackson Outline I. Viruses A. Structure of viruses B. Common Characteristics of Viruses C. Viral replication D. HIV Lecture Presentation
11/15/2011. Outline. Structural Features and Characteristics. The Good the Bad and the Ugly. Viral Genomes. Structural Features and Characteristics
Chapter 19 - Viruses Outline I. Viruses A. Structure of viruses B. Common Characteristics of Viruses C. Viral replication D. HIV II. Prions The Good the Bad and the Ugly Viruses fit into the bad category
HIV 101: Fundamentals of HIV Infection
HIV 101: Fundamentals of HIV Infection David H. Spach, MD Professor of Medicine University of Washington Seattle, Washington Learning Objectives After attending this presentation, learners will be able
Lecture 2: Virology. I. Background
Lecture 2: Virology I. Background A. Properties 1. Simple biological systems a. Aggregates of nucleic acids and protein 2. Non-living a. Cannot reproduce or carry out metabolic activities outside of a
Fayth K. Yoshimura, Ph.D. September 7, of 7 RETROVIRUSES. 2. HTLV-II causes hairy T-cell leukemia
1 of 7 I. Diseases Caused by Retroviruses RETROVIRUSES A. Human retroviruses that cause cancers 1. HTLV-I causes adult T-cell leukemia and tropical spastic paraparesis 2. HTLV-II causes hairy T-cell leukemia
Identification of Mutation(s) in. Associated with Neutralization Resistance. Miah Blomquist
Identification of Mutation(s) in the HIV 1 gp41 Subunit Associated with Neutralization Resistance Miah Blomquist What is HIV 1? HIV-1 is an epidemic that affects over 34 million people worldwide. HIV-1
CDC site UNAIDS Aids Knowledge Base http://www.cdc.gov/hiv/dhap.htm http://hivinsite.ucsf.edu/insite.jsp?page=kb National Institute of Allergy and Infectious Diseases http://www.niaid.nih.gov/default.htm
Lecture Readings. Vesicular Trafficking, Secretory Pathway, HIV Assembly and Exit from Cell
October 26, 2006 1 Vesicular Trafficking, Secretory Pathway, HIV Assembly and Exit from Cell 1. Secretory pathway a. Formation of coated vesicles b. SNAREs and vesicle targeting 2. Membrane fusion a. SNAREs
5/6/17. Diseases. Disease. Pathogens. Domain Bacteria Characteristics. Bacteria Viruses (including HIV) Pathogens are disease-causing organisms
5/6/17 Disease Diseases I. II. Bacteria Viruses (including HIV) Biol 105 Chapter 13a Pathogens Pathogens are disease-causing organisms Domain Bacteria Characteristics 1. Domain Bacteria are prokaryotic.
LESSON 4.6 WORKBOOK. Designing an antiviral drug The challenge of HIV
LESSON 4.6 WORKBOOK Designing an antiviral drug The challenge of HIV In the last two lessons we discussed the how the viral life cycle causes host cell damage. But is there anything we can do to prevent
Translation. Host Cell Shutoff 1) Initiation of eukaryotic translation involves many initiation factors
Translation Questions? 1) How does poliovirus shutoff eukaryotic translation? 2) If eukaryotic messages are not translated how can poliovirus get its message translated? Host Cell Shutoff 1) Initiation
Running Head: AN UNDERSTANDING OF HIV- 1, SYMPTOMS, AND TREATMENTS. An Understanding of HIV- 1, Symptoms, and Treatments.
Running Head: AN UNDERSTANDING OF HIV- 1, SYMPTOMS, AND TREATMENTS An Understanding of HIV- 1, Symptoms, and Treatments Benjamin Mills Abstract HIV- 1 is a virus that has had major impacts worldwide. Numerous
HIV Immunopathogenesis. Modeling the Immune System May 2, 2007
HIV Immunopathogenesis Modeling the Immune System May 2, 2007 Question 1 : Explain how HIV infects the host Zafer Iscan Yuanjian Wang Zufferey Abhishek Garg How does HIV infect the host? HIV infection
7.013 Spring 2005 Problem Set 7
MI Department of Biology 7.013: Introductory Biology - Spring 2005 Instructors: Professor Hazel Sive, Professor yler Jacks, Dr. Claudette Gardel 7.013 Spring 2005 Problem Set 7 FRIDAY May 6th, 2005 Question
number Done by Corrected by Doctor Ashraf
number 4 Done by Nedaa Bani Ata Corrected by Rama Nada Doctor Ashraf Genome replication and gene expression Remember the steps of viral replication from the last lecture: Attachment, Adsorption, Penetration,
Retroviruses. ---The name retrovirus comes from the enzyme, reverse transcriptase.
Retroviruses ---The name retrovirus comes from the enzyme, reverse transcriptase. ---Reverse transcriptase (RT) converts the RNA genome present in the virus particle into DNA. ---RT discovered in 1970.
How HIV Causes Disease Prof. Bruce D. Walker
How HIV Causes Disease Howard Hughes Medical Institute Massachusetts General Hospital Harvard Medical School 1 The global AIDS crisis 60 million infections 20 million deaths 2 3 The screen versions of
Severe Acute Respiratory Syndrome (SARS) Coronavirus
Severe Acute Respiratory Syndrome (SARS) Coronavirus Coronaviruses Coronaviruses are single stranded enveloped RNA viruses that have a helical geometry. Coronaviruses are the largest of RNA viruses with
Last time we talked about the few steps in viral replication cycle and the un-coating stage:
Zeina Al-Momani Last time we talked about the few steps in viral replication cycle and the un-coating stage: Un-coating: is a general term for the events which occur after penetration, we talked about
HIV/AIDS. Biology of HIV. Research Feature. Related Links. See Also
6/1/2011 Biology of HIV Biology of HIV HIV belongs to a class of viruses known as retroviruses. Retroviruses are viruses that contain RNA (ribonucleic acid) as their genetic material. After infecting a
Overview: Chapter 19 Viruses: A Borrowed Life
Overview: Chapter 19 Viruses: A Borrowed Life Viruses called bacteriophages can infect and set in motion a genetic takeover of bacteria, such as Escherichia coli Viruses lead a kind of borrowed life between
ARV Mode of Action. Mode of Action. Mode of Action NRTI. Immunopaedia.org.za
ARV Mode of Action Mode of Action Mode of Action - NRTI Mode of Action - NNRTI Mode of Action - Protease Inhibitors Mode of Action - Integrase inhibitor Mode of Action - Entry Inhibitors Mode of Action
AP Biology. Viral diseases Polio. Chapter 18. Smallpox. Influenza: 1918 epidemic. Emerging viruses. A sense of size
Hepatitis Viral diseases Polio Chapter 18. Measles Viral Genetics Influenza: 1918 epidemic 30-40 million deaths world-wide Chicken pox Smallpox Eradicated in 1976 vaccinations ceased in 1980 at risk population?
Human Immunodeficiency Virus
Human Immunodeficiency Virus 1. Identification of the AIDS Virus a) opportunistic infections observed in homosexual men (all had T4 helper cell depletion) -> termed Acquired Immune Deficiency Syndrome;
numbe r Done by Corrected by Doctor
numbe r 5 Done by Mustafa Khader Corrected by Mahdi Sharawi Doctor Ashraf Khasawneh Viral Replication Mechanisms: (Protein Synthesis) 1. Monocistronic Method: All human cells practice the monocistronic
Human Immunodeficiency Virus. Acquired Immune Deficiency Syndrome AIDS
Human Immunodeficiency Virus Acquired Immune Deficiency Syndrome AIDS Sudden outbreak in USA of opportunistic infections and cancers in young men in 1981 Pneumocystis carinii pneumonia (PCP), Kaposi s
HIV: RECEPTORS AND CO-RECEPTORS
HIV: RECEPTORS AND CO-RECEPTORS OVERVIEW This demonstration is part of a series of activities and demonstrations focusing on various aspects of the human immunodeficiency virus (HIV) life cycle. It focuses
Influenza viruses. Virion. Genome. Genes and proteins. Viruses and hosts. Diseases. Distinctive characteristics
Influenza viruses Virion Genome Genes and proteins Viruses and hosts Diseases Distinctive characteristics Virion Enveloped particles, quasi-spherical or filamentous Diameter 80-120 nm Envelope is derived
L I F E S C I E N C E S
1a L I F E S C I E N C E S 5 -UUA AUA UUC GAA AGC UGC AUC GAA AAC UGU GAA UCA-3 5 -TTA ATA TTC GAA AGC TGC ATC GAA AAC TGT GAA TCA-3 3 -AAT TAT AAG CTT TCG ACG TAG CTT TTG ACA CTT AGT-5 OCTOBER 31, 2006
Chapter 13 Viruses, Viroids, and Prions. Biology 1009 Microbiology Johnson-Summer 2003
Chapter 13 Viruses, Viroids, and Prions Biology 1009 Microbiology Johnson-Summer 2003 Viruses Virology-study of viruses Characteristics: acellular obligate intracellular parasites no ribosomes or means
Microbiology 507. Immune Response to Pathogens. Topics in Molecular Pathogenesis and Immunology. Zakaria Hmama, PhD UBC - Department of Medicine
Microbiology 507 Topics in Molecular Pathogenesis and Immunology Immune Response to Pathogens Zakaria Hmama, PhD UBC - Department of Medicine October 2012 ecture 1 Mechanisms of HIV pathogenesis 1- History
CDC site UNAIDS Aids Knowledge Base http://www.cdc.gov/hiv/dhap.htm http://hivinsite.ucsf.edu/insite.jsp?page=kb National Institute of Allergy and Infectious Diseases http://www.niaid.nih.gov/default.htm
VIROLOGY. Engineering Viral Genomes: Retrovirus Vectors
VIROLOGY Engineering Viral Genomes: Retrovirus Vectors Viral vectors Retrovirus replicative cycle Most mammalian retroviruses use trna PRO, trna Lys3, trna Lys1,2 The partially unfolded trna is annealed
Virology Introduction. Definitions. Introduction. Structure of virus. Virus transmission. Classification of virus. DNA Virus. RNA Virus. Treatment.
DEVH Virology Introduction Definitions. Introduction. Structure of virus. Virus transmission. Classification of virus. DNA Virus. RNA Virus. Treatment. Definitions Virology: The science which study the
Some living things are made of ONE cell, and are called. Other organisms are composed of many cells, and are called. (SEE PAGE 6)
Section: 1.1 Question of the Day: Name: Review of Old Information: N/A New Information: We tend to only think of animals as living. However, there is a great diversity of organisms that we consider living
Centers for Disease Control August 9, 2004
HIV CDC site UNAIDS Aids Knowledge Base http://www.cdc.gov/hiv/dhap.htm http://hivinsite.ucsf.edu/insite.jsp?page=kb National Institute of Allergy and Infectious Diseases http://www.niaid.nih.gov/default.htm
Overview of virus life cycle
Overview of virus life cycle cell recognition and internalization release from cells progeny virus assembly membrane breaching nucleus capsid disassembly and genome release replication and translation
AP Biology Reading Guide. Concept 19.1 A virus consists of a nucleic acid surrounded by a protein coat
AP Biology Reading Guide Name Chapter 19: Viruses Overview Experimental work with viruses has provided important evidence that genes are made of nucleic acids. Viruses were also important in working out
Virion Genome Genes and proteins Viruses and hosts Diseases Distinctive characteristics
Hepadnaviruses Virion Genome Genes and proteins Viruses and hosts Diseases Distinctive characteristics Hepatitis viruses A group of unrelated pathogens termed hepatitis viruses cause the vast majority
VIRUS TAXONOMY AND REPLICATION
VIRUS TAXONOMY AND REPLICATION Paulo Eduardo Brandão, PhD Department of Preventive Veterinary Medicine and Animal Health School of Veterinary Medicine University of São Paulo, Brazil I. VIRUS STRUCTURE
Introduction retroposon
17.1 - Introduction A retrovirus is an RNA virus able to convert its sequence into DNA by reverse transcription A retroposon (retrotransposon) is a transposon that mobilizes via an RNA form; the DNA element
Structure of HIV. Virion contains a membrane envelope with a single viral protein= Env protein. Capsid made up of Gag protein
Structure of HIV Virion contains a membrane envelope with a single viral protein= Env protein Important in receptor recognition Capsid made up of Gag protein (group-specific antigen) Icosahedral Interior
Viral structure م.م رنا مشعل
Viral structure م.م رنا مشعل Viruses must reproduce (replicate) within cells, because they cannot generate energy or synthesize proteins. Because they can reproduce only within cells, viruses are obligate
Immunodeficiencies HIV/AIDS
Immunodeficiencies HIV/AIDS Immunodeficiencies Due to impaired function of one or more components of the immune or inflammatory responses. Problem may be with: B cells T cells phagocytes or complement
Viral Genetics. BIT 220 Chapter 16
Viral Genetics BIT 220 Chapter 16 Details of the Virus Classified According to a. DNA or RNA b. Enveloped or Non-Enveloped c. Single-stranded or double-stranded Viruses contain only a few genes Reverse
8/13/2009. Diseases. Disease. Pathogens. Domain Bacteria Characteristics. Bacteria Shapes. Domain Bacteria Characteristics
Disease Diseases I. Bacteria II. Viruses including Biol 105 Lecture 17 Chapter 13a are disease-causing organisms Domain Bacteria Characteristics 1. Domain Bacteria are prokaryotic 2. Lack a membrane-bound
Chapter 19: Viruses. 1. Viral Structure & Reproduction. What exactly is a Virus? 11/7/ Viral Structure & Reproduction. 2.
Chapter 19: Viruses 1. Viral Structure & Reproduction 2. Bacteriophages 3. Animal Viruses 4. Viroids & Prions 1. Viral Structure & Reproduction Chapter Reading pp. 393-396 What exactly is a Virus? Viruses
CURRENT DEVELOMENTS AND FUTURE PROSPECTS FOR HIV GENE THERAPY USING INTERFERING RNA-BASED STRATEGIES
[Frontiers in Bioscience 5, d527-555, May 1, 2000] CURRENT DEVELOMENTS AND FUTURE PROSPECTS FOR HIV GENE THERAPY USING INTERFERING RNA-BASED STRATEGIES Betty Lamothe, Sadhna Joshi Department of Medical
ACQUIRED IMMUNODEFICIENCY SYNDROME AND ITS OCULAR COMPLICATIONS
ACQUIRED IMMUNODEFICIENCY SYNDROME AND ITS OCULAR COMPLICATIONS Acquired immunodeficiency syndrome (AIDS ) is an infectious disease caused by a retrovirus, the human immunodeficiency virus(hiv). AIDS is
Chapter 19: Viruses. 1. Viral Structure & Reproduction. 2. Bacteriophages. 3. Animal Viruses. 4. Viroids & Prions
Chapter 19: Viruses 1. Viral Structure & Reproduction 2. Bacteriophages 3. Animal Viruses 4. Viroids & Prions 1. Viral Structure & Reproduction Chapter Reading pp. 393-396 What exactly is a Virus? Viruses
, virus identified as the causative agent and ELISA test produced which showed the extent of the epidemic
1 Two attributes make AIDS unique among infectious diseases: it is uniformly fatal, and most of its devastating symptoms are not due to the causative agent Male to Male sex is the highest risk group in
Week 5 Section. Junaid Malek, M.D.
Week 5 Section Junaid Malek, M.D. HIV: Anatomy Membrane (partiallystolen from host cell) 2 Glycoproteins (proteins modified by added sugar) 2 copies of RNA Capsid HIV Genome Encodes: Structural Proteins
Diagnostic Tests for HIV
Mountain West AIDS Education and Training Center Diagnostic Tests for HIV David Spach, MD Principal Investigator, Mountain West AETC Professor of Medicine, University of Washington Last Updated: June 22,
The author hereby certifies that the use of any copyrighted material in the dissertation entitled:
The author hereby certifies that the use of any copyrighted material in the dissertation entitled: Characterization and Enhanced Processing of Soluble, Oligomeric gp140 Envelope Glycoproteins Derived from
Immunodeficiency. (2 of 2)
Immunodeficiency (2 of 2) Acquired (secondary) immunodeficiencies More common Many causes such as therapy, cancer, sarcoidosis, malnutrition, infection & renal disease The most common of which is therapy-related
INTERACTION-MEDIATING SEQUENCES WITHIN CLASS I VIRAL FUSION GLYCOPROTEINS: THEIR ROLES IN VIRAL INFECTION AND IN APPLICATIONS
INTERACTION-MEDIATING SEQUENCES WITHIN CLASS I VIRAL FUSION GLYCOPROTEINS INTERACTION-MEDIATING SEQUENCES WITHIN CLASS I VIRAL FUSION GLYCOPROTEINS: THEIR ROLES IN VIRAL INFECTION AND IN APPLICATIONS ZHANG
Sub-Topic Classification of HIV related Opportunistic Infections. Miguel Anderson and Joseph Fonseca
Sub-Topic Classification of HIV related Opportunistic Infections Miguel Anderson and Joseph Fonseca Introduction Image collected from the CDC https://www.cdc.gov/hiv/basics/statistics.html Background Info
Micropathology Ltd. University of Warwick Science Park, Venture Centre, Sir William Lyons Road, Coventry CV4 7EZ
www.micropathology.com info@micropathology.com Micropathology Ltd Tel 24hrs: +44 (0) 24-76 323222 Fax / Ans: +44 (0) 24-76 - 323333 University of Warwick Science Park, Venture Centre, Sir William Lyons
VIRUSES. 1. Describe the structure of a virus by completing the following chart.
AP BIOLOGY MOLECULAR GENETICS ACTIVITY #3 NAME DATE HOUR VIRUSES 1. Describe the structure of a virus by completing the following chart. Viral Part Description of Part 2. Some viruses have an envelope
Chapter 13B: Animal Viruses
Chapter 13B: Animal Viruses 1. Overview of Animal Viruses 2. DNA Viruses 3. RNA Viruses 4. Prions 1. Overview of Animal Viruses Life Cycle of Animal Viruses The basic life cycle stages of animal viruses
3. on T helper {cells / lymphocytes} ; 3. ACCEPT macrophages / dendritic cells / CD4 cells
1(a) 1. (structure G is {glycoprotein / gp120} ; 2. used for {attachment / eq} to CD4 (molecules / receptors /antigens) ; 1. IGNORE gp 41 and gp 160 and other wrong numbers 3. on T helper {cells / lymphocytes}
I. Bacteria II. Viruses including HIV. Domain Bacteria Characteristics. 5. Cell wall present in many species. 6. Reproduction by binary fission
Disease Diseases I. Bacteria II. Viruses including are disease-causing organisms Biol 105 Lecture 17 Chapter 13a Domain Bacteria Characteristics 1. Domain Bacteria are prokaryotic 2. Lack a membrane-bound
number Done by Corrected by Doctor Ashraf Khasawneh
number 3 Done by Mahdi Sharawi Corrected by Doctor Ashraf Khasawneh *Note: Please go back to the slides to view the information that the doctor didn t mention. Prions Definition: Prions are rather ill-defined
Picornaviruses. Virion. Genome. Genes and proteins. Viruses and hosts. Diseases. Distinctive characteristics
Picornaviruses Virion Genome Genes and proteins Viruses and hosts Diseases Distinctive characteristics Virion Naked icosahedral capsid (T=1) Diameter of 30 nm Genome Linear single-stranded RNA, positive
Hepatitis B Antiviral Drug Development Multi-Marker Screening Assay
Hepatitis B Antiviral Drug Development Multi-Marker Screening Assay Background ImQuest BioSciences has developed and qualified a single-plate method to expedite the screening of antiviral agents against
Chapter13 Characterizing and Classifying Viruses, Viroids, and Prions
Chapter13 Characterizing and Classifying Viruses, Viroids, and Prions 11/20/2017 MDufilho 1 Characteristics of Viruses Viruses Minuscule, acellular, infectious agent having either DNA or RNA Cause infections
Hepatitis virus immunity. Mar 9, 2005 Rehermann and Nascimbeni review Crispe review
Hepatitis virus immunity Mar 9, 2005 Rehermann and Nascimbeni review Crispe review HBV & HCV infection outcomes Both viruses cause immune-mediated active and chronic hepatitis HBV Vertical transmission
RAISON D ETRE OF THE IMMUNE SYSTEM:
RAISON D ETRE OF THE IMMUNE SYSTEM: To Distinguish Self from Non-Self Thereby Protecting Us From Our Hostile Environment. Innate Immunity Acquired Immunity Innate immunity: (Antigen nonspecific) defense
Reoviruses. Virion. Genome. Genes and proteins. Viruses and hosts. Diseases. Distinctive characteristics
Reoviruses Virion Genome Genes and proteins Viruses and hosts Diseases Distinctive characteristics Virion Naked icosahedral capsid (T=13), diameter 60-85 nm Capsid consists of two or three concentric protein
Peptide hydrolysis uncatalyzed half-life = ~450 years HIV protease-catalyzed half-life = ~3 seconds
Uncatalyzed half-life Peptide hydrolysis uncatalyzed half-life = ~450 years IV protease-catalyzed half-life = ~3 seconds Life Sciences 1a Lecture Slides Set 9 Fall 2006-2007 Prof. David R. Liu In the absence
5. Over the last ten years, the proportion of HIV-infected persons who are women has: a. Increased b. Decreased c. Remained about the same 1
Epidemiology 227 April 24, 2009 MID-TERM EXAMINATION Select the best answer for the multiple choice questions. There are 60 questions and 9 pages on the examination. Each question will count one point.
HIV-1 Neutralisation and Other Aspects of the Envelope Glycoprotein
HIV-1 Neutralisation and Other Aspects of the Envelope Glycoprotein Pei-Jen Lai Thesis submitted in fulfilment of the requirements for the degree of Doctor of Philosophy of Imperial College London 2009
Polyomaviridae. Spring
Polyomaviridae Spring 2002 331 Antibody Prevalence for BK & JC Viruses Spring 2002 332 Polyoma Viruses General characteristics Papovaviridae: PA - papilloma; PO - polyoma; VA - vacuolating agent a. 45nm
Combining Pharmacology and Mutational Dynamics to Understand and Combat Drug Resistance in HIV
Combining Pharmacology and Mutational Dynamics to Understand and Combat Drug Resistance in HIV A dissertation submitted for the degree of Doctor of Philosophy by Max von Kleist, B.Sc., M.Sc. Supervisor:
RAISON D ETRE OF THE IMMUNE SYSTEM:
RAISON D ETRE OF THE IMMUNE SYSTEM: To Distinguish Self from Non-Self Thereby Protecting Us From Our Hostile Environment. Innate Immunity Adaptive Immunity Innate immunity: (Antigen - nonspecific) defense
Nucleic acid: singled stranded, double stranded, RNA, or DNA, linear or circular. Capsid: protein coat that is most of the mass of the virus.
Viruses General Characteristics of Viruses 1. Depending on view may be regarded as exceptionally complex aggregates of nonliving chemicals or as exceptionally simple living microbes. 2. Contain a single
Viral reproductive cycle
Lecture 29: Viruses Lecture outline 11/11/05 Types of viruses Bacteriophage Lytic and lysogenic life cycles viruses viruses Influenza Prions Mad cow disease 0.5 µm Figure 18.4 Viral structure of capsid
Computational Simulations of the Human Immunodeficiency Virus Rev-RRE RRE Complex
Computational Simulations of the Human Immunodeficiency Virus Rev-RRE RRE Complex Peri Herman Mentor Dr. Nagan Truman State University Kirksville, MO People newly infected with HIV UNAIDS epidemic update,
Viruses. Picture from:
Viruses Understand the structure of bacteriophages & human immunodeficiency virus (HIV) Appreciate that viruses replicate in host cells (thereby destroying them) Picture from: http://eands.caltech.edu/articles/lxvii1/viruses.html
Structural biology of viruses
Structural biology of viruses Biophysical Chemistry 1, Fall 2010 Coat proteins DNA/RNA packaging Reading assignment: Chap. 15 Virus particles self-assemble from coat monomers Virus Structure and Function
DIFFERENTIAL IMPACT OF HIV-1 PROTEASE INHIBITORS ON SUBSETS OF CD4+ T-LYMPHOCYTES
DIFFERENTIAL IMPACT OF HIV-1 PROTEASE INHIBITORS ON SUBSETS OF CD4+ T-LYMPHOCYTES By CHRISTINA GAVEGNANO A THESIS PRESENTED TO THE GRADUATE SCHOOL OF THE UNIVERSITY OF FLORIDA IN PARTIAL FULFILLMENT OF
Virology. *Viruses can be only observed by electron microscope never by light microscope. The size of the virus: nm in diameter.
Virology We are going to start with general introduction about viruses, they are everywhere around us; in food; within the environment; in direct contact to etc.. They may cause viral infection by itself
Virus Structure. Characteristics of capsids. Virus envelopes. Virion assembly John Wiley & Sons, Inc. All rights reserved.
Virus Structure Characteristics of capsids Virus envelopes Virion assembly Capsids package viral genomes and transmit them to a new host cell Capsid rigid, symmetrical container composed of viral protein
Learning Objectives. New HIV Testing Algorithm from CDC. Overview of HIV infection and disease 3/15/2016
New HIV Testing Algorithm from CDC ASCLS-Michigan March 31, 2016 Dr. Kathleen Hoag Learning Objectives Following attendance and review of material provided, attendees will be able to: 1. Describe the new
Contribution of PDZD8 to Stabilization of the Human Immunodeficiency Virus (HIV-1) Capsid
Contribution of PDZD8 to Stabilization of the Human Immunodeficiency Virus (HIV-1) Capsid The Harvard community has made this article openly available. Please share how this access benefits you. Your story
2) What is the difference between a non-enveloped virion and an enveloped virion? (4 pts)
Micro 260 SFCC Spring 2010 Name: All diagrams and drawings shall be hand drawn (do not photo-copied from a publication then cut and pasted into work sheet). Do not copy other student s answers. Para phase
Micro 301 HIV/AIDS. Since its discovery 31 years ago 12/3/ Acquired Immunodeficiency Syndrome (AIDS) has killed >32 million people
Micro 301 HIV/AIDS Shiu-Lok Hu hus@uw.edu December 3, 2012 Since its discovery 31 years ago Acquired Immunodeficiency Syndrome (AIDS) has killed >32 million people In 2011 34.0 million [31.4 35.9 million]