BIOGRAPHICAL SKETCH. Research Associate, Department of Radiology, Stanford Univeristy. DEGREE (if applicable)

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1 BIOGRAPHICAL SKETCH NAME: Kogan, Feliks era COMMONS USER NAME (credential, e.g., agency login): FKOGAN POSITION TITLE: Research Associate, Department of Radiology, Stanford Univeristy EDUCATION/TRAINING INSTITUTION AND LOCATION DEGREE (if applicable) Completion Date MM/YYYY FIELD OF STUDY University of Rochester, Rochester, NY B.S. 05/2007 Optics, Applied Mathematics University of Pennsylvania, Philadelphia, PA Ph.D. 05/2013 Bioengineering, Imaging Sciences Stanford University, Stanford, CA Postdoctoral 10/2015 Radiology A. Personal Statement My career goal is to become an independent investigator in a clinically oriented imaging laboratory at a major academic medical center. I have strived to pursue rigorous training and mentorship thus far to equip me with the skills to accomplish my career goals. Through a Howard Hughes Medical Institute (HHMI) fellowship, I completed the full pre-clinical academic curriculum at the University Of Pennsylvania School Of Medicine, which equipped me with a background in clinical medicine. My graduate work in the lab of Dr. Ravinder Reddy provided the groundwork for my academic career by developing skills in all aspects of magnetic resonance imaging from scanning experiments to spin physics and pulse sequence design. My interest in musculoskeletal disorders led me to accept a postdoctoral position at Stanford with Dr. Garry Gold, who has a proven track record of mentorship and innovative research in addressing pressing issues in clinical medicine. Over the past 9 years, I have been working to develop molecularly specific imaging technologies geared toward early diagnosis of pathologies and quantitative evaluation of therapeutic efficacy. In particular, I have developed and implemented several MR sequences for volumetric imaging of biochemical changes in the glycosaminoglycan (GAG) content in articular cartilage, which have been shown to precede gross morphologic changes in osteoarthritis (OA). While cartilage degeneration is important, OA is a complex disease that involves all tissues of the joint. I am also working on the development and application novel combined PET and MR imaging of the knee to understand the relationship between bone remodeling and joint and tissue mechanics and morphology. I hope to combine my background in musculoskeletal MR with training from leading experts in PET imaging and joint biomechanics to develop novel imaging biomarkers to help understand and treat OA.

2 B. Positions and Honors Positions and Employment Jan 2005 May 2006 Research Assistant, Laboratory for Laser Energetics, Rochester, NY May 2006 Aug 2006 Research Assistant, Wellman Center, Massachusetts General Hosptial, Boston, MA Sept 2006 Jun 2007 Research Assistant, Department of Radiology, University of Rochester, Rochester, NY Aug 2007 May 2013 Bioengineering Researcher, Radiology, University of Pennsylvania, Philadelphia, PA May 2013 Aug 2013 Postdoctoral Researcher, Radiology, University of Pennsylvania, Philadelphia, PA Sept 2013 Oct 2015 Postdoctoral Fellow, Department of Radiology, Stanford University, Stanford, CA Oct 2015 present Research Associate, Department of Radiology, Stanford University, Stanford, CA Other Experience and Professional Memberships Optical Society of America (OSA) 2009 Present International Society for Magnetic Resonance in Medicine (ISMRM) 2014 Present Multiple Sclerosis (MS) Society Grant Reviewer 2014 Present Reviewer - ISMRM Annual Meeting 2015 Present Associate Editor Medical Physics 2015 Present Reviewer - Magnetic Resonance in Medicine 2015 Present Reviewer Journal of Translational Medicine 2015 Present ISMRM Publications Committee Member (Non-Voting) 2015 Present ISMRM Trainee Working Advisory Group Member Academic Honors 2003 Rush Rhees Scholarship for academic achievement 2007 Distinction in Applied Mathematics, University of Rochester 2007 High Distinction in Optics, University of Rochester 2007 University of Rochester Optics Faculty Award 2007 HHMI-NIBIB Interfaces Fellowship in Imaging Sciences 2007 National Science Foundation Graduate Fellowship Honorable Mention 2010 NIH National Institute of Biomedical Imaging and Bioengineering (NIBIB) Training Grant 2010 ENC Student Travel Stipend 2010 Juan Grana Graduate Teaching Assistantship ISMRM Educational Stipend 2012, 2014 ISMRM Summa Cum Laude Merit Award 2013 ISMRM Magna Cum Laude Merit Award 2015 Junior Fellow of the ISMRM 2015 Merit Award for Highest Scoring Trainee Abstract International Workshop on OA Imaging Invited Talks 2016 Evaluation of Bone Metabolism & Remodeling with PET/MR. 24 th Annual Meeting of ISMRM Educational Session. Singapore. May Advancing Volumetric GagCEST: Imaging strategies, Analysis, and Standardization of Methods. 5 th Annual Workshop on CEST Imaging. Philadelphia, PA Advanced Quantitative Cartilage Imaging Techniques. 23 rd Annual Meeting of ISMRM Combined Educational & Scientific Session. Toronto, Canada Combined PET-MRI Imaging of Osteoarthritis. Erasmus MC Department of Radiology Seminar Series. Rotterdam, Netherlands CEST: Description of Technique and Emerging Biomedical Applications. Annual CMROI Workshop on Imaging Biomarkers. Philadelphia, PA Amine Chemical Exchange Saturation Transfer Imaging. New York University Imaging Seminar. New York, NY 2013 Endogenous Amine Proton Exchange Based MRI and Their Applications. Vanderbilt University Institute of Imaging Sciences Founders Lectures. Nashville, Tn.

3 C. Contribution to Science Endogenous Chemical Exchange MRI Molecular imaging has the potential for the diagnosis of disease at the earliest causative stages, development of disease biomarkers, characterization of the preclinical stages of metabolic or molecular disturbance, and real-time monitoring of disease progression as well as therapeutic response. While many methods have been proposed for molecular imaging in vivo, factors such as suboptimal spatial resolution and the use of invasive contrast agents have limited their application in clinical settings. My early work focused on the development and application of chemical exchange saturation transfer (CEST) techniques that exploit the amine proton exchange phenomenon to quantify endogenous metabolites in biological tissues, in vivo. I developed and patented new MRI techniques that utilize CEST to quantitatively image glutamate in the brain and spinal cord to study glutamate function in the central nervous system as a potential biomarker for diagnosis and treatment of neurologic disorders. Additionally, I created MRI pulse sequence (CESTrho) to optimize contrast for metabolites with faster exchanging spins and to decouple confounding effects of changing ph from measurements of metabolite concentration in studies of stroke and other ph modifying disorders. Figure 1: GluCEST asym Maps of a human cervical spinal cord showing GM/WM variation 4 1. Cai K, Haris M, Singh A, Kogan F, Greenberg JH, Hariharan H, Detre J, Reddy R. Magnetic Resonance Imaging of Glutamate. Nature Medicine. 2012;18(2): PMID: Kogan F, Singh A, Cai K, Haris M, Hariharan H, Reddy R. Investigation of Chemical Exchange at Intermediate Exchange Rates using a Combination of Chemical Exchange Saturation Transfer (CEST) and Spin-Locking methods (CESTrho). Magnetic Resonance in Medicine. 2012;68(1): PMID: Kogan F, Hariharan H, Reddy R. Chemical Exchange Saturation Transfer (CEST) Imaging: Description of Technique and Potential Clinical Applications. Current Radiology Reports 2013: PMID: Kogan F, Singh A, DeBrosse C, Haris M, Cai K, Nanga RP, Hariharan H, Reddy R. Imaging of glutamate in the spinal cord using GluCEST. Neuroimage 2013; 77: PMID: High Resolution Imaging of Muscle Energetics MR techniques have been used extensively for noninvasive functional investigations of exercising muscle metabolism and are becoming increasingly more important for studying muscular diseases. 31 P MRS was the first and is currently the most utilized method to study oxidative metabolism of skeletal muscle but suffers from poor spatial resolution as well as low sensitivity. I helped develop a new MRI method to image endogenous creatine distribution in skeletal muscle with high spatial resolution. This technique offers the ability to provide key information about primary disorders muscle metabolism and secondary complications associated with heart failure, renal failure, and peripheral vascular disease. Most recently, this method has been adapted to study myocardial tissue viability post myocardial infarction. Figure 2: CrCEST asym maps of a human calf muscle before and every 48 seconds after 2 minutes of plantar flexion exercise 2 1. Haris M, Nanga RP, Singh A, Cai K, Kogan F, Hariharan H, Reddy R. Exchange rates of creatine kinase metabolites: feasibility of imaging creatine by chemical exchange saturation transfer MRI. NMR in Biomedicine. 2012;25(11): PMID: Kogan F, Haris M, Singh A, Cai K, DeBrosse C, Nanga RP, Hariharan H, Reddy R. A Method for high-resolution imaging of creatine in vivo using chemical exchange saturation transfer. Magnetic Resonance in Medicine 2014; 71(1): PMID:

4 3. Kogan F, Haris M, Singh A, DeBrosse C, Cai K, Nanga RP, Hariharan H, Reddy R. In vivo CEST Imaging of Creatine (CrCEST) at 3T. Journal of Magnetic Resonance Imaging. 2014;40(3): PMID: Haris M, Singh A, Cai K, Kogan F, McGarvey J, DeBrosse C, Zsido G, Witschey W, Koomalsingh K, Pilla J, Chirinos J, Ferrari V, Gorman J, Hariharan H, Gorman R, Reddy R. A Novel Technique for In Vivo Mapping of Myocardial Creatine Kinase Metabolism. Nature Medicine 2014; 20: PMID: Quantitative MRI of Articular Cartilage [a] [b] Osteoarthritis is the leading cause of disability in developed countries. While knee MRI is commonly performed, there is tremendous demand for imaging markers of OA that can be used to evaluate new drugs and therapies. In its early stages, OA is characterized by an increase in enzymatic degradation in cartilage, resulting in glycosaminoglycan (GAG) depletion. Our group has led the development, Figure 3: GagCESTasym maps [a] and T1ρ maps [b] of tibiotalar cartilage understanding and application of several quantitative MRI methods to map GAG content in articular cartilage. Most recent, I have focused efforts on novel pulse sequence design to use image GAG content in cartilage using exchange between hydroxyl (-OH) protons on GAG and bulk water protons (GagCEST). This is a promising new method due to its high sensitivity to GAG but is hampered long imaging times, which often limits acquisition to a single slice. I have developed faster GagCEST sequences to allow for volumetric GagCEST mapping to advance the clinical utility of GagCEST imaging of articular cartilage. 1. Singh, M. Haris, K. Cai, V. Kasse, Kogan F., D. Reddy, H. Hariharan, R. Reddy. Chemical Exchange Saturation Transfer Magnetic Resonance Imaging of Human Cartilage at 3T and 7T. Magnetic Resonance in Medicine. 2012;68(2): PMID: Matzat S, McWalter EJ, Kogan F, Chen W, Gold GE. T2 Relaxation time quantitation differs between pulse sequences in articular cartilage. Journal of Magnetic Resonance Imaging. 2015; 42(1): PMID: Matzat SJ, Kogan F, Fong G, Gold GE. Imaging strategies for assessing cartilage composition in osteoarthritis. Current Rheumatology Reports. 2014;16(11):462. PMID: Kogan F, Hargreaves B, Gold G. Multi-Slice gagcest Sequence for Whole-Joint gagcest mapping: Application to Articular Cartilage in the Ankle. Proceedings of the 23rd Annual Meeting of ISMRM, Toronto, Canada Simultaneous PET-MR Imaging of OA [a] [b] [c] New PET/MR systems allow for simultaneous, sensitive, and quantitative assessments of metabolic activity in OA. 18F-fluorodeoxyglucose (FDG) PET shows areas of acute phase inflammatory response (neutrophils or PMNs) in the bone marrow while 18F -NaF PET can be used to study osteoblast activity in the bone and has also been used as a marker of pain. This Figure 4: (a)t2w MRI, (b)pet and (c)fused PET/MR images of a metabolic bone data from PET can be correlated patient with moderate OA with high-resolution quantitative MR methods to study the pathogenesis of OA. We have demonstrated the feasibility and potential of simultaneous PET/MR hybrid imaging of all tissues in the knee. I have also investigated the bias in SUV measurements due to PET photon attenuation by MR hardware in knee scans. Results suggest that PET/MR may detect knee abnormalities unseen on MRI alone and is a promising tool for early detection of metabolic changes in OA.

5 1. Kogan F, Fan A, Brazina S, Holley D, Quon A, Gold G. 18F-FDG and 18F-NaF PET/MR Imaging of Osteoarthritis in the Knee: Considerations and Initial Results. Proceedings of the 23 rd Annual Meeting of ISMRM, Toronto, Canada Kogan F, Rosenberg J, Brazina S, Fan A, Holley D, Gold G. Effect of 16-Channel Flex Array Coil on PET Standardized Uptake Values for PET/MR Imaging of the knee. Proceedings of the 23 rd Annual Meeting of ISMRM, Toronto, Canada Kogan F, Fan A, Quon A, Gold G. PET-MR Imaging of Osseous and Inflammatory Metabolic Activity Post Knee Injury. 8 th International Workshop on Osteoarthritis. Pacific Grove, CA 2015 Complete List of Published Work in MyBibliography: scending D. Research Support Ongoing Research Support R01 EB (PI: Garry Gold, M.D.) 9/20/03 3/31/19 NIH/NIBIB Rapid MRI for Evaluation of Osteoarthritis The goal of this proposal is to develop and validate a comprehensive examination of osteoarthritis, which is a leading cause of chronic disability on the United States. Role: Co-Investigator