CURRICULUM VITAE Ikuko Funatogawa

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1 CURRICULUM VITAE Ikuko Funatogawa Personal Information: Ikuko Funatogawa University Address Department of Hygiene and Public Health, Teikyo University School of Medicine, Kaga, Itabashi-Ku Tokyo, , Japan Cancer Biostatistics Center Vanderbilt-Ingram Cancer Center 571 Preston Building Nashville, TN , USA Education: May 1994 School of Health Science and Nursing May 1996 Apr 2005 Bachelor of Science Master of Science Doctor of Philosophy Doctoral Dissertation: Title Advisor Dynamic Dose Modification based on bivariate autoregressive linear mixed effects model. Yasuo Ohashi, Ph.D. Professional Experience: Oct 2008 Present Department of Hygiene and Public Health Teikyo University School of Medicine Oct 2005 Sep 2008 Department of Hygiene and Public Health Teikyo University School of Medicine Associate Professor (Lecturer) Assistant Professor

2 Apr 2003 Present Apr Feb Chugai Pharmaceutical Co., Ltd. Visiting Researcher Biostatistician Publications: Funatogawa I, Funatogawa T, Nakao M, Karita K, Yano E. Changes in body mass index by birth cohort in Japanese adults: Results from the National Nutrition Survey of Japan Int J Epidemiol 2009; 38(1); Marui T, Funatogawa I, Koishi S, Yamamoto K, Matsumoto H, Hashimoto O et al. Association between autism and variants in the wingless-type MMTV integration site family member 2 ( WNT2) gene. Int J Neuropsychopharmacol Nov 9:1-7. [Epub ahead of print] Marui T, Funatogawa I, Koishi S, Yamamoto K, Matsumoto H, Hashimoto O et al. Association of the neuronal cell adhesion molecule (NRCAM) gene variants with autism. Int J Neurosychoph 2009;12(1):1-10. Furukawa T, Suzuki M, Funatogawa I, Isshiki T, Miyazawa Y, Teramoto T, Yano E. Screening method for severe sleep-disordered breathing in hypertensive patients without daytime sleepiness. J Cardiology 2009 ;53: Buadong D, Jinsart W, Funatogawa I, Karita K, Yano E. Association between PM10 and O3 and hospital visits for cardiovascular diseases in Bangkok, Thailand. J Epidemiol 2009; 19(4): Funatogawa I, Funatogawa T, Yano E. Do overweight children necessarily make overweight adults?: repeated cross-sectional annual nationwide survey of Japanese girls and women over nearly six decades. BMJ Aug 21;337:a802. doi: /bmj.a802. Funatogawa I, Funatogawa T, Ohashi Y. A bivariate autoregressive linear mixed effects model for the analysis of longitudinal data. Stat Med 2008; 30;27: Funatogawa T, Funatogawa I, Takeuchi M. An autoregressive linear mixed effects model for the analysis of longitudinal data which include dropouts and show profiles approaching asymptotes. Stat Med 2008; 30;27: Funatogawa I, Funatogawa T, Ohashi Y. An autoregressive linear mixed effects model for the analysis of longitudinal data which show profiles approaching asymptotes. Stat Med 2007;26: Funatogawa I, Funatogawa T. Revisiting the relation between change and initial value: a review and evaluation by Yu-Kang Tu and Mark S. Gilthorpe, Statistics in Medicine, 2006; DOI: /sim Stat Med 2007;26: (LETTER TO THE EDITOR) Funatogawa T, Funatogawa I, Yafune A. An estimation method of the half-life for a one-compartment model of a single bolus intravenous injection by a single sampling. J Biopharm Stat 2007;17:

3 Funatogawa T, Funatogawa I. The bayesian bias correction method of the first-order approximation of nonlinear mixed effects-models for population pharmacokinetics. J Biopharm Stat 2007;17: Marui T, Funatogawa I, Koishi S, Yamamoto K, Matsumoto H, Hashimoto O, Nanba E, Nishida H, Sugiyama T, Kasai K, Watanabe K, Kano Y, Kato N, Sasaki T. Tachykinin 1 (TAC1) gene SNPs and haplotypes with autism: A case-control study. Brain Dev 2007;29: Marui T, Koishi S, Funatogawa I, Yamamoto K, Matsumoto H, Hashimoto O, Ishijima M, Nanba E, Nishida H, Sugiyama T, Kasai K, Watanabe K, Kano Y, Kato N, Sasaki T. No association between the neuronal pentraxin II gene polymorphism and autism. Prog Neuropsychopharmacol Biol Psychiatry 2007;31: Funatogawa T, Funatogawa I, Yafune A. Profile likelihood-based confidence intervals using Monte Carlo integration for population pharmacokinetic parameters. J Biopharm Stat 2006;16: Marui T, Koishi S, Funatogawa I, Yamamoto K, Matsumoto H, Hashimoto O, Nanba E, Kato C, Ishijima M, Watanabe K, Kasai K, Kato N, and Sasaki T. No association of FOXP2 and PTPRZ1 on 7q31 with autism from the Japanese population. Neurosci Res 2005;53:91-4. Toyoda (Funatogawa) I, Matsuyama Y, and Ohashi Y. Estimation and comparison of rates of change in repeated-measures studies with planned dropout. Controlled Clinical Trials. 22: , Books: Funatogawa I, Nakao M, Yano E, Teikyo University EBM center (Edis). EBM Statistics in Medicine (in Japanese) Funatogawa I, Epidemiology 3 Measure of Efficacy, Estimation and Significance Test. in Yano E, Nomura K, Owaki K (Edis). Public Health Studying with Case 2 nd Edition (in Japanese) Funatogawa I, Epidemiology 6 Randomized Clinical Trial RCT. in Yano E, Nomura K, Owaki K (Edis). Public Health Studying with Case 2 nd Edition (in Japanese) Professional Societies: 2001 Member of the Biometric Society of Japan 2001 Member of International Biometric Society 2006 Member of International Society for Clinical Biostatistics 2006 Member of Japanese Society of Public Health (2008- council member) 2006 Member of Japan Society for Occupational Health (2008- a member of a delegation) 2006 Member of American Statistical Association 2007 Member of Japan Epidemiological Association 2008 Member of the Japanese Society for Hygiene 2009 Member of Japanese Society of Clinical Pharmacology and Therapeutics Research Grants 2009 Grant-in-Aid for Young Scientists (B) from the Ministry of Yen

4 2008 Grant-in-Aid for Young Scientists (B) from the Ministry of Yen Grant-in-Aid for Exploratory Research from the Ministry of Yen Grant-in-Aid for Young Scientists (B) from the Ministry of Yen Katou Kinen Bioscience Travel Grant Yen Grant-in-Aid for Young Scientists (B) from the Ministry of Yen Conference Presentations (International): Funatogawa I, Funatogawa T, Yano E. Changes in body mass index by birth cohort: Repeated cross sectional annual nationwide survey of Japan The 42 nd Annual Society for Epidemiologic Research Meeting. California, USA, June Funatogawa I, Funatogawa T, Yano E. Growth curves in body mass index by birth cohort in Japanese boys and young men: Repeated cross sectional annual nationwide survey over nearly six decades. 17 th European Congress on Obesity. Amsterdam, Netherlands, May Funatogawa I, Funatogawa T. State-space representation of an autoregressive linear mixed effects model for the analysis of longitudinal data Joint Statistical Meetings. Denver, USA, Aug 2008; Funatogawa T, Funatogawa I. The appropriate sampling point of the half-life for a one-compartment model of a single bolus intravenous injection by a single sampling Joint Statistical Meetings. Denver, USA, Aug 2008; Funatogawa I, Funatogawa T, Ohashi Y. Dynamic dose modification based on autoregressive linear mixed effects model. 28 th Annual Conference of International Society for Clinical Biostatistics. Alexandroupolis, Greece, Aug 2007; 74. Funatogawa T, Funatogawa I, Takeuchi M. Autoregressive linear mixed effects models for the analysis of longitudinal data with dropouts. 28 th Annual Conference of International Society for Clinical Biostatistics. Alexandroupolis, Greece, Aug 2007; 75. Funatogawa I, Ohashi Y. Conditional Linear Mixed Effects Model for Analysis of Longitudinal Data with Asymptotes. IBC 2004 XXIInd International Biometric Conference. Cairns, Australia, July 2004; 141. Conference Presentations (in Japanese): Funatogawa I, Funatogawa T. An estimation method of the half-life based on a single sampling. The 2007 Japanese Joint Statistical Meeting. Kobe, Japan, Sep 2007; 143. Funatogawa I, Funatogawa T. Analysis of Covariance with pre-test data as a covariate and data generating models in randomized controlled trials. The 2006 Japanese Joint Statistical Meeting. Sendai, Japan, Sep 2006; 267. Karita K, Tamura K, Funatogawa I, Yano E. Assessment of exposure to air pollution in driving on roadway exposure levels of several kinds of driver in Bangkok- Meeting of Japanese society of Public Health. Toyama, Japan, Oct Funatogawa I, Iwasaki M. A data generating model for Pretest-Posttest Data. The 2005 Japanese Joint Statistical Meeting. Hiroshima, Japan, Sep 2005; Funatogawa I. A state-space form for the autoregressive linear mixed effects model. The 2005 Japanese Joint Statistical Meeting. Hiroshima, Japan, Sep 2005; 288. Funatogawa I, Ohashi Y, Tanaka Y, Akiba T. Dose relationship of PTH and Ca for the Maxacalcitol administration in secondary hyperparathyroidism. Symposium of the Biometric Society of Japan. Tokyo, Japan, May 2005; Funatogawa I, Ohashi Y. Longitudinal Data Analysis Based on a Conditional Linear Mixed Effects. The 2004 Japanese Joint Statistical Meeting. Iwate, Japan, Sep 2004;

5 Funatogawa I, Ohashi Y, Tanaka Y, Akiba T. Dose relationship of PTH and Ca in the Maxacalcitol administration dor secondary hyperparathyroidism. 23 th Meeting of Kidney and Bone Metabolism., Sep 2004; 86. Funatogawa I, Ohashi Y. Prediction of Future Responses Based on Multivariate Longitudinal Data for the Dynamic Dose Modification. The 2003 Japanese Joint Statistical Meeting. Nagoya, Japan, Sep 2003; Funatogawa I, Ohashi Y. Analysis of longitudinal data with Attrition Using SAS Procedure. SAS Users Group International Japan., Oct 1996; 305. Funatogawa I. An example of longitudinal data analysis. - A dose-finding study for hyperparathyroidism- SAS Users Group International Japan., Oct 1995; 410. Funatogawa I, Ohashi Y. Analysis of Longitudinal Data with Informative Censoring. 23 th Meeting of the Japanese Statistical Society., July 1994; 238.