Autonoma University, Madrid, (Spain) University Hospital Gregorio Marañon, Madrid, (Spain) Master s Degree in Psychotherapy

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Curriculum Vitae PERSONAL INFORMATION Carmen Moreno Ruiz WORK EXPERIENCE July 2002 December 2002 Psychiatric Impatient Unit, Complejo Asistencial Benito Menni, Ciempozuelos, Madrid, (Spain) Diagnosis

1 Curriculum Vitae PERSONAL INFORMATION Carmen Moreno Ruiz WORK EXPERIENCE July 2002 December 2002 Psychiatric Impatient Unit, Complejo Asistencial Benito Menni, Ciempozuelos, Madrid, (Spain) Diagnosis and treatment of acutely ill patients, including: psychopharmacological treatment and psychotherapy group sessions on regular basis with patients who show promise in be treated with behaviour modification. January 2003 July 2004 Child and Adolescent Mental Health Service, Villa de Vallecas, Madrid, (Spain) Clinical work with children and adolescents in the Community. The main areas covered by the position were: Conducting psychiatric evaluations. Design of treatment plans. Psychopharmacological and psychotherapeutic intervention. July 2004 July 2006 Research Fellow Presbyterian Hospital, Columbia University,/New York State Psychiatric Institute, New York, (United States) Research Fellow in Child and Adolescent Psychiaty August 2006 Present Child and Adolescent Psychiatry Department, University Hospital Gregorio Marañón, Madrid, (Spain) The position includes working in the adolescent inpatient unit, in the early-onset psychosis program, and the autism spectrum disorders program. Main chores are clinical, diagnosis and treatment of severe psychiatric conditions in children and adolescents, but includes also research work (see projects developed and publications) EDUCATION AND TRAINING September 1990 June 1996 Medical Degree (MD) Autonoma University, Madrid, (Spain) May 1998 May 2002 Residency in Psychiatry University Hospital Gregorio Marañon, Madrid, (Spain) September 1999 June 2002 Master s Degree in Psychotherapy Alcalá University, Madrid, (Spain) European Union, Page 1 / 5

September 2000 June 2002 Master s Degree in Forensic Psychiatry Complutense University, Madrid, (Spain) February 2012 PhD in Psychiaty Complutense University, (Spain) Dissertation: Diagnostic and

2 September 2000 June 2002 Master s Degree in Forensic Psychiatry Complutense University, Madrid, (Spain) February 2012 PhD in Psychiaty Complutense University, (Spain) Dissertation: Diagnostic and treatment difficulties in early onset bipolar disorder: a multinational study ADDITIONAL INFORMATION Expertise Child and Adolescent Psychiatry Psychotic Disorders Depressive disorders, bipolar disorder and other affective disorders Autism spectrum disorders Publications Moreno C, Nuevo R, Chatterji S, Verdes E, Arango C, Ayuso-Mateos JL. Psychotic symptoms are associated with physical health problems independently of a mental disorder diagnosis results from the WHO World Health Survey. World Psychiatry (in press) IF Parellada M, Penzol MJ, Pina L, Moreno C, Gonzaez-Vioque E, Salzman G, Arango C. The Neurobiology of Autism Spectrum Disorders. European psychiatry. In press, ISSN: IF: Caamaño M, Boada L, Merchán-Naranjo J, Moreno C, Llorente C, Moreno D, Arango C, Parellada M. Psychopathology in Children and Adolescents with ASD WithoutMental Retardation. J Autism DevDisord Mar 8. [Epub ahead of print] PubMedPMID: A. IF: Fraguas D, Moreno C (2012). Eficacia y seguridad de Aripiprazol en el tratamiento de niños y adolescentes con trastornos psiquiátricos. Revista de Psiquiatria Infanto-juvenil (AEPNYA) 29(3): Díaz-Caneja CM, Espliego A, Parellada M, Arango C, Moreno C. Polypharmacy with antidepressants in children and adolescents. Int J Neuropsychopharmacol Nov 29:1-20. IF: Moreno C, Hasin DS, Arango C, Oquendo MA, Vieta E, Liu S, Grant BF, Blanco C (2013). The bipolar-depressive continuum in the National Epidemiologic Survey on Alcohol and Related Conditions. Bipolar Disorders 15(1):112-3 IF: Moreno C, Hasin DS, Arango C, Oquendo MA, Vieta E, Liu S, Grant BF, Blanco C (2012). Depression in Bipolar versus Major Depression Disorder: Results from the National Epidemiological Survey on Alcohol and Related Conditions. Bipolar Disorders 14 (3) : IF: Parellada M, Moreno C, Mac-Dowell K, Leza JC, Giráldez M, Bailón C, Castro C, Miranda-Azpiazu P, Fraguas D, Arango C (2012). Plasma antioxidant capacity is reduced in Asperger syndrome. Journal of Psychiatry Research 46(3): IF: Arango C, Rapado-Castro M, Reig S, Castro-Fornieles J, González-Pinto A, Otero S, Baeza I, Moreno C, Graell M, Janssen J, Parellada M, Moreno D, Bargalló N, Desco M (2012). Progressive brain changes in children and adolescents with first-episode psychosis. Archives of General Psychiatry 69(1): IF:12.02 Janssen J, Aleman Y, Reig S, Schnack HG, Parellada M, Graell M, Moreno C, Moreno D, Mateos- Perez JM, Udias JM, Arango C, Desco M. Regional specificity of thalamic volume deficits in male adolescents with early-onset psychosis (2012). The British Journal of Psychiatry 200(1): 30-6 IF:6.606 Parellada M, Moreno C, Moreno M, Espliego E, de Portugal E, Arango C (2012). Placebo effect in European Union, Page 2 / 5

3 child and adolescent psychiatric trials. European Neuropsychopharmacology 22(11): IF:4.595 Parellada M, Boada L, Moreno C, Llorente C, Romo J, Muela C, Arango C (2013). Specialty Care Programme for Autism Spectrum Disorders in an Urban Population: A case-management model for health care delivery in an ASD population. European Psychiatry 28(2):102-9) IF:3.285 Fraguas D, Correll CU, Merchán-Naranjo J, Rapado-Castro M, Parellada M, Moreno C, Arango C (2011). Efficacy and safety of second-generation antipsychotics in children and adolescents with psychotic and bipolar spectrum disorders. Comprehensive review of prospective head-to-head and placebo-controlled comparisons. Eur Neuropsychopharmacol 21(8): IF:4.595 Mayoral, M.; Merchán-Naranjo, J.; Rapado-Castro, M.; Leiva, M.; Moreno, C.; Giráldez, M.; Arango, C.; Parellada, M. Neurological soft signs in juvenile patients with Asperger syndrome, early-onset psychosis, and healthy controls. Early Intervention in Psychiatry, 4(4):283-90, IF.: Moreno C, Merchan-Naranjo J, Alvarez M, Baeza I, Alda JA, Martinez-Cantarero C, Parellada M, Sánchez B, de la Serna E, Giráldez M, Arango C (2010). Metabolic effects of second-generation antipsychotics in bipolar youth: comparison with other psychotic and non-psychotic diagnoses. Bipolar Disorders 12(2): IF: Moreno-Iniguez M, Parellada M, Moreno-Pardillo D, Mayoral M, Moreno-Ruiz C, Merchan J, Giraldez M, Leiva M, Rapado M, Delgado C, Llorente C, Tapia C, Espliego A, Rodríguez F, Arango C. UADO: a centre for the study of neuro-development within the CIBERSAM. European Journal of Psychiatry 23 (suppl 2009): Reig S, Moreno C, Moreno D, Burdalo M, Janssen J, Parellada M, Zabala A, Desco M, Arango C (2009). Progression of Brain Volume Changes in Adolescent-Onset Psychosis. Schizophrenia Bulletin 35 (1): IF: Sublette ME, Carballo JJ, Moreno C, Galfalvy HC, Brent DA, Birmaher B, Mann JJ, Oquendo MA (2009). Substance Use Disorders and Suicide Attempts in Bipolar Subtypes. Journal of Psychiatric Research 43(3): IF: Arango C, Moreno C, Martinez S, Parellada M, Desco M, Moreno D, Fraguas D, Gogtay N, James A, Rapoport J (2008). Longitudinal Brain Changes in Early-Onset Psychosis. Schizophrenia Bulletin 34(2): IF: Moreno C, Laje G, Blanco C, Jiang H, Schmidt AB, Olfson M (2007). National Trends in the Outpatient Diagnosis and Treatment of Bipolar Disorder in Youth. Archives of General Psychiatry 64(9): IF:12.02 Moreno C, Arango C, Parellada M, Shaffer D, Bird H (2007). Antidepressants in Child and Adolescent Depression, where are the Bugs?. Acta Psychiatrica Scandinavica 115: IF: Moreno C, Roche AM, Greenhill LL (2006). Pharmacotherapy of Child and Adolescent Depression. Child and Adolescent Psychiatric Clinics of North America 15(4): Olfson M, Blanco C, Liu L, Moreno C, Lage G (2006). National trends in the outpatient treatment of children and adolescents with antipsychotic drugs. Archives of General Psychiatry 63(6): IF: IF:12.02 Projects Researcher in the Spanish Biomedical Research Network for Mental Health (CIBERSAM) Neuroimaging platform for characterization of metabolic co-morbidities in psychotic disorders Funding: FP7-Health-2013-INNOVATION-1 I EPSS system number: SEP Euros. Duration: From autism to schizophrenia: Study of the genetic mechanisms underlying brain dysfunction and structural phenotypes in schizophrenia and autistic spectrum disorders. ERA-NET: NEURON. European Research Project on Mental Disorders Investigador Principal: Mara Parellada (Coordinador: Marie-Odile Krebs, Université Paris Descartes) Post: Research colaborator Funding: Instituto de Salud Carlos III. Exp.: PI10/ euros Duration: European Network of National Schizophrenia Networks Studying Gene-Environment Interactions (EU-GEI): Large Scale Integrating project. PI: Celso Arango; Coordinador: Jim van Os European Union, Page 3 / 5

4 Post: Research Colaborator Funding: Comisión Europea, VII Programa Marco Duration: Mecanismos biológicos implicados en la neuroprotección mediante ácidos grasos omega-3 en la psicosis de inicio temprano Post: Principal investigator Funding: Fundación Alicia Koplowitz. 50,000 Euros Duration: Pediatric European Risperidone Studies. Small or Medium-Scale Focused Research Project. (PERS) PI: Celso Arango; Coordinator: JanBuitelaar. Post: Research colaborator Funding: Comisión Europea, VII Programa Marco Duration: Evolución de las alteraciones neuroanatómicas en trastorno bipolar de inicio temprano y mecanismos etiofisiopatológicos implicados Post: Principal investigator Funding: Ministerio de Sanidad, Instituto de Salud Carlos III, F.I.S. PI10/ euros Duration: Project title: Analysis of the dystrobrevin-binding protein 1 gene (DTNBP1) in early onset bipolar disorder and the related neurocognitive phenotypes: an approach based in an association family study and in a complementary animal model design. Financing Entity: CIBERSAM (CIBER of Mental Health). 10,000 euros Duration: from 2009 to 2011 Project title: Two years follow-up study of children and adolescents offspringof patients with schizophrenia or bipolar disorder. Financing Entity: Fundació La Marató de TV3. 100,000 euros Duration: from 2009 to 2012 Project Title: Psychopathologic, neuropsychologic, and neuroimaging characteristics common and differential of children and adolescents offspring of patients with schizophrenia or bipolar disorder. Financing Entity: Ministry of Health, Instituto de Salud Carlos III. (PI07/0853). 62,000 euros. Project Title: Effect of 8 weeks' treatment with omega 3 polyunsaturated fatty acids on oxidative metabolism in patients with autism spectrum disorders. Financing Entity: Alicia Koplowitz Foundation. 100,000 euros. Duration: from 2007 to Project Title: Effect of 8 weeks' treatment with omega 3 polyunsaturated fatty acids on oxidative metabolism in patients with autism spectrum disorders. Financing Entity: Ministry of Health, Instituto de Salud Carlos III (EC07/90293). 61,000 euros Project Title: Detection of B-7-Casomorphine in urine in patients with autism European Union, Page 4 / 5

5 spectrum disorders Financing Entity: Mutua Madrileña Foundation. 19,000 euros Duration: from 2007 to 2009 Project Title: Implication of gene codifying the catechol-o-methyl transferase (COMT) in cognition and as risk factor for schizophrenia in its interaction with neurodevelopmental alterations such as neurological soft signs. Financing Entity: Mutua Madrileña Foundation. 15,970 euros Project title: RETICS Mental Illnesses Network- Affective and Psychotic Illnesses Financing Entity: Ministry of Health (RD06/0011/0000). Memberships American Academy of Child and Adolescent Psychiatry (AACAP), from Sociedad Española de Psiquitría Biológica (SEPB), from European College of Neuropsychopharmacology (ECNP) from Asociación Española de Psiquiatría del Niño y de Adolescente (AEPNYA) from Sociedad Española de Psiquiatria (SEP) from Other Relevant Information Premio para Investigadores de Referencia de la Sociedad Española de Psiquiatría Biológica, por el artículo Metabolic effects of second-generation antipsychotics in bipolar youth. Adjudicado durante el XII Congreso Nacional de Psiquiatría, Oviedo, Septiembre ECNP Fellowship Award. 23 ECNP Congress. Amsterdam, September Premio para Jóvenes Investigadores de la Sociedad Española de Psiquiatría Biológica, por el artículo Pharmacotherapy of Child and Adolescent Depression. Adjudicado durante el X Congreso Nacional de Psiquiatría, Santiago de Compostela, Septiembre European Union, Page 5 / 5

1996 Degree in Medicine and Surgery. Autonoma University of Madrid, Spain.

CURRICULUM VITAE EDUCATION Name: Carmen Moreno, M.D. Ph.D. Phone number: +34 91 426 5005 E-mail: cmoreno@hggm.es Fax: +34 91 426 5004 1996 Degree in Medicine and Surgery. Autonoma University of Madrid,