Preliminary Conference Program

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1 Preliminary Conference Program

2 Contents Scientific Organizing Committee... 1 ENETS Scientific Conference Program ENETS Postgraduate Course... 2 Welcome Reception Meet the Professor / Thursday... 4 Welcome and Introduction... 4 Session 1: New Understanding in NET Tumorigenesis... 4 Life Achievement Award Presentation ENETS Grant Winners Coffee Break and Poster Viewing... 5 Session 2A: Predictive Biomarkers for NETS... 5 Session 2B: Pancreas Session with Treatment... 5 Lunch and Satellite Symposium I, Industry - Sponsored - Symposium... 5 Session 3A: Basic Science Abstract Session... 6 Session 3B: Clinical Abstract Session... 6 Coffee Break and Poster Viewing... 6 Session 4: ENETS / EANM Joint Symposium: PRRT - Peptide Receptor Radionuclide Therapy... 6 ENETS General Assembly... 6 Satellite Symposium II, Industry - Sponsored - Symposium Meet the Professor / Friday... 8 Session 5: Surgical Debate - Transplant Versus Liver Resection... 8 Coffee Break and Poster Viewing... 8 Session 6A: Treatment of NET G3 OR NEC... 8 Session 6B: NET Models Cell and Primary Culture... 8 Session 7A: Molecular Targeted Agents and Angiogenesis... 9 Session 7B: ENETS NET Nurse Symposium... 9 Session 8: ENETS Surgical Trials ENETS Awards and Grants Ceremony Lunch and Satellite Symposium III, Industry - Sponsored - Symposium Session 9: What s New in the Field?... 10

3 Contents Closing Comment Annual Meeting Contact info... 11

4 Scientific Organizing Committee 1 Prof. Martyn Caplin, United Kingdom Prof. Massimo Falconi, Italy Prof. Kjell Öberg, Sweden Prof. Bertram Wiedenmann, Germany Prof. Aurel Perren, Switzerland Prof. Rocio Garcia-Carbonero, Spain Prof. Reza Kianmanesh, France Prof. Dermot O Toole, Ireland Prof. Marianne Pavel, Germany Prof. Wouter de Herder, The Netherlands

5 ENETS Scientific Conference Program 2 Wednesday, ENETS Postgraduate Course Wednesday 08:15-17:15 The postgraduate program is designed for clinicians and researchers new to NET diagnosis and therapy. Limited seats, prior online registration required! 08:15-09:15 Registration and Coffee 09:15-09:30 Introduction and Overview of GEP NETs Martyn Caplin, GBR 09:30-09:50 Carcinoid Syndrome Management and New Advances Gregory Kaltsas, GRE 09:50-10:10 Somatostatin Analogues Anti-Tumour Effect: More Understanding in the Last Year Marianne Ellen Pavel, GER 10:10-10:20 Ectopic Hormones and Paraneoplastic Syndromes Associated with NETs Wouter de Herder, NED 10:20-10:40 Discussion 10:40-11:00 Case Study David Gross, ISR 11:00-11:30 Coffee break 11:30-11:50 Management for Pancreatic NET Towards a New Algorithm Juan Valle, GBR 11:50-12:10 Locoregional Therapy for Liver Disease: Transarterial Embolization - Yttrium Radioembolization, Radiofrequency Ablation 12:10-12:20 Discussion 12:20-12:40 Case Presentation Christos Toumpanakis, GBR 12:40-13:40 Lunch 13:40-14:00 Where are we with Personalised Management? Tim Meyer, GBR 14:00-14:20 Quality of Life Measurement in NET Patients John Ramage, GBR 14:20-14:40 How Best to Manage Non-Secretory Causes of Diarrhea Ulrich-Frank Pape, GER 14:40-14:50 Discussion 14:50-15:10 Coffee Break 15:10-15:30 Appendix Neuroendocrine Tumors Ulrich Peter Knigge, DEN 15:30-15:50 Management of NETs in Unusual Sites: Brain, Heart, Eyes, Ovaries Kjell Öberg, SWE 15:50-16:00 Discussion 16:00-16:20 Diagnosis of Pulmonary NETs Pier Luigi Filosso, ITA 16:20-16:40 Management of Pulmonary NETs Eric Baudin, FRA 16:40-17:00 Medullary Thyroid Carcinoma Ashley Grossman, GBR

6 ENETS Scientific Conference Program 3 17:00-17:10 Discussion 17:10-17:15 Closing Remarks Martyn Caplin, GBR Welcome Reception Wednesday 17:15-18:15

7 ENETS Scientific Conference Program 4 Thursday, Meet the Professor, Thursday 07:30-08:25 Role of Transarterial Embolisation Philippe Ruszniewski, FRA Tricks for Controlling Difficult NET Syndromes Barbro Eriksson, SWE Advance in Paraganglioma and Phaeochromocytoma Ashley Grossman, GBR How do I Choose Chemotherapy? Nicola Fazio, ITA Genomics and Epigenomics in NETs Christina Thirlwell, GBR Welcome and Introduction Thursday 08:30-08:45 08:30-08:45 Welcome and Introduction Martyn Caplin, GBR Session 1: New Understanding in NET Tumorigenesis Thursday 08:45-10:10 Chairs: Kjell Öberg, SWE; Aldo Scarpa, ITA 08:45-09:10 Overview - Profiling in GEP NET Aurel Perren, SUI 09:10-09:35 Hallmarks on Neuroendocrine Tumor Development Christopher Heaphy, USA 09:35-10:00 Metabolism and Cancer Dimitrios Anastasiou, GBR 10:00-10:10 Discussion Life Achievement Award 2016 Thursday 10:10-10:30 Chair: Martyn Caplin, GBR 10:10-10:15 Dedication Emanuel Christ, SUI 10:15-10:30 Recipient and Keynote Presentation Jean Claude Reubi, SUI

8 ENETS Scientific Conference Program 5 Presentation ENETS Grant Winners 2015 Thursday 10:30-10:45 Chair: Martyn Caplin, GBR 10:30-10:35 CoE Excellence Academy Fellowship Henning Jann, GER 10:35-10:40 CoE Young Investigator Grant Jerome Cros, FRA 10:40-10:45 ENETS Translational Medicine Fellowship Su-Chen Li, SWE Coffee Break and Poster Viewing Thursday 10:45-11:20 Poster reviewing will take place in the poster exhibition area on the ground floor.... Concurrent sessions Session 2A: Predictive Biomarkers for NETS Thursday 11:20-12:30, Chairs: Anne Couvelard, FRA; Tim Meyer, GBR 11:20-11:35 Tissue Markers Jean-Yves Scoazec, FRA 11:35-11:50 Circulating RNA Mark Kidd, USA 11:50-12:05 Circulating DNA Christina Thirlwell, GBR 12:05-12:15 Discussion 12:15-12:30 Presidential Abstract Session 2B: Pancreas Session with Treatment Thursday 11:20-12:30, Chairs: Ivan Borbath, BEL; Frederico Costa, BRA 11:20-11:35 Molecular Imaging for Pancreatic Neuroendocrine Tumors Damian Wild, SUI 11:35-11:50 Laparoscopic Versus Open Surgery for Pancreatic NETs Elisabeth Nieveen van Dijkum, NED 11:50-12:05 Update on Molecular Targeted Agents Versus Chemotherapy for P-NET Rocio Garcia-Carbonero, ESP 12:05-12:15 Discussion 12:15-12:30 Presidential Abstract Lunch and Satellite Symposium I, Industry - Sponsored - Symposium Thursday 12:30-14:00... Concurrent sessions

9 ENETS Scientific Conference Program 6 Session 3A: Basic Science Abstract Session Thursday 14:00-15:15, Chairs: Anne Couvelard, FRA; Staffan Welin, SWE 14:00-14:15 14:15-14:30 14:30-14:45 14:45-15:00 15:00-15:15 Session 3B: Clinical Abstract Session Thursday 14:00-15:15, Chairs: Nicholas Simon Reed, GBR; Philippe Ruszniewski, FRA 14:00-14:15 14:15-14:30 14:30-14:45 14:45-15:00 15:00-15:15 Discussion Coffee Break and Poster Viewing Thursday 15:15-15:40 Poster reviewing will take place in the poster exhibition area on the ground floor. Session 4: ENETS / EANM Joint Symposium: PRRT - Peptide Receptor Radionuclide Therapy Thursday 15:40-17:15 Chairs: Lisa Bodei, ITA; Bertram Wiedenmann, GER 15:40-16:20 PRRT Versus Medical Therapy for Intestinal NET Debate: 15:40-15:50 PRRT Richard P. Baum, GER 15:50-16:00 Medical Treatments Kjell Öberg, SWE 16:00-16:05 Rebuttal Comments Richard P. Baum, GER, Kjell Öberg, SWE 16:05-16:20 Audience Discussion 16:20-16:35 Are we Ready for Combination Therapy with PRRT and Chemo or Biotherapy? Rodney Hicks, AUS 16:35-16:50 Novel Isotopes Helmut Maecke, GER 16:50-17:00 Discussion 17:00-17:15 Presidential Abstract PRRT ENETS General Assembly Thursday 17:15-18:10

10 ENETS Scientific Conference Program 7 Members Only! Entry is free of charge. Satellite Symposium II, Industry - Sponsored - Symposium Thursday 18:15-19:45

11 ENETS Scientific Conference Program 8 Friday, Meet the Professor, Friday 07:30-08:25 Role of Transarterial Embolisation Philippe Ruszniewski, FRA Tricks for Controlling Difficult NET Syndromes Barbro Eriksson, SWE Advance in Paraganglioma and Phaeochromocytoma Ashley Grossman, GBR How do I Choose Chemotherapy? Nicola Fazio, ITA Genomics and Epigenomics in NETs Christina Thirlwell, GBR Session 5: Surgical Debate - Transplant Versus Liver Resection Friday 08:30-09:50 Chairs: Göran Åkerström, SWE; Massimo Falconi, ITA 08:30-09:10 Management of Liver Metastases Debate: 08:30-08:45 Liver Transplantation in NET (Pro) Vincenzo Mazzaferro, ITA 08:45-09:00 Liver Transplantation in NET (Con) Andreas Pascher, GER 09:00-09:10 Discussion 09:10-09:50 Intestinal Surgery in Patients with Unresectable Liver Metastases Debate: 09:10-09:25 Resection of Primary Tumor (Pro) Graeme Poston, GBR 09:25-09:40 No Resection of Primary Tumor (Con) Reza Kianmanesh, FRA 09:40-09:50 Discussion Coffee Break and Poster Viewing Friday 09:50-10:20 Poster reviewing will take place in the poster exhibition area on the ground floor.... Concurrent sessions Session 6A: Treatment of NET G3 OR NEC Friday 10:20-11:20, Chairs: Anja Rinke, GER; Ramon Salazar, ESP 10:20-10:35 Histopathology NET G3 Versus NEC G3 Laura Tang, USA Session 6B: NET Models Cell and Primary Culture Friday 10:20-11:20, Chairs: Christian Fischer, GER; Simona Glasberg, ISR

12 ENETS Scientific Conference Program 9 10:35-10:50 Medical Management of GEP NET/C G3 Halfdan Sorbye, NOR 10:50-11:05 Management of Atypical Pulmonary NET is Different to SCLC? Eric Baudin, FRA 11:05-11:20 Presidential Abstract 10:20-10:35 Slice Culture Anne Couvelard, FRA 10:35-10:50 Primary Cell Culture and Classical Cell Lines Maria Chiara Zatelli, ITA 10:50-11:05 Zebrafish Holger Gerhard, GER 11:05-11:20 Mouse Models (MEN1 and RIP-Tag) Rajesh Thakker, GBR Session 7A: Molecular Targeted Agents and Angiogenesis Friday 11:20-12:20 Chairs: Diego Ferone, ITA; Jonathan Strosberg, USA 11:20-11:40 Angiogenesis Inhibitors: Where are we Now? Jaume Capdevila, ESP 11:40-12:00 PI3 Kinase Pathways and mtor Inhibitors: Where are we Now? Marianne Ellen Pavel, GER 12:00-12:20 What Is The Future for New Molecular Targeted Agents? Eric Raymond, SUI Session 7B: ENETS NET Nurse Symposium Friday 11:20-12:35 Chairs: Philippa Davies, GBR; Jenny Falkerby, SWE 11:20-11:25 Introduction Jenny Falkerby, SWE 11:25-11:35 Update, What s New in the Field? Joakim Crona, SWE 11:35-11:45 Is 5HIAA Measurement in Blood Useful in Neuroendocrine Patients? Camilla Schalin-Jantti, FIN 11:45-11:55 Temzolomide/Capecitabine in Neuroendocrine Tumours: A Single Centre Review Lynne McCallum, GBR 11:55-12:00 Question and Answer 12:00-12:10 The Effect of Patient and Doctors Delay in Patients with Neuroendocrine Tumors Lisette Saveur, NED 12:10-12:20 NET Patient Cancer Experience Survey Catherine Bouvier, GBR 12:20-12:30 Question and Answer 12:30-12:35 Summary and close Philippa Davies, GBR

13 ENETS Scientific Conference Program 10 Session 8: ENETS Surgical Trials Friday 12:20-12:35 Chairs: Massimo Falconi, ITA; Reza Kianmanesh, FRA 12:20-12:30 Intestine 1: Resection of Primary Intestinal Tumour vs. Conservative Care in Patients with Unresectable Liver Metastases 12:25-12:35 Pancreas 1: Follow-up Protocol of Sub-2cm Pancreatic NETs ENETS Awards and Grants Ceremony 2016 Friday 12:35-12:45 Chair: Martyn Caplin, GBR Lunch and Satellite Symposium III, Industry - Sponsored - Symposium Friday 12:45-14:15 Session 9: What s New in the Field? Friday 14:15-15:15 Chair: Diane Reidy Lagunes, USA 14:15-14:35 Overview of Best Clinical and Basic Science Abstracts 14:35-14:55 What s New in NET Understanding Guido Rindi, ITA 14:55-15:15 Overview of Ongoing and Planned Clinical Trials Ulrich-Frank Pape, GER Closing Comment Annual Meeting Friday 15:15-15:25 15:15-15:25 Closing Comment Annual Meeting Massimo Falconi, ITA

14 Contact info 11 ENETS Conference Contacts ENETS - European Neuroendocrine Tumor Society 13th Annual ENETS Conference c/o Charité - Universitätsmedizin Berlin Campus Virchow-Klinikum Department of Internal Medicine Division of Hepatology and Gastroenterology Augustenburger Platz Berlin, Germany ENETS Conference Registration Fax: +49 (30) enets-annual-conference(a)charite.de Web: Web: Program, Communication and Exhibitors Information Tel.: +49 (30) Fax: +49 (30) enets.office(a)charite.de Web: Venue address: Centro de Convenciones Internacional de Barcelona (CCIB) GL events CCIB, SL Willy Brandt Square Barcelona, Spain

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