14th International Workshop Multiple Endocrine Neoplasia and other rare endocrine tumors. September 25 27, Vienna - Austria.

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1 14th International Workshop Multiple Endocrine Neoplasia and other rare endocrine tumors September 25 27, 2014 Vienna - Austria Congress Venue Gesellschaft der Ärzte in Wien - Billrothhaus Frankgasse 8, A-1090 Wien Programme Version 40 1 Seite

2 International Scientific Committee (alphabetical order) A. Beckers (Belgium) J. Bertherat (France) M.L. Brandi (Italy) H. Dralle (Germany) R.F. Gagel S.J. Marx B. Niederle (Austria) F. Raue (Germany) B.G. Robinson (Australia) C.A. Stratakis R.V. Thakker (United Kingdom) B. Wiedenmann (Germany) Programme Version 40 1 Seite

3 Local Organisers (Austria) B. Niederle, Vienna man C. Scheuba, Vienna Vice man P. Riss, Vienna A. Selberherr, Vienna St. Strobl, Vienna National Delegates (Austria) S. Baumgartner-Parzer, Vienna O.A. Haas, Vienna A.Luger, Vienna V. Stepan, Graz I. Virgolini, Innsbruck Jakob Erdheim ( ) reported a necropsy case of a pituitary adenoma and enlarged parathyroid glands in the first published case of Multiple Endocrine Neoplasia 1 Erdheim J. Zur Normalen und Pathologischen Histologie der Glandula Thyroidea, Parathyroidea und Hypophysis. Beitr z Path Anat u z Allg Path 1903;33: ) The international workshop WorldMEN2014 is dedicated to this very famous Austrian pathologist! Programme Version 40 1 Seite

4 Scientific Program Thursday, September 25, :00 15:30 Arrival in Vienna 16:00 18: min Topic 1 - Genetic aspects of pituitary tumors Clinical and genetic aspects of familial isolated pituitary adenomas How AIP mutations cause aggressive pituitary adenomas M.L. Jaffrain-Rea (Italy) A. Daly (Liège) A.Luger (Austria) A. Beckers (Belgium) A. Karhu (Finland) Micro-RNAs in pituitary adenoma pathology: culprits or bystanders? M.C. Zatelli Programme Version 40 1 Seite

5 (Italy) Pituitary gland in MEN1 syndrome: from histo-pathology to prognosis Clinical features an therapeutic outcomes in aggressive pituitary adenomas and carcinomas What we know and don t know about the pathophysiology of MEN 1 pituitary adenomas C. Villa (France) G. Raverot (France) S. Agarwal 18:00 20: min Welcome Reception and Poster Party Poster Discussion Friday, September 26, 2014 Programme Version 40 1 Seite

6 08:00 10: min Topic 2 MEN 1 and hyperparathyroid syndromes Partly sponsored by AMGEN Europe 5 min 25 min (20+5) 20 min (15+5) 20 min (15+5) Introduction FIRMO Parathyroid Medal to E.M.Brown The calcium sensing receptor (CaSR) and disordered of Ca2+sensing: from the gene to the patient Genetics of parathyroid tumors Medical Management of primary hyperparathyroidism R.V. Thakker (United Kingdom) M.L. Brandi (Italy) O.A. Haas (Austria) M.L. Brandi (Italy) E.M. Brown R.V. Thakker (United Kingdom) M.L. Brandi (Italy) Programme Version 40 1 Seite

7 20 min (15+5) Management of primary hyperparathyroidism in pregnancy: why and when? R. Eastell (United Kingdom) 10:00-10:30 30 min Historical Lecture 5 min Introduction B. Niederle (Austria) G. 20 min Jakob Erdheim and his period the importance for endocrinology Schmidt-Wyklicky (Austria) 10:30-11:00 30 min Coffee break 11:00 12:50 1 Topic 3 MEN 1 and the pancreas Programme Version 40 1 Seite

8 Under the auspices of the European Society of Endocrine Surgeons (ESES) (7+5) Indication for surgery in MEN1 neuroendocrine pancreatic tumors: Biology Indication for surgery in MEN1 neuroendocrine pancreatic tumors: Size Indication for surgery in MEN1 neuroendocrine pancreatic tumors: Molecular genetic aspects Resection (Thompson procedure) or total pancreatectomy Surgical concepts of MEN1 gastrinoma H. Dralle (Germany) M. Falconi (Italy) NN A. Perren (Switzerland) F. Triponez (Switzerland) P. Goudet France) G. Doherty D.K. Bartsch (Germany) Programme Version 40 1 Seite

9 20 min (15+5) Clinical features and surgical management of MEN1 insulinomas Is laparoscopic surgery in patients with neuroendocrine pancreatic tumors associated with multiple endocrine neoplasia type 1 adequate? F. Tonelli (Italy) L. Fernández-Cruz (Spain) 12:50 13:00 Break Lunch Symposium 13:00 14:00 60 min Coordinator Medical treatment of advanced neuroendocrine pancreatic neoplasia Sponsored by Novartis Oncology Under the auspices of the European Neuroendocrine Tumor Society (ENETS) Molecular Subtypes of Pancreatic NETs and their Distinct Phenotypes Somatostatin analogs what do we learn from the current clinical trails? M. Pavel (Germany) K. Öberg (Sweden) A. Sadanandam (United Kingdom) M. Raderer Programme Version 40 1 Seite

10 (Austria) Integration of targeted- therapy into treatment regimens: Sunitinib and Everolimus - Competition or completion Sunitinib in the treatment of advanced pancreatic neuroendocrine tumors current data Everolimus in advanced pancreatic neuroendocrine tumors: the clinical experience E. Raymond (France) J.C. Yao 14:00 14:10 Break 14:10-15:00 50 min Case presentations 5 x a 7+3 min Coordinator Local organizers after review by members of the International Scientific Committee NN NN Case 1 Case 2 Programme Version 40 1 Seite

11 Case 3 Case 4 Case 5 15:00 15:30 25 min Jakob Erdheim Honorary Lecture 5 min Introduction 20 min Monoclonality and polyclonality in MEN1 and other endocrine tumors B. Niederle (Austria) S.J. Marx 5 min Break 15:30-17: min Topic 4 MEN 2 and rare RET mutations/ Programme Version 40 1 Seite

12 Medullary thyroid cancer F. Raue (Germany) R.F. Gagel S. Baumgartner-Parzer (Austria) The clinical case discussion TED min Clinical data F. Raue/R. F. Gagel (Germany/USA) Diagnostic perspectives Cytological and Biochemical findings Functional Imaging Treatment perspectives R. Elisei (Italy) G. Treglia (Switzerland) Surgical perspectives H. Dralle Programme Version 40 1 Seite

13 (Germany) Medical perspectives R. F. Gagel Discussion TED 2 New developments in the guidelines for management of MEN 2 and medullary thyroid carcinoma K. Frank-Raue (Germany) 17:30 18:00 30 min Coffee break 18:00-19:00 60 min New experimental and clinical developments Programme Version 40 1 Seite

14 Nuclear RET Increases Survival by Suppression of ATF4-mediated Apoptosis Molecular profiling of intestinal NET: future application Epigenetic regulation of Hedgehog signaling in MEN1 tumor syndrome. Value of gene transcripts in the diagnosis and follow-up of NETs S.J. Marx B. Wiedenmann (Germany) I.Virgolini (Austria) R.F. Gagel M.S. Banck X. Hua I.M. Modlin 20:00 Evening Event Programme Version 40 1 Seite

15 Saturday, September 27, :00-10: min Topic 5 - Treatment of advanced endocrine tumors (excluded: pancreatic neuorendocrine neoplasia) B. Wiedenmann (Germany) R.F. Gagel 20 min (15+5) Treatment landscape of NET Advanced medullary thyroid carcinoma: Integration of tyrosine kinase therapy into treatment regimens Vandetanib and Cabozantinib Competition or completion Vandetanib - Current perspectives M. Pavel (Germany) R.F. Gagel Cabozantinib - Current perspectives R. Elisei Programme Version 40 1 Seite

16 (Italy) 20 min (15+5) Current aspects of a personalized treatment approach in advanced adrenocortical cancer J. Bertherat (France) 10:00-10:30 30 min Coffee break 10:30 11:30 60 min Presentations of selected posters 6 x a 7+3 min Coordinator Local organizers Programme Version 40 1 Seite

17 11:30-13: min Poster 1 Poster 2 Poster 3 Poster 4 Poster 5 Poster 6 Topic 6 Hereditary pheochromocytoma and paraganglioma B.G. Robinson (Australia) C.A. Stratakis Programme Version 40 1 Seite

18 20 min (15+5) 20 min (15+5) Recent advances in the genetics of SDH-related paraganglioma and pheochromocytoma The Carney-Stratakis Dyad The role of imaging in screening for pheochromocytoma and paraganglioma Clinical experience from the French paraganglioma network (PGL.EVA study). A new paraganglioma-polycythemia syndrome: Clinical presentations, genetics, and pathogenesis Malignant hereditary pheochromocytoma and paraganglioma: focus on therapeutics V. Stepan (Austria) B.G. Robinson (Australia) C.A. Stratakis R. Hicks (Australia) Ch. Lepoutre (France) K. Pacak E. Baudin (France) Programme Version 40 1 Seite

19 13:30-14:00 Closure Poster prize/best presentation Programme Version 40 1 Seite

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