Imaging of Demyelinating Processes

Size: px
Start display at page:

Download "Imaging of Demyelinating Processes"

Transcription

1 Acta Radiológica Portuguesa, Vol.XXI, nº 82, pág , Abr.-Jun., 2009 Imaging of Demyelinating Processes Alice Boyd Smith, MD Chief, Neuroradiology - Department of Radiologic Pathology, Armed Forces Institute of Pathology Washington, DC Assistant Professor of Radiology & Radiological Sciences - Uniformed Services University of the Health Sciences, Bethesda, MD ARP 81

2 82 ARP

3 ARP 83

4 84 ARP

5 ARP 85

6 86 ARP

7 References Lisanti CJ, Asbach P, Bradley WG, Jr. The Ependymal Dot-Dash Sign: An MR Imaging Finding of Early Multiple Sclerosis. AJNR Am. J. Neuroradiol., Sep 2005; 26: Benedict HB, Zivadinov R, Carone DA, Weinstock-Guttman B, Gaines J, Maggiore C, Sharma J, Tomassi M, Bakshi R. Regional Lobar Atrophy Predicts Memory Impairment in Multiple Sclerosis. AJNR Am. J. Neuroradiol., Aug 2005; 26: Bakshi R, Ariyaratana S, Benedict RH, Jacobs L. Fluid-attenuated inversion recovery magnetic resonance imaging detects cortical and juxtacortical multiple sclerosis lesions. Arch Neurology 2001;58: Miller DH, Grossman RI, Reingold SC, McFarland HF. The role of magnetic resonance techniques in understanding and managing multiple sclerosis. Brain 1998;121:3 24 Noseworthy JH, Lucchinetti C, Rodriguez M, Weinshenker BG. Multiple sclerosis. N Engl J Med 2000;343: Cha S, Pierce S, Knopp EA, Johnson G, Yang C, Ton A, Litt AW, Zagzag D.Dynamic contrast-enhanced T2*-weighted MR imaging of tumefactive demyelinating lesions.ajnr Am J Neuroradiol Jun-Jul;22(6): Prayson RA Neuropathology. Philadelphia, PA: Elsevier. p Barkovich AJ. Pediatric Neuroimaging 4 th ed. Philadelphia, PA: Lippincott. p Grossman RI, Yousem DM. The Requistes: Neuroradiology 2 nd ed. Philadelphia, PA: Moby. P Caracciolo JT, Murtagh RD, Rojiani AM, Murtagh FR. Pathognomonic MR Imaging Findings in Balo Concentric Sclerosis. AJNR Am. J. Neuroradiol., Feb 2001; 22: Honkaniemi J, Dastidar P, Kähärä V, Haapasalo H. Delayed MR Imaging Changes in Acute Disseminated Encephalomyelitis. AJNR Am. J. Neuroradiol., Jun 2001; 22: Bonsack TA, Robertson RL, Lacson A, Casadonte JA, Buonomo C. Pediatric case of the day. Myelinoclastic diffuse sclerosis (MDS) (Schilder disease). RadioGraphics 1996; 16: Donovan Post MJ, Yiannoutsos C, Simpson D, Booss J, Clifford DB, Cohen B, McArthur JC, Hall CD. Progressive Multifocal Leukoencephalopathy in AIDS: Are There Any MR Findings Useful to Patient Management and Predictive of Patient Survival? AJNR Am. J. Neuroradiol., Nov 1999; 20: Usiskin SI, Bainbridge A, Miller RF, Jäger HR. Progressive Multifocal Leukoencephalopathy: Serial High-b-Value Diffusion-Weighted MR Imaging and Apparent Diffusion Coefficient Measurements to Assess Response to Highly Active Antiretroviral Therapy. AJNR Am. J. Neuroradiol., Feb 2007; 28: Sener RN. Subacute Sclerosing Panencephalitis Findings at MR Imaging, Diffusion MR Imaging, and Proton MR Spectroscopy. AJNR Am. J. Neuroradiol., May 2004; 25: Garg RK. Subacute sclerosing panencephalitis. Postgrad Med J2002; 78 :63 70 Singhal S, Rich P, Markus HS. The spatial distribution of MR imaging abnormalities in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy and their relationship to age and clinical features.ajnr Am J Neuroradiol Nov- Dec;26(10): ARP 87

8 Ruzek KA, Campeau NG, Miller GM. Early Diagnosis of Central Pontine Myelinolysis with Diffusion-Weighted Imaging. AJNR Am. J. Neuroradiol., Feb 2004; 25: Fisher MJ, Khademian ZP, Simon EM, Zimmerman RA, Bilaniuk LT. Diffusion-Weighted MR Imaging of Early Methotrexate-Related Neurotoxicity in Children.AJNR Am. J. Neuroradiol., Aug 2005; 26: Keogh CF, Andrews GT, Spacey SD, Forkheim KE, Graeb DA. Neuroimaging features of heroin inhalation toxicity. AJR 2003; 180: Filley CM, Kleinschmidt-DeMasters BK. Toxic leukoencephalopathy. N Engl J Med 2001;345: Barkovich AJ. Concepts of myelin and myelination in neuroradiology. AJNR Am J Neuroradiol Jun-Jul;21(6): Polman CH, Reingold SC, Edan G et al. Diagnostic criteria for multiple sclerosis: 2005 revisions to the McDonald Criteria. Annals of Neurology. 2005;35(6): ARP

MRI diagnostic criteria for multiple sclerosis: an update

MRI diagnostic criteria for multiple sclerosis: an update MRI diagnostic criteria for multiple sclerosis: an update Poster No.: C-0285 Congress: ECR 2013 Type: Educational Exhibit Authors: L. Valls Masot, A. M. Quiles Granado, J. Puig Alcántara, L. RamióTorrentà,

More information

2015 Diagnostic Slide Session

2015 Diagnostic Slide Session 2015 Diagnostic Slide Session Case 3 R.S. Tashjian, MD A.M. Langer-Gould, MD S. Natarajan, MD B.K. Kleinschmidt-DeMasters, MD H.V. Vinters, MD Disclosures No financial disclosures or conflicts of interest

More information

Neuroradiologic Manifestations of HIV

Neuroradiologic Manifestations of HIV Acta Radiológica Portuguesa, Vol.XXI, nº 82, pág. 73-80, Abr.-Jun., 2009 Neuroradiologic Manifestations of HIV Alice Boyd Smith, MD Chief, Neuroradiology - Department of Radiologic Pathology, Armed Forces

More information

Neuroradiology of AIDS

Neuroradiology of AIDS Neuroradiology of AIDS Frank Minja,, HMS IV Gillian Lieberman MD September 2002 AIDS 90% of HIV patients have CNS involvement 1 10% of AIDS patients present first with neurological symptoms 2 73-80% of

More information

Acute Disseminated Encephalomyelitis Presenting as Rhombencephalitis: An Atypical Case Presentation

Acute Disseminated Encephalomyelitis Presenting as Rhombencephalitis: An Atypical Case Presentation pissn 2384-1095 eissn 2384-1109 imri 2015;19:186-190 http://dx.doi.org/10.13104/imri.2015.19.3.186 Acute Disseminated Encephalomyelitis Presenting as Rhombencephalitis: An Atypical Case Presentation Joonseok

More information

MRI in MS. MRI in multiple sclerosis. MS T2 Lesions: Pathology. Brain lesions Morphology Matters. Sagittal FLAIR Morphology Matters

MRI in MS. MRI in multiple sclerosis. MS T2 Lesions: Pathology. Brain lesions Morphology Matters. Sagittal FLAIR Morphology Matters MRI in multiple sclerosis MRI in MS Rohit Bakshi, MD, MA Breakstone Professor of Neurology & Radiology Director, Laboratory for Neuroimaging Research Senior Neurologist, MS Center Brigham & Women s Hospital

More information

Neuroradiological, clinical and genetic characterization of new forms of hereditary leukoencephalopathies

Neuroradiological, clinical and genetic characterization of new forms of hereditary leukoencephalopathies Neuroradiological, clinical and genetic characterization of new forms of hereditary leukoencephalopathies Principal Investigator: Dr. Donatella Tampieri, MD, FRCPC, Department of Neuroradiology, Montreal

More information

Interactive Cases: Demyelinating Diseases and Mimics. Disclosures. Case 1 25 yo F with nystagmus; look for tumor 4/14/2017

Interactive Cases: Demyelinating Diseases and Mimics. Disclosures. Case 1 25 yo F with nystagmus; look for tumor 4/14/2017 Interactive Cases: Demyelinating Diseases and Mimics Disclosures None Brad Wright, MD 27 March 2017 Case 1 25 yo F with nystagmus; look for tumor What do you suspect? A. Demyelinating disease B. Malignancy

More information

1 Maiser. 5-Fluorouracil (5-FU) Induced Acute Toxic Leukoencephalopathy. Samuel Maiser, MD. Department of Neurology, University of Minnesota

1 Maiser. 5-Fluorouracil (5-FU) Induced Acute Toxic Leukoencephalopathy. Samuel Maiser, MD. Department of Neurology, University of Minnesota 1 Maiser 5-Fluorouracil (5-FU) Induced Acute Toxic Leukoencephalopathy Samuel Maiser, MD Department of Neurology, University of Minnesota Case This is a 57-year-old right-handed male with a history of

More information

Refractive Index As Surrogate Biological Marker Of Tumefactive And Other Form Of Multiple Sclerosis And Its Superiority Over Other Methods

Refractive Index As Surrogate Biological Marker Of Tumefactive And Other Form Of Multiple Sclerosis And Its Superiority Over Other Methods ISPUB.COM The Internet Journal of Radiology Volume 19 Number 1 Refractive Index As Surrogate Biological Marker Of Tumefactive And Other Form Of Multiple Sclerosis And Its Superiority Over Other Methods

More information

Dean Shibata, M.D. Department of Radiology, University of Washington. White Matter, Metabolic, and Degenerative Disease.

Dean Shibata, M.D. Department of Radiology, University of Washington. White Matter, Metabolic, and Degenerative Disease. White Matter, Metabolic, and Degenerative Disease UW Radiology Review 2015 Dean Shibata, M.D Neuroradiology Department of Radiology, University of Washington MS (Multiple Sclerosis) ADEM (Acute Disseminated

More information

The Role of MRI in Multiple Sclerosis

The Role of MRI in Multiple Sclerosis September 2006 The Role of MRI in Multiple Sclerosis David Cochran, Harvard Medical School Year IV Meet our patient WM 49yoF presents to Multiple Sclerosis Clinic for follow-up regarding worsening symptoms

More information

Diffusion-Weighted and Conventional MR Imaging Findings of Neuroaxonal Dystrophy

Diffusion-Weighted and Conventional MR Imaging Findings of Neuroaxonal Dystrophy AJNR Am J Neuroradiol 25:1269 1273, August 2004 Diffusion-Weighted and Conventional MR Imaging Findings of Neuroaxonal Dystrophy R. Nuri Sener BACKGROUND AND PURPOSE: Neuroaxonal dystrophy is a rare progressive

More information

Presence and severity of carotid siphon calcification on computed tomography images in mild cognitive impairment

Presence and severity of carotid siphon calcification on computed tomography images in mild cognitive impairment Presence and severity of carotid siphon calcification on computed tomography images in mild cognitive impairment Poster No.: C-2117 Congress: ECR 2013 Type: Scientific Exhibit Authors: S. Rutkauskas, S.

More information

Susac Syndrome: Brain MRI findings in 3 patients at our institution and review of literature.

Susac Syndrome: Brain MRI findings in 3 patients at our institution and review of literature. Susac Syndrome: Brain MRI findings in 3 patients at our institution and review of literature. Poster No.: C-0395 Congress: ECR 2014 Type: Educational Exhibit Authors: H. Chaves, M. S. TORONCHIK, P. M.

More information

Pediatric Retroperitoneal Masses Radiologic-Pathologic Correlation

Pediatric Retroperitoneal Masses Radiologic-Pathologic Correlation Acta Radiológica Portuguesa, Vol.XVIII, nº 70, pág. 61-70, Abr.-Jun., 2006 Pediatric Retroperitoneal Masses Radiologic-Pathologic Correlation Marilyn J. Siegel Mallinckrodt Institute of Radiology, Washington

More information

Index. aneurysm, 92 carotid occlusion, 94 ICA stenosis, 95 intracranial, 92 MCA, 94

Index. aneurysm, 92 carotid occlusion, 94 ICA stenosis, 95 intracranial, 92 MCA, 94 A ADC. See Apparent diffusion coefficient (ADC) Aneurysm cerebral artery aneurysm, 93 CT scan, 93 gadolinium, 93 Angiography, 13 Anoxic brain injury, 25 Apparent diffusion coefficient (ADC), 7 Arachnoid

More information

ORIGINAL RESEARCH. with AIDS develop PML during the course of their disease, 1 and PML is the cause of death in 0.7% of them. 2

ORIGINAL RESEARCH. with AIDS develop PML during the course of their disease, 1 and PML is the cause of death in 0.7% of them. 2 ORIGINAL RESEARCH C. Buckle M. Castillo Use of Diffusion-Weighted Imaging to Evaluate the Initial Response of Progressive Multifocal Leukoencephalopathy to Highly Active Antiretroviral Therapy: Early Experience

More information

EVALUATION OF CHRONIC HEADACHE BY COMPUTED TOMOGRAPHY: A RETROSPECTIVE STUDY

EVALUATION OF CHRONIC HEADACHE BY COMPUTED TOMOGRAPHY: A RETROSPECTIVE STUDY EVALUATION OF CHRONIC HEADACHE BY COMPUTED TOMOGRAPHY: A RETROSPECTIVE STUDY Abstract: Anish Subedee Objective: To find out the proportion of intracranial abnormalities in patients with chronic headache

More information

mr brain volume analysis using brain assist

mr brain volume analysis using brain assist mr brain volume analysis using brain assist This Paper describes the tool named BrainAssist, which can be used for the study and analysis of brain abnormalities like Focal Cortical Dysplasia (FCD), Heterotopia

More information

Demyelinating Diseases of the Brain

Demyelinating Diseases of the Brain Department of Radiology University of California San Diego Demyelinating Diseases of the Brain John R. Hesselink, M.D. T1-Weighted Images Normal White Matter Contents Axons with envelope of myelin Neuroglia

More information

MR Imaging of White Matter Disease in Children

MR Imaging of White Matter Disease in Children 359 Martha A. NowelF Robert I. Grossman David B. Hackney Robert A. Zimmerman Herbert I. Goldberg Larissa T. Bilaniuk This article appears in the May/June 1988 issue ofajnr and the August 1988 Issue of

More information

The relationship of multiple sclerosis and cerebral developmental venous anomaly with an advantageous role in the multiple sclerosis diagnosis

The relationship of multiple sclerosis and cerebral developmental venous anomaly with an advantageous role in the multiple sclerosis diagnosis Iranian Journal of Neurology Original Paper Iran J Neurol 2017; 16(4): 168-72 The relationship of multiple sclerosis and cerebral developmental venous anomaly with an advantageous role in the multiple

More information

Amyotrophic lateral sclerosis (ALS) is a motor neuron disease

Amyotrophic lateral sclerosis (ALS) is a motor neuron disease ORIGINL RESERCH S. Ngai Y.M. Tang L. Du S. Stuckey Hyperintensity of the Precentral Gyral Subcortical White Matter and Hypointensity of the Precentral Gyrus on Fluid-ttenuated Inversion Recovery: Variation

More information

Dural Arteriovenous Fistula of the Cavernous Sinus Presenting with Progressive Venous Congestion of the Pons and Cerebrum: Report of one case

Dural Arteriovenous Fistula of the Cavernous Sinus Presenting with Progressive Venous Congestion of the Pons and Cerebrum: Report of one case Dural Arteriovenous Fistula of the Cavernous Sinus Presenting with Progressive Venous Congestion of the Pons and Cerebrum: Report of one case Soo-Bin Yim, M.D., Jong-Sung Kim, M.D., Yang Kwon,M.D.*, Choong-Gon

More information

PATIENTS WITH MULTIPLE SCLEROSIS

PATIENTS WITH MULTIPLE SCLEROSIS 3 PATIENTS WITH MULTIPLE SCLEROSIS PREFER EARLY DIAGNOSIS Abstract The new diagnostic criteria for multiple sclerosis (MS) allow for a definite diagnosis in earlier stages of disease. Yet, clinicians may

More information

ORIGINAL ARTICLE. Keywords: Multiple Sclerosis; Magnetic Resonance Imaging; Diffuse. Introduction. Abstract Objective

ORIGINAL ARTICLE. Keywords: Multiple Sclerosis; Magnetic Resonance Imaging; Diffuse. Introduction. Abstract Objective ORIGINAL ARTICLE Comparison of Diffuse Weighted Imaging and Fluid Attenuation Inversion Recovery Sequences of MRI in Brain Multiple Sclerosis Plaques Detection How to Cite This Article: Nafisi-Moghadam

More information

Magnetization Transfer Study of HIV Encephalitis and Progressive Multifocal Leukoencephalopathy

Magnetization Transfer Study of HIV Encephalitis and Progressive Multifocal Leukoencephalopathy Magnetization Transfer Study of HIV Encephalitis and Progressive Multifocal Leukoencephalopathy Vincent Dousset, Jean-Pierre Armand, Denis Lacoste, Stéphane Mièze, Luc Letenneur, Jean-François Dartigues,

More information

The Low Sensitivity of Fluid-Attenuated Inversion-Recovery MR in the Detection of Multiple Sclerosis of the Spinal Cord

The Low Sensitivity of Fluid-Attenuated Inversion-Recovery MR in the Detection of Multiple Sclerosis of the Spinal Cord The Low Sensitivity of Fluid-Attenuated Inversion-Recovery MR in the Detection of Multiple Sclerosis of the Spinal Cord Mark D. Keiper, Robert I. Grossman, John C. Brunson, and Mitchell D. Schnall PURPOSE:

More information

Laura Tormoehlen, M.D. Neurology and EM-Toxicology Indiana University

Laura Tormoehlen, M.D. Neurology and EM-Toxicology Indiana University Laura Tormoehlen, M.D. Neurology and EM-Toxicology Indiana University Disclosures! No conflicts of interest to disclose Neuroimaging 101! Plain films! Computed tomography " Angiography " Perfusion! Magnetic

More information

Case of the Month September 2015: Toxic Leukoencephalopathy Chasing the Dragon. Andrew Plum, Chasing the Dragon 2012

Case of the Month September 2015: Toxic Leukoencephalopathy Chasing the Dragon. Andrew Plum, Chasing the Dragon 2012 Case of the Month September 2015: Toxic Leukoencephalopathy Chasing the Dragon Andrew Plum, Chasing the Dragon 2012 Kate Hames PGY2 September 2015 Case Report 28 y/o M with a known history of drug abuse

More information

MRI and differential diagnosis in patients suspected of having MS

MRI and differential diagnosis in patients suspected of having MS Andrea Falini Italy MRI and differential diagnosis in patients suspected of having MS IMPROVING THE PATIENT S LIFE THROUGH MEDICAL EDUCATION www.excemed.org Outline of presentation - Diagnostic criteria

More information

MDWISE PRIOR AUTHORIZATION CRITERIA TYSABRI (natalizumab): 300mg/15mL single use vial

MDWISE PRIOR AUTHORIZATION CRITERIA TYSABRI (natalizumab): 300mg/15mL single use vial MDWISE PRIOR AUTHORIZATION CRITERIA TYSABRI (natalizumab): 300mg/15mL single use vial Formulary Status: Non-Formulary requiring prior authorization PA CRITERIA FOR INITIAL AUTHORIZATION FOR USE IN MULTIPLE

More information

Magnetic resonance imaging in multiple sclerosis

Magnetic resonance imaging in multiple sclerosis APRIL 2002 103 Magnetic resonance imaging in multiple sclerosis Beside the ability to detect the Olga Ciccarelli and David H. Miller NMR Unit, Institute of Neurology, University College London, Queen Square,

More information

Role of MRI in acute disseminated encephalomyelitis

Role of MRI in acute disseminated encephalomyelitis Original Research Article Role of MRI in acute disseminated encephalomyelitis Shashvat Modiya 1*, Jayesh Shah 2, C. Raychaudhuri 3 1 1 st year resident, 2 Associate Professor, 3 HOD and Professor Department

More information

MULTIPLE SCLEROSIS Update

MULTIPLE SCLEROSIS Update MULTIPLE SCLEROSIS Update E. Torage Shivapour, M.D. Clinical Professor Department of Neurology University of Iowa Hospitals & Clinics Disclosures I do not have any disclosures. Multiple Sclerosis Most

More information

All relapsing multiple sclerosis patients should be managed at a specialist clinic- YES. Dr W J Brownlee FRACP 1. O Ciccarelli FRCP 1,2

All relapsing multiple sclerosis patients should be managed at a specialist clinic- YES. Dr W J Brownlee FRACP 1. O Ciccarelli FRCP 1,2 All relapsing multiple sclerosis patients should be managed at a specialist clinic- YES Dr W J Brownlee FRACP 1 O Ciccarelli FRCP 1,2 1 Queen Square Multiple Sclerosis Centre, Department of Neuroinflammation,

More information

University of Minnesota Diagnostic Radiology Residency Curriculum, Department of Radiology Rotation Duty Sheet - UMNE

University of Minnesota Diagnostic Radiology Residency Curriculum, Department of Radiology Rotation Duty Sheet - UMNE Department of Radiology Rotation Duty Sheet - UMNE ROTATION DUTY SHEET FOR: UMNE The resident will review Duty Sheet regularly throughout the rotation. Please review documents posted on moodle about detailed

More information

The MRI Appearance of Tumefactive Demyelinating Lesions

The MRI Appearance of Tumefactive Demyelinating Lesions ownloaded from www.ajronline.org by 37.44.198.148 on 12/05/17 from IP address 37.44.198.148. opyright RRS. For personal use only; all rights reserved The MRI ppearance of Tumefactive emyelinating Lesions

More information

Multiple sclerosis: High prevalence of the central vein sign in white matter lesions on susceptibility-weighted images

Multiple sclerosis: High prevalence of the central vein sign in white matter lesions on susceptibility-weighted images Original article Multiple sclerosis: High prevalence of the central vein sign in white matter lesions on susceptibility-weighted images The Neuroradiology Journal 0(00) 1 6! The Author(s) 2018 Reprints

More information

Peking University People's Hospital, Peking University Institute of Hematology

Peking University People's Hospital, Peking University Institute of Hematology Qian Jiang, M.D. Peking University People's Hospital, Peking University Institute of Hematology No. 11 Xizhimen South Street, Beijing, 100044, China. Phone number: 86-10-66583802 Mobile: 86-13611115100

More information

Research Article Optic Nerve and Spinal Cord Are the Major Lesions in Each Relapse of Japanese Multiple Sclerosis

Research Article Optic Nerve and Spinal Cord Are the Major Lesions in Each Relapse of Japanese Multiple Sclerosis International Scholarly Research Network ISRN Neurology Volume 211, Article ID 9476, 4 pages doi:1.542/211/9476 Research Article Optic Nerve and Spinal Cord Are the Major Lesions in Each Relapse of Japanese

More information

Analysis of prognostic significance of clinical and paraclinical indices in case of different types of acute disseminated encephalomyelitis course.

Analysis of prognostic significance of clinical and paraclinical indices in case of different types of acute disseminated encephalomyelitis course. 1 2 Analysis of prognostic significance of clinical and paraclinical indices in case of different types of acute disseminated encephalomyelitis course. 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21

More information

Patologie infiammatorie encefaliche e midollari

Patologie infiammatorie encefaliche e midollari Patologie infiammatorie encefaliche e midollari Maria Laura Stromillo Department of Medicine, Surgery and Neuroscience Inflammatory disorders of the CNS NMOSD ADEM Multiple Sclerosis Neuro-Myelitis Optica

More information

Radiologic-Pathologic Correlation of White Matter Disease

Radiologic-Pathologic Correlation of White Matter Disease The Neuroradiology Journal 22 (Suppl. 1): 26-32, 2009 www. centauro. it Radiologic-Pathologic Correlation of White Matter Disease J.G. SMIRNIOTOPOULOS 1,2,3,.. SMITH 1,2, E. RUSHING 2,4, F.M. MURPHY 2,

More information

Subacute Sclerosing Panencephalitis in a Child with HIV Co-Infection

Subacute Sclerosing Panencephalitis in a Child with HIV Co-Infection CM&R Rapid Release. Published online ahead of print October 24, 2016 as doi:10.3121/cmr.2016.1331 Case Report Subacute Sclerosing Panencephalitis in a Child with HIV Co-Infection Pradeep Kumar Maurya,

More information

ORIGINAL CONTRIBUTION. Infratentorial Lesions Predict Long-term Disability in Patients With Initial Findings Suggestive of Multiple Sclerosis

ORIGINAL CONTRIBUTION. Infratentorial Lesions Predict Long-term Disability in Patients With Initial Findings Suggestive of Multiple Sclerosis ORIGINAL CONTRIBUTION Infratentorial Lesions Predict Long-term Disability in Patients With Initial Findings Suggestive of Multiple Sclerosis Arjan Minneboo, MD; Frederick Barkhof, MD; Chris H. Polman,

More information

Long-Term Changes of Magnetization Transfer Derived Measures from Patients with Relapsing-Remitting and Secondary Progressive Multiple Sclerosis

Long-Term Changes of Magnetization Transfer Derived Measures from Patients with Relapsing-Remitting and Secondary Progressive Multiple Sclerosis AJNR Am J Neuroradiol 20:821 827, May 1999 Long-Term Changes of Magnetization Transfer Derived Measures from Patients with Relapsing-Remitting and Secondary Progressive Multiple Sclerosis Maria A. Rocca,

More information

Magnetic resonance imaging (MR!) provides

Magnetic resonance imaging (MR!) provides 0 Wallerian Degeneration of the Pyramidal Tract in Capsular Infarction Studied by Magnetic Resonance Imaging Jesiis Pujol, MD, Josep L. Marti-Vilalta, MD, Carme Junqu6, PhD, Pere Vendrell, PhD, Juan Fernandez,

More information

ISSN No: Distribution of brain plaques in patients with clinically definite Multiple Sclerosis diagnosis in Kerman city

ISSN No: Distribution of brain plaques in patients with clinically definite Multiple Sclerosis diagnosis in Kerman city Available online at www.ijmrhs.com ISSN No: 2319-5886 International Journal of Medical Research & Health Sciences, 2016, 5, 4:216-223 Distribution of brain plaques in patients with clinically definite

More information

Supplementary Online Content

Supplementary Online Content Supplementary Online Content Schlaeger R, Papinutto N, Zhu AH, et al. Association between thoracic spinal cord gray matter atrophy and disability in multiple sclerosis. JAMA Neurol. Published online June

More information

ORIGINAL CONTRIBUTION

ORIGINAL CONTRIBUTION ORIGINAL CONTRIBUTION Neuromyelitis Optica Treatment Analysis of 3 s Denis Bernardi Bichuetti, MD; Enedina Maria Lobato de Oliveira, MD, PhD; Daniel May Oliveira, MD; Nilton Amorin de Souza, MD; Alberto

More information

Magnetization-Transfer Histogram Analysis of the Cervical Cord in Patients with Multiple Sclerosis

Magnetization-Transfer Histogram Analysis of the Cervical Cord in Patients with Multiple Sclerosis AJNR Am J Neuroradiol 20:1803 1808, November/December 1999 Magnetization-Transfer Histogram Analysis of the Cervical Cord in Patients with Multiple Sclerosis Marco Bozzali, Maria A. Rocca, Giuseppe Iannucci,

More information

MEDICAL POLICY EFFECTIVE DATE: 12/18/08 REVISED DATE: 12/17/09, 03/17/11, 05/19/11, 05/24/12, 05/23/13, 05/22/14

MEDICAL POLICY EFFECTIVE DATE: 12/18/08 REVISED DATE: 12/17/09, 03/17/11, 05/19/11, 05/24/12, 05/23/13, 05/22/14 MEDICAL POLICY SUBJECT: CT (COMPUTED TOMOGRAPHY) PAGE: 1 OF: 5 If the member's subscriber contract excludes coverage for a specific service it is not covered under that contract. In such cases, medical

More information

Evaluation of Patients Treated with Natalizumab for Progressive Multifocal Leukoencephalopathy

Evaluation of Patients Treated with Natalizumab for Progressive Multifocal Leukoencephalopathy The new england journal of medicine original article Evaluation of Patients Treated with Natalizumab for Progressive Multifocal Leukoencephalopathy Tarek A. Yousry, Dr.Med.Habil., Eugene O. Major, Ph.D.,

More information

THE ROLE OF IMAGING IN DIAGNOSIS OF SUBDURAL HEMATOMA: REVIEW ARTICLE

THE ROLE OF IMAGING IN DIAGNOSIS OF SUBDURAL HEMATOMA: REVIEW ARTICLE THE ROLE OF IMAGING IN DIAGNOSIS OF SUBDURAL HEMATOMA: REVIEW ARTICLE * Dr. Sumendra Raj Pandey, Prof. Dr. Liu Pei WU, Dr. Sohan Kumar Sah, Dr. Lalu Yadav, Md. Sadam Husen Haque and Rajan KR. Chaurasiya

More information

Low sensitivity of McDonald MRI criteria in the diagnosis of multiple sclerosis among Asians

Low sensitivity of McDonald MRI criteria in the diagnosis of multiple sclerosis among Asians Neurology Asia 2006; 11 : 129 133 Low sensitivity of McDonald MRI criteria in the diagnosis of multiple sclerosis among Asians 1 Heng-Thay CHONG MRCP, 1 Norlisah RAMLI FRCR, 2 Kwang-Ho LEE MD, 2 Byung-Joon

More information

Imaging the Premature Brain- New Knowledge

Imaging the Premature Brain- New Knowledge Imaging the Premature Brain- New Knowledge Stein Magnus Aukland Haukeland University Hospital University of Bergen NORWAY No disclosure Imaging modalities O Skull X-ray O Computer Tomography O Cerebral

More information

Isolated Demyelinating Syndromes: Comparison of Different MR Imaging Criteria to Predict Conversion to Clinically Definite Multiple Sclerosis

Isolated Demyelinating Syndromes: Comparison of Different MR Imaging Criteria to Predict Conversion to Clinically Definite Multiple Sclerosis AJNR Am J Neuroradiol 21:702 706, April 2000 Isolated Demyelinating Syndromes: Comparison of Different MR Imaging Criteria to Predict Conversion to Clinically Definite Multiple Sclerosis Mar Tintoré, Alex

More information

Magnetic Resonance Imaging. Basics of MRI in practice. Generation of MR signal. Generation of MR signal. Spin echo imaging. Generation of MR signal

Magnetic Resonance Imaging. Basics of MRI in practice. Generation of MR signal. Generation of MR signal. Spin echo imaging. Generation of MR signal Magnetic Resonance Imaging Protons aligned with B0 magnetic filed Longitudinal magnetization - T1 relaxation Transverse magnetization - T2 relaxation Signal measured in the transverse plane Basics of MRI

More information

Tumefactive multiple sclerosis lesions: Diagnostic challenge for the radiologist

Tumefactive multiple sclerosis lesions: Diagnostic challenge for the radiologist Tumefactive multiple sclerosis lesions: Diagnostic challenge for the radiologist Poster No.: C-0679 Congress: ECR 2015 Type: Educational Exhibit Authors: A. Gargallo Vaamonde, M. Iridoy Zulet, I. Rubio

More information

Atypical idiopathic inflammatory demyelinating lesions: prognostic implications and relation to multiple sclerosis.

Atypical idiopathic inflammatory demyelinating lesions: prognostic implications and relation to multiple sclerosis. Atypical idiopathic inflammatory demyelinating lesions: prognostic implications and relation to multiple sclerosis. Wallner-Blazek, M; Rovira, A; Fillipp, M; Rocca, MA; Miller, DH; Schmierer, K; Frederiksen,

More information

ABSTRACT Background In patients with isolated syndromes that are clinically suggestive of multiple sclerosis,

ABSTRACT Background In patients with isolated syndromes that are clinically suggestive of multiple sclerosis, A LONGITUDINAL STUDY OF ABNORMALITIES ON MRI AND DISABILITY FROM MULTIPLE SCLEROSIS PETER A. BREX, M.D., OLGA CICCARELLI, M.D., JONATHON I. O RIORDAN, M.D., MICHAEL SAILER, M.D., ALAN J. THOMPSON, M.D.,

More information

Imaging in a confused patient: Infections and Inflammation

Imaging in a confused patient: Infections and Inflammation American Society of Neuroimaging Imaging in a confused patient: Infections and Inflammation January 21, 2017 Los Angeles, California Joshua P. Klein, MD, PhD, FANA, FAAN, FASN Chief, Division of Hospital

More information

Hypoglycemic encephalopathy mimicking acute ischemic stroke in clinical presentation and magnetic resonance imaging: a case report

Hypoglycemic encephalopathy mimicking acute ischemic stroke in clinical presentation and magnetic resonance imaging: a case report Chuang et al. BMC Medical Imaging (2019) 19:11 https://doi.org/10.1186/s12880-019-0310-z CASE REPORT Hypoglycemic encephalopathy mimicking acute ischemic stroke in clinical presentation and magnetic resonance

More information

Multiple sclerosis (MS) is a disabling chronic demyelinating disease

Multiple sclerosis (MS) is a disabling chronic demyelinating disease Diagn Interv Radiol 2010; 16:106 111 Turkish Society of Radiology 2010 NEURORADIOLOGY ORIGINAL ARTICLE Imaging of active multiple sclerosis plaques: efficiency of contrast-enhanced magnetization transfer

More information

62 yo F, RHD Epilepsy onset: 44 yo Seizure type: 1) Dyscognitive seizure 2) Somatosensory aura (abnormal feeling at both feet) Seizures disappeared

62 yo F, RHD Epilepsy onset: 44 yo Seizure type: 1) Dyscognitive seizure 2) Somatosensory aura (abnormal feeling at both feet) Seizures disappeared 62 yo F, RHD Epilepsy onset: 44 yo Seizure type: 1) Dyscognitive seizure 2) Somatosensory aura (abnormal feeling at both feet) Seizures disappeared since age 56 years Seizure period: 12 years (44 56 yrs)

More information

MRI of Pathological Aging Brain

MRI of Pathological Aging Brain MRI of Pathological Aging Brain Yukio Miki Department of Radiology, Osaka City University A variety of pathological changes occur in the brain with aging, and many of these changes can be identified by

More information

Pharmacoresistant temporal lobe epilepsy - a diagnostic performance of standardized MRI protocol in detection of epileptogenic lesion

Pharmacoresistant temporal lobe epilepsy - a diagnostic performance of standardized MRI protocol in detection of epileptogenic lesion Pharmacoresistant temporal lobe epilepsy - a diagnostic performance of standardized MRI protocol in detection of epileptogenic lesion Poster No.: C-2226 Congress: ECR 2013 Type: Scientific Exhibit Authors:

More information

Sicle-cell disease and silent cerebral infarcts evaluated with magnetic resonance imaging

Sicle-cell disease and silent cerebral infarcts evaluated with magnetic resonance imaging Sicle-cell disease and silent cerebral infarcts evaluated with magnetic resonance imaging Poster No.: C-0243 Congress: ECR 2015 Type: Educational Exhibit Authors: E. Solomou, A. Rigopoulou, P. Kraniotis,

More information

Toxins in Brain! Magnetic Resonance (MR) Imaging of Toxic Leukoencephalopathy A Pictorial Essay

Toxins in Brain! Magnetic Resonance (MR) Imaging of Toxic Leukoencephalopathy A Pictorial Essay Signature: Pol J Radiol, 2017; 82: 311-319 DOI: 10.12659/PJR.901791 REVIEW ARTICLE Received: 2016.10.02 Accepted: 2016.10.11 Published: 2017.06.13 Authors Contribution: A Study Design B Data Collection

More information

Epidemiology, Diagnosis, Natural History & Clinical Course

Epidemiology, Diagnosis, Natural History & Clinical Course Epidemiology, Diagnosis, Natural History & Clinical Course Multiple Sclerosis Immune-mediated, chronic, inflammatory disease precipitated by unknown environmental factors in genetically susceptible individuals

More information

Vague Neurological Conditions

Vague Neurological Conditions Vague Neurological Conditions Dr. John Lefebre, MD, FRCPC Chief Regional Medical Director Europe, India, South Africa, Middle East and Turkey Canada 2014 2 3 4 Agenda Dr. John Lefebre, M.D., FRCPC 1. TIA

More information

Relevance of Hypointense Lesions on Fast Fluid- Attenuated Inversion Recovery MR Images as a Marker of Disease Severity in Cases of Multiple Sclerosis

Relevance of Hypointense Lesions on Fast Fluid- Attenuated Inversion Recovery MR Images as a Marker of Disease Severity in Cases of Multiple Sclerosis AJNR Am J Neuroradiol 20:813 820, May 1999 Relevance of Hypointense Lesions on Fast Fluid- Attenuated Inversion Recovery MR Images as a Marker of Disease Severity in Cases of Multiple Sclerosis Marco Rovaris,

More information

Infantile-onset Alexander disease in a child with long-term follow-up by serial magnetic resonance imaging: a case report

Infantile-onset Alexander disease in a child with long-term follow-up by serial magnetic resonance imaging: a case report Nishibayashi et al. Journal of Medical Case Reports 2013, 7:194 JOURNAL OF MEDICAL CASE REPORTS CASE REPORT Open Access Infantile-onset Alexander disease in a child with long-term follow-up by serial magnetic

More information

ORIGINAL CONTRIBUTION. Determinants of Cerebral Atrophy Rate at the Time of Diagnosis of Multiple Sclerosis. imaging (MRI) provides

ORIGINAL CONTRIBUTION. Determinants of Cerebral Atrophy Rate at the Time of Diagnosis of Multiple Sclerosis. imaging (MRI) provides ORIGINAL CONTRIBUTION Determinants of Cerebral Atrophy Rate at the Time of Diagnosis of Multiple Sclerosis Bas Jasperse, MD; Arjan Minneboo, MD; Vincent de Groot, MD; Nynke F. Kalkers, MD, PhD; Paul E.

More information

MEDIA BACKGROUNDER. Multiple Sclerosis: A serious and unpredictable neurological disease

MEDIA BACKGROUNDER. Multiple Sclerosis: A serious and unpredictable neurological disease MEDIA BACKGROUNDER Multiple Sclerosis: A serious and unpredictable neurological disease Multiple sclerosis (MS) is a complex chronic inflammatory disease of the central nervous system (CNS) that still

More information

MR Imaging of Leptomeningeal Metastases: Comparison of Three Sequences

MR Imaging of Leptomeningeal Metastases: Comparison of Three Sequences AJNR Am J Neuroradiol 23:817 821, May 2002 MR Imaging of Leptomeningeal Metastases: Comparison of Three Sequences Sanjay K. Singh, Norman E. Leeds, and Lawrence E. Ginsberg BACKGROUND AND PURPOSE: Recent

More information

A Comparison of MR Imaging with Fast-FLAIR, HASTE-FLAIR, and EPI-FLAIR Sequences in the Assessment of Patients with Multiple Sclerosis

A Comparison of MR Imaging with Fast-FLAIR, HASTE-FLAIR, and EPI-FLAIR Sequences in the Assessment of Patients with Multiple Sclerosis AJNR Am J Neuroradiol 20:1931 1938, November/December 1999 A Comparison of MR Imaging with Fast-FLAIR, HASTE-FLAIR, and EPI-FLAIR Sequences in the Assessment of Patients with Multiple Sclerosis Massimo

More information

Brain Volume Regulation in Response to Hypo-osmolality and Its Correction

Brain Volume Regulation in Response to Hypo-osmolality and Its Correction The American Journal of Medicine (2006) Vol 119 (7A), S12 S16 Brain Volume Regulation in Response to Hypo-osmolality and Its Correction Richard H. Sterns, MD,* and Stephen M. Silver, MD Department of Medicine,

More information

Fluid-Attenuated Inversion-Recovery Fast Spin-Echo MR: A Clinically Useful Tool in the Evaluation of Neurologically Symptomatic HIV-Positive Patients

Fluid-Attenuated Inversion-Recovery Fast Spin-Echo MR: A Clinically Useful Tool in the Evaluation of Neurologically Symptomatic HIV-Positive Patients Commentary Fluid-Attenuated Inversion-Recovery Fast Spin-Echo MR: A Clinically Useful Tool in the Evaluation of Neurologically Symptomatic HIV-Positive Patients M. Judith Donovan Post, Neuroradiology Section,

More information

Cranial Ultrasonography in Maple Syrup Urine Disease

Cranial Ultrasonography in Maple Syrup Urine Disease Cranial Ultrasonography in Maple Syrup Urine Disease Giuseppe Fariello, Carlo Dionisi-Vici, Cinzia Orazi, Saverio Malena, Andrea Bartuli, Paolo Schingo, Enza Carnevale, Isora Saponara, and Gaetano Sabetta

More information

Reversible Posterior Leukoencephalopathy Syndrome: A Case Report and Review of the Literature

Reversible Posterior Leukoencephalopathy Syndrome: A Case Report and Review of the Literature 196 Reversible Posterior Leukoencephalopathy Syndrome: Case Report and Review of the Literature Ching-Sen Shih, Yu-Te Lin, Sui-Hing Yan, and Yuk-Keung Lo bstract- 23-year-old man with minimal-changed nephrotic

More information

Neuroradiology Original Research

Neuroradiology Original Research MRI of Multiple Sclerosis Lesions Neuroradiology Original Research Ender Uysal 1 Sukru Mehmet Erturk 1 Hakan Yildirim 1 Feray Seleker 2 Muzaffer Basak 1 Uysal E, Erturk SM, Yildirim H, et al. Keywords:

More information

Pituitary Apoplexy: Early Detection with Diffusion-Weighted MR Imaging

Pituitary Apoplexy: Early Detection with Diffusion-Weighted MR Imaging AJNR Am J Neuroradiol 23:1240 1245, August 2002 Case Report Pituitary Apoplexy: Early Detection with Diffusion-Weighted MR Imaging Jeffrey M. Rogg, Glenn A. Tung, Gordon Anderson, and Selina Cortez Summary:

More information

Neuroimaging and Other Biomarkers. MRI for Diagnosis, Prognosis and Treatment Decisions in MS

Neuroimaging and Other Biomarkers. MRI for Diagnosis, Prognosis and Treatment Decisions in MS Neuroimaging and Other Biomarkers MRI for Diagnosis, Prognosis and Treatment Decisions in MS Eric Klawiter, MD MSc Massachusetts General Hospital May 30, 2014 Disclosures and Funding Disclosures: Consulting

More information

A characteristic feature of acute haematomas in the brain on echo-planar diffusion-weighted imaging

A characteristic feature of acute haematomas in the brain on echo-planar diffusion-weighted imaging Neuroradiology (2002) 44: 907 911 DOI 10.1007/s00234-002-0860-5 DIAGNOSTIC NEURORADIOLOGY N. Morita M. Harada K. Yoneda H. Nishitani M. Uno A characteristic feature of acute haematomas in the brain on

More information

ORIGINAL CONTRIBUTION. Multiple Sclerosis Lesions and Irreversible Brain Tissue Damage

ORIGINAL CONTRIBUTION. Multiple Sclerosis Lesions and Irreversible Brain Tissue Damage ORIGINAL CONTRIBUTION Multiple Sclerosis Lesions and Irreversible Brain Tissue Damage A Comparative Ultrahigh-Field Strength Magnetic Resonance Imaging Study Tim Sinnecker; Paul Mittelstaedt; Jan Dörr,

More information

Scope. EEG patterns in Encephalopathy. Diffuse encephalopathy. EEG in adult patients with. EEG in diffuse encephalopathy

Scope. EEG patterns in Encephalopathy. Diffuse encephalopathy. EEG in adult patients with. EEG in diffuse encephalopathy Scope EEG patterns in Encephalopathy Dr.Pasiri Sithinamsuwan Division of Neurology Department of Medicine Phramongkutklao Hospital Diffuse encephalopathy EEG in specific encephalopathies Encephalitides

More information

1 MS Lesions in T2-Weighted Images

1 MS Lesions in T2-Weighted Images 1 MS Lesions in T2-Weighted Images M.A. Sahraian, E.-W. Radue 1.1 Introduction Multiple hyperintense lesions on T2- and PDweighted sequences are the characteristic magnetic resonance imaging (MRI) appearance

More information

Hypoxic ischemic brain injury in neonates - early MR imaging findings

Hypoxic ischemic brain injury in neonates - early MR imaging findings Hypoxic ischemic brain injury in neonates - early MR imaging findings Poster No.: C-1208 Congress: ECR 2015 Type: Authors: Keywords: DOI: Educational Exhibit E.-M. Heursen, R. Reina Cubero, T. Guijo Hernandez,

More information

Case report. Open Access. Abstract

Case report. Open Access. Abstract Open Access Case report Demyelinating disease masquerading as a surgical problem: a case series Saufi M Awang 1 *, Nayan M Saiful 1, Mohan Madhavan 2, Jafri Abdullah 1 and John K Tharakan 1 Addresses:

More information

Multifocal inflammatory leukoencephalopathy induced by accidental consumption of levamisole: A case report

Multifocal inflammatory leukoencephalopathy induced by accidental consumption of levamisole: A case report Iranian Journal of Neurology Case Report Ir J neurol 2012; 11(2): 65-69 Multifocal inflammatory leukoencephalopathy induced by accidental consumption of levamisole: A case report Received: 25 Oct 2011

More information

Multiple sclerosis (MS) is an inflammatory disease of the central nervous. Magnetic Resonance Imaging in Multiple Sclerosis

Multiple sclerosis (MS) is an inflammatory disease of the central nervous. Magnetic Resonance Imaging in Multiple Sclerosis DIAGNOSIS AND MANAGEMENT UPDATE Magnetic Resonance Imaging in Multiple Sclerosis Salvatore Q. Napoli, MD, * Rohit Bakshi, MD * *Partners, Multiple Sclerosis Center, Boston, MA, Center for Neurological

More information

Imaging of Coronary Artery Disease: II

Imaging of Coronary Artery Disease: II Acta Radiológica Portuguesa, Vol.XIX, nº 74, pág. 45-51, Abr.-Jun., 2007 Imaging of Coronary Artery Disease: II Jean Jeudy University of Maryland School of Medicine Department of Diagnostic Radiology Armed

More information

ORIGINAL CONTRIBUTION. Magnetic Resonance Imaging Effects of Interferon Beta-1b in the BENEFIT Study

ORIGINAL CONTRIBUTION. Magnetic Resonance Imaging Effects of Interferon Beta-1b in the BENEFIT Study ORIGINAL CONTRIBUTION Magnetic Resonance Imaging Effects of Interferon in the BENEFIT Study Integrated 2-Year Results Frederik Barkhof, MD, PhD; Chris H. Polman, MD, PhD; Ernst-Wilhelm Radue, MD; Ludwig

More information

The Journal of the Korean Society of Fractures Vol.16, No.1, January, 2003

The Journal of the Korean Society of Fractures Vol.16, No.1, January, 2003 The Journal of the Korean Society of Fractures Vol16, No1, January, 2003 : 351 ( )463-712 TEL: (031) 780-5270/5271 FAX : (031) 708-3578 E-mail: bskima@netsgocom 16,, ( > 20mm ) 5, ) 20 % 1 ), 6,, 3 8 8

More information

The estimated annual incidence of central nervous system

The estimated annual incidence of central nervous system ORIGINAL RESEARCH Y. Hayashida T. Hirai S. Morishita M. Kitajima R. Murakami Y. Korogi K. Makino H. Nakamura I. Ikushima M. Yamura M. Kochi J.-i. Kuratsu Y. Yamashita Diffusion-weighted Imaging of Metastatic

More information

myelin in the CNS Multiple axons are oligodendrocyte

myelin in the CNS Multiple axons are oligodendrocyte Pathologic classification of white matter disorders d Demyelinating - loss of normal myelin autoimmune/inflammatory component Dysmyelinating - loss of chemically abnormal myelin Hypomyelinating - paucity

More information

Rapid Regression of White Matter Changes in Hypoglycemic Encephalopathy

Rapid Regression of White Matter Changes in Hypoglycemic Encephalopathy www.ksmrm.org JKSMRM 18(4) : 357-361, 2014 pissn 1226-9751 / eissn 2288-3800 Case Report Rapid Regression of White Matter Changes in Hypoglycemic Encephalopathy Sang-wook Son, Kye-ho Lee, Dong-soo Yoo

More information