CNR-IPCF permanent position researcher (April 2008) at the Physics Department of Sapienza" University of Rome.

Transcription

1 Curriculum Vitae of Silvia Capuani Personal details Name : Silvia Capuani Place of birth : Rome Nationality : Italian Marital status : single with two children (one 13 year old boy and one 10 year old boy) Home address : Piazza dei Consoli 11, Rome, Italy Work address: Nuclear Magnetic Resonance Laboratory, Physics Department Sapienza University of Rome, Piazzale Aldo Moro 5, Rome, Italy. Telephone/Fax: Silvia.Capuani@roma1.infn.it Dr. Silvia Capuani, PhD CNR-IPCF Sapienza Roma Kerberos group head Nuclear Magnetic Resonance Laboratory Physics Department - Sapienza University of Rome, P.le Aldo Moro, Roma Italy Tel./FAX (Office) Tel (Lab) silvia.capuani@roma1.infn.it Web: anomalous-diffusion-by-nmr/ bynmr/ Education PhD in physics, obtained at Sapienza University of Rome, with a thesis concerning the theoretical and applicative development of Nuclear Magnetic double resonance on less sensitive and quadrupolar nuclei (Supervisor, Prof. B. Maraviglia) Post Graduate degree at the School in Medical Physics (Sapienza University of Rome) obtained with a score of 60/60 discussing a thesis concerning MR Spectroscopy and MR Imaging of carbon-13 for metabolic studies (advisors: Professors B. Maraviglia and F. De Luca) Master Degree in Physics at Sapienza University of Rome obtained discussing a thesis concerning MR Indirect Imaging and spectroscopy at low field to detect boron-10 drugs used for BNCT (Boron Neutron Capture Therapy) (advisors: Professors B. Maraviglia and F. De Luca). Current position Employment history May April CNR-IPCF permanent position researcher (April 2008) at the Physics Department of Sapienza" University of Rome. Researcher without tenure at the INFM (Istituto Nazionale per la Fisica della materia). Researcher (tenure track) at the CNR-INFM SOFT of the Physics Department of Sapienza" University of Rome. Research activity My research activity was partially founded by Italian agencies (INFM, Enrico Fermi Center and Scientific Research and University Ministry, MIUR) trough my supervisor proposal. My research interests include theoretical speculation and experimental investigation in the field of Nuclear Magnetic Resonance. Part of my research has been focused on developing new NMR techniques and innovative NMR diagnostic approaches. All may activities have been characterized by a specific orientation to applicative fields with a potentially high clinical impact. Some of my research lines are currently at the stage of basic research, some others are in a transitional stage between basic research and clinical application. My main research tools are NMR related techniques (diffusion, heteronuclei, multi-quantum coherences), including both Spectroscopy and Imaging. Moreover, I am also an expert of other experimental procedures, such as techniques based on x-rays, light scattering, or dielectric spectroscopy. My investigation targets are: materials and biomaterials (confined water, gels, ancient bones and teeth, macromolecules, bone marrow) and living systems (cells, ex-vivo tissues, in-vivo animal models, human bone, human brain). Specific research activities: -1-Development of new non Gaussian and anomalous diffusion NMR approaches with the final goal to identify new sources of contrast in biological tissues. -basic research applied on controlled heterogeneous samples (packed polystyrene micro-beads in water solution) and excised tissues such as bone marrow (research activity)

2 -neuroimaging applications in normal and diseased human brains (translational clinical research) -Comparison between DTI, Kurtosis Imaging and Anomalous Diffusion Imaging in brain tissues. -2- MR investigations of skeletal system (cancellous bone, cartilage) using multi-parametric approach: - conventional relaxation parameters, internal gradient and diffusion coefficient correlated to spectroscopic quantitative analysis (translational clinical research) - non convention NMR technique, such as DTI or 23 Na-triple-quantum (research activity) -3- MR investigations at high magnetic field (7T) of glioma animal model to optimize BNCT (Boron Neutron Capture Therapy) using: - Conventional and non conventional (DTI) techniques and Imaging and spectroscopic techniques performed on 19 F nuclei to detect spatial distribution of BNCT-carriers and study their pharmacokinetics - other biophysical approaches together with MR strategies to improve BNCT effectiveness. -4-Study and Development of new MR Multi Quantum coherences approaches for 1) Materials application and investigation 2) Tissue investigation (spongy bone, brain) -5- MR, light scattering and x-rays investigations of cement, ancient wood and stone materials of historical and artistic interest and archaeological bones and teeth. Associations -Historical Museum of Physics and Centre for Studies and Research Enrico Fermi ( -ESR (European Society of Radiology), associate member -ISMRM (International Society of Magnetic Resonance in Medicine), full member. Skills -Use of NMR spectrometers and tomographs (Siemens, Bruker) small-scale (samples, animals) and large scale (humans). NMR tomograph Siemens Allegra 3T (head dedicated), located at the IRCCS Santa Lucia foundation NMR spectrometer Bruker Avance 9.4T and Bruker 7T Biospec, located in the Physics Department of Sapienza University of Rome. NMR tomograph Philips Achieva 3T (all body) located at Radiology Department of tor Vergata University of Rome. -Development of diagnostic procedures and new NMR techniques to study materials (confined water, gels, bone), biological systems (bone marrow, cartilage, cancellous bone), animal models (glioma C6 rat brain) and human subjects (healthy volunteers and patients with osteoporosis, gliomas, meningiomas, Alzheimer). Publications: I m co-author of more than 40 publications on international journals and 70 publications as abstracts and papers in Proceedings of scientific meetings. Prizes: 2000 Young Investigator Award ESMRMB (European Society Magnetic Resonance in Medicine and Biology) Paris, September 2000, for a work concerning the first application of multiple-quantum coherences to study spongy bone. Review invitations Magnetic Resonance in Medicine Magnetic Resonance Imaging Solid State Nuclear Magnetic Resonance International Journal of Radiation Oncology Biology Physics Applied Radiation and Isotopes

3 Teaching experience , teaching assistant of the Physics courses: Atomic and Molecular Spectroscopy, Condensed Matter Physics, and of the Biomedical Technology course of Post-graduate School in Healthy Physics at the Sapienza University of Rome teaching assistant of Biophysics Laboratory From 2007-today teaching assistant of the courses: Biophysics Laboratory, and Physics Methodologies for cultural heritage (teaching professor contract for this last course) From 2011-today professor teacher of the course: radio-frequency spectroscopy and NMR imaging Supervised students: n= 5 students for their First Degree in physics n=15 student for their Master Degree in physics n=3 doctors for their Post Graduate School in Medical Physics n=7 PhD students (five in biophysics and two in physics) Publications: There is reported here a list of papers published on international peer-reviewed journals ( peer-reviewed journals) 1) "Double resonance spectra of J-coupled I=1/2 and S=3 nuclear spins." S. Capuani, F. De Luca and B. Maraviglia, J. Chem. Phys. 1994;101: ) "Sensitivity enhancement in quadrupolar nuclei double resonance detection" S. Capuani, G.H.Raza, F. De Luca, and B. Maraviglia Appl. Magn. Reson. 1995;9: ) "Coherence-Transfer Processes by Adiabatic Pulses" S. Capuani, F. De Luca, L. Marinelli and B. Maraviglia J. Magn. Reson. A 1996;121:1-7. 4) A structural and kinetic study by Energy Dispersion X-ray Diffraction: interaction between 1,4- dihydropyridines and biological membranes. F. Boffi, R. Caminiti, C. Sadun, S. Capuani, A. Giovannelli and A. Congiu Castellano, Chem. Phys. Lett. 1998;286: ) 13 C Imaging by Double Resonance scalar coupling editing S. Capuani, C. Casieri, F. De Luca, B. Maraviglia, G.H. Raza, Magn. Reson. Imaging 1998;16: ) Product-Operator Formalism in I 1/2 and S 3/2 J-coupled spins. Application to J assessment via SEDOR experiment S. Capuani, F. De Luca and B. Maraviglia. J. Chem. Phys. 1998;109(16): ) "Selective detection of C containing metabolites by 1 H Double Resonance BLISS sequence" S. Capuani, L. Mancini, and B. Maraviglia Appl. Magn. Reson. 1998;15:383. 8) Novel double Resonance Pulse Sequence for Low Sensitivity Nuclei Selection S. Capuani, L. Mancini, B. Maraviglia, M. Sette and M. Paci. Chem. Phys. Lett. 2000;316:222. 9) Characterisation of trabecular bone by dipolar demagnetising field MR imaging S. Capuani, F. Curzi, F.M. Alessandri, B. Maraviglia A. Bifone Magn. Reson. Med. 2001;46,: ) Characterization of porous media micro- structure by non linear NMR methods S. Capuani, M. Alesiani, F.M. Alessandri and B. Maraviglia Magn. Reson. Imaging 2001;19: ) NMR approaches to brain function studies S. Capuani, G. Garreffa, M.A. Macrì, S. Mangia, F. Di Salle, B. Maraviglia. Appl. Magn. Reson. 2001;20: ) Effect of Higher Rank Multipoles on Relaxation of I=3 Spin System

4 W. Nosel, S. Capuani, D. Capitani and F. De Luca J. Magn. Reson. 2001;150: ) Multiple Spin Echoes for the Evaluation of Trabecular Bone Quality S. Capuani, F.M. Alessandri, A. Bifone, B. Maraviglia. Magn. Reson Mater Phys Biol Med, 2002;14(1): ) Multiple Spin Echoes in heterogeneous systems: Physical origins of the observed dips F. M. Alessandri, S. Capuani, B. Maraviglia J. Magn. Reson. 2002;156: ) Radiowave dielectric investigation of boron compounds distribution in cultured tumor cells: relevance to boron neutron capture therapy S. Capuani, T. Gili, C. Cametti, B. Maraviglia, M. Colasanti, M. Muolo, G. Venturini. Chem. Phys. Lett. 2002;360: ) In vivo Multiple Spin Echoes Imaging of trabecular bone on a Clinical 1.5T MR Scanner S. Capuani, G. Hagberg, F. Fasano, I. Indovina, A. Castriota-Scanderbeg, B. Maraviglia. Magn. Reson. Imag 2002;20: ) Effects induced on marbles by water-repellent compounds: the NMR contribution. M. Alesiani, S. Capuani, B. Maraviglia, R. Giorgi, P. Baglioni. Appl. Magn. Reson. 2002;23: ) Intermolecular Double-Quantum techniques to probe Microstructures on porous media. S.Capuani, R.T. Branca, M. Alesiani, B. Maraviglia. Magn. Reson. Imag 2003;21: ) NMR study on the early stages of hydration of a porous carbonate stone M. Alesiani, S. Capuani, B. Maraviglia. Magn. Reson. Imaging 2003;21: ) NMR application to low porosity carbonate stones M. Alesiani, S. Capuani, B. Maraviglia. Magn. Reson. Imag 2003;21: ) Intermolecular double quantum coherences (idqc) and diffusion-weighted imaging (DWI) imaging of the human brain at 1.5 T. F. Fasano, S. Capuani, G.E. Hagberg, R.T. Branca, I. Indovina, A. Castriota-Scanderbeg and B. Maraviglia. Magn Reson Imaging 2003;21: ) New Openings for porous systems research from intermolecular double quantum NMR S. Capuani, M. Alesiani, R.T. Branca, B. Maraviglia Solid State NMR 2004;25: ) About CRAZED Sequence R.T. Branca, S. Capuani, B. Maraviglia. Concepts in Magnetic Resonance part A, 2004;21: ) Multiple Quantum Coherences: new NMR tools to study materials and living systems. S. Capuani, R.T. Branca, M. Alesiani, B. Maraviglia. Appl. Magn. Reson. 2004;27; ) The influence of cellulosic additives on the tricalcium silicate hydration: a Nuclear Magnetic Resonance relaxation-times analysis M. Alesiani, S. Capuani, R. Giorgi, B. Maraviglia, I. Pirazzoli, F. Ridi, P. Baglioni. J. Phys. Chem. B, 2004;108: ) Dipolar field effect described by boson operators techniques: case of intermolecular multiple quantum coherences in liquids W. Nosel, T. Gili, S. Capuani, B. Maraviglia. Chem. Phys. Lett. 2005;406: ) The influence of superplasticizers on the first steps of tricalcium silicate hydratation studied by NMR techniques. I. Pirazzoli, M. Alesiani, S. Capuani, B. Maraviglia, R. Giorni, F. Ridi, P. Baglioni. Magn Reson Imag 2005;23: ) 13 C CPMAS NMR Spectroscopy Analysis of Recent and Archeological Wood M. Alesiani, F. Proietti, S. Capuani, B. Maraviglia, M. Fioravanti, M. Paci. Appl. Magn. Reson 2005;29:

5 29) DTI of trabecular bone marrow C. Rossi, S. Capuani, F. Fasano, M. Alesiani, B. Maraviglia. Magn Reson Imag, 2005;23, ) Diffusion tensor imaging to study anisotropy in a particular porous system: The trabecular bone network S. Capuani, C. Rossi, M. Alesiani, B. Maraviglia Solid State NMR, 2005;28: ) Multi-nuclear MRS and 19 F MRI of 19 F-labelled and 10 B-enriched L-p-boronophenylalanine fructose complex to optimize Boron Neutron Capture Therapy: phantom studies at high magnetic fields P. Porcari, S. Capuani, R. Campanella, M.L. Migneco, A. La Bella, B. Maraviglia. Phys. Med. Biol. 2006;51: ) Nonergodic Arrested State in Diluted Clay Suspensions Monitored by Triple-Quantum 23 Na Nuclear Magnetic Resonance T. Gili, S. Capuani, B. Maraviglia. J. Phys. Chem. B. 2007;111: ) Molecular diffusion anisotropy in white and gray matter of the human spinal cord C. Rossi, A. Boss, G. Steidle, P. Martirosian, U. Klose, S. Capuani, B. Maraviglia, C.D. Claussen F. Schick J. Magn. Reson. Imag. 2008; 27: ) Influence of steady background gradients on the accuracy of molecular diffusion anisotropy measurements C. Rossi, A. Boss, P. Martirosian G. Steidle, S. Capuani, CD Claussen, B. Maraviglia, F. Schick Magn. Reson. Imaging 2008;26: ) 10 B-editing 1 H-detection and 19 F MRI strategies to optimize Boron Neutron Capture Therapy (BNCT) S. Capuani, P. Porcari, F. Fasano, R. Campanella, B. Maraviglia Magn. Reson. Imaging 2008;26(7): ) L-DOPA Preloading Increases the Uptake of Borophenylalanine in C6 Glioma Rat Model: A New Strategy to Improve BNCT Efficacy S. Capuani, T. Gili, M. Bozzali, S. Russo, P. Porcari, C. Cametti, E. D amore, M. Colasanti, G. Venturini, B. Maraviglia, G. Lazzarino, FS Pastore. Int. J. Radiat. Oncol. Biol. Phys. 2008;72(2): ) In vivo 19F MRI and 19F MRS of 19F-labelled Boronophenylalanine-fructose complex on C6 rat glioma model to optimize Boron Neutron Capture Therapy (BNCT). P. Porcari, S. Capuani, E. D Amore, M. Lecce, A. La Bella, F. Fasano, R. Campanella, L. M. Migneco, F.S. Pastore and B. Maraviglia. Phys. Med. Biol. 2008;53: ) Characterization of archeological human bone tissue by enhanced backscattering of light M. Leonetti, S. Capuani, M. Peccianti, G. Ruocco, C. Conti. Appl. Phys. Lett. 2009;94:no ) Boronophenylalanine uptake in C6-glioma model is dramatically increased by L-DOPA preloading S. Capuani, T. Gili, M. Bozzali, S. Russo, P. Porcari, C. Cametti, M. Muolo, E. D Amore, B. Maraviglia, G. Lazzarino, F. S. Pastore. Appl. Rad. Isot. 2009;67:S34-S36. 40) In vivo 19 F MR Imaging and Spectroscopy for the BNCT optimization P. Porcari, S. Capuani, E. D Amore, M. Lecce, A. La Bella, F. Fasano, L.M. Migneco, R. Campanella, B. Maraviglia, F. S. Pastore. Appl. Rad. Isot. 2009;67:S365-S ) In vitro and in vivo MR evaluation of internal gradient to assess trabecular bone density. S. De Santis, M. Rebuzzi, G. Di Pietro, B. Maraviglia, S. Capuani Phys Med Biol Volume: 2010;55: ) Anisotropic Anomalous diffusion assessed in the human brain by scalar invariant indeces

6 S. De Santis, A. Gabrielli, M. Bozzali, B. Maraviglia, E. Macaluso, S. Capuani Magn Reson Med 2011;65(4): ) Spatio-temporal anomalous diffusion in heterogeneous media by nuclear magnetic resonance M. Palombo, A. Gabrielli, S. De Santis, C. Cametti, G. Ruocco, S. Capuani J. Chem. Phys. 2011;135, ) Non-Gaussian diffusion Imaging: a brief practical review S. De Santis, A. Gabrielli, M. Palombo, B. Maraviglia, S. Capuani Magn. Reson. Imaging 2011 in press. 46) The parameter of the stretched exponential model is influenced by internal gradients: validation in phantom M. Palombo, A. Gabrielli, S. De Santis, S. Capuani J. Magn. Reson in press. Rome, November 2011.