Facilitating Lu 177 Personalized Dosimetry for Neuroendocrine Tumours CANM 2017
|
|
- Samuel Barnett
- 5 years ago
- Views:
Transcription
1 Facilitating Lu 177 Personalized Dosimetry for Neuroendocrine Tumours CANM 2017
2 CANM ANNUAL SCIENTIFIC MEETING APRIL 20-23, 2017 TORONTO, ONTARIO I do not have a financial interest, arrangement or affiliation including receipt of honoraria or expenses with a commercial organization that may have a direct interest in the subject matter of my presentation.
3 Outline Brief Overview of NET-PRRT Trial Who are QIPCM? What is QIPCM s involvement with NET-PRRT? Using Medical Internal Radiation Dosimetry (MIRD) for Lu 177 SPECT Sensitivity Calibration and QC Walkthrough of the Dosimetry Report Generation process Some preliminary personalized dosimetry results Questions 3
4 NET-PRRT A Prospective Phase II, Single-Arm, Multi-Centre Study of the Efficacy and Safety of Lutetium 177 Octreotate (Lu-DOTATATE) Treatment in Patients with Somatostatin Receptor Positive Neuroendocrine Tumours (PI Dr. Wong). Ga 68 PET/CT to identify eligible patients for Lu 177 Octreotate therapy. Patients receive 4 cycles of Lu 177 Octreotate therapy based on individualized dosimetry based on SPECT-CT imaging. 4
5 Quantitative Imaging for Personalized Cancer Medicine
6 Trial Support Services Scanner QA Harmonize imaging results from multicentre clinical trials, Focus on functional imaging (4D CT, 4D PET, PET-CT, PET-MR and DCE-CT, DCE-MR) Imaging Protocol Development Mitigate the challenges of multi-site clinical trials in advance. Image Anonymization & Transfer with Centralized Storage Collect and anonymize images from multiple sites through RSNAs CTP pipeline Centralized QIPCM PACS with trial by trial permissions and audit logs. Remote Image Review & Analysis VMWare TM infrastructure in place for remote image review. Custom image analysis tools Commercial Image Processing Software available Users can install their own applications on their Windows virtual machine. 6
7 QICPM Architecture 7
8 Key Performance Indices Total # of Trials on the QIPCM Platform 30 Trials currently active 17 CTP Transfer Pipelines 37 Remote Desktops Assigned 47 Active Trials using QIPCM analysis service/tools 8/12 Patient exams on platform Images on platform Storage Capacity 466pts/1523 studies 3.0 million 60 TB 8
9 Active QIPCM Sites International St. Vincent s Health Australia, Adelaide, Australia Columbia University Medical Center, New York, NY UCLA, Los Angeles, CA MD Anderson, Houston, TX Canada BC Cancer Agency, Vancouver, BC CHUM, Montreal, QC Cross Cancer Center, Edmonton, AB Grand River Hospital, Kitchener, ON London Health Sciences Centre, London, ON Nova Scotia Cancer Centre Halifax, NS Odette Cancer Centre, Toronto, ON Ottawa Hospital Regional Cancer Centre, Ottawa, ON Princess Margaret Cancer Centre, Toronto, ON St Joseph s Healthcare Hamilton, Hamilton, ON Southlake Regional Cancer Centre, Newmarket, ON Toronto General Hospital, Toronto, ON 9
10 The QIPCM Team 10
11 Supporting the NET Lu 177 DOTATATE trial Study Description & Challenges 190 Patients to receive Lu-DOTATATE therapy at 4 centres in Ontario Patients receive Ga 68 PET-CT to determine eligibility Patients receive 4 cycles of Lu 177 DOTATATE Therapy based on individualized dosimetry based on SPECT-CT. QIPCM Solution Install CTP Client at each institution Work with sites to determine individual SPECT camera sensitivity Provide centralized hosting of Lu 177 SPECT-CT and Ga 68 PET imaging Provide a means to segment organs at risk from SPECT-CT images and generate personalized dosimetry report 11
12 Patient Identification by Ga 68 PET Most NETs express cell surface somatostatin receptors Allows therapeutic application of somatostatin analogs (SSA) Ga 68 linked to the SSA in the same manner as Lu 177 for treatment 68 Ga PET-CT will be used wherever feasible to determine whether patients are somatostatin receptor positive. 12
13 A very brief summary of Lu Dosimetry Dose calculations for 177 Lu-DOTATATE will be performed with the Medical Internal Radiation Dosimetry (MIRD) formalism such that: Where: D (T s): The dose to a target from a particular source organ, is the product of : : The average energy of those decays; Lu 177 : 6.65 day HL Multiple gammas 208 kev 113 kev 4 beta - emissions : = 134 kev T s : m T : A s : From Dr. S Breen absorbed fraction which is the fraction of energy emitted from the source ; absorbed in the target of mass The number of nuclear decays in the source (the cumulated activity); = 1 = OAR vol x 1 g/cc From SPECT. In MBq hours? 13
14 Converting SPECT Counts to MBq x Hr 2 Parts to this challenge Convert Counts to MBq SPECT Sensitivity from Phantom scans Convert MBq to MBqxHr SPECT is done at 4, 24 and 72 hours post injection Need to find area under the curve From Dr JM Beauregard 14
15 Determining Scanner Sensitivity Protocol developed by Dr. Curtis Caldwell Fill a Water Phantom with a known quantity of Lu 177 Select 6 circular 2D ROIs and record the total counts and ROI area. Determine the ratio of CPM (counts per minute) to MBq Example Lu177 injected MBq Lu177 residual MBq Phantom Volume 6716 cc Activity in Phantom MBq/cc Slice 1 counts other 6 slices Total counts Total area of slices 1698 cm 2 Slice Thickness 4.42 mm Total Volume cc Scan Duration 45 min Sensitivity CPM/MBq 15
16 An overview of the personalized dosimetry process Anonymized Images Received Syringe measurements performed and compared to Nuc Med Worksheet OAR and Tumours Contoured by RT Contours Reviewed by Rad Onc Dosimetry Report Created Determine OAR Dose Determine Tumour Dose Propose next cycle injection activity Report Reviewed & signed by Rad Onc. and Medical Physicist Dose for next cycle ordered. 16
17 Centralized Storage of Anonymized Patient Images Each site is provided with a unique CTP (clinical trial processor) client Program designed by RSNA Anonymized Ga 68 PET and Lu 177 SPECT images sent to QIPCM via the client Anonymizes the data according to trial protocol Leave fields required for SPECT analysis Retain patient birth year/month Remove all non-essential patient information 17
18 SPECT QC with Standards Many factors go into the SPECT reconstruction Scatter Correction (On/Off) Scatter Window(s) Emission Window(s) Attenuation Correction (on/off) Frame Duration Number of Frames Additional outside factors such as Dose Calibrator Recalibration Each Patient is scanned with a syringe containing Lu 177 of a known concentration. Syringe measurements used to plot a control chart to check for variations in image reconstruction or external factors 18
19 Patient OAR contouring in MIM Trial RT receives notification that a new patient is ready for contouring RT logs in to their QIPCM Remote Desktop and launches MIM Searches for patient, selects image sets and launches workflow. 19
20 Contouring Walkthrough 20
21 Contouring Review and Report Generation Trial RT notifies the Radiation Oncologist that patient contours are ready for review. 21
22 Contouring Review and Report Generation 22
23 The Dosimetry Report OARs Bone Left Right Marrow Kidney 23
24 Dose Summary 24
25 Prescription Dose Report reviewed and signed by Radiation Oncologist & Medical Physicist Then provided to treating physician 25
26 Prescription & Dose Graphically 26
27 Results to Date Overall Accuracy Mean 0.67 Gy +/- 1.3 Gy OAR prediction within 1 Gy 24/34 (71%) Room for improvement Most outliers occur when predicting cycle 2 based on only 1 data point Changes in contouring may contribute 27
28 Tumour Absorbed Dose Example Tumour Absorbed Doses are also collected Next steps will involve producing detailed reports with results. 28
29 Challenges for Lu 177 Dosimetry Validating SPECT/CT systems from 3 different manufacturers across 4 sites to ensure correct conversion of counts to activity to dose. Creating a robust dosimetry report generation extension while also adapting to ever changing requirements and specifications. Continuously attempting to ensure that all documentation and software is up to regulatory standards for possible audits. 29
30 Acknowledgements QIPCM Team Members Dr. Harry Keller Dr. Ivan Yeung Tina Shek Julia Publicover Trial PI Dr. Rebecca Wong Nuclear Medicine Technologist Ed Sun Trial Physicists Dr. Stephen Breen Dr. Troy Farncombe Dr. Rob Stodilka Dr. Curtis Caldwell Dr. J.M. Beauregard CanProbe Ga 68 / Lu 177 DOTATATE production 30
CANM ACMN Annual Meeting April
117 Lu-DOTATATE & 68 Ga-DOTATATE A Prospective Single-Arm, Multi-Centre, Study of the Efficacy and Safety of 177 Lu- DOTATATE Treatment, with individualized dosimetry, in Patients with 68 Ga-DOTATATE PET
More informationAustin Radiological Association Ga-68 NETSPOT (Ga-68 dotatate)
Austin Radiological Association Ga-68 NETSPOT (Ga-68 dotatate) Overview Ga-68 dotatate binds to somatostatin receptors, with highest affinity for subtype 2 receptors (sstr2). It binds to cells that express
More informationQuantitative Theranostics in Nuclear Medicine
Quantitative Theranostics in Nuclear Medicine M. Lassmann Klinik und Poliklinik für Nuklearmedizin Direktor: Prof. Dr. A. Buck Contents What is Theranostics? Potential Targets Basic Principles of Quantitative
More informationAustin Radiological Association Nuclear Medicine Procedure THYROID UPTAKE MEASUREMENT (I-123 or I-131 as Sodium Iodide)
Austin Radiological Association Nuclear Medicine Procedure THYROID UPTAKE MEASUREMENT (I-123 or I-131 as Sodium Iodide) Overview Indications The Thyroid Uptake Measurement measures the metabolic activity
More informationQuantitative Imaging: A hospital physicist s perspective James Scuffham
Quantitative Imaging: A hospital physicist s perspective James Scuffham Clinical Scientist, Royal Surrey County Hospital NHS Foundation Trust Associate Tutor, University of Surrey Background The Royal
More informationPrecision of pre-sirt predictive dosimetry
International Course on THERANOSTICS AND MOLECULAR RADIOTHERAPY Precision of pre-sirt predictive dosimetry Hugo Levillain Department of Nuclear Medicine Medical Physics Jules Bordet Institute, Université
More informationLu-DOTATATE PRRT dosimetry:
177 Lu-DOTATATE PRRT dosimetry: From theory to practice Silvano Gnesin Medical Physics department Institute of Radiation Physics, Lausanne University Hospital, Lausanne, Switzerland Gwennaëlle Marin Medical
More informationFAZA-PET Imaging for Tumour Hypoxia
FAZA-PET Imaging for Tumour Hypoxia Doug Vines BSc, MRT(N), CNMT, PET, CTIC Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network. Techna Institute, STTARR Innovation Centre,
More informationApplication of 3D Printing to Molecular Radiotherapy Phantoms. Nick Calvert Nuclear Medicine Group The Christie NHS Foundation Trust, Manchester
Application of 3D Printing to Molecular Radiotherapy Phantoms Nick Calvert Nuclear Medicine Group The Christie NHS Foundation Trust, Manchester Molecular Radiotherapy Radionuclide administered to patient
More informationA. DeWerd. Michael Kissick. Larry. Editors. The Phantoms of Medical. and Health Physics. Devices for Research and Development.
Larry Editors A. DeWerd Michael Kissick The Phantoms of Medical and Health Physics Devices for Research and Development ^ Springer Contents 1 Introduction to Phantoms of Medical and Health Physics 1 1.1
More informationCalculation methods in Hermes Medical Solutions dosimetry software
Calculation methods in Hermes Medical Solutions dosimetry software Helena McMeekin MSc. Clinical Applications Scientist, Hermes Medical Solutions MRTDosimetry Scientific Workshop The Principals and Clinical
More informationMETROLOGY TO SUPPORT INNOVATION IN MOLECULAR RADIOTHERAPY. Glenn Flux
METROLOGY TO SUPPORT INNOVATION IN MOLECULAR RADIOTHERAPY Glenn Flux Head of Radioisotope Physics Royal Marsden Hospital & Institute of Cancer Research Sutton UK CGPM 2018 glenn.flux@icr.ac.uk Overview
More informationDosimetry and radiobiology for Peptide Receptor Radionuclide Therapy
Dosimetry and radiobiology for Peptide Receptor Radionuclide Therapy Short-ranged particle emitters for targeted radionuclide therapy require specific dosimetry and radiobiology Mark Konijnenberg Melodi
More informationErasmus Experience. Lu-DOTA-octreotate PRRT
Erasmus Experience 177 Lu-DOTA-octreotate PRRT Mark Konijnenberg Erasmus MC, Rotterdam, Netherlands METRO/MRT meeting 2015, NPL, Teddington Leading questions? 1. For which MRT procedure dosimetry is used?
More informationAustin Radiological Association Nuclear Medicine Procedure SPHINCTER OF ODDI STUDY (Tc-99m-Mebrofenin)
Austin Radiological Association Nuclear Medicine Procedure SPHINCTER OF ODDI STUDY (Tc-99m-Mebrofenin) Overview Indications The successively demonstrates hepatic perfusion, hepatocyte clearance, hepatic
More informationTheragnostics for bone metastases. Glenn Flux Royal Marsden Hospital & Institute of Cancer Research Sutton UK
Theragnostics for bone metastases Glenn Flux Royal Marsden Hospital & Institute of Cancer Research Sutton UK NPL 2015 Ra-223 Biodistribution & dosimetry Ra-223: 11.4 days half-life, range of 100 µm Six
More informationUse Of MCNP With Voxel-Based Image Data For Internal Dosimetry Applications
Use Of MCNP With Voxel-Based Image Data For Internal Dosimetry Applications The Monte Carlo Method: Versatility Unbounded In A Dynamic Computing World Chattanooga, TN, USA, April 17-21, 2005 M. G. Stabin
More informationIART and EBRT, an innovative approach
External beam radiotherapy and nuclear medicine therapy: which kind of integration? Mahila Ferrari mahila.ferrari ferrari@ieo.it A different NM and RT integration... Radionuclide therapy combined to EBRT
More informationPhysical Bases : Which Isotopes?
Physical Bases : Which Isotopes? S. Gnesin Institute of Radiation Physics, Lausanne University Hospital, Lausanne, Switzerland 1/53 Theranostic Bruxelles, 2 Octobrer 2017 Theranostic : use of diagnostic
More informationMajor accidents in radiotherapy
Major accidents in radiotherapy related to treatment units (a) IAEA International Atomic Energy Agency Incorrect decay data (USA) IAEA International Atomic Energy Agency Background A cobalt unit was used
More informationIsotopes in Functional Cancer Imaging
Seeing and Believing: i Medical Isotopes in Functional Cancer Imaging François Bénard, MD, FRCPC BCCancer Cancer Agency and University of British Columbia Nuclear Medicine 101 A radioactive atom is produced
More informationSARCOPHAGINE CHELATORS AND COPPER ISOTOPES FOR IMAGING AND THERAPY
SEEING IS BELIEVING SARCOPHAGINE CHELATORS AND COPPER ISOTOPES FOR IMAGING AND THERAPY Sydney Vital and STEaM Neuroendocrine Tumour Preceptorship May 2018 Amos Hedt Head of Clinical Development 1 CLARITY
More informationDose Estimates for Nuclear Medicine Procedures: What are they? Where do they come from?
Dose Estimates for Nuclear Medicine Procedures: What are they? Where do they come from? SNM Continuing Education Lecture Salt Lake City, UT -- June 6, 2010 Darrell R. Fisher Pacific Northwest National
More informationPublishable Summary for 15HLT06 MRTDosimetry Metrology for clinical implementation of dosimetry in molecular radiotherapy
Publishable Summary for 15HLT06 MRTDosimetry Metrology for clinical implementation of dosimetry in molecular radiotherapy Overview The overall aim of this project is to provide the metrology for the clinical
More informationTypical PET Image. Elevated uptake of FDG (related to metabolism) Lung cancer example: But where exactly is it located?
Typical PET Image Elevated uptake of FDG (related to metabolism) Lung cancer example: But where exactly is it located? PET/CT Oncology Imaging Anatometabolic fusion images are useful in the management
More informationPeptide Receptor Radionuclide Therapy (PRRT) of NET
Peptide Receptor Radionuclide Therapy (PRRT) of NET Dr. Tuba Kendi Associate Prof of Radiology, Mayo Clinic, Rochester, MN 2014 MFMER slide-1 Relevant Financial Relationship(s) None Off Label Usage None
More informationEORTC Member Facility Questionnaire
Page 1 of 9 EORTC Member Facility Questionnaire I. Administrative Data Name of person submitting this questionnaire Email address Function Phone Institution Address City Post code Country EORTC No Enter
More informationDosimetry (Dose Estimation) of Internal Emitters. Outline. For Radiation Effects, is Dose the only Answer? Estimation of Dose and not Dosimetry
Dosimetry (Dose Estimation) of Internal Emitters. Lawrence E. Williams, PhD City of Hope National Medical Center Duarte CA 91010 lwilliams@coh.org Outline 1. Dose Estimation Formula D = S*Ã 2. Determination
More informationAustin Radiological Association Nuclear Medicine Procedure GASTRIC EMPTYING STUDY (Tc-99m-Sulfur Colloid in Egg)
Austin Radiological Association Nuclear Medicine Procedure GASTRIC EMPTYING STUDY (Tc-99m-Sulfur Colloid in Egg) Overview Indications The Gastric Emptying Study demonstrates the movement of an ingested
More informationPET/CT Value: Rocky Mountain Cancer Centers
PET/CT Value: Rocky Mountain Cancer Centers Glenn Balasky Executive Director Rocky Mountain Cancer Centers glenn.balasky@usoncology.com CANM/CAMRT Joint Conference March 22, 2018 Vancouver, British Columbia
More informationA Comparison of IMRT and VMAT Technique for the Treatment of Rectal Cancer
A Comparison of IMRT and VMAT Technique for the Treatment of Rectal Cancer Tony Kin Ming Lam Radiation Planner Dr Patricia Lindsay, Radiation Physicist Dr John Kim, Radiation Oncologist Dr Kim Ann Ung,
More informationJoint ICTP-IAEA Advanced School on Internal Dosimetry. Trieste, April 2010
Joint ICTP-IAEA Advanced School on Internal Dosimetry Trieste, 12-16 April 2010 Dosimetry in PRRT: what for Dosimetry has the purpose to address %&!"# '!&!"#!(%)* $ *!$+ Most Used Radiopeptides for PRRT
More informationThe IAEA BSS and development of an international dosimetry protocol
The BSS and development of an international dosimetry protocol MetroMRT 3 rd Workshop National Physical Laboratory, Teddington, UK 20-21 April 2015 Gian Luca POLI International Atomic Energy Agency Dosimetry
More information45 Hr PET Registry Review Course
45 HR PET/CT REGISTRY REVIEW COURSE Course Control Document Timothy K. Marshel, MBA, R.T. (R), (N)(CT)(MR)(NCT)(PET)(CNMT) The PET/CT Training Institute, Inc. SNMMI-TS 028600-028632 45hr CEH s Voice Credits
More informationAustin Radiological Association Nuclear Medicine Procedure PROSTATE CANCER STUDY (In-111-Capromab Pendetide [ProstaScint ])
Austin Radiological Association Nuclear Medicine Procedure PROSTATE CANCER STUDY (In-111-Capromab Pendetide [ProstaScint ]) Overview Indications The Prostate Cancer Study with an indium-111 labeled murine
More informationAlfred Health's CT quality control program
Alfred Health's CT quality control program Poster No.: R-0037 Congress: Type: Authors: 2014 CSM Scientific Exhibit A. Perdomo, Z. Brady, N. Tran, L. Hudson, K. Provis; PRAHRAN/ AU Keywords: Quality assurance,
More informationIndividualised Treatment Planning for Radionuclide therapy (Molecular Radiotherapy)
Individualised Treatment Planning for Radionuclide therapy (Molecular Radiotherapy) FMU/ICRP workshop 2017 Glenn Flux Royal Marsden Hospital & Institute of Cancer Research Sutton UK ICRP Task Group 101
More informationCalculation of Effective Doses for Radiotherapy Cone-Beam CT and Nuclear Medicine Hawkeye CT Laura Sawyer
Calculation of Effective Doses for Radiotherapy Cone-Beam CT and Nuclear Medicine Hawkeye CT Laura Sawyer Department of Medical Physics and Bioengineering, Royal United Hospital, Bath Overview Varian Acuity
More informationAustin Radiological Association Nuclear Medicine Procedure PET SODIUM FLUORIDE BONE SCAN (F-18 NaF)
Austin Radiological Association Nuclear Medicine Procedure PET SODIUM FLUORIDE BONE SCAN (F-18 NaF) Overview Indication Sodium Fluoride F18 injection is a radioactive diagnostic agent for positron emission
More informationCURRICULUM OUTLINE FOR TRANSITIONING FROM 2-D RT TO 3-D CRT AND IMRT
CURRICULUM OUTLINE FOR TRANSITIONING FROM 2-D RT TO 3-D CRT AND IMRT Purpose The purpose of this curriculum outline is to provide a framework for multidisciplinary training for radiation oncologists, medical
More informationQuarter Performance Report
Canadian Cancer Clinical Trials Network Quarter Performance Report Quarter, FY 08/9 (Year 5): July Sept. 30, 08 Report Created: January 4, 09 Table of Contents Section A: Patient access and recruitment
More informationA Snapshot on Nuclear Cardiac Imaging
Editorial A Snapshot on Nuclear Cardiac Imaging Khalil, M. Department of Physics, Faculty of Science, Helwan University. There is no doubt that nuclear medicine scanning devices are essential tool in the
More informationEN TERAPIA METAByLICA NO ESTrNDAR CON 177 Lu, 90 Y y 223 Ra
Jornada científica RADIOFuSICA DE LA DOSIMETRuA INTERNA EN LOS PROCEDIMIENTOS TERAPÉUTICOS CON RADIOFrRMACOS DOSIMETRIA FuSICA Y CLuNICA EN TERAPIA METAByLICA NO ESTrNDAR CON 177 Lu, 90 Y y 223 Ra Pablo
More informationTheranostics in Nuclear Medicine
Theranostics in Nuclear Medicine Patrick FLAMEN, MD, PhD Head Nuclear Medicine Institut Jules Bordet Université Libre de Bruxelles (U.L.B.) n Theranostics in Nuclear Medicine n A form of (nuclear) diagnostic
More informationAustin Radiological Association Nuclear Medicine Procedure BONE MINERAL STUDY (Tc-99m-MDP, Tc-99m-HMDP)
Austin Radiological Association Nuclear Medicine Procedure BONE MINERAL STUDY (Tc-99m-MDP, Tc-99m-HMDP) Overview The Bone Mineral Study, with either Tc-99m-MDP or Tc-99m-HMDP, depicts the distribution
More informationAccuracy and reproducibility of simplified QSPECT dosimetry for personalized 177 Luoctreotate
Del Prete et al. EJNMMI Physics (2018) 5:25 https://doi.org/10.1186/s40658-018-0224-9 EJNMMI Physics ORIGINAL RESEARCH Open Access Accuracy and reproducibility of simplified QSPECT dosimetry for personalized
More informationGLUCEPTATE. Technetium Tc 99m Gluceptate Kit DIAGNOSTIC DESCRIPTION
27194 0001E m TM GLUCEPTATE Technetium Tc 99m Gluceptate Kit DIAGNOSTIC DESCRIPTION The kit consists of reaction vials which contain the sterile, non-pyrogenic, nonradioactive ingredients necessary to
More informationOneMatch : A Closer Look. Gail Morris Principal Case Manager April 2017
OneMatch : A Closer Look Gail Morris Principal Case Manager April 2017 Donor Recruitment Recruitment Managed by the CBS Donor Relations Team staff across Canada Danny, OneMatch Registrant Canadians register
More informationAccuracy Requirements and Uncertainty Considerations in Radiation Therapy
Departments of Oncology and Medical Biophysics Accuracy Requirements and Uncertainty Considerations in Radiation Therapy Introduction and Overview 6 August 2013 Jacob (Jake) Van Dyk Conformality 18 16
More informationClinical Trial Credentialing:
IROC Mission Clinical Trial Credentialing: Provide integrated radiation oncology and diagnostic Where imaging to Start quality and control programs in support of the NCI s NCTN Network thereby Resources
More informationAustin Radiological Association Nuclear Medicine Procedure WHITE BLOOD CELL MIGRATION STUDY (In-111-WBCs, Tc-99m-HMPAO-WBCs)
Austin Radiological Association Nuclear Medicine Procedure WHITE BLOOD CELL MIGRATION STUDY (In-111-WBCs, Tc-99m-HMPAO-WBCs) Overview Indications The White Blood Cell Migration Study demonstrates the distribution
More informationAustin Radiological Association Nuclear Medicine Procedure LYMPHOSCINTIGRAPHY (Tc-99m-Sulfur Colloid [Filtered])
Austin Radiological Association Nuclear Medicine Procedure LYMPHOSCINTIGRAPHY (Tc-99m-Sulfur Colloid [Filtered]) Overview Indications The Lymphoscintigraphy Study demonstrates the flow of lymph from the
More information3D Pre-treatment Dose Verification for Stereotactic Body Radiation Therapy Patients
3D Pre-treatment Dose Verification for Stereotactic Body Radiation Therapy Patients G Asuni *1, T vanbeek 1, E VanUtyven 1, P McCowan 1,2, and B.M.C. McCurdy 1,2,3 1 Medical Physics Department, CancerCare
More information8/2/2018. Disclosure. Online MR-IG-ART Dosimetry and Dose Accumulation
Online MR-IG-ART Dosimetry and Dose Accumulation Deshan Yang, PhD, Associate Professor Department of Radiation Oncology, School of Medicine Washington University in Saint Louis 1 Disclosure Received research
More informationRPC s Credentialing Programs for Clinical Trials
RPC s Credentialing Programs for Clinical Trials July 19, 2010 Geoffrey S. Ibbott, Ph.D. and RPC Staff Mission The mission of the Radiological Physics Center is to assure NCI and the Cooperative Groups
More informationIntroduction to REM-NM Radiation Exposure Monitoring for Nuclear Medicine. Jeff Pohlhammer, Charles Smith
Introduction to REM-NM Radiation Exposure Monitoring for Nuclear Medicine Jeff Pohlhammer, Charles Smith Agenda A Little History The REM Profile Introduction of REM-NM Profile Features Functional Requirements
More informationHow effective is current clinical trial QA
How effective is current clinical trial QA Elizabeth Miles UK National RadioTherapy Trials QA (RTTQA) group Mount Vernon Cancer Centre United Kingdom ESTRO 35 29 April 3 May Turin, Italy Contents QA processes
More informationWhy is CT Dose of Interest?
Why is CT Dose of Interest? CT usage has increased rapidly in the past decade Compared to other medical imaging CT produces a larger radiation dose. There is direct epidemiological evidence for a an increase
More informationMVCT Image. Robert Staton, PhD DABR. MD Anderson Cancer Center Orlando. ACMP Annual Meeting 2011
MVCT Image Guidance and QA Robert Staton, PhD DABR MD Anderson Cancer Center Orlando ACMP Annual Meeting 2011 Disclosures MDACCO has received grant funding from TomoTherapy, Inc. Overview TomoTherapy MVCT
More informationRadiation Assurance Research Exposure Form
Radiation Assurance Research Exposure Form F1: To be completed by the applicant This section is to be completed by the applicant before submission of the application for Radiation Assurance. The HRA will
More informationClick Here to Continue. Click Here to Return to Table of Contents
Hippuran I 131 Injection Package inserts are current as of January, 1997. Contact Professional Services, 1-888-744-1414, regarding possible revisions Click Here to Continue Click Here to Return to Table
More informationThe PET-NET Study 2016 CNETS Grant Award
The PET-NET Study 2016 CNETS Grant Award CANM Meeting April 21, 2017 Hagen Kennecke, MD, MHA, FRCPC Medical Oncology, BC Cancer Agency Associate Professor, University of British Columbia Raja Ampat, Indonesia
More informationSodium Iodide I 131 Solution. Click Here to Continue. Click Here to Return to Table of Contents
Sodium Iodide I 131 Solution Package inserts are current as of January, 1997. Contact Professional Services, 1-888-744-1414, regarding possible revisions Click Here to Continue Click Here to Return to
More informationPlease follow all instructions carefully.
Nuclear Medicine Accreditation Program 1891 Preston White Drive, Reston VA 20191-4397 NUCLEAR MEDICINE TESTING INSTRUCTIONS General Instructions Please follow all instructions carefully. The enclosed labels
More informationImplementation of the 2012 ACR CT QC Manual in a Community Hospital Setting BRUCE E. HASSELQUIST, PH.D., DABR, DABSNM ASPIRUS WAUSAU HOSPITAL
Implementation of the 2012 ACR CT QC Manual in a Community Hospital Setting BRUCE E. HASSELQUIST, PH.D., DABR, DABSNM ASPIRUS WAUSAU HOSPITAL Conflict of Interest Disclaimer Employee of Aspirus Wausau
More informationNeuroendocrine Tumors Positron Emission Tomography (PET) Imaging and Peptide Receptor Radionuclide Therapy
Neuroendocrine Tumors Positron Emission Tomography (PET) Imaging and Peptide Receptor Radionuclide Therapy Lawrence Saperstein, M.D. Assistant Professor of Radiology and Biomedical Imaging Chief, Nuclear
More informationNONE. Disclosures. Accreditation Update
ACR Ultrasound Accreditation: Requirements and Pitfalls Presented to: American Association of Physicists in Medicine Presented by: Jennifer Walter RDMS,RVT, RT(R) ACR Quality & Safety August 03, 2016 Disclosures
More informationSUPPLEMENT TO CHAPTER 6: QUALITY MANAGEMENT
SUPPLEMENT TO CHAPTER 6: QUALITY MANAGEMENT Clinical Practice Parameters and Standards Sleep Medicine 4th Edition, October 2016 Supplement to Chapter 6 - Quality Management Guide to Selecting and Preparing
More information8/1/2017. Disclosures. Outline. SAM Imaging Education Course 90Y-Microsphere Therapy: Emerging Trends and Future Directions
SAM Imaging Education Course Y-Microsphere Therapy: Emerging Trends and Future Directions Matt Vanderhoek, PhD Henry Ford Health System, Detroit, MI Vanessa Gates, MS Northwestern University, Chicago,
More informationCT Optimisation for Paediatric SPECT/CT Examinations. Sarah Bell
CT Optimisation for Paediatric SPECT/CT Examinations Sarah Bell Sarah.bell14@nhs.net Outline 1. Introduction 2. Aims and Objectives 3. Methods 4. Results 5. Discussion 6. Conclusions 7. References Introduction
More informationNATIONAL HOUSEHOLD SURVEY BRIEF FERTILITY RATES OF OTTAWA'S JEWISH COMMUNITY
NATIONAL HOUSEHOLD SURVEY BRIEF FERTILITY RATES OF OTTAWA'S JEWISH COMMUNITY BY CHARLES SHAHAR APRIL 2015 2011 National Household Survey Brief Fertility Rates of Ottawa's Jewish Community This brief examines
More informationQA for Clinical Dosimetry with Emphasis on Clinical Trials
QA for Clinical Dosimetry with Emphasis on Clinical Trials Geoffrey S. Ibbott, Ph.D. and RPC Staff G. Ibbott, AAPM Summer School, June 24, 2009 1 QA Infrastructure for Clinical Trials Participating Institutions
More informationSimulations of Preclinical andclinical Scans in Emission Tomography, Transmission Tomography and Radiation Therapy. Using GATE
GATE Simulations of Preclinical andclinical Scans in Emission Tomography, Transmission Tomography and Radiation Therapy Using GATE Quick tour & Highlights! GATE Training, INSTN-Saclay, October 2015 Albertine
More informationAgenda: Dental Cone Beam Imaging
Cone Beam Imaging Agenda: Dental Cone Beam Imaging *Definition and Functionality *Usage and diagnostics benefits *Comparative radiation information *Federal regulatory responsibilities: manufacturing *State
More informationDianna Cody, PhD, DABR, FAAPM Professor & Clinical Operations Director Imaging Physics U.T. M.D. Anderson Cancer Center Houston, TX
Dianna Cody, PhD, DABR, FAAPM Professor & Clinical Operations Director Imaging Physics U.T. M.D. Anderson Cancer Center Houston, TX Learning Objectives: Limitations for estimating patient dose for CT Methods
More informationJournal of Radiation Research and Applied Sciences 8 (2015) 317e322. Available online at ScienceDirect
Journal of Radiation Research and Applied Sciences 8 (2015) 317e322 HOSTED BY Available online at www.sciencedirect.com ScienceDirect Journal of Radiation Research and Applied Sciences journal homepage:
More informationFMU-ICRP Workshop on Radiological Protection in Medicine Current Status in Radionuclide Therapy Tuesday, October 3, 2017 Makoto Hosono, MD PhD Kindai
FMU-ICRP Workshop on Radiological Protection in Medicine Current Status in Radionuclide Therapy Tuesday, October 3, 2017 Makoto Hosono, MD PhD Kindai University Faculty of Medicine, Osaka, Japan Current
More informationDRAXIMAGE SODIUM IODIDE I 131 CAPSULES, USP DIAGNOSTIC. For Oral Use DESCRIPTION
DRAXIMAGE SODIUM IODIDE I 131 CAPSULES, USP DIAGNOSTIC For Oral Use DESCRIPTION Sodium Iodide I 131 Capsules, USP are color-coded capsules containing sodium iodide I 131 for diagnostic use by oral administration.
More information1ª Jornada de Análisis de Riesgos en RT. 10 de Dic 2014 José Luis Roldán
Risk in Dosimetry. Industry Stand point 1ª Jornada de Análisis de Riesgos en RT. 10 de Dic 2014 José Luis Roldán Agenda IBA. IBA Dosimetry Risks in Dosimetry Product development Product manufacturing Product
More informationPeptide Receptor Radionuclide Therapy using 177 Lu octreotate
Peptide Receptor Radionuclide Therapy using 177 Lu octreotate BLR Kam, Erasmus Medical Centre, Rotterdam DJ Kwekkeboom, Erasmus Medical Centre, Rotterdam Legal aspects As 177 Lu-[DOTA 0 -Tyr 3 ]octreotate
More informationR: March, E D T P A. Kit for the Preparation of Technetium Tc 99m Pentetate Injection. DIAGNOSTIC - For Intravenous Use
R: March, 1998 27227 0002E m TM DESCRIPTION D T P A Kit for the Preparation of Technetium Tc 99m Pentetate Injection DIAGNOSTIC - For Intravenous Use Each kit consists of reaction vials which contain the
More informationSpecialised Services Policy CP66: 68-gallium DOTA- peptide scanning for the Management of Neuroendocrine Tumours (NETs)
Specialised Services Policy CP66: Management of Neuroendocrine Tumours (NETs) Document Author: Assistant Planner for Cancer and Blood Executive Lead: Director of Quality and Nursing Approved by: Management
More informationSite Planning and Design of PET/CT Facilities. Melissa C. Martin, M.S., FACR, FAAPM AAPM Annual Meeting, Orlando, FL August 2, 2006
Site Planning and Design of PET/CT Facilities Melissa C. Martin, M.S., FACR, FAAPM AAPM Annual Meeting, Orlando, FL August 2, 2006 Acknowledgements: AAPM Task Group #108 on PET and PET/CT Shielding Requirements
More informationIn Vivo Measurement and Characterization of a Novel Formulation of [ 177 Lu]-DOTA-Octreotate
In Vivo Measurement and Characterization of a Novel Formulation of [ 177 Lu]-DOTA-Octreotate Dale L Bailey 1,*, Thomas M Hennessy 2, Kathy P Willowson 3, E Courtney Henry 3, David LH Chan 1, Alireza Aslani
More informationEJNMMI Physics. Pedro L. Esquinas 1,2*, Ajit Shinto 3, Koramadai K. Kamaleshwaran 3, Jephy Joseph 3 and Anna Celler 1,2
Esquinas et al. EJNMMI Physics (2018) 5:30 https://doi.org/10.1186/s40658-018-0227-6 EJNMMI Physics ORIGINAL RESEARCH Open Access Biodistribution, pharmacokinetics, and organ-level dosimetry for 188 Re-AHDD-
More informationClick Here to Continue. Click Here to Return to Table of Contents
TechneScan Gluceptate Package inserts are current as of January, 1997. Contact Professional Services, 1-888-744-1414, regarding possible revisions. Click Here to Continue Click Here to Return to Table
More informationData sharing in Canada through the COGR:
Data sharing in Canada through the COGR: a unified clinical genome database as a community resource for standardizing and sharing genetic interpretations Dr. Matthew Lebo, Kathleen-Rose Zakoor, Dr. Jordan
More information8/3/2016. The EPID Strikes Back! - EPID In-Vivo Dosimetry. EPID Research Number of Publications. Why EPID in-vivo? Detectable errors: patient
Number of Publications Number of publications 8/3/2016 The Strikes Back! - In-Vivo Dosimetry AAPM, Washington D.C, USA, 2016 Peter Greer 1,2 (1) University of Newcastle, Australia, (2) Calvary Mater Newcastle,
More informationPHYS 383: Applications of physics in medicine (offered at the University of Waterloo from Jan 2015)
PHYS 383: Applications of physics in medicine (offered at the University of Waterloo from Jan 2015) Course Description: This course is an introduction to physics in medicine and is intended to introduce
More informationAdvanced Technology Consortium (ATC) Credentialing Procedures for 3D Conformal Therapy Protocols 3D CRT Benchmark*
Advanced Technology Consortium (ATC) Credentialing Procedures for 3D Conformal Therapy Protocols 3D CRT Benchmark* Purpose: To evaluate an institution s 3D treatment planning process and the institution
More informationCanadian Partnership for Quality Radiotherapy. Technical Quality Control Guidelines for Gamma Knife Radiosurgery. A guidance document on behalf of:
Canadian Partnership for Quality Radiotherapy Technical Quality Control Guidelines for Gamma Knife Radiosurgery A guidance document on behalf of: Canadian Association of Radiation Oncology Canadian Organization
More informationMONTE CARLO BASED SPECT ACTIVITY QUANTIFICATION AND TUMOR DOSIMETRY FOR 177 LU-DOTATATE TREATMENTS
SAHLGRENSKA ACADEMY MONTE CARLO BASED SPECT ACTIVITY QUANTIFICATION AND TUMOR DOSIMETRY FOR 177 LU-DOTATATE TREATMENTS Ida Marin Essay/Thesis: Program and/or course: Level: Semester/year: Supervisors:
More informationGALLIUM CITRATE Ga 67 INJECTION
511945-0903 September 2003 USA Bristol-Myers Squibb Medical Imaging 331 Treble Cove Road N. Billerica, MA 01862 USA GALLIUM CITRATE Ga 67 INJECTION FOR DIAGNOSTIC USE DESCRIPTION: Gallium Citrate Ga 67
More informationDosimetry in Targeted Radionuclide Therapy: The Bad Berka Dose Protocol Practical Experience
10.5005/jp-journals-10028-1058 REVIEW ARTICLE Dosimetry in Targeted Radionuclide Therapy: The Bad Berka Dose Protocol Practical Experience Christiane Schuchardt, Harshad Kulkarni, Carolin Zachert, Richard
More informationThe Physics of Oesophageal Cancer Radiotherapy
The Physics of Oesophageal Cancer Radiotherapy Dr. Philip Wai Radiotherapy Physics Royal Marsden Hospital 1 Contents Brief clinical introduction Imaging and Target definition Dose prescription & patient
More informationGUNDERSEN HEATLH SYSTEM NUCLEAR MEDICINE DEPARTMENT PROTOCOL MANUAL
GUNDERSEN HEATLH SYSTEM NUCLEAR MEDICINE DEPARTMENT PROTOCOL MANUAL PROCEDURE: POSITRON EMISSION TOMOGRAPHY (PET) SECTION: PET 12.1 ORIGINAL DATE: 2 13 02 DATE REVISED: 6 14-17 REVIEWED: ANNUAL 1 Indications
More informationStandardization of Radiopharmaceutical Dosimetry
Standardization of Radiopharmaceutical Dosimetry Jonathon A. Nye, PhD Department of Radiology and Imaging Sciences Emory University SEAAPM 2011 Myrtle Beach, SC Review of Dosimetry Nomenclature Dose Gray
More informationAustin Radiological Association Nuclear Medicine Procedure THERAPY FOR THYROID CANCER (I-131 as Sodium Iodide)
Austin Radiological Association Nuclear Medicine Procedure THERAPY FOR THYROID CANCER (I-131 as Sodium Iodide) Overview Indications I-131 therapy for Thyroid Cancer, of the papillo-follicular type, is
More informationDRAXIMAGE SODIUM IODIDE I 131 SOLUTION USP DIAGNOSTIC. For Oral Use DESCRIPTION
DRAXIMAGE SODIUM IODIDE I 131 SOLUTION USP DIAGNOSTIC For Oral Use DESCRIPTION Sodium Iodide I 131 Solution is an aqueous solution of sodium iodide I-131 for diagnostic use by oral administration. The
More information